Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36314-97-3, name is 2-Amino-4-chloro-6-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines
Examples 19-22; Using the following general method, Examples 19-22 were prepared; A suspension of Intermediate A (1.0 mmol), Intermediate B (1.0 mmol), and HCl (0.1 mL) in H2O (1.0 mL) was heated to 70 C. in a 5 mL reaction vial overnight. The reaction mixture was diluted with MeOH, treated with saturated NaHCO3, coated on silica and purified by MPLC (Biotage) with 5% MeOH in CH2Cl2.; Example 19; Preparation of N-(2-amino-6-phenyl-4-pyrimidinyl)-N-[3,5-dichloro-4-(4-pyridinylsulfanyl)phenyl]amine; Prepared in 40% yield from A17 and B14: TLC (4% MeOH in CH2Cl2) Rf 0.42; MS (ES) 440 [M+H]+; 1H-NMR (DMSO-d6) delta6.53 (s, 1H), 6.67 (bs, 2H), 6.94 (d, J=6.1 Hz, 2H), 7.47-7.51 (m, 3H), 7.93-7.96 (m, 2H), 8.18 (s, 2H), 8.36 (d, J=5.7 Hz, 2H), 9.88 (bs, 1H).
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Reference:
Patent; BAYER CORPORATION; US2004/2508; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia