With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.93587-23-6, name is 7-Bromo-1H-pyrrolo[3,2-d]pyrimidin-4(5H)-one, molecular formula is C6H4BrN3O, molecular weight is 214.02, as common compound, the synthetic route is as follows.COA of Formula: C6H4BrN3O
Under argon atmosphere, a solution of 7-Bromo-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (500 mg, 2.33 mmol) in phosphorus(V) oxychoride (6 rriL) was refluxed for 2 hours. The reaction mixture was then cooled to room temperature, concentrated and the residue was diluted with ethyl acetate. The organic layer was washed with a solution of sodium bicarbonate, brine, dried over sodium sulfate, filtered and evaporated under reduced pressure to afford compound (66a) as a pale solid (490 mg, 2.10 mmol, 90%) without further purification. lH NMR (400 MHz, DMSO-i delta 8.24 (d, J = 3.0 Hz, 1H), 8.72 (s, 1H), 12.95 (bs, 1H). MS m/z ([M+H]+) 232/234
At the same time, in my other blogs, there are other synthetic methods of this type of compound,93587-23-6, 7-Bromo-1H-pyrrolo[3,2-d]pyrimidin-4(5H)-one, and friends who are interested can also refer to it.
Reference:
Patent; LABORATOIRE BIODIM; ATAMANYUK, Dmytro; CHEVREUIL, Francis; FAIVRE, Fabien; GERUSZ, Vincent; GOLD, Johan; MOREAU, Francois; SIMON, Christophe; WO2015/128334; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia