Tag: 100-200

On June 11, 2007, Harbottle, Gareth W.; Feeder, Neil; Gibson, Karl R.; Glossop, Mel; Maw, Graham N.; Million, William A.; Morel, Florence F.; Osborne, Simon; Poinsard, Cedric published an article.Application In Synthesis of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine The title of the article was Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen, and oxygen linked derivatives of pyrido[3,4-d]pyrimidin-4-ylamines. And the article contained the following:

The syntheses of 6-fluoropyrido[3,4-d]pyrimidin-4-ylamine derivatives is reported herein. Methods for generating C-, N-, and O-linked analogs by subsequent nucleophilic aromatic substitution of fluoride with alcs. or amines under microwave irradiation are described. The experimental process involved the reaction of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine(cas: 175357-98-9).Application In Synthesis of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine

The Article related to pyridopyrimidinylamine mglur1 ligand preparation, fluoropyridopyrimidinylamine amine nucleophilic aromatic substitution, alc fluoropyridopyrimidinylamine nucleophilic aromatic substitution and other aspects.Application In Synthesis of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 30, 2021, Kuramochi, Hidekazu; Yamada, Takeshi; Yoshida, Yoichiro; Matsuda, Akihisa; Kamiyama, Hirohiko; Kosugi, Chihiro; Ishibashi, Keiichiro; Fukazawa, Atsuko; Ihara, Keisuke; Sonoda, Hiromichi; Yoshimatsu, Kazuhiko; Yoshida, Hiroshi; Hasegawa, Suguru; Sakamoto, Kazuhiro; Ishida, Hideyuki; Koda, Keiji; TAS CC3 Study Group published an article.Safety of 5-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was The pre-treatment lymphocyte-to-monocyte ratio predicts efficacy in metastatic colorectal cancer treated with TAS-102 and bevacizumab. And the article contained the following:

Our multicenter phase II TAS-CC3 study demonstrated favorable median progression-free survival (PFS) and overall survival (OS) of 32 metastatic colorectal cancer (mCRC) patients treated with TAS-102 + bevacizumab as 3rd-line treatment. We investigated the predictive and prognostic values of pre-treatment blood inflammation-based scores, including the neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte ratio (LMR) on disease-control (DC), PFS and OS by a post-hoc anal. Receiver operating characteristic curve analyses of the 3 inflammation-based scores vs. DC showed the best predictive performance for LMR, followed by NLR and PLR. The high-LMR group had a significantly higher DC rate than the low group (87.5 vs. 43.8%). The high-LMR group showed significantly longer survival than the low group (4.9 vs. 2.3 m for median PFS) (21.0 vs. 6.1 m for median OS). The pre-treatment LMR is a valid predictive and prognostic biomarker for mCRC patients undergoing TAS-102 and bevacizumab treatment. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Safety of 5-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to tas102 bevacizumab lymphocyte monocyte inflammation colorectal cancer, tas-102, bevacizumab, colorectal cancer, lymphocyte-to-monocyte ratio (lmr), neutrophil-to-lymphocyte ratio (nlr) and other aspects.Safety of 5-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 30, 2020, Fujimoto, Yoshiaki; Nakanishi, Ryota; Nukatsuka, Mamoru; Matsuoka, Kazuaki; Ando, Koji; Wakasa, Takeshi; Kitao, Hiroyuki; Oki, Eiji; Maehara, Yoshihiko; Mori, Masaki published an article.Electric Literature of 65-71-4 The title of the article was Detection of trifluridine in tumors of patients with metastatic colorectal cancer treated with trifluridine/tipiracil. And the article contained the following:

Trifluridine (FTD) is the active component of the nucleoside chemotherapeutic drug trifluridine/tipiracil (FTD/TPI), which is approved worldwide for the treatment of patients with metastatic gastrointestinal cancer. FTD exerts cytotoxic effects via its incorporation into DNA, but FTD has not been detected in the tumor specimens of patients. The purpose of this study was to detect FTD in tumors resected from metastatic colorectal cancer (mCRC) patients who were administered FTD/TPI. Another purpose was to investigate the turnover rate of FTD in tumors and bone marrow in a mouse model. Tumors and normal tissue specimens were obtained from mCRC patients who were administered FTD/TPI or placebo at Kyushu University Hospital. Tumors and bone marrow were resected from mice with peritoneal dissemination treated with FTD/TPI. To detect and quantitate FTD incorporated into DNA, immunohistochem. staining of paraffin-embedded specimens (IHC-p staining) and slot-blot anal. of DNA purified from these tissues were performed using an anti-BrdU antibody. IHC-p staining of proliferation and apoptosis markers was also performed. FTD was detected in metastatic tumors obtained from mCRC patients who were administered FTD/TPI, but who had discontinued the treatment several weeks before surgery. In a peritoneal dissemination mouse model, FTD was still detected in tumors 13 days after the cessation of FTD/TPI treatment, but had disappeared from bone marrow within 6 days. These results indicate that FTD persists longer in tumors than in bone marrow, which may cause a sustained antitumor effect with tolerable hematotoxicity. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Electric Literature of 65-71-4

The Article related to trifluridine tipiracil metastatic colorectal cancer human, anti-brdu antibody, liver metastasis, peritoneal dissemination, tas-102), trifluridine (ftd), trifluridine/tipiracil (ftd/tpi and other aspects.Electric Literature of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Akbarzadeh, Marzieh; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Azizollahi, Hamid; Mague, Joel T. published an article in 2018, the title of the article was Synthesis of 2-substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxaline as a new heterocyclic system.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

2-Substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxalines, e.g., I, were synthesized through cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with 3-aminoquinoxaline-2-thiol and subsequent substitution by various secondary amines. Regioselective heterocyclization was confirmed by X-ray crystallog. anal. for 4-methyl-2-(pyrrolidin-1-yl)-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxaline (I). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to chloropyrimidinylmethylthio quinoxalinamine heterocyclization, chloropyrimidothiazepinoquinoxaline preparation secondary amine amination, aminopyrimidothiazepinequinoxaline preparation and other aspects.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 5, 2021, Aybastier, Onder; Demir, Cevdet published an article.HPLC of Formula: 4433-40-3 The title of the article was Optimization and validation of ultrasensitive GC-MS/MS method to measure oxidatively induced DNA damage products and role of antioxidants in oxidation mechanism. And the article contained the following:

Oxidation of DNA due to exposure to reactive oxygen species (ROS) is a major source of DNA damage. ROS induced damage to DNA plays an important role in some diseases such as various cancers, aging and neurodegenerative diseases. The detection of DNA oxidation products plays a major role in assessing the mutagenicity potential of specific exposure. The GC-MS/MS method was developed for the ultrasensitive determination of individual DNA damage products. The validation results revealed that the proposed method was reliable and sensitive. Multiple response surface methodol. (MRSM) was used to optimize derivatization conditions of oxidatively DNA base damage products before GC-MS/MS anal. The optimum derivatization conditions were determined as 40 min for derivatization time, 120°C for derivatization temperature and 1.4 for BSTFA/pyridine ratio under nitrogen atm. The effects of thymol, carvacrol and thymoquinone as antioxidants were investigated on oxidative DNA damage. The determination of the oxidatively induced DNA damage products was performed after adding DNA and antioxidants with different concentrations under oxidative stress. Eighteen DNA base damage products were analyzed simultaneously using GC-MS/MS. This study showed a significant decrease in the amount of DNA base damage products when the antioxidants were present in the medium. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).HPLC of Formula: 4433-40-3

The Article related to dna damage derivatization multiple response surface methodol oxidative stress, dna damage, derivatization, gc–ms/ms, multiple response surface methodology, oxidative stress, validation and other aspects.HPLC of Formula: 4433-40-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 15, 2012, Matyugina, Elena; Khandazhinskaya, Anastasia; Chernousova, Larisa; Andreevskaya, Sofia; Smirnova, Tatiana; Chizhov, Alexander; Karpenko, Inna; Kochetkov, Sergey; Alexandrova, Ludmila published an article.Product Details of 626-48-2 The title of the article was The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivatives. And the article contained the following:

A series of new carbocyclic uracil derivatives, e.g. I, were synthesized and evaluated as potential antituberculosis agents. Racemic hydroxy-cyclopentenyl-5-tetradecynyluracil I completely inhibited the growth of Mycobacterium tuberculosis H37Rv in vitro at a concentration of 10 μg/mL. Individual (+) and (-) isomers of the above uracil derivative were isolated and showed the same level of activity against two strains of Mycobacterium tuberculosis: laboratory sensitive (H37Rv) and drug resistant to five top antituberculosis drugs (MS-115). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to drug resistance antituberculosis mycobacterium tuberculosis carbocyclic nucleoside preparation, carbocyclic nucleoside uracil preparation antituberculosis hydroxycyclopentenyltetradecynyluracil mycobacterium tuberculosis antibacterial and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Abakir, Abdulkadir; Ruzov, Alexey published an article in 2021, the title of the article was Detection of Low-Abundance DNA Modifications Using Signal Amplification-Based Immunocytochemistry.Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione And the article contains the following content:

A review. Immunocytochem. can be instrumental in assessing the spatial distribution and relative levels of epigenetic modifications. Although conventional immunostaining has been utilized for the detection of 5-methylcytosine (5mC) in animal cells and tissues for several decades, the sensitivity of techniques based on the use of fluorophore-conjugated secondary antibodies is not always sufficient for studying DNA modifications that are less abundant in DNA compared with 5mC. Here we describe a protocol for sensitive immunocytochem. that utilizes peroxidase-conjugated secondary antibodies coupled with catalyzed reporter deposition and allows for detection of low-abundance noncanonical bases (e.g., 5-carboxylcytosine, 5caC, 5-formylcytosine, 5fC, 5-hydroxymethyluracil, 5hmU) in mammalian DNA. This method can be employed for evaluation of the levels and nuclear distribution of DNA modifications and permits their colocalization with protein markers in animal cells. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to review dna modification signal amplification immunocytochem, 5-carboxylcytosine, 5-formylcytosine, dna (de)methylation, dna modifications, immunocytochemistry, immunofluorescence, immunohistochemistry, oxi-mcs, signal amplification and other aspects.Safety of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 7, 2021, SenGupta, Tanima; Palikaras, Konstantinos; Esbensen, Ying Q.; Konstantinidis, Georgios; Galindo, Francisco Jose Naranjo; Achanta, Kavya; Kassahun, Henok; Stavgiannoudaki, Ioanna; Bohr, Vilhelm A.; Akbari, Mansour; Gaare, Johannes; Tzoulis, Charalampos; Tavernarakis, Nektarios; Nilsen, Hilde published an article.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. And the article contained the following:

Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, the underlying mechanisms are poorly understood. Here, we show that base excision repair generates genomic stress, promoting age-related neurodegeneration in a Caenorhabditis elegans PD model. A physiol. level of NTH-1 DNA glycosylase mediates mitochondrial and nuclear genomic instability, which promote degeneration of dopaminergic neurons in older nematodes. Conversely, NTH-1 deficiency protects against α-synuclein-induced neurotoxicity, maintaining neuronal function with age. This apparent paradox is caused by modulation of mitochondrial transcription in NTH-1-deficient cells, and this modulation activates LMD-3, JNK-1, and SKN-1 and induces mitohormesis. The dependence of neuroprotection on mitochondrial transcription highlights the integration of BER and transcription regulation during physiol. aging. Finally, whole-exome sequencing of genomic DNA from patients with idiopathic PD suggests that base excision repair might modulate susceptibility to PD in humans. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to caenorhabditis parkinson disease single stranded dna base excision repair, c. elegans, dna-glycosylase, nth-1, parkinson disease, aging, base excision repair, hydrogen peroxide, mitohormesis, neurodegeneration, oxidative dna damage and other aspects.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Tabernero, Josep; Taieb, Julien; Prager, Gerald W.; Ciardiello, Fortunato; Fakih, Marwan; Leger, Catherine; Fougeray, Ronan; Amellal, Nadia; van Cutsem, Eric published an article in 2021, the title of the article was Trifluridine/tipiracil plus bevacizumab for third-line management of metastatic colorectal cancer: SUNLIGHT study design.Related Products of 65-71-4 And the article contains the following content:

Preliminary studies of FTD/TPI plus bevacizumab have produced encouraging results in the treatment of refractory metastatic colorectal cancer. Here, we describe the design of the multinational Phase III SUNLIGHT, an open-label study of FTD/TPI plus bevacizumab as third-line treatment for patients with unresectable metastatic colorectal cancer. A total of 490 patients will be randomized 1:1 to receive either FTD/TPI plus bevacizumab, or FTD/TPI monotherapy. The primary objective is to significantly improve overall survival with FTD/TPI plus bevacizumab compared with FTD/TPI monotherapy. The first patient was enrolled in Nov. 2020. Lay abstract : Trifluridine/tipiracil is a cancer treatment used in patients with bowel cancer that has spread to other parts of the body (this is called ‘metastatic bowel cancer’). This medicine is taken by mouth. Recently, a number of studies have suggested that better results might be obtained when trifluridine/tipiracil is used in combination with another cancer drug, bevacizumab. This article describes the design of a new clin. trial. The SUNLIGHT is being set up to confirm whether the combination of trifluridine/tipiracil plus bevacizumab is indeed better than trifluridine/tipiracil alone for patients who have already had two different treatments for metastatic bowel cancer. The trial began in late 2020. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Related Products of 65-71-4

The Article related to trifluridine tipiracil bevacizumab third management metastatic colorectal cancer sunlight, ftd/tpi, phase iii, bevacizumab, metastatic colorectal cancer, randomized controlled trial, refractory, third line, trifluridine/tipiracil and other aspects.Related Products of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 2021, McKnight, Ian; Hart, Christoph; Park, In-Hyun; Shim, Joon W. published an article.Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions. And the article contained the following:

A review. Congenital hydrocephalus (CH) is caused by genetic mutations, but whether factors impacting human genetic mutations are disease-specific remains elusive. Given two factors associated with high mutation rates, we reviewed how many disease-susceptible genes match with (i) proximity to telomeres or (ii) high adenine and thymine (A + T) content in human CH as compared to other disorders of the central nervous system (CNS). We extracted genomic information using a genome data viewer. Importantly, 98 of 108 genes causing CH satisfied (i) or (ii), resulting in >90% matching rate. However, such a high accordance no longer sustained as we checked two factors in Alzheimers disease (AD) and/or familial Parkinsons disease (fPD), resulting in 84% and 59% matching, resp. A disease-specific matching of telomere proximity or high A + T content predicts causative genes of CH much better than neurodegenerative diseases and other CNS conditions, likely due to sufficient number of known causative genes (n = 108) and precise determination and classification of the genotype and phenotype. Our anal. suggests a need for identifying genetic basis of both factors before human clin. studies, to prioritize putative genes found in preclin. models into the likely (meeting at least one) and more likely candidate (meeting both), which predisposes human genes to mutations. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to review congenital hydrocephalus alzheimers parkinsons disease dna telomere, alzheimer’s disease, a + t content, mutation, chromosome, homologous recombination, familial parkinson’s disease, congenital hydrocephalus, telomeres and other aspects.Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia