Tag: 100-200

On September 18, 2014, Chesworth, Richard; Moradei, Oscar Miguel; Shapiro, Gideon; Jin, Lei; Babine, Robert E. published a patent.Name: 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride The title of the patent was 1-Amino-3-(aryloxy)propanol derivatives as CARM1 inhibitors and uses thereof. And the patent contained the following:

Provided herein are compounds of formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; and their use for inhibiting CARM1 activity and for treating CARM1-mediated disorders. Compounds of formula I wherein X is O, S and CH2; R1 is H and (un)substituted C1-4 alkyl; R1a is H; each R2 are independently H, halo, CN, NO2, acyl, etc.; HET is 6-membered monocyclic nitrogen-containing heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their CARM1 inhibitory activity (data given). The experimental process involved the reaction of 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride(cas: 1187830-46-1).Name: 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride

The Article related to amino aryloxypropanol preparation carm1 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 16, 2019, Blake, James F.; Burgess, Laurence E.; Chicarelli, Mark Joseph; Christensen, James Gail; Cook, Adam; Fell, Jay Bradford; Fischer, John P.; Marx, Matthew Arnold; Mejia, Macedonio J.; Savechenkov, Pavel; Vigers, Guy P.A.; Smith, Christopher Ronald; Rodriguez, Martha E. published a patent.Electric Literature of 175357-98-9 The title of the patent was 5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine derivatives as KRas G12C inhibitors and their preparation. And the patent contained the following:

The invention relates to compounds of formula I that inhibit KRas G12C. The invention relates to compounds of formula I that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor. Compounds of formula I wherein L is a bond, CO and C1-3 alkylene; ring X is a 4- to 12-membered (mono/spiro)cyclic or bridged ring; Y is a bond, O, S and NH and derivatives; R1 is (un)substituted alkenoyl, (un)substituted alkynoyl, (un)substituted ethenylsulfonyl, etc.; R2 is H, alkyl, hydroxyalkyl, aryl, etc.; R3 is C1-3 alkyl, oxo, haloalkyl, etc.; R4 is H, cycloalkyl, aryl, etc.; n is 0, 1 and 2; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their KRas G12C inhibitory activity. From the assay, it was determined that compound II exhibited > 25 % inhibition at 5 μM concentration The experimental process involved the reaction of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine(cas: 175357-98-9).Electric Literature of 175357-98-9

The Article related to pyridopyrimidine preparation kras g12c inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 175357-98-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 26, 2015, Blaquiere, Nicole; Burch, Jason; Castanedo, Georgette; Feng, Jianwen A.; Hu, Baihua; Lin, Xingyu; Staben, Steven; Wu, Guosheng; Yuen, Po-Wai published a patent.Quality Control of Methyl 6-amino-2-chloropyrimidine-4-carboxylate The title of the patent was Alkynyl alcohols as NIK kinase inhibitors and their preparation. And the patent contained the following:

The invention relates to compounds of formula I and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed Compounds of formula I wherein ring A is monocycle and bicycle; A1 is N and CR1; A2 is N, NR2 and CR2; A3 is N, NR3 and CR3; A4 is N and CH; provided that one, two or three of A1 – A4 are N; one of A5 – A8 is N and the remaining are CR6 or all A5 – A8 are CR6; R1 is H, halo, OH, amino, C1-3 alkyl, etc.; R2 is H, OH, amino, C1-6 alkyl, etc.; R3 is H, (un)substituted C1-6 alkyl, C1-6 alkoxy, etc.; R1R2 or R2R3 can be taken together to form a C3-7 cycloalkyl, Ph and 3- to 11-membered heterocyclyl; R4 is C1-6 alkyl, CH2F and CH2OH; R5 is (un)substituted 3- to 11-membered heterocycle; R4R5 can be taken together to form (un)substituted C3-11 cycloalkyl and 3- to 11-membered heterocyclyl; each R6 is independently H, F, Cl, NH2, OH, etc.; and stereoisomers, and salts thereof, are claimed. Example compound II was prepared by cross-coupling of 2-chloropyrimidine-4-carboxamide with potassium (S)-trifluoro(3-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)borate. The invention compounds were evaluated for their NIK inhibitory activity (data given). The experimental process involved the reaction of Methyl 6-amino-2-chloropyrimidine-4-carboxylate(cas: 944129-00-4).Quality Control of Methyl 6-amino-2-chloropyrimidine-4-carboxylate

The Article related to alkynyl alc preparation nik inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of Methyl 6-amino-2-chloropyrimidine-4-carboxylate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 25, 2012, Liu, Wei-dong; Deng, Xi-ling; Zhang, Zhi-li; Wang, Xiao-wei; Liu, Jun-yi published an article.Electric Literature of 626-48-2 The title of the article was Synthesis of 6-(bromomethyl)-4-methoxy-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-2-ol from 6-methylpyrimidine-2,4-diol. And the article contained the following:

6-(Bromomethyl)-4-methoxy-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-2-ol was synthesized starting from 6-methylpyrimidine-2,4-diol through 6-Me alkylation and intramol. reductive cyclization as key steps. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Electric Literature of 626-48-2

The Article related to hydropyridopyrimidinol preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 24, 1997, Showalter, Howard Daniel Hollis; Winter, Roy Thomas; Rewcastle, Gordon William; Denny, William Alexander published a patent.Application of 175357-98-9 The title of the patent was Improved process for preparing 4,6-disubstituted pyrido[3,4-d]pyrimidines. And the patent contained the following:

The title compounds [I; R = aryl, alkyl, arylalkyl; R1, R2 = H, alkyl, hydroxyalkyl, etc.; R1R2 = 5-6 membered ring] were prepared Thus, reaction of 5-amino-2-fluoropyridine with di-tert-Bu dicarbonate followed by treatment of the resulting 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine with CO2, deprotection of 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine-4-carboxylic acid with CF3CO2H, reaction of 5-amino-2-fluoropyridine-4-carboxylic acid with formamidine acetate, treatment of 6-fluoropyrido[3,4-d]pyrimidin-4(3H)-one with SOCl2, reaction of 4-chloro-6-fluoropyrido[3,4-d]pyrimidine with 3-bromoaniline, and reaction of 4-[(3-bromophenyl)amino]-6-fluoropyrido[3,4-d]pyrimidine with MeNH2 afforded I [R = 3-BrC6H4; R1 = H; R2 = Me]. The experimental process involved the reaction of 4-Chloro-6-fluoropyrido[3,4-d]pyrimidine(cas: 175357-98-9).Application of 175357-98-9

The Article related to pyridopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 175357-98-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

del Arco, Jon; Acosta, Javier; Pereira, Humberto M.; Perona, Almudena; Lokanath, Neratur K.; Kunishima, Naoki; Fernandez-Lucas, Jesus published an article in 2018, the title of the article was Enzymatic Production of Non-Natural Nucleoside-5′-Monophosphates by a Thermostable Uracil Phosphoribosyltransferase.Formula: C5H6N2O2 And the article contains the following content:

The use of enzymes as biocatalysts applied to synthesis of modified nucleoside-5′-monophosphates (NMPs) is an interesting alternative to traditional multistep chem. methods which offers several advantages, such as stereo-, regio-, and enantioselectivity, simple downstream processing, and mild reaction conditions. Herein we report the recombinant expression, production, and purification of uracil phosphoribosyltransferase from Thermus themophilus HB8 (TtUPRT). The structure of TtUPRT has been determined by protein crystallog., and its substrate specificity and biochem. characteristics have been analyzed, providing new structural insights into the substrate-binding mode. Biochem. characterization of the recombinant protein indicates that the enzyme is a homotetramer, with activity and stability across a broad range of temperatures (50-80 °C), pH (5.5-9) and ionic strength (0-500 mM NaCl). Surprisingly, TtUPRT is able to recognize several 5 and 6-substituted pyrimidines as substrates. These exptl. results suggest TtUPRT could be a valuable biocatalyst for the synthesis of modified NMPs. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Formula: C5H6N2O2

The Article related to uracil phosphoribosyltransferase nucleoside monophosphate, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

del Arco, Jon; Acosta, Javier; Pereira, Humberto M.; Perona, Almudena; Lokanath, Neratur K.; Kunishima, Naoki; Fernandez-Lucas, Jesus published an article in 2018, the title of the article was Enzymatic Production of Non-Natural Nucleoside-5′-Monophosphates by a Thermostable Uracil Phosphoribosyltransferase.Formula: C5H6N2O3 And the article contains the following content:

The use of enzymes as biocatalysts applied to synthesis of modified nucleoside-5′-monophosphates (NMPs) is an interesting alternative to traditional multistep chem. methods which offers several advantages, such as stereo-, regio-, and enantioselectivity, simple downstream processing, and mild reaction conditions. Herein we report the recombinant expression, production, and purification of uracil phosphoribosyltransferase from Thermus themophilus HB8 (TtUPRT). The structure of TtUPRT has been determined by protein crystallog., and its substrate specificity and biochem. characteristics have been analyzed, providing new structural insights into the substrate-binding mode. Biochem. characterization of the recombinant protein indicates that the enzyme is a homotetramer, with activity and stability across a broad range of temperatures (50-80 °C), pH (5.5-9) and ionic strength (0-500 mM NaCl). Surprisingly, TtUPRT is able to recognize several 5 and 6-substituted pyrimidines as substrates. These exptl. results suggest TtUPRT could be a valuable biocatalyst for the synthesis of modified NMPs. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Formula: C5H6N2O3

The Article related to uracil phosphoribosyltransferase nucleoside monophosphate, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Formula: C5H6N2O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 31, 2015, Borodkin, G. I.; Elanov, I. R.; Shubin, V. G. published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Electrophilic fluorination of 6-methyl- and 1,3,6-trimethyluracils in water. And the article contained the following:

The reaction of 4-chloromethyl-1-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) with 6-methyl- and 1,3,6-trimethyluracil in water was studied. According to the kinetic data, the fluorination follows a bimol. mechanism with intermediate formation of cationic σ-complexes. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to electrophilic fluorination methyluracil trimethyluracil water, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 30, 2013, Chernikova, I. B.; Khursan, S. L.; Spirikhin, L. V.; Yunusov, M. S. published an article.Computed Properties of 626-48-2 The title of the article was Electrophilic ipso-substitution in uracil derivatives. And the article contained the following:

Treatment of 5-iodo-1,3,6-trimethyluracil with 50% H2SO4 gives 1,3,6-trimethyluracil; with 5-bromo-1,3,6-trimethyluracil, a mixture of 1,3,6-trimethyluracil and 6-bromomethyl-1,3-dimethyluracil is obtained. 5-Chloro-1,3,6-trimethyluracil remains inert under these conditions. According to the DFT modeling of the reactions of 5-halo-1,3,6-trimethyluracils, a nucleophilic agent can abstract either Hal+ or the Me proton from the carbocation formed by protonation of the starting halouracil at position 5, which accounts for the formation of two products from the 5-bromo derivative Under similar conditions, 6-methyluracil dibromohydrin yields N-bromo-5-bromo-6-hydroxymethyluracil. Bromination or chlorination of 5-hydroxymethyl- or 5-formyl-6-methyluracils follows the ipso-substitution scheme leading to 6-methyluracil 5-halo- and 5,5-dihalohydrins. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Computed Properties of 626-48-2

The Article related to electrophilic ipso substitution uracil derivative, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Computed Properties of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 31, 2022, Chernikova, I. B.; Yunusov, M. S. published an article.Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was On the mechanism of deiodination of 5-iodo-1,3,6-trimethyluracil. And the article contained the following:

Dehalogenation of 5-iodo-1,3,6-trimethyluracil in acidic medium in the presence of either KCl or KBr as the nucleophile sources proceeded as the halophilic reaction to give 1,3,6-trimethyluracil. This compound can be iodinated with ICl or IBr generated in the course of the reaction to recover the starting 5-iodo-1,3,6-trimethyluracil. This reverse process can be suppressed by addition of 6-methyluracil. The plausible reaction mechanism is discussed. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to iodo trimethyluracil dehalogenation mechanism, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia