Synthetic Route of 1195-08-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1195-08-0, name is 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.
General procedure: To a stirred solution of free amine ester (1 equiv was previously isolated: 1 equiv of the corresponding hydrochloride with 1.3 equiv K2CO3, in a mixture of AcOEt/H2O during 1h. It was washed with water and the organic fase evaporated), in toluene (2 mL) was added 5-formyluracile (1 equiv, 0.5 mmol). After that, dipolarophile (1.0 equiv, 0.5 mmol) and AgOAc (5 mol%). The solvent was removed under reduced pressure. The crude mixture was filtrated through Celite with warm EtOH to furnish the corresponding product.
Statistics shows that 1195-08-0 is playing an increasingly important role. we look forward to future research findings about 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde.
Reference:
Article; Selva, Elisabet; Castello, Luis M.; Mancebo-Aracil, Juan; Selva, Veronica; Najera, Carmen; Foubelo, Francisco; Sansano, Jose M.; Tetrahedron; vol. 73; 49; (2017); p. 6840 – 6846;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia