As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10320-42-0, name is 2-Chloro-5-nitropyrimidine, molecular formula is C4H2ClN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C4H2ClN3O2
General procedure: A mixture of compound 8 (10.0 g, 23.4 mmol) and 2-chloro-5-nitropyrimidine (3.90 g, 24.5 mmol) in THF (80 mL) was refluxed overnight. After removal of the solvent, the residue was purified by silica gel column chromatography (hexane/AcOEt = 70:30 to 0:100) to give the title compound (11.0 g, 20.0 mmol, 98percent) as a yellow solid.
With the rapid development of chemical substances, we look forward to future research findings about 10320-42-0.
Reference:
Article; Sato, Kenjiro; Takahagi, Hiroki; Kubo, Osamu; Hidaka, Kousuke; Yoshikawa, Takeshi; Kamaura, Masahiro; Nakakariya, Masanori; Amano, Nobuyuki; Adachi, Ryutaro; Maki, Toshiyuki; Take, Kazumi; Takekawa, Shiro; Kitazaki, Tomoyuki; Maekawa, Tsuyoshi; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4544 – 4560;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia