Tag: 100-200

Selective mono-amination of dichlorodiazines was written by Sengmany, Stephane;Lebre, Julie;Le Gall, Erwan;Leonel, Eric. And the article was included in Tetrahedron in 2015.Safety of 4-(2-Chloropyrimidin-4-yl)morpholine This article mentions the following:

3,6-Dichloropyridazine, 4,6-dichloropyrimidine, 2,4-dichloropyrimidine, and 3,5-dichloropyridazine underwent chemoselective monosubstitution reactions with amines using triethylamine as a base in ethanol at either ambient temperature or reflux to give monoamino monochloro pyridazines and pyrimidines. The methodol. is general and efficient despite noticeable differences in reactivity between diazines; while dichloropyridazine and dichloropyrazine require several hours of heating at reflux for the reaction to proceed, dichloropyrimidines reach completion within minutes at room temperature In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Safety of 4-(2-Chloropyrimidin-4-yl)morpholine).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Safety of 4-(2-Chloropyrimidin-4-yl)morpholine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heterocyclic amplifiers of phleomycin. I. Some pyrimidinylpurines, pyrimidinylpteridines and phenylpyrimidines was written by Brown, Desmond J.;Cowden, William B.;Lan, Shu Bin;Mori, Kenya. And the article was included in Australian Journal of Chemistry in 1984.Synthetic Route of C5H2ClN3 This article mentions the following:

Synthetic routes are described to 5,6-diamino-2,4′-bipyrimidin-4-ones and thence to 2-(pyrimidin-4-yl)purines and 2-(pyrimidin-4-yl)pteridines, some of which bear an S or N-linked basic side chain; also reported are routes to a series of phenyl- and diphenylpyrimidines, with similar S-, N-, or O-linked side chains. Members of all the above systems show activity as amplifiers of phleomycin in a bacterial screen but the phenylpyrimidines with a sulfur-linked side chain are especially active. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4Synthetic Route of C5H2ClN3).

2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Synthetic Route of C5H2ClN3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers was written by Kemnitzer, William;Sirisoma, Nilantha;May, Chris;Tseng, Ben;Drewe, John;Cai, Sui Xiong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Category: pyrimidines This article mentions the following:

We report the discovery of N-((benzo[d][1,3]dioxol-5-yl)methyl)-6-phenylthieno[3,2-d]pyrimidin-4-amine (2a) as an apoptosis inducer using our proprietary cell- and caspase-based ASAP HTS assay, and SAR study of HTS hit 2a which led to the discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers. Compounds 5d and 5e were the most potent with EC₅₀ values of 0.008 and 0.004 μM in T47D human breast cancer cells, resp. Compound 5d was found to be highly active in the MX-1 breast cancer model. Functionally, compounds 5d and 5e both induced apoptosis through inhibition of tubulin polymerization In the experiment, the researchers used many compounds, for example, 4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0Category: pyrimidines).

4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Continuous-flow reactors for the rapid evolution and validation of kinetic motifs was written by Hone, Christopher A.;Bourne, Richard A.;Muller, Frans L.. And the article was included in Chimica Oggi in 2015.Product Details of 62968-37-0 This article mentions the following:

In this paper we apply the concept of a kinetic motif as a simple way to represent all the lime-dependent behavior in a single-step or multi-step reaction system. Small-scale continuous-flow reactors offer the potential to rapidly collect large amounts of data while accessing conventionally challenging exptl. conditions. The scope of the approach is demonstrated on reaction case study examples. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Product Details of 62968-37-0).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Product Details of 62968-37-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Microwave-assisted three-component synthesis and in vitro antifungal evaluation of 6-cyano-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones was written by Quiroga, Jairo;Cisneros, Carlos;Insuasty, Braulio;Abonia, Rodrigo;Cruz, Silvia;Nogueras, Manuel;Manuel de la Torre, Jose;Sortino, Maximiliano;Zacchino, Susana. And the article was included in Journal of Heterocyclic Chemistry in 2006.Electric Literature of C6H9N3OS This article mentions the following:

The reaction of 6-aminopyrimidin-4-ones with benzaldehydes and β-iminobutyronitrile or benzoylacetonitrile under microwave irradiation in dry media yields 6-cyano-5,8-dihydropyrido[2,3-d]-pyrimidinones. The structure of the synthesized compounds was determined on the basis of NMR measurements, especially by ¹H,¹H-, ¹H,¹³C COSY, DEPT, and NOESY experiments In contrast with other pyrido[2,3-d]pyrimidine derivatives, these compounds did not show any antifungal in vitro activity â‰?50 μg/mL. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Electric Literature of C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Electric Literature of C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reactions of 6-aminopyrimidines with 2-dimethylaminomethylenetetralone. Regiospecific synthesis of 5,6-dihydrobenzo[h]pyrimido[4,5-b]quinolines was written by Quiroga, Jairo;Insuasty, Braulio;Insuasty, Henry;Abonia, Rodrigo;Ortiz, Antonio;Sanchez, Adolfo;Nogueras, Manuel. And the article was included in Journal of Heterocyclic Chemistry in 2001.Synthetic Route of C6H9N3OS This article mentions the following:

Benzo[h]pyrimido[4,5-b]quinolines, e.g. I (R = H, Me; X = MeO, MeS, NH₂), were prepared via a regiospecific cyclocondensation reaction between 6-aminopyrimidines, e.g. II, and 2-dimethylaminomethylentetralone hydrochloride (III). The linear structures of the final compounds were determined by NMR measurements, especially by ¹H, ¹H-, ¹H, ¹³C COSY and DEPT experiments In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Synthetic Route of C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

5,5′-Methylenebis[6-amino-3-methyl-2-methylsulfanylpyrimidin-4(3H)-one]: an unusual molecular geometry within a hydrogen-bonded molecular ribbon was written by Trilleras, Jorge;Ramos, Juan;Cobo, Justo;Glidewell, Christopher. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2013.Related Products of 54030-56-7 This article mentions the following:

The mols. of the title compound, C₁₃H₁₈N₆O₂S₂, lie across 2-fold rotation axes in the space group C2/c. Although the pyrimidine ring is effectively planar, the bridging methylene C atom is displaced from the plane of the pyrimidine ring by 0.213(2) Å, while the C-C-C angle at the bridging C atom is 120.3(2)°. The mol. contains two symmetry-related N-H···O H bonds, generating S(8) motifs, and intermoecular N-H···O H bonds link the mols. into a ribbon of edge-fused rings. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Related Products of 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Nucleosides 11: synthesis of new derivatives of pyrido[2,3-d]pyrimidines and their nucleosides was written by Mohamed, Mosselhi A. M.;Abdel-Hafez, Shams H.;Gobouri, Adil A.. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2021.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:

Reaction of 6-amino-2-methylthio-3-methyluracil with Et ethoxymethyleneoxaloacetate or methyl(Z)-2-acetylamino-3-dimethylaminopropenoates afforded di-Et 2-(1,6-dihydro-1-methyl-2-(methylthio)-6-oxo-pyrimidin-4-yl-amino)methylene malonate or (2E)-Me 3-(1,6-dihydro-1-methyl-2-(methylthio)-6-oxo-pyrimidin-4-yl-amino)-2-acetamidoacrylate, resp. Cyclization of each of the latter products by sodium ethoxide afforded new pyrido[2,3-d]pyrimidines, which were ribosylated with 1-O-acetyl-2,3,5-O-benzoyl-β-D-ribofuranose by the silylation method yielded the protected nucleosides. The protected nucleosides were debenzoylated by sodium methoxide to afford novel pyrido[2,3-d]pyrimidine nucleosides, e.g. I (R = CO₂Et, NHAc). The structural assignments for the new compounds were based on their elemental anal. and spectroscopic data. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The strength and directionality of a halogen bond are co-determined by the magnitude and size of the σ-hole was written by Kolar, Michal;Hostas, Jiri;Hobza, Pavel. And the article was included in Physical Chemistry Chemical Physics in 2014.Recommanded Product: 16879-39-3 This article mentions the following:

The σ-holes of halogen atoms on various aromatic scaffolds were described in terms of their size and magnitude. The electrostatic potential maps at the CAM-B3LYP-D3(bj)/def2-QZVP level were calculated and the σ-holes of >100 aromatic analogs were thoroughly analyzed to relate the σ-holes to the binding preferences of the halogenated compounds Both the size and magnitude of the σ-hole increase when passing from chlorinated to iodinated analogs. Also, the σ-hole properties were studied upon chem. substitution of the aromatic ring as well as in the aromatic ring. Further, the angular variations of the interactions were studied on a selected set of halogenbenzene complexes with argon and hydrogen fluoride (HF). To analyze interaction energy components, DFT-SAPT angular scans were performed. The interaction energies of bromobenzene complexes were evaluated at the CCSD(T)/complete basis set level providing the benchmark energetic data. The strength of the halogen bond between halogenbenzenes and Ar atoms and HF mols. increases while its directionality decreases when passing from chlorine to iodine. The decrease of the directionality of the halogen bond is larger for a HF-containing complex and is caused by electrostatic and exchange-repulsion energies. These findings are especially valuable for protein-halogenated ligand-binding studies, applied in the realm of rational drug development and lead optimization. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Recommanded Product: 16879-39-3).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 16879-39-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A theoretical investigation on the reactivity of 6-amino-3-methylpyrimidin-4(3H)-ones towards DMAD. Tandem Diels-Alder retro Diels-Alder (DA/RDA) reaction was written by Cobo, Justo;Melguizo, Manuel;Nogueras, Manuel;Sanchez, Adolfo;Dobado, Jose A.;Nonella, Marco. And the article was included in Tetrahedron in 1996.COA of Formula: C6H9N3OS This article mentions the following:

The reactivity of 6-aminopyrimidin-4(3H)-ones towards DMAD is successfully explained by theor. investigation (PM3 semiempirical methods). All the PM3 results (activation energies (AE) for the transition states and the heat of formation (ΔH) for the products) support our previous exptl. work. In those reactions two main products were obtained: the pyridine derivatives as major ones, which are formed by a tandem DA/RDA reaction with extrusion of the Me isocyanate fragment; and 5-ethenylpyrimidin-4(3H)-ones as minor ones, which arose from a Michael addition, being in competition with the above normal DA. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7COA of Formula: C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.COA of Formula: C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia