Tag: 100-200

Kinetics of the reaction of 2-thiouracil derivatives with chloroacetic acid amides was written by Jasinskas, L.;Urbonas, A.;Dienyte, J.. And the article was included in Lietuvos TSR Aukstuju Mokyklu Mokslo Darbai, Chemija ir Chemine Technologija in 1971.Application In Synthesis of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one The following contents are mentioned in the article:

Rate constants and activation energies were determined for the reaction of 2-thiouracil anions (I; R = Me, NH2, CO2Bu; R1 = H, Me, Et) with ClCH2COR2 (R2 = NHPh, NEt2, morpholino, NHC6H4NO2-m). The reaction occurred by an SN2 mechanism. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Application In Synthesis of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application In Synthesis of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Microwave promoted efficient synthesis of substituted uracils and thiouracils under solvent-free conditions was written by Mojtahedi, Mohammad M.;Saidi, Mohammad R.;Shirzi, Jafar S.;Bolourtchian, Mohammad. And the article was included in Synthetic Communications in 2002.Related Products of 39083-15-3 The following contents are mentioned in the article:

Several substituted uracils and thiouracils were synthesized in good yields by one-pot condensation reaction of Me or Et β-ketoesters and urea (or thiourea) in solvent-free conditions under microwave irradiation and in short time. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Related Products of 39083-15-3).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 39083-15-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Iodocyclization of 2-(allylthio)-4(3H)-pyrimidinones was written by Kim, D. G.;Shmygarev, V. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1995.Application of 39083-15-3 The following contents are mentioned in the article:

The title reaction gave thiazolopyrimidinium triiodides (I; R¹ = R² = H; R¹ = H, R² = Me; R¹ = Et, R² = Me). This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Application of 39083-15-3).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application of 39083-15-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors was written by Reigan, Philip;Gbaj, Abdul;Stratford, Ian J.;Bryce, Richard A.;Freeman, Sally. And the article was included in European Journal of Medicinal Chemistry in 2008.Name: 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine The following contents are mentioned in the article:

Thymidine phosphorylase (TP) is over-expressed in various tumor types and plays an important role in tumor angiogenesis, growth, invasion and metastasis. The enzymic activity of TP is required for the angiogenic effect of TP, therefore, inhibitors of TP are of significant interest in cancer chemotherapy. A series of xanthine oxidase (XO) activated prodrugs of known inhibitors of TP have been designed and synthesized with the ultimate intent of improving tumor selectivity and pharmacokinetic characteristics. These prodrugs were not inhibitors of TP, but were selectively oxidized by XO at C-2 and/or C-4 of the uracil ring moiety to generate the desired TP inhibitor. Mol. modeling of both the TP inhibitors and XO-activated prodrugs rationalized their binding in the active site of the human TP crystal structure. This study involved multiple reactions and reactants, such as 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine (cas: 1041864-02-1Name: 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine).

5-Chloro-7H-pyrrolo[2,3-d]pyrimidine (cas: 1041864-02-1) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis in the heterocyclic series. IX. Syntheses and reactions of 4,6-disubstituted pyrimidine-5-aldehydes was written by Bredereck, Hellmut;Simchen, Gerhard;Santos, Antonio A.. And the article was included in Chemische Berichte in 1967.HPLC of Formula: 14160-85-1 The following contents are mentioned in the article:

cf. CA 66, 94992n. In the reactions of dihydroxypyrimidines with Vilsmeier reagents, uracil gave (Me2N+:CHNHCOCH:CHOH)Cl-, and 4-hydroxy-6-oxodihydropyrimidines (I, R = H, Me, or Ph) were formylated at their 5-position to give 4-hydroxy-6-oxo-5-dimethylaminomethylene-5,6-dihydropyrimidine-HCl derivatives (II) which were converted, by POCl3/PhNMe2, into 4,6-dichloro-5-formylpyrimidine derivatives (III). III were converted, by nucleophilic agents (RR’NH or MeNH2), into 4-amino-6-chloro-5-formylpyrimidine derivatives (IV, R = H, Me, or Ph, R’ = H or Me) or 4,6-bis(methylamino)-5-methylaminomethylenepyrimidine. II were treated with Et malonate to give 7H-pyrano[2,3-d]pyrimidine derivatives (V). This study involved multiple reactions and reactants, such as 4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1HPLC of Formula: 14160-85-1).

4,6-Dihydroxy-2-methylpyrimidine-5-carbaldehyde (cas: 14160-85-1) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.HPLC of Formula: 14160-85-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hydrazones based on 5-ethyl-4-methyl-2-thiouracil was written by Vainilavicius, P.;Jasinskas, L.;Kuznecovaite, V.;Kimtys, L.. And the article was included in Liet. TSR Aukst. Mokyklu Mokslo Darb., Chem. Chem. Technol. in 1972.Recommanded Product: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one The following contents are mentioned in the article:

R1COCH2Br (0.11 mole) was added to a refluxing mixture of 0.1 mole 4-(ethylthio)- or 2-thio-5-ethyl-6-methyluracil, and the mixture refluxed 4-5 hr to give the following I (R, R1, Z, and % yield given): OH, Ph, S, 60; OH, m-O2NC6H4, S, 67; EtS, Ph, O, 40; and EtS, m-O2NC6H4, O, 40. I (0.02 mole) and 0.032 mole R2CONHNH2 in MeOH refluxed 12-25 hr, then kept 12 hr at 0° gave the following II (R, R1, R2, Z, and % yield given): OH, Ph, Ph, S, 90; OH, Ph, m-O2NC6H4, S, 74; OH, Ph, ο-HOC6H4, S, 67; OH, Ph, m-HOC6H4, S, 83; OH, p-HOC6H4, Ph, S, 59; OH, Ph, p-H2NC6H4, S, 57; OH, Me, Ph, S, 65; OH, m-O2NC6H4, Ph, S, 63; OH, m-O2NC6H4, m-O2NC6H4, S, 44; OH, m-O2NC6H4, ο-HOC6H4, S, 50; OH, m-O2NC6H4, m-HOC6H4, S, 50; OH, m-O2NC6H4, p-HOC6H4, S, 50; OH, m-O2NC6H4, Me, S, 54; EtS, Ph, Ph, O, 40; EtS, Ph, m-O2NC6H4, O, 59; EtS, Ph, p-HOC6H4, O, 54; EtS, Ph, m-O2NC6H4, O, 60; EtS, m-O2NC6H4, m-O2NC6H4, O, 32; and EtS, m-O2NC6H4, p-HOC6H4, O, 36. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Recommanded Product: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Isocytosine H₂-receptor histamine antagonists. I. Oxmetidine and related compounds was written by Brown, Thomas H.;Blakemore, Robert C.;Durant, Graham J.;Emmett, John C.;Ganellin, C. Robin;Parsons, Michael E.;Rawlings, D. Anthony;Walker, Terence F.. And the article was included in European Journal of Medicinal Chemistry in 1988.Quality Control of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one The following contents are mentioned in the article:

2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-4-pyrimidones I (R = H, Me, PhO, substituted benzyl, etc.; R¹ = H, Me, Pr, PhCH₂) were prepared via substitution of (methylthio)pyrimidinones with 5-methyl-4-[(2-aminomethyl)thiomethyl]imidazole. The model compound I (R = R¹ = H) has modest H₂-antagonist activity as shown by its ability to antagonize histamine-stimulated tachycardia in guinea pig right atrium in vitro and inhibit histamine-stimulated gastric acid secretion in the lumen-perfused stomach of the anesthetized rat. Investigation of the effect of substituents in the pyrimidone ring showed that suitable substitution at the 5-position gave compounds with greatly increased activity, whereas substituents at other positions in the ring were not favorable for activity. Some structure-activity and structure-toxicity correlations are discussed. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Quality Control of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1 was written by Piechowicz, Katarzyna A.;Truong, Eric C.;Javed, Kashif M.;Chaney, Rachelle R.;Wu, Johnny Y.;Phuan, Puay W.;Verkman, Alan S.;Anderson, Marc O.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016.COA of Formula: C7H10N2OS The following contents are mentioned in the article:

Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca²⁺ activated Cl^– channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and elec. excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. The authors found that very little structural variation of was tolerated, with most compounds showing no activity at 10 渭M. The most potent compound in the series, which substitutes 4-methoxyphenyl in with 2-thiophene, had IC₅₀ éˆ? 渭M for inhibition of TMEM16A chloride conductance. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3COA of Formula: C7H10N2OS).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C7H10N2OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1 was written by Piechowicz, Katarzyna A.;Truong, Eric C.;Javed, Kashif M.;Chaney, Rachelle R.;Wu, Johnny Y.;Phuan, Puay W.;Verkman, Alan S.;Anderson, Marc O.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2016.COA of Formula: C7H10N2OS The following contents are mentioned in the article:

Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca²⁺ activated Cl^– channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and elec. excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. The authors found that very little structural variation of was tolerated, with most compounds showing no activity at 10 渭M. The most potent compound in the series, which substitutes 4-methoxyphenyl in with 2-thiophene, had IC₅₀ 鈭? 渭M for inhibition of TMEM16A chloride conductance. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3COA of Formula: C7H10N2OS).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C7H10N2OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidines. LXIV. Synthesis of 4-Methyl-5-ethyleytosine was written by Johnson, Treat B.;Bailey, George C.. And the article was included in Journal of the American Chemical Society in 1913.Application of 39083-15-3 The following contents are mentioned in the article:

2-Thio-4-methyl-5-ethyl-6-oxypyrimidine, from CS(NH₂)₂, AcCHEtCO₂Et and Na in alc. 3-4 hrs. on the H₂O bath, prisms, m. 212° (yield, 60%); its Na. salt in alc. gives with PhCH₂Cl the 2-benzyltnercapto derivative, blocks, m. 160°; 2-ethylmercapto derivative, m. 138°, converted by PCl₆ at 100° after 10-12 hrs. into 2-ethylmercapto-4-methyl-5-ethyl-6-chloropyrimidine, b_23-1 177-80°, and by PhNH₂ in hot alc. into 2-anilino-4-methyl-5-ethyl-6-oxypyrimidine, m. 195°, while alc. NH₃, 3 hrs. at 150-60, instead of PhNH₂ gives the 2-amino compound, Minute Prisms, m. 281-20 (decompose); hydrobromide, needles, m. 160-75°, depending on the rate of heating; hydrochloride, apparently seps. with 1 H₂O, shrivels 80°, m. 11.5°. 2-Ethylmercapto-4-methyl-5-etlzyl-6-aminopyrimidine, from the above 6-Cl compound and alc. NH₃ at 140-50°, stout blocks, m. 89-91°, hydrolyzed by b. concentrate HCl to the hydrochloride, powder, decompose 125°, of 2-oxy-4-methyl-5-ethyl-6-aminopyrimidine (methylethylcylosine), blocks or rectangular prisms, m. 295° (decompose); hydrobromide, blocks, dedomp. about 260°. 4-Methyl-5-ethyluracil is obtained quant. by b. 2-ethylmereapto-4-methyl-5-ethyl-6-oxypyrimidine with 2 parts of ClCH₂CO₂H in H₂O. 2-Diphenylmethylmercapto-4-methyl-6-oxypyrimidine, from Ph₂CHBr, 2-thio-4-methyluracil and Na in alc., m. 214. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Application of 39083-15-3).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application of 39083-15-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia