Tag: 100-200

On June 30, 2018, Kataev, V. A.; Meshcheryakova, S. A.; Meshcheryakova, E. S.; Tyumkina, T. V.; Khalilov, L. M.; Lazarev, V. V.; Kuznetsov, V. V. published an article.HPLC of Formula: 626-48-2 The title of the article was Direction of the Reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione with 2-Chloromethylthiirane: N1- or N3-Thietanyl Derivative. And the article contained the following:

The reaction of 6-methylpyrimidine-2,4(1H,3H)-dione with 2-chloromethylthiirane gave 6-methyl-N-thietan-3-ylpyrimidine-2,4(1H,3H)-dione. Its oxidation and subsequent reaction of the resulting N-1,1-dioxo-λ6-thietan-3-yl derivative with Et chloroacetate afforded the corresponding Et pyrimidinylacetate. The structure of the latter was determined by X-ray anal., which confirmed the formation of N3-thietan-3-yl derivative rather than its N1-substituted isomer in the title reaction. According to the results of B3LYP/6-31G++d,p, PBE/3ζ, MP2/6-31G++d,p quantum chem. calculations, the N3-thietanyl derivative is more stable than the N1-isomer. It was also found that the calculated barrier to internal rotation of the thietanyl group about the N-C bond in 6-methyl-3-thietan-3-yl-pyrimidine-2,4(1H,3H)-dione is lower than in the N1-isomer. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to methyl thietanylpyrimidine dione preparation, chloromethylthiirane methylpyrimidine dione, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 1, 2011, Barba, Oscar; Bell, James Charles; Dupree, Tom Banksia; Fry, Peter Timothy; Bertram, Lisa Sarah; Fyfe, Matthew Colin Thor; Gattrell, William; Jeevaratnam, Revathy Perpetua; Keily, John; Krulle, Thomas Martin; Mcdonald, Russell Walker; Morgan, Trevor; Rasamison, Chrystelle Marie; Schofield, Karen Lesley; Stewart, Alan John William; Swain, Simon Andrew; Withall, David Matthew published a patent.Name: 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of heteroarylpiperidinylmethoxypyrimidinylpyrrolidinylamine derivatives and analogs for use as GPR119 antagonists. And the patent contained the following:

Title compounds I [A = para-substituted Ph or para-substituted heteroaryl containing 1 to 3 N atoms; each Q independently = (CHR9)p; X = O, CH2, NH, etc.; Y = O, CH2, N-alkyl, etc.; Z = CO2aryl, SO2heteroaryl, C(O)alkyl, etc.; R1 = H, halo, CN, alkyl, etc.; R2 = (un)substituted Ph, pyridyl, N-pyrazolyl, etc.; R9 = H, halo, OH, alkyl, etc.; R11 = H, halo, alkyl, haloalkyl, or alkoxy; n = 0 or 1; each p independently = 0 to 2; with provisions], and their pharmaceutically acceptable salts, are prepared and disclosed as GPR119 antagonists. Thus, e.g., II·HCl was prepared by a multistep procedure (preparation given). Select I were evaluated in GPR119 yeast reporter assays (data given). The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Name: 2-Chloro-5-isopropylpyrimidine

The Article related to pyrimidinylpyrrolidinylamine piperidinylmethoxy derivative preparation gpr119 antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 2-Chloro-5-isopropylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 28, 2013, Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Afrough, Toktam; Tajabadi, Javad published an article.Synthetic Route of 626-48-2 The title of the article was Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils [Erratum to document cited in CA159:399291]. And the article contained the following:

On page 8470, the third paragraph in the first column contained incorrect text; the corrected text is given. On page 8474, an important citation was omitted from the Exptl. section; the omitted citation is given. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to erratum hmds chemoselective o alkylation uracil, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 30, 2013, Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Afrough, Toktam; Tajabadi, Javad published an article.Product Details of 626-48-2 The title of the article was Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils. And the article contained the following:

The sodium salts of the conjugated bases of uracils undergo highly chemoselective O4-monoalkylation when treated with various alkyl halides in dry DMF, while the use of Me iodide results in N1+N3-dimethylation. Theor. evaluations of the chemo- and regioselectivity along with x-ray crystallog. data are presented. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to hmds chemoselective o alkylation uracil, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 30, 2014, Kawamura, Madoka; Shiozawa, Fumiyasu; Kakinuma, Hiroyuki; Otake, Kenichi; Matsuda, Daisuke; Kobashi, Yohei; Suga, Yoichiro; Fusegi, Keiko published a patent.Quality Control of 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of azaspiroalkane compounds as GPR119 agonists. And the patent contained the following:

The title compounds [I; p = 0-2; q = 1 or 2; ring A = benzene ring or 6-membered heteroaryl; R11-R13 = independently H, halo, carbamoyl, etc.; X = -O- or -NR3-; R3 = H or alkyl; Y = alkanediyl; R2 = alkyl (optionally substituted with cycloalkyl or aryl), alkylsulfonyl, alkylcarbonyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of diabetes, were prepared For example, treatment of tert-Bu 2-(methoxymethylidene)-7-azaspiro[3.5]nonane-7-carboxylate (preparation given) with CF3CO2H/water, reaction with NaH/triethyl phosphonoacetate, hydrogenation, reduction using LiAlH4, reaction with 4-cyano-3-fluorophenol in the presence of N,N,N’,N’-tetramethylazodicarbamide, hydrolysis, and EDCI-mediated amidation with 2-aminoethanol afforded compound (II). In GPR119 agonist activity test, EC50 of II was 9 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Quality Control of 2-Chloro-5-isopropylpyrimidine

The Article related to azaspiroalkane preparation gpr119 agonist, diabetes treatment azaspiroalkane gpr119 agonist, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Quality Control of 2-Chloro-5-isopropylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 4, 2014, Kawamura, Madoka; Shiozawa, Fumiyasu; Matsuda, Daisuke; Kakinuma, Hiroyuki; Otake, Kenichi published a patent.Related Products of 596114-50-0 The title of the patent was Preparation of azaspiroalkane compounds as GPR119 agonists. And the patent contained the following:

Title compounds I [spiro moiety represented by Q1 in I is optionally substituted with alkyl or fluoro, may combine with cycloalkane to form a spiro ring, and may form a bridged ring with alkanediyl or alkenediyl; p = 0-3; q = 1-3; n1 = 0-2; n2 = 0-2 such as n1 + n2 = 1 or 2; ring A = benzene ring or 6-membered heteroaryl; R11-R13 = independently H, halo, carbamoyl, etc.; X = -O-, -S- or -NRx-; Rx = H or alkyl; Y = alkanediyl; R2 = alkyl (optionally substituted with cycloalkyl), haloalkyl, cycloalkyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of diabetes, were prepared For example, treatment of tert-Bu 2-(methoxymethylidene)-7-azaspiro[3.5]nonane-7-carboxylate (preparation given) with CF3CO2H/water, reaction with NaH/triethyl phosphonoacetate, hydrogenation, reduction, reaction with 4-cyano-3-fluorophenol in the presence of N,N,N’,N’-tetramethylazodicarbamide, hydrolysis, and EDCI-mediated amidation with 2-aminoethanol afforded compound II. In GPR119 agonist activity test, EC50 of II was 9 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Related Products of 596114-50-0

The Article related to azaspiroalkane preparation gpr119 agonist, diabetes treatment azaspiroalkane gpr119 agonist, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Related Products of 596114-50-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 20, 2012, Kawamura, Madoka; Kobashi, Yohei; Matsuda, Daisuke; Shiozawa, Fumiyasu; Suga, Yoichiro; Fusegi, Keiko; Kakinuma, Hiroyuki; Otake, Norikazu published a patent.Name: 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of azaspiroalkane compounds as GPR119 agonists. And the patent contained the following:

Title compounds I [p = 0-2; q = 1 or 2; ring A = benzene ring or 6-membered heteroaryl; R11-R13 = independently H, halo, carbamoyl, etc.; X = -O- or -NR3-; R3 = H or alkyl; Y = alkanediyl; R2 = alkyl (optionally substituted with cycloalkyl or aryl), alkylsulfonyl, alkylcarbonyl, etc.; or pharmaceutically acceptable salts thereof], useful for the treatment of diabetes, were prepared For example, treatment of tert-Bu 2-(methoxymethylidene)-7-azaspiro[3.5]nonane-7-carboxylate (preparation given) with CF3CO2H/water, reaction with NaH/triethyl phosphonoacetate, hydrogenation, reduction using LiAlH4, reaction with 4-cyano-3-fluorophenol in the presence of N,N,N’,N’-tetramethylazodicarbamide, hydrolysis, and EDCI-mediated amidation with 2-aminoethanol afforded compound II. In GPR119 agonist activity test, EC50 of II was 9 nM. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Name: 2-Chloro-5-isopropylpyrimidine

The Article related to azaspiroalkane preparation gpr119 agonist, diabetes treatment azaspiroalkane gpr119 agonist, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Name: 2-Chloro-5-isopropylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sahin, Saliha; Karkar, Buesra published an article in 2019, the title of the article was The antioxidant properties of the chestnut bee pollen extract and its preventive action against oxidatively induced damage in DNA bases.Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Chestnut bee pollen has potential nutritional and medicinal effects and is an important natural bee product. This study focused on the investigation of the antioxidant capacity and DNA damage inhibition ability of chestnut bee pollen (CBP) from Bursa (Turkey). The phenolic compounds (rosmarinic acid, vitexin, hyperoside, pinocembrin, trans-chalcone, apigenin, protocatechuic, and galangin) and carotenoids in CBPE were determined by HPLC-DAD (high-performance liquid chromatog.-diode array detection). Addnl., the protective ability of CBPE against DNA damage by oxidation was investigated. In this study, it was determined that CBPE has a high total phenolic compound content, and the antioxidant capacity of CBPE inhibits DNA oxidation (34% reduction of DNA damage in Fenton reaction media). This study could reveal new information regarding the use of CBPE as a protective agent for DNA in the future. Practical applications : Phenolic compounds and carotenoids prevent some diseases because of their important biol. activities. One of the potential food sources chestnut bee pollen contains sugar, carbohydrates, amino acids, proteins, lipids, vitamins, hormones, enzymes, and flavonoids. Chestnut bee pollen, which has protective activity against DNA oxidation, could be an excellent potential source of a protective agent against some degenerative diseases through future applications. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to antioxidant property chestnut bee pollen extract, dna oxidation, fenton, antioxidant, carotenoid, phenolic content, Food and Feed Chemistry: Additives, Sweeteners, Flavorings, Condiments, and Confectionery and other aspects.Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 2, 2017, Kubica, Dominika; Molchanov, Sergey; Gryff-Keller, Adam published an article.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Solvation of Uracil and Its Derivatives by DMSO: A DFT-Supported 1H NMR and 13C NMR Study. And the article contained the following:

1H NMR and 13C NMR spectra of uracil, thymine, 5-hydroxymethyluracil, 5,6-dihydrouracil, and 5,6-dihydrothymine in DMSO-d6 solutions have been measured. Addnl., mol. structures as well as NMR parameters of these compounds and their various solvates have been calculated using DFT B3LYP/6-311++G(2d,p) PCM(DMSO) method. The anal. of the chem. shift data for these compounds has shown that, indeed, in DMSO solutions they occur as equilibrium mixtures of free mols. and solvates in which solute and solvent mols. are joined by NH···O or OH···O hydrogen bonds. The populations of particular species present in the solutions have been estimated Moreover, it has been found that 5,6-dihydrothymine exists in DMSO solution preferentially in conformation with the Me group occupying the pseudoequatorial position. This finding is based on the mol. energy calculations and remains in full agreement with the interpretation of NMR data and theor. calculations of NMR parameters. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to uracil thymine hydroxymethyluracil dihydrouracil dihydrothymine solvation dmso nmr dft, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Qiu, Ran; Sun, Jiamu; Zhang, Xin; Zhao, Wenbo; Qin, Zhen; Luo, Hai published an article in 2016, the title of the article was Isomer differentiation through supramolecular self-assembly in microdroplets of milliseconds life-time.Product Details of 626-48-2 And the article contains the following content:

Supramol. recognition of thymine (or its analogs) with various central cations can form magic number clusters. Dual nano-ESI via theta tip emitters was used to online synthesize clusters. Even thermodynamically unstable clusters can be detected by MS thanks to the very short life-time ( approx. ms) of the generated microdroplets. By recording characteristic cluster distributions, isomers can be clearly differentiated in a novel bottom-up way. Theor. calculations were performed to explain the MS results. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to isomer differentiation supramol selfassembly microdroplet millisecond lifetime, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia