Tag: 200-300

CsOH/γ-Al₂O₃: a heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4,6-diaryl pyrimidines was written by Ramana, Amey Nimkar M. M. V.;Betkar, Rahul;Ranade, Prasanna;Mundhe, Balaji. And the article was included in New Journal of Chemistry in 2016.HPLC of Formula: 40230-24-8 This article mentions the following:

New strategy for a one-pot synthesis of 2-amino-4,6-diaryl pyrimidines using CsOH/γ-Al₂O₃ as a heterogeneous, reusable basic catalyst was presented. Developed synthetic protocol for pyrimidines was a one-pot three-component reaction of acetophenone, aromatic aldehydes and guanidine hydrochloride in ethanol. Characterization of the catalyst CsOH/γ-Al₂O₃ was performed by using FT-IR, XRD, TG-DTA, SEM, BET surface area and CO₂-TPD anal. techniques. Anal. data prove that the catalyst had excellent reusability and also indicated their good thermal stability. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8HPLC of Formula: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Occurrence and variations of pharmaceuticals and personal-care products in rural water bodies: A case study of the Taige Canal (2018-2019) was written by Jiang, Xinshu;Zhu, Yongqing;Liu, Liquan;Fan, Xueqi;Bao, Yixiang;Deng, Shanshan;Cui, Yunxia;Cagnetta, Giovanni;Huang, Jun;Yu, Gang. And the article was included in Science of the Total Environment in 2021.Related Products of 1220-83-3 This article mentions the following:

A systematic monitoring campaign of pharmaceuticals and personal-care products (PPCPs) was performed in the Taige Canal basin, which is located in a rural area of the Yangtze River Delta. A total of 55 out of 61 monitored PPCPs were detected, with concentrations up to 647 ng/L. The maximum concentrations of 75% of monitored antibiotics and 80% of non-antibiotics were above the median values of previously reported maximum concentrations in China, indicating that the basin is heavily contaminated. It is estimated that the PPCP mass flow of the Taige Canal (0.06-0.58 kg/day) entering into Lake Taihu is similar to that of the influent of a wastewater treatment plant. Anal. of the seasonal variation shows that, during the wet season, the average total concentration of sulfonamides was 8 and 11 times that of the normal season and dry season, resp. The concentration of sulfachlorpyridazine accounted for 40.37% of total antibiotics, suggesting heavy pollution from the animal-breeding industry in this area. The PPCP mass flow rates observed in 2019 were lower than those of 2018 in the same season, and this interannual variation is mainly attributable to water pollution controls in the watershed. Combined anal. of ordination and clustering indicates that the distribution of PPCPs in the Taige Canal is affected by the confluence with Yong’an River and human activities such as water pollution control. Water-sediment distribution anal. demonstrates that the sediment-water distribution coefficients of quinolone and macrolide were higher than those of sulfonamide, lincosamide and chloramphenicol. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Related Products of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Related Products of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Palladium-catalyzed cross-coupling reaction of 2- and/or 5-substituted 4,6-dichloropyrimidines with arylboronic acids was written by Tumkevicius, S.;Dodonova, J.;Baskirova, I.;Voitechovicius, A.. And the article was included in Journal of Heterocyclic Chemistry in 2009.Quality Control of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

The Suzuki-Miyaura reaction of some 4,6-dichloropyrimidines bearing methylthio-, methyl-, amino-, cyano-, formyl-, and nitro groups in positions 2 and/or 5 of the pyrimidine ring with arylboronic acids has been investigated. Influence of palladium catalyst, ligand, base, and solvent on the reaction outcome was studied. The reaction was found to give the corresponding 4,6-diarylpyrimidines in reasonable yields using Pd(OAc)₂/PPh₃/K₃PO₄ or Pd(PPh₃)₂Cl₂/K₃PO₄ as catalyst systems. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Quality Control of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Quality Control of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Occurrence and distribution of antibiotics and antibiotic resistance genes in the guts of shrimp from different coastal areas of China was written by Li, Wei;Li, Yaying;Zheng, Ningguo;Ge, Chaorong;Yao, Huaiying. And the article was included in Science of the Total Environment in 2022.Formula: C11H12N4O3S This article mentions the following:

With the continuous increase in shrimp (Litopenaeus vannamei) aquaculture production, the widespread use of antibiotics as a means of preventing and treating diseases has adversely affected the environment, animal health and symbiotic microorganisms in gut environments. At the same time, antibiotic resistance genes (ARGs) are widespread in aquaculture and pose a great threat to aquatic organisms and humans. Therefore, in the present study, the occurrence and distribution of 17 antibiotics, ARGs and mobile genetic elements (MGEs) were detected in the guts of shrimp collected from 12 coastal regions of China. The results showed that sulfadiazine, ciprofloxacin and norfloxacin were detectable in the guts of L. vannamei at all sampling sites. Sul1, sul2, floR and intI-1 were also detected in the guts of L. vannamei at all sampling sites. The total relative abundances of ARGs and MGEs were significantly pos. correlated according to Pearson correlation anal. Sulfonamide resistance genes (sul1 and sul2) were significantly pos. correlated with intI-1. These results indicated that MGEs could increase the risk of horizontal gene transfer of ARGs in a gut environment. MGEs are the most important factors promoting the spread of ARGs. Correlation anal. showed that sulfadiazine was significantly pos. correlated with sul1 and sul2 and that fluoroquinolone antibiotics were significantly pos. correlated with floR, indicating that antibiotics could induce the production of ARGs. Network anal. indicated that Iamia and Alkaliphilus species may harbor the most antibiotic resistance genes, and these bacteria were closely related to the proliferation and spread of ARGs in a gut environment. Antibiotic use and the spread of ARGs in mariculture systems may have neg. effects on shrimp and human health. The use of antibiotics should be strictly regulated to control contaminants in mariculture systems, including pathogens and ARGs, thereby reducing potential risks to human health. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Formula: C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Accurate Quantification of Sulfonamide Metabolites in Goat Meat: A New Strategy for Minimizing Interaction between Sheep Serum Albumin and Sulfonamide Metabolites was written by Jia, Wei;Zhang, Min;Du, An;Zhang, Rong;Xu, Mudan;Shi, Lin. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Product Details of 1220-83-3 This article mentions the following:

To date, the determination of sulfonamide metabolites in animal-derived food has universal disadvantages of low throughput and no integrated metabolites involved. In this study, a powerful and reliable strategy for high-throughput screening of sulfonamide metabolites in goat meat was proposed based on an aqueous two-phase separation procedure (ATPS) combined with ultrahigh-performance liquid chromatog. quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap). Noncovalent interactions including van der Waals force, hydrogen bonding, and hydrophobic effect were determined to be staple interactions between the sulfonamide metabolites and sheep serum albumin by fluorescence spectroscopy and mol. docking technol., and an 80% acetonitrile-water solution/(NH₄)₂SO₄ was used as ATPS in order to release combined sulfonamide metabolites and minimize the influence of sheep serum albumin. Sulfonamide metabolites in the matrix were screened based on a mechanism of mass natural loss and core structure followed by identification combined with the pharmacokinetic. The developed strategy was validated according to EU standard 2002/657/EC with CCα ranging from 0.07 to 0.98μg kg^-1, accuracy recovery with 84-107%, and RSDs lower than 8.9%. Eighty seven goat meat samples were used for determination of 26 sulfonamides and 8 potential metabolites. On the basis of the established innovative process, this study has successfully implemented the comprehensive detection of sulfonamide metabolites, including N⁴-acetylated substitution, N⁴-hydroxylation, 4-nitroso, azo dimers, oxidized nitro, N⁴ monoglucose conjugation, β-D-glucuronide, and N-4-aminobenzenesulfonyl metabolites, which were shown to undergo oxidation, hydrogenation, sulfation, glucuronidation, glucosylation, and O-aminomethylation. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Product Details of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Product Details of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001 was written by Nagy, Mark A.;Hilgraf, Robert;Mortensen, Deborah S.;Elsner, Jan;Norris, Stephen;Tikhe, Jayashree;Yoon, Won;Paisner, David;Delgado, Mercedes;Erdman, Paul;Haelewyn, Jason;Khambatta, Godrej;Xu, Li;Romanow, William J.;Condroski, Kevin;Bahmanyar, Sogole;McCarrick, Meg;Benish, Brent;Blease, Kate;LeBrun, Laurie;Moghaddam, Mehran F.;Apuy, Julius;Canan, Stacie S.;Bennett, Brydon L.;Satoh, Yoshitaka. And the article was included in Journal of Medicinal Chemistry in 2021.SDS of cas: 59549-51-8 This article mentions the following:

This manuscript reported the synthesis and structure-activity relationship (SAR) studies for a novel series of JNK inhibitors demonstrating an increased JNK1 bias. SAR optimization on a series of 2,4-dialkylamino-pyrimidine-5-carboxamides, e.g. I resulted in the identification of compounds possessing low nanomolar JNK inhibitory potency, overall kinome selectivity, and the ability to inhibit cellular phosphorylation of the direct JNK substrate c-Jun. Optimization of physicochem. properties in this series resulted in compounds that demonstrated excellent systemic exposure following oral dosing, enabling in vivo efficacy studies and the selection of a candidate for clin. development, CC-90001, which is currently in clin. trials (Phase II) in patients with idiopathic pulmonary fibrosis (NCT03142191). In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-4-(methylthio)pyrimidine (cas: 59549-51-8SDS of cas: 59549-51-8).

5-Bromo-2-chloro-4-(methylthio)pyrimidine (cas: 59549-51-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 59549-51-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Antibiotics in elderly Chinese population and their relations with hypertension and pulse pressure was written by Li, Zhenkun;Liu, Kaiyong;Zhao, Jianing;Yang, Linsheng;Chen, Guimei;Liu, Annuo;Wang, Qunan;Wang, Sufang;Li, Xiude;Cao, Hongjuan;Tao, Fangbiao;Zhang, Dongmei. And the article was included in Environmental Science and Pollution Research in 2022.Electric Literature of C11H12N4O3S This article mentions the following:

Although antibiotic exposure in the general population has been well documented by a biomonitoring approach, epidemiol. data on the relationships between urinary antibiotic burden in the elderly with blood pressure (BP) are still lacking. The current study revealed thirty-four antibiotics in urine specimens from 990 elderly patients in Lu’an City, China, with detection frequencies ranging from 0.2 to 35.5%. Among the elderly, the prevalence of hypertension was 72.0%, and 12 antibiotics were detected in more than 10% of individuals with hypertension. The elderly with hypertension had the maximum daily exposure (5450.45μg/kg/day) to fluoroquinolones (FQs). Multiple linear regression analyses revealed significant associations of BP and pulse pressure (PP) with exposure to specific antibiotics. The estimated β values (95% confidence interval) of associations with systolic blood pressure (SBP) in the right arm were 4.42 (1.15, 7.69) for FQs, 4.26 (0.52, 8.01) for the preferred as human antibiotics (PHAs), and 3.48 (0.20, 6.77) for the mixtures (FQs + tetracyclines [TCs] (tertile 3 vs. tertile 1)), resp. Increased concentrations of TCs were associated with decreased diastolic BP (DBP; tertile 3: -1.75 [-3.39, -0.12]) for the right arm. Higher levels of FQs (tertile 3: 4.28 [1.02, 7.54]), PHAs (tertile 3: 4.25 [0.49, 8.01]), and FQs + TCs (tertile 3: 3.99 [0.71, 7.26]) were associated with increased SBP, and an increase in DBP for FQs (tertile 3: 1.82 [0.22, 3.42]) was shown in the left arm. Also, higher urinary concentrations of FQs (tertile 3: 3.18 [0.53, 5.82]), PHAs (tertile 3: 3.42 [0.40, 6.45]), and FQs + TCs (tertile 3: 3.06 [0.40, 5.72]) were related to increased PP, whereas a decline in PP for TCs (tertile 2: -2.93 [-5.60, -0.25]) in the right arm. And increased concentrations of penicillin V (tertile 3: 5.31 [1.53, 9.10]) and FQs + TCs (tertile 3: 2.84 [0.19, 5.49]) were related to higher PP in the left arm. By utilizing restricted cubic splines, our current study revealed a potential nonlinear dose-response association between FQ exposure and hypertension risk. In conclusion, this investigation is the first to present antibiotic exposure using a biomonitoring approach, and informs understanding of impacts of antibiotic residues, as emerging hazardous pollutants, on the hypertension risk in the elderly. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Electric Literature of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Electric Literature of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis with pyrimidinyllithium compounds and properties of a series of 4,4′- and 4,5′-bipyrimidine derivatives was written by Strekowski, Lucjan. And the article was included in Seria Chemia (Uniwersytet im. Adama Mickiewicza w Poznaniu) in 1976.Name: 5-Bromo-2-chloro-4-(methylthio)pyrimidine This article mentions the following:

4,5′-Bipyrimidines with methoxy or methylthio substituents at positions 4′ and 6 were prepared In a typical run, a 5-bromo-4-methoxypyrimidine was treated with ∼0.6-0.8 molar equivalent BuLi, kept, then quenched with H2O. 5-Bromo-2,4-bis(alkylthio)pyrimidines and 5-bromo-2,4-di-tert-butoxypyrimidine (I) in THF gave rise to mixtures of 4,4′- and 4,5′-bipyrimidine, but in Et2O I gave rise to the 4,5′-bipyrimidine only. The bipyrimidines can be formed through the nucleophilic addition of pyrimidinyl-lithiums to 4,5-didehydropyrimidines or to the N(1)-C(6) azomethine bond in the pyrimidine ring of the substrates. 5-Bromo-2,4-dichloropyrimidine on treatment with controlled quantities of nucleophiles, such as alkoxide and alkylmercaptide anions and secondary amines, could exchange its Cl at position 4 with high selectivity. A nucleophilic displacement of the Cl at position 2 in the products gave rise to 5-bromopyrimidines with various substituents at positions 2 and 4. Mass spectra of the pyrimidine derivatives were reported. Some of the compounds showed unusual decomposition patterns of the mol. ions. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-4-(methylthio)pyrimidine (cas: 59549-51-8Name: 5-Bromo-2-chloro-4-(methylthio)pyrimidine).

5-Bromo-2-chloro-4-(methylthio)pyrimidine (cas: 59549-51-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Name: 5-Bromo-2-chloro-4-(methylthio)pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Nickel-Catalyzed Synthesis of Pyrimidines via Dehydrogenative Functionalization of Alcohols was written by Chakraborty, Gargi;Sikari, Rina;Mondal, Rakesh;Mandal, Sutanuva;Paul, Nanda D.. And the article was included in Asian Journal of Organic Chemistry in 2020.Recommanded Product: 40230-24-8 This article mentions the following:

Herein, a comparative study of nickel-catalyzed syntheses of pyrimidines via dehydrogenative multi-component coupling of alcs. and amidines using two different classes of nickel catalysts differing with respect to their mode of action during catalysis is reported. The catalysts are either two tetracoordinate Ni(II)-complexes containing two apparently redox-inactive tetraaza macrocyclic ligands or square planar Ni(II)-complexes featuring redox-active diiminosemiquinonato type scaffolds. Tetracoordinate Ni(II) catalysts dehydrogenate alcs. via a two-electron hydride transfer pathway involving energetically demanding nickel-centered redox events while in the presence of square planar Ni(II)-complexes dehydrogenation of alcs. proceeds via a one-electron hydrogen atom transfer (HAT) pathway via synergistic participation of metal and ligand centered redox processes avoiding high energy nickel centered redox events. Detailed substrate screening and control experiments were performed to unveil the reaction sequence and understand the advantages/disadvantages of these two pathways. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Removal of refractory organic pollutants by cobalt-doped graphene aerogel activated peroxymonosulfate oxidation was written by Li, Yukun;Chao, Cong;Zhang, Dan;Chen, Qishi;Sun, Junhong. And the article was included in Materials Science in Semiconductor Processing in 2022.Synthetic Route of C11H12N4O3S This article mentions the following:

Recently, peroxymonosulfate-based advanced oxidation process has been widely applied in the removal of refractory organic pollutants. In the present study, cobalt-doped graphene aerogel (Co-GA) composites have been fabricated as a promising activator for peroxymonosulfate (PMS) via in-situ synthesis successfully. The phys.-chem. properties of composite catalysts were carefully characterized and the activation performance was evaluated by the degradation of sulfamonomethoxine (SMM), ciprofloxacin (CIP), sulfanilamide (SN) and rhodamine B (RhB) aqueous solution, resp. The results showed that Co-GA could effectively degrade refractory organics and keep macroscopic morphol. intact under the reaction conditions of 15 mg/L simulated wastewater, 0.3 g/L PMS, 0.2 g/L Co-GA. Furthermore, the effect of reaction parameters on SMM degradation was investigated. Co-GA/PMS system exhibited consistent performance over a wide pH range (3-11). The degradation mechanism of SMM is free radical oxidation dominated by sulfate radical (SO^•-₄) combined with non-radical reaction initiated by GA. Benefiting from its flexibility and recyclability, the as-prepared Co-GA is suitable for practical wastewater purification In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia