Tag: 200-300

Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2-Aminopyrimidines with Selectfluor was written by Wang, Chenxi;Cai, Juewang;Zhang, Min;Zhao, Xiaoming. And the article was included in Journal of Organic Chemistry in 2017.COA of Formula: C16H13N3 This article mentions the following:

In the presence of Ag₂CO₃, arylpyrimidinamines I (R = Ph, 4-MeC₆H₄, 4-FC₆H₄; R¹ = PhCH₂, 4-MeC₆H₄CH₂, 4-FC₆H₄CH₂; R = R¹ = Ph, 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 3-ClC₆H₄, 4-MeC₆H₄, 2-thienyl; R² = H) underwent regioselective fluorination with Selectfluor® in MeCN to yield 5-fluoro-2-pyrimidinamines I (R = Ph, 4-MeC₆H₄, 4-FC₆H₄; R¹ = PhCH₂, 4-MeC₆H₄CH₂, 4-FC₆H₄CH₂; R = R¹ = Ph, 4-FC₆H₄,4-ClC₆H₄, 4-BrC₆H₄, 3-ClC₆H₄, 4-MeC₆H₄, 2-thienyl; R² = F) in 44-72% yields. The structures of I (R = Ph; R¹ = PhCH₂; R² = F), I (R = R¹ = 2-thienyl; R² = F), and of the tetrasilver perchlorate complex of I (R = R¹ = Ph; R² = H) with Ph₂PCH₂PPh₂ were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Rapid and ultra-trace levels analysis of 33 antibiotics in water by on-line solid-phase extraction with ultra-performance liquid chromatography-tandem mass spectrometry was written by Shen, Fei;Xu, Yan-Juan;Wang, Ye;Chen, Jing;Wang, Shuo. And the article was included in Journal of Chromatography A in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

A method was developed for the determination of 33 antibiotics belonging to 4 different antibiotic groups, including sulfonamides (16), fluoroquinolones (12), macrolides (1), and tetracyclines (4) in water samples using online solid-phase extraction-ultra performance liquid chromatog.-electrospray ionization tandem mass spectrometry (online SPE-UPLC-MS/MS). The enrichment and anal. conditions were optimized for the determination of trace concentrations (nanogram per L). Aliquots of the water samples (5 mL) were filtered through a membrane and enriched on an online polymeric column with hydrophilic-lipophilic balance (HLB). The analyte was eluted by the mobile phase during online SPE and separated on an Acquity BEH130 column, detected by tandem mass spectrometry, and quantified using an external standard method. The optimization of the anal. methods was discussed, which included optimization of pH of the sample, filtration membrane, Na2EDTA, chromatog. column, formic acid and aqueous ammonia in mobile phase. The detection limit for all test compounds by this method was in the range of 0.2-1.5 ng/L, with recoveries of 76.6-118%. The precision of the method, as indicated by the relative standard deviation, was 2.4-7.9%. Results of anal. of surface water samples demonstrated the ability of the proposed method to analyze ultra-trace levels of antibiotics, without the need for complex manual pretreatment. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Development and validation of a multiclass confirmatory method for the determination of over 60 antibiotics in eggs using liquid-chromatography high-resolution mass spectrometry was written by Paoletti, Fabiola;Sdogati, Stefano;Barola, Carolina;Giusepponi, Danilo;Moretti, Simone;Galarini, Roberta. And the article was included in Food Control in 2021.Category: pyrimidines This article mentions the following:

A multiclass method for the determination of antimicrobial substances in eggs has been developed and validated, covering sixty-three antibiotics belonging to ten families. After extraction with acidified acetonitrile and EDTA, the analytes were injected into a liquid-chromatog. high-resolution mass-spectrometry system operating in pos. ionization mode. The procedure was successfully validated as confirmatory method evaluating selectivity, linearity, precision, recovery, decision limit, detection capability, limits of detection and quantitation. The here developed is the first method including all the antibiotics with Maximum Residue Limit (MRL) in eggs, except very polar drugs (aminoglycosides and colistins), which require specific protocols. Finally, a wide survey was carried out analyzing 100 com. eggs samples from local markets. Only 3% contained residues of authorized substances at concentrations ower than the relevant MRLs. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Category: pyrimidines).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chemotherapy. XII. Some sulfanilamido heterocycles was written by Clark, J. H.;English, J. P.;Winnek, P. S.;Marson, H. W.;Cole, Q. P.;Clapp, J. W.. And the article was included in Journal of the American Chemical Society in 1946.Reference of 40230-24-8 This article mentions the following:

2-Sulfanilamido-4-methoxypyrimidine (I) (C.A. 36, 2532.9) (40 g.) in 400 cc. MeOH and 200 g. NH₃, heated at 110° for 1 h., gives 57% of 2-sulfanilamido-4-aminopyrimidine, m. 225-6° (m.ps. corrected) (C.A. 37, 1402.2). 2-Amino-4-methoxypyrimidine did not react with NH₃ under these conditions; at 200° for 4 h., 2,4-diaminopyrimidine is formed. I (8 g.) and 3.8 g. Et₂N(CH₂)₃NH₂, heated at 100-10° for 45 min., give 45% of 2-sulfanilamido-4-(3-diethylaminopropylamino)pyrimidine, m. 230-2°. Guanidine carbonate (II) (18 g.) and EtOCH₂COCH₂Ac, heated 4 h. on the steam bath, give 69% of 2-amino-4-ethoxymethyl-6-methylpyrimidine, m. 106-8°; the 2-sulfanilamido compound, m. 158-60°, 40%. II (25 g.) and 46.4 g. CH₂Bz₂, heated 3 h. at 180-210°, give 39% of 2-amino-4,6-diphenylpyrimidine, m. 135-7°; 2-sulfanilamido compound, m. 266-8°. The Na salt of 2,2-dimethyl-1,3-dioxolane-4-methanol in 200 cc. dioxane and 20 g. 2-amino-4-chloropyrimidine (extracted with the dioxane in a Soxhlet apparatus by refluxing overnight) give 70% of 2-amino-4-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)pyrimidine, m. 105°; this yields 51% of the N⁴-Ac derivative, m. 249-51°, of the 2-sulfanilamido compound, m. 228-30°. II (50 g.), 43.2 g. of the Cu salt of 4,4-dimethyl-1,3-pentanedione, and 100 cc. EtOH, refluxed 1 h., the residue heated with stirring at 150-70° for 2 h., the cooled mass broken up under 500 cc. 1:4 HCl, the filtrate made basic with NH₄OH, and the precipitate refluxed with hexane, give 44% of 2-amino-4-tert-butylpyrimidine, m. 103-5.5°; the free ketone gives only 18%; 2-sulfanilamido compound, m. 236-7°, 45%; the N⁴-Ac derivative m. 248-51°, 63%. 2-Aminopyrimidine gives 50% of the N⁴-Ac derivative, m. 268°, of 2-(2-methylsulfanilamido)pyrimidine, m. 243-6°. II (10.6 g.) and 13.5 g. 3-methyl-2,4-pentanedione, heated at 150-60° for 1.5 h., give 65% of 2-amino-4,5,6-trimethylpyrimidine, m. 206-7°; 2-sulfanilamido compound, m. 242-4° (N⁴-Ac derivative, m. 286-8°). 2-Aminothiazole (100 g.), added to 200 cc. 20% oleum with cooling during 1 h., heated on a steam bath for 2 h., and poured into 450 cc. H₂O, give 69% of 2-amino-5(or 4)-thiazolesulfonic acid, m. 248° (analyzed as the Ba salt); 2-sulfanilamido comp., m. 258°. 2-Amino-4-methyl-5-thiazolesulfonic acid did not react with 4-AcNHC₆H₄SO₂Cl. H₂NNHCONH₂ (4.6 g.) and 12.7 g. EtO₂CCH₂COCl, heated at 60-70° for 30 min., give 37% of Et 2-amino-1,3,4-thiadiazole-5-acetate, m. 158-60°; coupling and hydrolysis give 2-sulfanilamido-1,3,4-thiadiazole-5-acetic acid, m. 209-12°. Et 2-amino-1,3,4-thiadiazole-5-butyrate, m. 153-4° (41%), yields 2-sulfanilamido-1,3,4-thiadiazole-5-butyric acid, m. 185.5-6.5°. Data are given for the maximum blood level (mg.-% following a single oral dose of 0.5 g. per kg.), bacteriostatic, and antimalarial activities. Only the tri-Me derivative approaches the activity of sulfadiazine in the bacteriostatic test; the extremely low relative activities of the others serve to point out that other factors in addition to the acidity of the compounds in question are important. Simple alkyl substitution of the pyrimidine ring or of the sulfanilamide nucleus does not markedly affect the maximum blood level as compared with sulfadiazine; more complicated substituents reduce this value somewhat; the value is still further reduced by amino substitution; the sulfonic acid group reduces the maximum blood level of sulfathiazole. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Reference of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Reference of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate was written by Wang, Jiawang;Zhao, Jianhong;Gong, Hegui. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Related Products of 257280-25-4 This article mentions the following:

This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with Me tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4Related Products of 257280-25-4).

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 257280-25-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Molybdenum disulfide (MoS₂): A novel activator of peracetic acid for the degradation of sulfonamide antibiotics was written by Wang, Jingwen;Wang, Zongping;Cheng, Yujie;Cao, Lisan;Bai, Fan;Yue, Siyang;Xie, Pengchao;Ma, Jun. And the article was included in Water Research in 2021.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Sulfonamide antibiotics (SAs) are typical antibiotics and have attracted increasing concerns about their wide occurrence in environment as well as potential risk for human health. In this study, we applied a novel advanced oxidation process in SAs degradation by combining molybdenum sulfide and peracetic acid (MoS₂/PAA). Reactive oxygen species (ROS) including HO•, CH₃C(O)O•, CH₃C(O)OO•, and ¹O₂ were generated from PAA by MoS₂ activation and contributed to SAs degradation The effects of initial pH, the dosages of PAA and MoS₂, and humic acid for SAs degradation were further evaluated by selecting sulfamethoxazole (SMX) as a target SA in the MoS₂/PAA process. Results suggested that the optimum pH for SMX removal was 3, where the degradation efficiency of SMX was higher than 80% after reaction for 15 min. Increasing PAA (0.075-0.45 mM) or MoS₂ (0.1-0.4 g/L) dosages facilitated the SMX degradation, while the presence of humic acids retarded the SMX removal. This MoS2/PAA process also showed good efficiencies in removing other SAs including sulfaguanidine, sulfamonomethoxine and sulfamerazine. Their possible degradation pathways were proposed based on the products identification and DFT calculation, showing that apart from the oxidation of amine groups to nitro groups in SAs, MoS₂/PAA induced SO₂ extrusion reaction for SAs that contained six-membered heterocyclic moieties. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Solution-phase parallel synthesis using ion-exchange resins was written by Suto, Mark J.;Gayo-Fung, Leah M.;Palanki, Moorthy S. S.;Sullivan, Robert. And the article was included in Tetrahedron in 1998.Recommanded Product: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate This article mentions the following:

Ion-exchange resins are useful as scavengers in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins to facilitate the formation of products and to remove reaction byproducts. Acidic ion-exchange resins have been used as selective amine scavengers in the synthesis of urea and amine libraries. Several compound libraries have been prepared using the basic ion-exchange resin Amberlyst 21 as part of our lead optimization program. The utility of ion-exchange resins as a means of generating both large and small focused libraries is reviewed. In the experiment, the researchers used many compounds, for example, Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6Recommanded Product: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate).

Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Changes of antibiotic occurrence and hydrochemistry in groundwater under the influence of the South-to-North Water Diversion (the Hutuo River, China) was written by Wang, Jialin;Zhang, Chong;Xiong, Ling;Song, Guangdong;Liu, Fei. And the article was included in Science of the Total Environment in 2022.Computed Properties of C11H12N4O3S This article mentions the following:

The occurrence of antibiotics in groundwater has significant spatial variability, owing to the complexity of pollutant properties, pollution sources and groundwater recharge and discharge conditions. This study aimed to identify the relationship between antibiotic occurrence and hydrochem. in groundwater. Thus, we undertook this study in a characteristic alluvial-diluvial aquifer where groundwater receives unidirectional recharge from surface water. In total, 47 samples were collected from the Hutuo River before and after an artificial replenishment project. We screened up to four classes of antibiotics and detected 28 types. The statistical anal. of antibiotic concentrations, indicated that there were two pollution areas. Next, we discussed the results pertaining to the occurrence and source of antibiotics by comparing them with hydrochem. data. In the study area, a pos. correlation has been found between inorganic compounds, as SO₄^2-and Cl^–, and the most mobile antibiotics given that both share the same source. This shows that a previous sound geochem. study may provide evidence of the extend of antibiotic occurrence, as in the Hutuo River aquifer. The relationship between antibiotics and hydrochem. in groundwater is determined by recharge sources (rainwater and surface water contaminated with antibiotics). Antibiotics from wastewater treatment plants enter groundwater indirectly through surface water with high SO₄^2- in lightly polluted areas, while in heavily polluted areas, there are high concentrations of inorganic components in garbage leachate and wastewater leakage that carry antibiotics directly into groundwater. In summarized, the relationship between antibiotics and hydrochem. observed in this study shows that a previous sound geochem. study may provide evidence of the extend of antibiotic occurrence. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Computed Properties of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Computed Properties of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cropping system exerts stronger influence on antibiotic resistance gene assemblages in greenhouse soils than reclaimed wastewater irrigation was written by Liu, Yuan;Neal, Andrew L.;Zhang, Xiaoxian;Fan, Haiyan;Liu, Honglu;Li, Zhongyang. And the article was included in Journal of Hazardous Materials in 2022.Category: pyrimidines This article mentions the following:

The effects of reclaimed wastewater (RW) irrigation on the spread of antibiotic resistance genes (ARGs) in soil is modulated by a myriad of biotic and abiotic factors and their relative significance remains vague. We compared microbial communities, assemblages of genes associated with microbial resistance to antibiotics, biocides and metals, and insertion sequences (ISs) in soils following 16 years of irrigation with groundwater (GW), RW or alternately with GW and RW in two greenhouses with different cropping systems, using shotgun metagenome sequencing. The results showed that cropping system exerted greater influence than irrigation on the profile of ISs and resistance genes. This influence was most strongly associated with concentrations of copper, mercury and perfloxacin in the soils. There was no significant difference in soil ARG profiles between continuous RW irrigation and alternating GW and RW irrigation. Proteobacteria, Actinobacteria and Firmicutes and a limited number of ISs were closely associated with the detected ARGs. Most ARGs were found to co-occur with metal and biocide resistance genes through the mechanism of efflux pumps. These findings highlight the significance of understanding and improving crop management in mitigating the dissemination of ARGs in soils irrigated with RW. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Category: pyrimidines).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Suspect screening and untargeted analysis of veterinary drugs in food by LC-HRMS: Application of background exclusion-dependent acquisition for retrospective analysis of unknown xenobiotics was written by Zhu, Chunyan;Lai, Guoyin;Jin, Ying;Xu, Dunming;Chen, Jiayun;Jiang, Xiaojuan;Wang, Suping;Liu, Guoqiang;Xu, Niusheng;Shen, Rong;Wang, Luxiao;Zhu, Mingshe;Wu, Caisheng. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The presence of veterinary drug and pesticide residues in food products pose considerable threats to human health. Monitoring of these residues in food is mainly carried out using targeted anal. by triple quadrupole mass spectrometry. However, these methods are not suitable for suspect screening and untargeted anal. of unknowns. The main objectives of this study were to develop a new high-resolution mass spectrometry (HRMS)-based anal. strategy for retrospective anal. of suspect and unknown xenobiotics and to evaluate its performance in the tentative identification of 48 veterinary drugs as “unknowns” spiked in a pork sample. In the anal., a newly developed background exclusion data-dependent acquisition (BE-DDA) technique was employed to trigger the product ion (MS/MS) spectral acquisition of the “unknowns”, and an inhouse precise-and-thorough background-subtraction (PATBS) technique was applied to detect these “unknowns”. Showed that untargeted data mining of the acquired LC-MS dataset by PATBS was able to find all the 48 veterinary drugs and 46 of them were triggered by BE-DDA to generate accurate MS/MS spectra. The dataset of recorded accurate full-scan mass and MS/MS spectra of all the xenobiotics of the test pork sample is defined as the xenobiotics profile. Searching the xenobiotic profile of the test pork sample using mass spectral data of selected veterinary drugs (as suspects) from the mzCloud spectral library led to the correct hits. Searching against the mzCloud spectral library using the mass spectral data of selected individual veterinary drugs (as unknowns) from the xenobiotics profile tentatively confirmed their identities. In contrast, anal. of the same sample using ion intensity-data dependent acquisition only recorded the MS/MS spectra for 34 veterinary drugs. In addition, a data independent acquisition method enabled the acquisition of the fragment spectra for 44 veterinary drugs, but their spectral data displayed only one or a few true product ions of individual analytes of interest along with many fragments from coeluted biol. components and background noises. This study demonstrates that this anal. strategy has a potential to become a practical tool for the retrospective suspect screening and untargeted anal. of unknown xenobiotics in a biol. sample such as veterinary drugs and pesticides in food products. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia