Tag: 100-200

On December 31, 2019, Gainullina, Yu. Yu.; Gus’kov, V. Yu.; Timofeeva, D. V. published an article.Synthetic Route of 626-48-2 The title of the article was Polarity of Thymine and 6-Methyluracil-Modified Porous Polymers, According to Data from Inverse Gas Chromatography. And the article contained the following:

Abstract: The affinity of surfaces of porous polymer Polysorb-1 samples modified with thymine (5-methyluracil) and 6-methyluracil toward sorbates capable of various intermol. interactions is studied via inverse gas chromatog. in the infinite dilution mode. It is found that the first modifier yields one-dimensional tape supramol. structures as a result of self-assembling, while the second produces two-dimensional network structures. The contributions from intermol. interactions to the Helmholtz energy of adsorption are calculated via the linear decomposition of retention parameters. The dispersion and specific components of the energy of adsorption are determined according to Dong. It is shown that modifying the surface of a porous polymer with thymine increases both specific and dispersive components of the energy of adsorption, while the contributions from different intermol. interactions and the polarity of the surface as a result of modifying with thymine change slightly. Modifying a porous polymer with the same amount of 6-methyluracil results in a notable rise in polarity, due to an increase in the contributions from interactions of induction and orientation. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to thymine methyluracil divinylbenzene styrene copolymer surface polarity, Plastics Manufacture and Processing: Physical Properties and Testing Methods and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 30, 2015, Akbarzadeh, Marzieh; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Tajabadi, Javad published an article.Category: pyrimidines The title of the article was Synthesis of dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepines; derivatives of a novel ring system. And the article contained the following:

Several derivatives of the novel dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine ring system I (NR1 = piperidinyl, morpholinyl, pyrrolidino, etc.) have been synthesized through the initial heterocyclization of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with o-aminothiophenol followed by treatment with various secondary amines in boiling ethanol. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Category: pyrimidines

The Article related to dihydrobenzopyrimidothiazepine preparation, chloromethylmethylpyrimidine aminothiophenol heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 7, 2021, Krajewski, Allison E.; Lee, Jeehiun K. published an article.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Gas-phase experimental and computational studies of 5-halouracils: Intrinsic properties and biological implications. And the article contained the following:

The gas-phase acidity and proton affinity (PA) of 5-halouracils (5-fluorouracil, 5-chlorouracil, 5-bromouracil, and 5-iodouracil) have been examined using both theor. and exptl. methods. This work represents a comprehensive study of the thermochem. properties of these nucleobases. Other than 5-fluorouracil acidity, the intrinsic acidity and PA of these halouracils have not been heretofore measured; these new exptl. data provide a benchmark for the computational values. Furthermore, we examine these 5-halouracils in the context of the enzyme thymine DNA glycosylase (TDG), which is an enzyme that protects the genome by cleaving these substrates from DNA. Our gas-phase results are compared and contrasted to TDG excision rates to afford insights into the TDG mechanism. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to human thymine dna glycosylase mechanism 5 halouracil antitumor agent, halouracil gas phase acidity proton affinity thymine dna glycosylase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Reference of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 18, 2014, Amans, Dominique; Atkinson, Stephen John; Harrison, Lee Andrew; Hirst, David Jonathan; Law, Robert Peter; Lindon, Matthew; Preston, Alexander; Seal, Jonathan Thomas; Wellaway, Christopher Roland published a patent.Application of 596114-50-0 The title of the patent was Preparation of acylaminotetrahydroquinoline derivatives for use as bromodomain inhibitors. And the patent contained the following:

Title compounds I [A = NH, O, S, SO, etc.; V = (un)substituted Ph, heteroaromatic, or pyridone; W and Z independently = CH or N; X or Y independently = C or N; R1 = alkyl; R2 = alkyl, cycloalkyl, heterocyclyl, CH2CF3, or CH2OMe; R3 = alkyl, CH2F, CH2OH, or CH2OC(O)Me; R4 = absent, H, OH, halo, CN, CO2H, etc.; R5 = absent, H, halo, OH, or alkoxy], and their pharmaceutically acceptable salts, are prepared and disclosed as bromodomain inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in BRD4 BD2 TR-FRET assays, e.g., II demonstrated a pIC50 value of ≥7.0. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Application of 596114-50-0

The Article related to quinoline acylaminotetrahydro preparation bromodomain inhibitor, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Application of 596114-50-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 31, 2021, Ting, Chien-Yu; Huang, Ching-Ying; Chen, Hung-Chih; Chiu, Yi-Wen; Hsieh, Patrick C. H.; Lee, Jia-Jung published an article.Synthetic Route of 65-71-4 The title of the article was Generation of induced pluripotent stem cells from a Bardet-Biedl syndrome patient carrying a homologous BBS2 c.534 + 1G > T mutation. And the article contained the following:

Bardet-Biedl syndrome is a autosomal recessive hereditary disorder characterized by polydactyly, multiple renal cysts, retinal cone-rod dystrophy, obesity, and variable neural development or cognitive impairment. We reported the generation and characterization of an iPS cell line, IBMS-iPSC-063-06, from a patient carrying the BBS2 homologous c534 + 1G > T mutation. The generated iPS cell line retains the mutation and exhibits pluripotency and differentiation ability both in vivo and in vitro condition. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Synthetic Route of 65-71-4

The Article related to bardet biedl syndrome induced pluripotent stem cell bbs2, Mammalian Pathological Biochemistry: Metabolic and Hereditary Diseases and other aspects.Synthetic Route of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 31, 2018, Chestnova, T. V.; Zilov, V. G.; Gladkikh, P. G.; Khadartsev, A. A.; Korotkova, A. S.; Buzulukov, Yu. P. published an article.SDS of cas: 626-48-2 The title of the article was Combined Effect of Silver Nanoparticles, Ceftriaxone, and Methyluracil during Experimental Purulent Peritonitis. And the article contained the following:

Bacterial biofilms provoke and/or promote the most chronic and recurrent infectious diseases. Previously, exptl. models of purulent peritonitis and meningoencephalitis revealed pos. antibiofilm effect of metallic nanoparticles and the absence of resistance against such nanoparticles in microorganisms. This study examines the combined effect of silver nanoparticles with ceftriaxone and methyluracil on recovery mechanisms during inflammatory diseases exemplified by purulent peritonitis in exptl. animals. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).SDS of cas: 626-48-2

The Article related to purulent peritonitis silver nanoparticle ceftriaxone methyluracil, bacterial biofilms, ceftriaxone, methyluracil, nanoparticles, peritonitis, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.SDS of cas: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2022, Oba, Yasuhiro; Takano, Yoshinori; Furukawa, Yoshihiro; Koga, Toshiki; Glavin, Daniel P.; Dworkin, Jason P.; Naraoka, Hiroshi published an article.Product Details of 626-48-2 The title of the article was Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites. And the article contained the following:

The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chem. models and laboratory experiments have predicted that these compounds can also be produced from chem. precursors found in meteorites. Here we report the detection of nucleobases in three carbonaceous meteorites using state-of-the-art anal. techniques optimized for small-scale quantification of nucleobases down to the range of parts per trillion (ppt). In addition to previously detected purine nucleobases in meteorites such as guanine and adenine, we identify various pyrimidine nucleobases such as cytosine, uracil, and thymine, and their structural isomers such as isocytosine, imidazole-4-carboxylic acid, and 6-methyluracil, resp. Given the similarity in the mol. distribution of pyrimidines in meteorites and those in photon-processed interstellar ice analogs, some of these derivatives could have been generated by photochem. reactions prevailing in the interstellar medium and later incorporated into asteroids during solar system formation. This study demonstrates that a diversity of meteoritic nucleobases could serve as building blocks of DNA and RNA on the early Earth. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to carbonaceous meteorite extraterrestrial purine pyrimidine nucleobase identifying wide diversity, Mineralogical and Geological Chemistry: Cosmochemistry and Meteorites and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Semenov, Vyacheslav E.; Giniyatullin, Rashit Kh.; Lushchekina, Sofya V.; Kots, Ekaterina D.; Petrov, Konstantin A.; Nikitashina, Alexandra D.; Minnekhanova, Oksana A.; Zobov, Vladimir V.; Nikolsky, Evgeny E.; Masson, Patrick; Reznik, Vladimir S. published an article in 2014, the title of the article was Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Novel pyrimidinophanes possessing two o-nitrobenzylethyldialkylammonium heads bridging with different spacers were prepared Pyrimidinophanes 2a, 2b and 3 are reversible inhibitors of cholinesterases. They show a very good selectivity for human acetylcholinesterase (AChE), with an inhibitory power 100-200 times higher than for human butyrylcholinesterase (BChE). Docking simulations indicate specific binding of pyrimidinophanes 2a and 4 onto the peripheral anionic site of AChE. Other compounds bind to the active center of AChE as well as to the peripheral anionic site. These compounds are dual binding site inhibitors. Pyrimidinophane 2b and its acyclic counterpart 1 were tested in the animal model of myasthenia gravis and may be considered as valuable candidates for the treatment of pathol. muscle weakness syndromes. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to macrocyclic derivative methyluracil ligand peripheral anionic site acetylcholinesterase, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2020, Hua, Yan; Cao, Heqin; Wang, Jiao; He, Fengping; Jiang, Guangshun published an article.SDS of cas: 4433-40-3 The title of the article was Gut microbiota and fecal metabolites in captive and wild North China leopard (Panthera pardus japonensis) by comparsion using 16 s rRNA gene sequencing and LC/MS-based metabolomics. And the article contained the following:

Gut microbes significantly contribute to nutrient digestion and absorption, intestinal health and immunity, and are essential for the survival and environmental adaptation of wild animals. However, there are few studies on the gut microbiota of captive and wild North China leopard (Panthera pardus japonensis). A total of 10 mainly bacterial phyla were identified in the fecal microbiota of North China leopard, Lachnoclostridium (p = 0.003), Peptoclostridium (p = 0.005), Bacteroides (p = 0.008), Fusobacterium (p = 0.017) and Collinsella (p = 0.019) were significantly higher than those of wild North China leopard. Distinct differences in the fecal metabolic phenotypes of captive and wild North China leopard were found, such as content of l-methionine, n-acetyl-l-tyrosine, pentadecanoic acid and oleic acid. Differentially abundant gut microbes were associated with fecal metabolites, especially the bacteria in Firmicutes and Bacteroidetes, involved in the metabolism of N-acetyl-L-alanine and D-quinovose. This study reports for the first time the differences in gut microbiota abundance between captive and wild North China leopard, as well as significant differences in fecal metabolic phenotypes between two groups. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).SDS of cas: 4433-40-3

The Article related to gut microbiota fecal metabolite panthera pardus rrna gene metabolomics, 16s rrna gene sequencing, fecal metabolites, north china leopard, gut microbiota, metabolomics, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.SDS of cas: 4433-40-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 1, 2021, Liu, Xiangyong; Qiu, Changyong; Sheng, Haitong; Liu, Mengqiang; Shen, Qichao; Du, Guolong; Song, Xiaodong; Ding, Lieming; Wang, Jiabing published a patent.Related Products of 596114-50-0 The title of the patent was Egfr inhibitor, composition and preparation method therefor. And the patent contained the following:

A compound of formula I, a method for using these compounds as an EGFR inhibitor, and a pharmaceutical composition comprising these compounds The compound was used in the treatment, prevention or amelioration of diseases or conditions such as cancer or infection. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Related Products of 596114-50-0

The Article related to heterocyclic phosphine oxide preparation egfr inhibitor, antitumor activity heterocyclic phosphine oxide, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Related Products of 596114-50-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia