Pteridines, LXIV. Synthesis and properties of thiolumazines was written by Southon, Ian W.;Pfleiderer, Wolfgang. And the article was included in Chemische Berichte in 1978.Application of 54030-56-7 This article mentions the following:
Thiolumazines I (R = Me, R1 = H, Me, Ph, 2-pyridyl) were prepared in 82, 70, 50, and 8% yields by cyclizing diaminopyrimidine II with R1COCOR1. Cyclization of I (R = H, R1 = H, Me, Ph) with Br(CH2)nBr (n = 2, 3) in aqueous N NaOH or DMF-K2CO3 gave preferentially, 44, 35, and 88% thiazolo- (III, R1 = H, Me, Ph, n = 2) and 14 and 68% thiazinopteridines III (R1 = H, Ph, n = 3), with the [3,2-a]isomers as minor products (thiazolopteridine IV was isolated in 5% yield). Stirring I (R = Me, R1 = Me, Ph) with CH2Br2 and K2CO3 in DMF 4.5 h at 60鎺?gave 87 and 53% sulfide V (R1 = Me, Ph; m = 1), whereas refluxing with THF 2 h gave 56 and 22% V (R1 = Me, Ph; m = 0), 7% VI (R = R1 = Me), and 11% pteridine VII. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Application of 54030-56-7).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application of 54030-56-7
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia