Tag: 200-300

Yang, Yang et al. published their research in Organic Letters in 2014 | CAS: 187035-79-6

Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 187035-79-6

Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides was written by Yang, Yang;Niedermann, Katrin;Han, Chong;Buchwald, Stephen L.. And the article was included in Organic Letters in 2014.HPLC of Formula: 187035-79-6 This article mentions the following:

The highly selective palladium-catalyzed Negishi coupling of secondary alkylzinc reagents with heteroaryl halides is described [e.g., using a palladacycle precatalyst ligated by CPhos, 3-chlorobenzisothiazole was coupled with i-PrZnBr.LiCl to afford 3-isopropylbenzisothiazole in 78% yield (normal:rearranged ratio = 98:2)]. The development of a series of biarylphosphine ligands has led to the identification of an improved catalyst for the coupling of electron-deficient heterocyclic substrates. Preparation and characterization of oxidative addition complex (L)(Ar)PdBr provided insight into the unique reactivity of catalysts based on CPhos-type ligands in facilitating challenging reductive elimination processes. In the experiment, the researchers used many compounds, for example, Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6HPLC of Formula: 187035-79-6).

Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 187035-79-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Yan, Xiao-Ting et al. published their research in Science of the Total Environment in 2022 | CAS: 1220-83-3

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 1220-83-3

Hypothetical scenarios estimating and simulating the fate of antibiotics: Implications for antibiotic environmental pollution caused by manure application was written by Yan, Xiao-Ting;Zhai, Yun-Qiu;Cai, Ya-ya;Guo, Zhao;Zhang, Qian-Qian;Ying, Guang-Guo. And the article was included in Science of the Total Environment in 2022.Recommanded Product: 1220-83-3 This article mentions the following:

The application of animal manure containing antibiotic residues as an organic fertilizer to farmlands, poses a major threat to the health of river basin ecosystems. Waste treatment processes can help reduce antibiotic pollution levels in river basins following manure application, but the overall influence of these processes remains unclear. This study evaluates the impact of manure treatment methods on the emission and subsequent river pollution caused by 14 frequently detected antibiotics in a typical pig breeding area in China, by using hypothetical scenarios method. Three scenarios were constructed based on possible fate pathways of antibiotics, representing in 47.0, 55.3, and 81.6 ton·yr-1 antibiotic emissions into the river basin. The soil and water assessment tool (SWAT) model successfully simulated the transport of antibiotics from farmland to surface water, with calibration and verification performed using hydrol. station monthly data over 8 consecutive years. Field measured concentrations also verified the reliability of the model and were used to determine the most realistic scenario. In basins applied with manure, environmental antibiotic pollution is most affected by the wastewater treatment process and manure applied patterns, followed by changes in streamflow. The antibiotic pollution in manure applied areas showed significant spatial and temporal differences, resulting from the different manure application patterns. The simulated total outflow of antibiotics in the river basin accounted for 18.1% of the inflow, with the loss of target antibiotics by degradation, volatilization and sedimentation deposition in the river basin being 0.23, 0.01 and 33.2 ton·yr-1, resp. This study can help to clarify the environmental fate of antibiotics in the basin following manure application, provide guidance for policy makers and help to design the effective corrective interventions for reducing the environmental pollution. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Lehotay, Steven J. et al. published their research in Analytical and Bioanalytical Chemistry in 2021 | CAS: 1220-83-3

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Category: pyrimidines

Comparison of four different multiclass, multiresidue sample preparation methods in the analysis of veterinary drugs in fish and other food matrices was written by Lehotay, Steven J.;Lightfield, Alan R.. And the article was included in Analytical and Bioanalytical Chemistry in 2021.Category: pyrimidines This article mentions the following:

In 2018, AOAC International issued Standard Method Performance Requirements (SPMR) 2018.010 – Screening and Identification Method for Regulated Veterinary Drug Residues in Food. In response, we compared 4 different multiresidue methods of sample preparation using the same anal. method entailing ultrahigh-performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS). Tilapia was chosen for testing, and the analytes and monitoring levels were from SPMR 2018.010. The methods consist of efficient procedures with published validation results from the US Department of Agriculture (USDA), Food and Drug Administration (FDA), and Canadian Food Inspection Agency (CFIA), and an enhanced-matrix removal (EMR)-Lipid protocol from China. Each method was used to prepare 102 final extracts of tilapia spiked or not at different levels with the 78 targeted analytes plus metabolites. The same FDA/USDA rules of mass spectral identification were employed in all analyses to assess rates of false positives and negatives. Quant. accuracy of the methods was also compared in terms of recoveries and reproducibility of spiked tilapia, incurred catfish, and spiked and certified reference material of bovine muscle. Each method yielded generally acceptable results for the targeted veterinary drugs, but the USDA “extract & inject” method was the fastest, simplest, and cheapest to achieve equally or more acceptable results for the widest scope of analytes for the tested food matrixes. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Category: pyrimidines).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Li, Bo et al. published their research in Tetrahedron Letters in 2020 | CAS: 257280-25-4

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C10H7BrN2O

Microwave-assisted synthesis of 2,5-disubstituted pyrimidine derivatives via Buchwald-Hartwig amination was written by Li, Bo;Etheve-Quelquejeu, Melanie;Yen-Pon, Expedite;Garbay, Christiane;Chen, Huixiong. And the article was included in Tetrahedron Letters in 2020.Formula: C10H7BrN2O This article mentions the following:

Various 2,5-disubstituted pyrimidine derivatives I (R = 4-cyanophenyl, 3-tert-butyl-1-methyl-1H-pyrazol-5-yl, 4-[ethoxy(oxo)methane]phenyl, etc.; R1 = H; RR1 = -(CH2)2O(CH2)2-, -(CH2)2CH(N-(CH2)4-)(CH2)2-; R2 = H, Ph, dimethylaminyl, 4-cyclohexylpiperazin-1-yl, etc.) were synthesized under microwave irradiation via Buchwald-Hartwig amination. This concise approach provides interesting scaffolds in good to high yields and with large functional group compatibility. These novel chem. entities could be used as building blocks in drug design. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4Formula: C10H7BrN2O).

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C10H7BrN2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gallagher, John F. et al. published their research in Acta Crystallographica, Section C: Crystal Structure Communications in 2004 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Product Details of 40230-24-8

N-H…N hydrogen bonding in 4,6-diphenyl-2-pyrimidinylamine isolated from the plant Justicia secunda (Acanthaceae) was written by Gallagher, John F.;Goswami, Shyamaprosad;Chatterjee, Baidyanath;Jana, Subrata;Dutta, Kalyani. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2004.Product Details of 40230-24-8 This article mentions the following:

The title compound, C16H13N3, isolated from Justicia secunda (Acanthaceae), comprises two mols. (which differ slightly in conformation) in the asym. unit of space group P1̅. Crystallog. data are given. Intermol. Namino-H…Npyrm interactions (Npyrm is a pyrimidine ring N atom) involve only one of the two donor amino H atoms and pyrimidine N atoms per mol., forming dimeric units via R22(8) rings, with N…N distances of 3.058(2) and 3.106(3) Å, and N-H…N angles of 172.7(18) and 175.8(17)°. The dimers are linked by C-H…π(arene) contacts, with an H…centroid distance of 2.77 Å and a C-H…centroid angle of 141°. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Product Details of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Product Details of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sengar, Ragini et al. published their research in International Journal of Chemical Sciences in 2007 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 4,6-Diphenylpyrimidin-2-amine

Synthesis and characterization of some pyrimidine compounds was written by Sengar, Ragini;Tyagi, Sushma;Gazal, Umaima;Pathak, Vishal;Verma, Ranu;Pathak, P.. And the article was included in International Journal of Chemical Sciences in 2007.Name: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Some pyrimidine compounds have been synthesized via heterocyclization of dibromochalcones. The structures of the prepared compounds were characterized using elementary anal., IR, NMR and mass spectrometry. Fragmentation patterns for these compounds were given. The important IR-bands were assigned to the corresponding groups. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Name: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Okafor, Charles O. et al. published their research in European Journal of Medicinal Chemistry in 1977 | CAS: 63931-22-6

5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine (cas: 63931-22-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine

Studies in the heterocyclic series. XIII. New CNS-depressants derived from 1,9-diazaphenoxazine and two isomeric triazaphenothiazine ring systems was written by Okafor, Charles O.;Steenberg, Marie L.;Buckley, Joseph P.. And the article was included in European Journal of Medicinal Chemistry in 1977.Safety of 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine This article mentions the following:

Triazaphenothiazines I (R = NH2, H, SMe, OMe; R1 = NH2, Me, Cl, OH, OMe) and II (R = H, NH2, Cl; R1 = NH2, OH, Cl; R2 = MeO, Cl) were prepared in 78-93% yield. Reaction of 2-amino-3-mercapto-6-picoline with 2-amino-5-bromo-4-chloro-6-methylpyrimidine in the presence of H2SO4 and Na2SO3 gave 77% I (R = NH2, R1 = Me). All I and II showed appreciable CNS depressant activities comparable with the activity of chlorpromazine when tested in mice and rats; I (R = H, R1 = NH2) and II (R = R1 = Cl, R2 = MeO) were the most promising. All I and II decreased motor activity and rate of respiration within 30 min and body temperature was decreased by 0.5-1.9° compared to 0.8° with chlorpromazine. In the experiment, the researchers used many compounds, for example, 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine (cas: 63931-22-6Safety of 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine).

5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine (cas: 63931-22-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

D’Alarcao, Marc et al. published their research in Journal of Organic Chemistry in 1985 | CAS: 4319-77-1

5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 4319-77-1

Synthesis of imidazo[4,5-h]-1,3-diazabiphenylene (lin-benzocyclobutadienopurine), a ring system having a benzocyclobutadieno spacer between the terminal rings of purine was written by D’Alarcao, Marc;Bakthavachalam, Venkatesalu;Leonard, Nelson J.. And the article was included in Journal of Organic Chemistry in 1985.Application of 4319-77-1 This article mentions the following:

Two distinct syntheses of the pyrimido[6,5-i]imidazo[4,5-g]cinnoline ring system were accomplished. The first of these began with 2-acetamido-4-chloro-5-nitroacetophenone, which was elaborated sequentially by fusion of the imidazole, pyridazine, and pyrimidine rings to provide the tetracyclic system. The second synthesis made use of a Pd-catalyzed cross-coupling reaction of (4,6-dimethoxypyrimidin-5-yl)zinc chloride and 3,4-dinitrobromobenzene, followed by closure of the imidazole and pyridazine rings. The flash vacuum pyrolysis (810-860°, 10-3 torr) of the unsubstituted tetracyclic compound, pyrimido[4,5-i]imidazo[4,5-g]cinnoline, resulted in the extrusion of N to provide imidazo[4,5-h]-1,3-diazabiphenylene (I), the parent mol. to a new class of linearly extended purine analogs. In the experiment, the researchers used many compounds, for example, 5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1Application of 4319-77-1).

5-Bromo-4,6-dimethoxypyrimidine (cas: 4319-77-1) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 4319-77-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Liu, Yuan et al. published their research in Journal of Hazardous Materials in 2022 | CAS: 1220-83-3

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Category: pyrimidines

Bioassay-based identification and removal of target and suspect toxicants in municipal wastewater: Impacts of chemical properties and transformation was written by Liu, Yuan;Li, Faxu;Li, Huizhen;Tong, Yujun;Li, Weizong;Xiong, Jingjing;You, Jing. And the article was included in Journal of Hazardous Materials in 2022.Category: pyrimidines This article mentions the following:

Municipal wastewater contains numerous chems. and transformation products with highly diverse physiochem. properties and intrinsic toxicity; thus, it is imperative but challenging to identify major toxicants. Herein, toxicity identification evaluation (TIE) was applied to identify major toxicants in a typical municipal wastewater treatment plant (WWTP). Impacts of chem. properties on the removal of contaminants and toxicity at individual treatment stages were also examined The WWTP influent caused 100% death of Daphnia magna and zebrafish embryos, and toxicity characterization suggested that organics, metals, and volatiles all contributed to the toxicity. Toxicity identification based on 189 target and approx. one-thousand suspect chems. showed that toxicity contributions of organic contaminants, metals, and ammonia to D. magna were 77%, 4%, and 19%, resp. Galaxolide, pyrene, phenanthrene, benzo[a]anthracene, fluoranthene, octinoxate, silver, and ammonia were identified as potential toxicants. Comparatively, the detected transformation products elicited lower toxicity than their resp. parent contaminants. In contrast, the analyzed contaminants showed negligible contributions to the toxicity of zebrafish embryos. Removal efficiencies of these toxicants in WWTP were highly related to their hydrophobicity. Diverse transformation and removal efficiencies of contaminants in WWTPs may influence the chem. compositions in effluent and ultimately the risk to aquatic organisms in the receiving waterways. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Category: pyrimidines).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kong, Ming et al. published their research in Journal of Environmental Management in 2021 | CAS: 1220-83-3

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Distribution, abundance, and risk assessment of selected antibiotics in a shallow freshwater body used for drinking water, China was written by Kong, Ming;Bu, Yuan-Qing;Zhang, Qin;Zhang, Sheng-Hu;Xing, Li-Qun;Gao, Zhan-Qi;Bi, Feng-Zhi;Hu, Guan-Jiu. And the article was included in Journal of Environmental Management in 2021.Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

With rapid improvements in industrialization and urbanization, antibiotics are now extensively used to prevent and treat human and animal diseases and husbandry and aquaculture. Some research has been conducted to assess the environmental distribution and risk level of antibiotics, but their distribution remains largely uncharacterized. Thus, this study investigated the distribution and abundance of 39 antibiotics belonging to five groups, and their associated risks in surface water around Luoma Lake in the north of Jiangsu province, China. Nineteen antibiotics were detected, at a detection frequency (DF) ranging from 2.27% to 100%. The total antibiotics (ΣABs) concentrations ranged from 34.91 to 825.93 ng/L, with a median concentration of 195.45 ng/L. Among these antibiotics, chlortetracycline (DF: 100%; median: 172.02 ng/L) was the dominant antibiotic, accounting for a median percentage of 91.0% of ΣABs concentrations Spearman rank correlation method found a significant correlation between clindamycin (DF: 72.7%; median: 2.01 ng/L) and lincomycin (DF: 79.5%; median: 4.58 ng/L). The ecol. risk quotient (RQ) values for two out of 44 sampling sites were higher than 1, indicating a high risk; 11.4% of the RQ values fell between 0.1 and 1, indicating a medium risk. Moreover, roxithromycin was found to be the dominant contributor to the ecol. risk, accounting for a median of 79.7% of ΣABs. However, the total non-carcinogenic (<6.54 x 10-4) and carcinogenic risks (<1.64 x 10-7) of ΣABs were negligible at the detected concentrations In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia