Related Products of 36315-01-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.
A sealed tube was charge with 21-2 (1 mmol), 21-3 (1 mmol) and sodium tert-butoxide (310 mmol) in toluene (5 mL). The resulting mixture was degassed with Argon for about 10 minutesfollowed by the addition ofPd2(dba)3 (0.1 mmol) and XantPhos (0.2 mmol). Reaction mixture washeated at 100C for 16 hours to produce 21-4(a-e). It was then cooled to room temperature, filteredthrough a cartridge and the filtrate was partitioned between ethyl acetate and water. Organic layerwas separated, washed with water, brine, dried over anhydrous Na2S04 and concentrated under15 reduced pressure. Crude mass was purified by column chromatography (silica, gradient: 0-25%ethyl acetate in hexane) to afford 21-4(a-e).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,36315-01-2, its application will become more common.
Reference:
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Christoper, G.; HENDERSON, James, A.; LIANG, Yanke; HE, Minsheng; DUPLESSIS, Martin; CHEN, Chi-Li; (791 pag.)WO2018/237026; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia