Tag: 100-200

In 1972,Acta Biochimica Polonica included an article by Kazimierczuk, Z.; Lipski, M.; Shugar, D.. Recommanded Product: 6297-80-9. The article was titled 《Intermediates in the synthesis of purines and pteridines. Selective hydrolysis of chloropyrimidines》. The information in the text is summarized as follows:

Alk. hydrolysis of 2,4,6-trichloropyrimidine gave 4,6-dichloro-2-hydroxypyrimidine (I), which gave 6-chlorouracil on acid hydrolysis. Treatment of I with NH3 in anhydrous EtOH gave 4,6-diamino-2-hydroxypyrimidine, but Me2NH in anhydrous EtOH gave 4,6-bis(methylamino)-2-hydroxypyrimidine. Alk. hydrolysis of 2,4-dichloropyrimidine gave 4-chloro-2-hydroxypyrimidine (II), which reacted with NH3 in anhydrous EtOH to give cytosine. Treatment of II with Na and anhydrous EtOH gave 4-ethoxy-2-hydroxypyrimidine. The experimental process involved the reaction of 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9Recommanded Product: 6297-80-9)

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 6297-80-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Utilizing triazine/pyrimidine acceptor and carbazole-triphenylamine donor based bipolar novel host materials for highly luminescent green phosphorescent OLEDs with lower efficiency roll-off》 was written by Braveenth, Ramanaskanda; Ahn, Dae Hyun; Han, Ji-Hun; Moon, Ji Su; Kim, Si Woo; Lee, Hyuna; Qiong, Wu; Kwon, Jang Hyuk; Chai, Kyu Yun. Safety of 2,4,6-TrichloropyrimidineThis research focused ontriazine pyrimidine acceptor carbazole triphenylamine donor host material; host material luminescent green phosphorescent efficiency. The article conveys some information:

In this work, two novel bipolar host materials were designed, synthesized and applied in green phosphorescent based OLEDs. Both the host materials, 4-(2-(4,6-diphenyl-1,3,5-triazin-2-yl)-9H-carbazol-9-yl)-N,N-diphenylaniline (TRZ 1) and 4-(2-(4,6-diphenylpyrimidin-2-yl)-9H-carbazol-9-yl)-N,N-diphenylaniline (PYR 1) exhibited high thermal stability, with decomposition temperatures of 425 °C and 400 °C, resp. The triplet energy of PYR 1 (2.63 eV) was higher than that of TRZ 1 (2.44 eV), and facilitated suitable energy transfer to the green dopant. The PYR 1 based green device demonstrated an excellent maximum current efficiency of 48.7 cd/A and external quantum efficiency of 16.4%. Interestingly, the green device with PYR 1 showed an outstanding brightness of 95,870 cd/m2, which is three times greater than that of the reference CBP based device (31,370 cd/m2). The bipolar host PYR 1 is a promising material for high luminescent and low efficiency roll off applications, especially for green PhOLEDs. In the part of experimental materials, we found many familiar compounds, such as 2,4,6-Trichloropyrimidine(cas: 3764-01-0Safety of 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Safety of 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2022,Skaisgiris, Rokas; Serevicius, Tomas; Dodonova, Jelena; Banevicius, Dovydas; Kazlauskas, Karolis; Tumkevicius, Sigitas; Jursenas, Saulius published an article in Journal of Luminescence. The title of the article was 《Tuning of HOMO-LUMO localization for achieving thermally activated delayed fluorescence》.Safety of 4,6-Dichloropyrimidine The author mentioned the following in the article:

High emission yield and rapid reverse intersystem crossing are essential for efficient thermally activated delayed fluorescence (TADF) compounds In this paper, we show that efficient TADF can be achieved by enhancing the localization of HOMO and LUMO in carbazole-pyrimidine compounds with rather flat mol. structure. Simple carbazole-pyrimidine Cbz-PYR was selected as a reference compound due to the pronounced room-temperature phosphorescence activity. The subsequent modifications of carbazole and pyrimidine units with diphenylamine and Ph fragments resulted in weakened HOMO-LUMO communication, leading to the minimized singlet-triplet energy gap of only 111 meV. Due to the rather flat mol. geometry, TADF compounds showed remarkable radiative decay rate reaching 4.6 x 107 s-1 for the most efficient TADF-active carbazole-pyrimidine compound dCbz-pPYR, followed by high emission yield of 0.75. Efficient green electroluminescence with peak EQE of 18.3%. was shown for OLED device with dCbz-pPYR emitter. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Safety of 4,6-Dichloropyrimidine)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Safety of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chen, Xing; Yan, Yaoyao; Zhang, Zhaoyan; Zhang, Faming; Liu, Mingming; Du, Leran; Zhang, Haixia; Shen, Xiaobao; Zhao, Dahai; Shi, Jing Bo; Liu, Xinhua published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor》.Application of 3934-20-1 The article contains the following contents:

Cathepsin C (Cat C) participates in inflammation and immune regulation by affecting the activation of neutrophil serine proteases (NSPs). Therefore, cathepsin C is an attractive target for treatment of NSP-related inflammatory diseases. Here, the complete discovery process of the first potent “”non-peptidyl non-covalent cathepsin C inhibitor”” was described with hit finding, structure optimization, and lead discovery. Starting with hit 14, structure-based optimization and structure-activity relationship study were comprehensively carried out, and lead compound 54 was discovered as a potent drug-like cathepsin C inhibitor both in vivo and in vitro. Also, compound 54 (with cathepsin C Enz IC50 = 57.4 nM) exhibited effective anti-inflammatory activity in an animal model of chronic obstructive pulmonary disease. These results confirmed that the non-peptidyl and non-covalent derivative could be used as an effective cathepsin C inhibitor and encouraged us to continue further drug discovery on the basis of this finding. In the experiment, the researchers used many compounds, for example, 2,4-Dichloropyrimidine(cas: 3934-20-1Application of 3934-20-1)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Application of 3934-20-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,Journal of Medicinal Chemistry included an article by Rageot, Denise; Bohnacker, Thomas; Melone, Anna; Langlois, Jean-Baptiste; Borsari, Chiara; Hillmann, Petra; Sele, Alexander M.; Beaufils, Florent; Zvelebil, Marketa; Hebeisen, Paul; Loscher, Wolfgang; Burke, John; Fabbro, Doriano; Wymann, Matthias P.. Name: 2,4,6-Trichloropyrimidine. The article was titled 《Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders》. The information in the text is summarized as follows:

Mechanistic target of rapamycin (mTOR) promotes cell proliferation, growth, and survival and is overactivated in many tumors and central nervous system disorders. I is a novel, potent, selective, and brain penetrable inhibitor of mTORC1/2 kinase. I showed excellent selectivity for mTOR over PI3K and protein kinases and efficiently prevented cancer cell growth in a 66 cancer cell line panel. In C57BL/6J and Sprague-Dawley mice, maximum concentration (Cmax) in plasma and brain was reached after 30 min, with a half-life (t1/2) > 5 h. In an ovarian carcinoma mouse xenograft model (OVCAR-3), daily dosing of I inhibited tumor growth significantly. Moreover, I attenuated epileptic seizures in a tuberous sclerosis complex (TSC) mouse model. In conclusion, I inhibits mTOR kinase potently and selectively, shows antitumor effects in vitro and in vivo, and promises advantages in CNS indications due to its brain/plasma distribution ratio. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0Name: 2,4,6-Trichloropyrimidine)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Name: 2,4,6-Trichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,Chen, Dizhong; Soh, Chang Kai; Goh, Wei Huang; Wang, Haishan published 《Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma》.Journal of Medicinal Chemistry published the findings.Electric Literature of C6H3Cl2N3 The information in the text is summarized as follows:

Class I histone deacetylases (HDACs) are highly expressed and/or upregulated in hepatocellular carcinoma (HCC) and are associated with aggressiveness, spread, and increased mortality of HCC. Activation of phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway was involved in the development of HCC and acquired resistance to sorafenib. A series of purine or 5H-pyrrolo[3,2-d]pyrimidine based hydroxamates were designed and developed as multitarget drugs to modulate both HDACs and the PI3K/Akt/mTOR pathway. Among 39 cell lines screened, the mols. (e.g., I, II, and III) were the most selective against leukemia, lymphoma, and HCC cells; they also demonstrated target modulation in cancer cell lines and in mice bearing MV4-11 and HepG2 tumors. Compound II in particular showed significant single agent oral efficacy in hypervascular liver cancer models (e.g., HepG2, HuH-7, and Hep3B) and was well-tolerated. These encouraging results, along with its favorable target profile and tissue distribution, warrant further development of II. The experimental process involved the reaction of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Electric Literature of C6H3Cl2N3)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Electric Literature of C6H3Cl2N3They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Liang, Xuewu; Zang, Jie; Zhu, Mengyuan; Gao, Qianwen; Wang, Binghe; Xu, Wenfang; Zhang, Yingjie published 《Design, Synthesis, and Antitumor Evaluation of 4-Amino-(1H)-pyrazole Derivatives as JAKs Inhibitors》.ACS Medicinal Chemistry Letters published the findings.Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine The information in the text is summarized as follows:

Abnormalities in the JAK/STAT signaling pathway lead to many diseases such as immunodeficiency, inflammation, and cancer. Herein, we designed and synthesized a series of 4-amino-(1H)-pyrazole derivatives as potent JAKs inhibitors for cancer treatment. Results from in vitro protein kinase inhibition experiments indicated that some compounds are potent JAKs inhibitors. For example, the IC50 values of compound I against JAK1, JAK2, and JAK3 were 3.4, 2.2, and 3.5 nM, resp. In cell culture experiments, compound I showed potent antiproliferative activity against various cell lines (PC-3, HEL, K562, MCF-7, and MOLT4) at low micromolar levels, while compound II showed selective cytotoxicity at submicromolar levels against HEL (IC50: 0.35 μM) and K562 (IC50: 0.37 μM) cell lines. It is worth noting that both I and II showed more potent antiproliferative activities than the approved JAKs inhibitor Ruxolitinib. In addition to this study using 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, there are many other studies that have used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine) was used in this study.

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Quality Control of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2016,Zhang, Ji-Quan; Luo, Yong-Jie; Xiong, Yan-Shi; Yu, Yang; Tu, Zheng-Chao; Long, Zi-Jie; Lai, Xiao-Ju; Chen, Hui-Xuan; Luo, Yu; Weng, Jiang; Lu, Gui published 《Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors》.Journal of Medicinal Chemistry published the findings.HPLC of Formula: 3764-01-0 The information in the text is summarized as follows:

Three series of substituted pyrimidines were designed and synthesized. All target compounds were screened for kinase inhibitory activities against PI3Kα, and most IC50 values were found within the nanomolar range. Compounds 5d and 5p displayed comparable activities relative to the pos. control 5a. P also showed a significant isoenzyme selectivity (PI3Kβ/α). Also, the cytotoxicities of these pyrimidines against human cancer cell lines were evaluated and the in vivo anticancer effect of 5d was also tested. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trichloropyrimidine(cas: 3764-01-0HPLC of Formula: 3764-01-0)

2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.HPLC of Formula: 3764-01-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Oppenlaender, Thomas; Pfoertner, Karl Heinz; Schoenholzer, Peter published an article in Helvetica Chimica Acta. The title of the article was 《Photooxygenation of 5-aryl-2,4-diaminopyrimidines leading to 4-amino-1,3,5-triazin-2-yl ketones and, in the presence of sodium borohydride, to 5,6-dihydro-4(3H)-pyrimidinones》.Related Products of 15400-54-1 The author mentioned the following in the article:

The photosensitized oxygenation of 5-aryl-2,4-diaminopyrimidines I (R = 4-ClC6H4, Ph; R1 = Et, H Me, Ph) in protic solvents led to the formation of the new 4-amino-1,3,5-triazin-2-yl ketones II in high yields. The structures of II were elucidated by spectroscopic means, especially by 13C-NMR and UV data. Photooxygenation of I (R = 4-ClC6H4, R1 = Et) under reductive conditions, e.g. in the presence of excess of NaBH4, gave 5,6-dihydro-5-hydroxy-4(3H)-pyrimidinone III, the structure of which was determined by x-ray anal. In the proposed mechanisms for both types of reactions, a dipolar ion formed by attack of 1O2 on C5 is assumed to be a common intermediate. For the new efficient synthesis of 1,3,5-triazines from 2,4-diaminopyrimidines, a 5-aryl substituent seems to be essential. In the experiment, the researchers used many compounds, for example, Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1Related Products of 15400-54-1)

Ethyl 2,4-diaminopyrimidine-5-carboxylate(cas: 15400-54-1) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 15400-54-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1971,Journal of Medicinal Chemistry included an article by Cohen, Sasson; Ashani, Yacov. COA of Formula: C5H5N3O. The article was titled 《Nucleophilicity of some reactivators of phosphorylated acetylcholinesterase. 5》. The information in the text is summarized as follows:

Reactivation of diisopropyl phosphorofluoridate-inactivated acetylcholinesterase by 14 heterocyclic oximes, was related with the nucleophilicity and basicity of these oximes. The value of kr (the 1st-order rate constant) at pH 7.4 was a function of both the nucleophilicity of the reactor mol., and its basicity, reaching an optimum for compounds with a pKa value in the range of 7.6-8.0, e.g., 1-methyl-4-formylrimidinium oxime iodide (I). The experimental process involved the reaction of Pyrimidine-4-carbaldehyde oxime(cas: 1073-65-0COA of Formula: C5H5N3O)

Pyrimidine-4-carbaldehyde oxime(cas: 1073-65-0) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.COA of Formula: C5H5N3O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia