Tag: 100-200

4-aminopyrimidine-5-carbaldehydes as intermediates in a Friedlander-type synthesis of 7-arylpyrido[2,3-d]pyrimidines was written by Quiroga, Jairo;Trilleras, Jorge;Abonia, Rodrigo;Insuasty, Braulio;Nogueras, Manuel;Cobo, Justo;de la Torre, Jose M.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2009.HPLC of Formula: 54030-56-7 This article mentions the following:

A study of formylation of 6-aminopyrimidines leads to the conclusion that the formylation at C5 occurs only when there is no contribution of heteroaromaticity in the pyrimidine ring and that the corresponding pyrimidoformamides are formed in heteroaromatic pyrimidines. Once 4-aminopyrimidin-4(3H)-one-5-carboxaldehydes were prepared, a series of 7-arylpyrido[2,3-d]pyrimidines derivatives were synthesized by a Friedlander type reaction with acetophenones under solvent-free conditions and in the presence of BF₃·Et₂O. The yields of 7-arylpyrido[2,3-d]pyrimidines range from moderate to good and the reaction times were quite short. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7HPLC of Formula: 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Behavior of some 2-(ω-bromoalkylthio)-4,6-dimethylpyrimidines during heating was written by Mikhailov, A. S.;Pashkurov, N. G.;Reznik, V. S.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1981.Application of 16879-39-3 This article mentions the following:

The thermal behavior of I (n = 4, 5, 6) on heating in vacuo to 150-240° depended on the value of n; cyclization played a significant role in the reaction patterns only when n = 4. Products found included, e.g., II and thiophane, as well as more complex compounds In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application of 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cinchona alkaloid thiourea-catalyzed one-pot synthesis and bioselective activities of β-amino acid ester derivatives containing a pyrimidine moiety was written by Bai, Song;Liu, Shan;Zhu, Yunying;Wei, Xian;Zhao, Kunhong;Li, Weihua;Wu, Qin. And the article was included in Heterocycles in 2018.Electric Literature of C7H11N3O2 This article mentions the following:

Both enantiomers of β-amino acid ester derivatives I (R¹ = cyclohexyl, Ph, 4-ClC₆H₄, 4-MeC₆H₄, 4-MeOC₆H₄, 2-furyl; R² = Me, Et) that contain a pyrimidine moiety were produced from 2-amino-4-(dimethoxymethyl)pyrimidine, aldehydes R¹CHO and malonates H₂C(CO₂R²)₂ in an enantioselective Mannich-type one-pot reaction in good yields and with excellent enantiomeric excess (up to >99% ee) using chiral cinchona alkaloid thiourea catalysts. An evaluation of the antiviral activities of reaction products against tobacco mosaic virus (TMV) was promising with high and selective biol. activities. Compound (-)-I (R¹ = 2-furyl; R² = Me) showed an excellent anti-TMV activity (curative activity, 56.1%; inactivation activity, 70.7%; protection activity, 95.7%) at 500 μg/mL. These values exceeded those of the com. available antiviral agent, ningnanmycin (curative activity, 52.6%; inactivation activity, 62.0%; protection activity, 90.2%). These novel chiral compounds were used as protective agents against TMV disease. In the experiment, the researchers used many compounds, for example, 4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6Electric Literature of C7H11N3O2).

4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Electric Literature of C7H11N3O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The tautomeric equilibria of thio analogs of nucleic acid bases. Part 1. 2-Thiouracil: background, preparation of model compounds, and gas-phase proton affinities was written by Katritzky, Alan R.;Baykut, Gokhan;Rachwal, Stanislaw;Szafran, Miroslaw;Caster, Kenneth C.;Eyler, John. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1989.Formula: C5H5ClN2O This article mentions the following:

The preparation is reported of all four of the monoalkyl derivatives of 2-thiouracil and of four of the six possible dialkyl derivatives required as models for a study of the tautomeric equilibrium by phys. methods. Gas-phase proton affinities are determined using ion cyclotron resonance mass spectrometry, and are used to provide quant. estimates of individual tautomer stabilities in the vapor state. These quant. results agree well with qual. deductions of predominant structures for the monoalkyl derivatives from IR spectroscopy. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-methoxypyrimidine (cas: 51421-99-9Formula: C5H5ClN2O).

4-Chloro-2-methoxypyrimidine (cas: 51421-99-9) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Formula: C5H5ClN2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Transformations of substituted 5-aminopyrimidines under conditions of diazotization was written by Nemeryuk, Michal P.;Sedov, Andrej L.;Safonova, Tamara S.;Cerny, Antonin;Krepelka, Jiri. And the article was included in Collection of Czechoslovak Chemical Communications in 1986.Computed Properties of C4H5N3O This article mentions the following:

Diazotization of aminopyrimidines I (R = H; R¹ = SMe, SCH₂Ph, OMe, H, OH; R² = OMe, Cl, OH, etc.) gave triazoles II (R³ = CO₂Me, COSMe, COSCH₂Ph, CONH₂, etc.). Under similar conditions diaminopyrimidines I [R = NH₂, R¹ = SCH₂C₆H₄R⁴-4 (R⁴ = NO₂, CO₂Et, CONHCHMe₂, H), R² = Me] gave pyrimidotriazine N-oxides III. In the experiment, the researchers used many compounds, for example, 5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0Computed Properties of C4H5N3O).

5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Computed Properties of C4H5N3O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Studies on 5H-pyrimidothiazines. Part I. Synthesis of 6- and 7-carboxyalkyl derivatives of 5H-pyrimido[4,5-b][1,4]thiazine was written by Duro, F.;Santagati, N. A.;Scapini, G.. And the article was included in Farmaco, Edizione Scientifica in 1978.Formula: C4H5N3O This article mentions the following:

Primidothiazines I (R = H, R¹ = CO₂Me; R = Me, Ph, R¹ = CO₂Et; R = CO₂Et, R¹ = H) were obtained by treating 4-mercapto-5-aminopyrimidine (II) with HCOCHClCO₂Me, AcCHClCO₂Et, BzCHClCO₂Et, or BrCH₂COCO₂Et resp. I (R = CO₂Et, R¹ = H) was hydrolyzed to the acid. Reaction of I (R = Ph, R¹ = CO₂Et) with N₂H₄ gave the pyrazolone III, which was cleaved by N₂H₄ to II and 3-phenyl-3-pyrazoline-5-one. Reaction of II with BzCHClCO₂Et in the presence of NaOMe gave the ester IV, which was hydrolyzed to the acid and cyclized by HOAc to 5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one. In the experiment, the researchers used many compounds, for example, 5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0Formula: C4H5N3O).

5-Aminopyrimidin-4(3H)-one (cas: 69785-94-0) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Formula: C4H5N3O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gas- and liquid-phase C-H acidity of terminal acetylenes was written by Tupitsyn, I. F.;Popov, A. S.;Shibaev, A. Yu.. And the article was included in Zhurnal Obshchei Khimii in 1992.Safety of 2-Ethynylpyrimidine This article mentions the following:

Both corrected AM1 and MINDO/3 methods constituted acceptable approximations for calculation of proton affinity of ethynyde carbanions. Decrease in heat of deprotonation along the series H_nXCCH (X = 2nd period element C, N, O, F) testifies to the predominant role of electronegativity in C-H acidity; bond-length variations along this series, however, indicate repulsive interactions between the carbanion center and heteroatom. Carbanion stability increases (proton affinity decreases) upon 2nd- to 3rd row exchange, e.g., from H₃CCC^– to H₃SiCC^–; that this stabilization originates in dπ-conjugation is substantiated by decreasing Si-C bond length in the carbanion vs. acid. Heat of deprotonation decreases from HCCH to RCCH (R = aryl, N-containing heteroaryl) regardless of the degree of electron deficiency or electron excess in the ring. Correlations of heat of deprotonation with exptl. pK_a (thermodn. acidity) and k_D (kinetics of H-D exchange, as measure of kinetic acidity) were discussed. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Safety of 2-Ethynylpyrimidine).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The efficient one-step chlorination of methylsulfanyl group on pyrimidine ring system with sulfuryl chloride was written by Ham, Young Jin;Lee, Duck-Hyung;Choi, Hwan Geun;Hah, Jung-Mi;Sim, Taebo. And the article was included in Tetrahedron Letters in 2010.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine This article mentions the following:

A facile one-step transformation of methylsulfanyl and arylsulfanyl groups on pyrimidine ring system into the corresponding chloride group was achieved using sulfuryl chloride in acetonitrile/dichloromethane. In the experiment, the researchers used many compounds, for example, 4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine).

4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Aminopyrimidines and derivatives. XIV. Preparation and study of 5-amino-4-(glycosylamino)-2-methoxy-(and 2-(methylthio))-6-oxopyrimidines was written by Nogueras Montiel, M.;Sanchez Rodrigo, A.;Asenjo Asenjo, R.;Melgarejo Sampedro, M.;Rodriguez Alonso, M.;Rodriguez Melgarejo, C.. And the article was included in Anales de Quimica, Serie C: Quimica Organica y Bioquimica in 1984.Formula: C6H9N3OS This article mentions the following:

(Glycosylamino)pyrimidinones (I; R = H, Me; R¹ = H; R² = H, CH₂OH; Z = O, S; 7 compounds) on treatment with NaNO₂ in AcOH or HCl gave the corresponding 5-nitroso compounds (I; R¹ = NO), which on reduction with (NH₄)₂S gave the title compounds (I; R¹ = NH₂). In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Formula: C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Highly efficient one-pot synthesis of α-aminophosphonates using nanoporous AlSBA-15 catalyst in a three-component system was written by Kolli, Murali Krishna;Palani, Elamathi;Govindasamy, Chandrasekar;Katta, Vishweshwar Rao. And the article was included in Research on Chemical Intermediates in 2020.Product Details of 90905-32-1 This article mentions the following:

Nanoporous AlSBA-15 catalysts with different nSi/nAl ratios (41, 129, and 210) were synthesized using a hydrothermal method. These catalysts were characterized by XRD, N₂ sorption, TPD-NH₃, FT-IR, SEM and TEM. XRD analyses of AlSBA-15 catalysts confirmed the presence of well-ordered crystalline structure with p6mm symmetry. The sp. surface area and specific pore volume of the AlSBA-15 catalysts are in the range of 480 to 757 m²/g and 0.65 to 0.95 cm³/g, resp. The catalytic performance of nanoporous AlSBA-15 catalysts are used as an outstanding catalytic system for one-pot synthesis of α-aminophosphonates via Kabachnik-Fields reaction in a three-component system using amines (primary/secondary), carbonyl compounds (aldehydes/ketones) and di-Et phosphite. The major advantages of the present contributions are excellent yields, short reaction time, simple exptl. technique, high chemo-selectivity, catalyst recyclability, easy work-up procedure and green approach. Three-component synthesis of α-aminophosphonates follows first imine formation from amine and aldehyde/ketone followed by phosphate addition The exptl. findings suggest that the nanoporous AlSBA-15 catalysts can be recycled and reused up to six cycles without any loss in the catalytic performance. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Product Details of 90905-32-1).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Product Details of 90905-32-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia