Electric Literature of 3934-20-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3934-20-1, name is 2,4-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of ethyl 3-methyl-iH-pyrazole-4-carbaldehyde (6.4 g, 58.0 mmol) in 60 mL of anhydrous N,N- dimethylformamide were added potassium carbonate (10.8 g, 77.8 mmol) and 2,4-dichloropyrimidine (8.64 g, 58.0 mmol) at room temperature. The resulting suspension was stirred for 14 hours at room temperature with monitoring a reaction with LC-MS or thin layer chromatography (TLC). The reaction mixture was diluted with ethyl acetate and washed with brine (x2). The collected organic layer was dried over anhydrous sodium sulfate and then concentrated in vacuo. The resulting residue was purified by silica gel chromatography using a mixture of heptanes and ethyl acetate to afford the desired intermediate 2 as a white solid (5.47 g, 42 %); MS (ESI) m/z 223 [M+H]+, 1H NMR (300 MHz, CDCls) delta 10.06 (s, 1H), 9.04 (s, 1H), 8.70 (d, 1H, / = 5.4 Hz), 7.87 (1H, d, / = 5.4 Hz), 2.59 (s, 3H).
According to the analysis of related databases, 3934-20-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GENOSCO; OSCOTEC, INC.; CHOI, Jang-Sik; HWANG, Hae-Jun; LEE, Eunho; LEE, Jaekyoo; SONG, Ho-Juhn; KIM, Se Won; KIM, Jung-Ho; KOH, Jong, Sung; CHANG, Sunhwa; LEE, Tae-im; CHOI, Yung-geun; HAN, Ik-hwan; LEE, Jaesang; WO2013/109882; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia