With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1235451-38-3, name is tert-Butyl ((5-bromopyrimidin-2-yl)methyl)carbamate, molecular formula is C10H14BrN3O2, molecular weight is 288.14, as common compound, the synthetic route is as follows.Formula: C10H14BrN3O2
A mixture of tert- butyl Af-[( 5 -brom opyri idin -2-yl )m ethyl ] curb am ate (100 mg, 347 pmol, 1.00 equiv), Pin2B2 (176 mg, 694 pmol, 2.00 equiv), KOAc (68.1 mg, 694 pmol, 2.00 equiv) and Pd(dppf)Cl2 (25.4 mg, 34.7 pmol, 0.10 equiv) in dioxane (2.00 mL) was purged with N2 and then stirred at 100 C for 2 h. The reaction mixture was filtered and concentrated in vacuo to afford [2-[(/er/-butoxycarbonylamino)methyl]pyrimidin-5-yl]boronic acid (100 mg, crude) as a red oil. LCMS [M-55]: 198.1
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235451-38-3, tert-Butyl ((5-bromopyrimidin-2-yl)methyl)carbamate, and friends who are interested can also refer to it.
Reference:
Patent; MIRATI THERAPEUTICS, INC; MARX, Matthew, Arnold; LEE, Matthew, Randolph; BOBINSKI, Thomas, P.; BURNS, Aaron, Craig; ARORA, Nidhi; CHRISTENSEN, James, Gail; KETCHAM, John, Nichael; (225 pag.)WO2019/152419; (2019); A1;,
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