Synthetic Route of 3764-01-0, Adding some certain compound to certain chemical reactions, such as: 3764-01-0, name is 2,4,6-Trichloropyrimidine,molecular formula is C4HCl3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3764-01-0.
2,4,6-trichloropyrimidine (8) 10.00 g, 54.52 mmol) was added to a 250 mL three-necked flask.Add 100mL of dichloroMethane, stirred and dissolved, added DIEA (8.50 mL, 48.70 mmol), cooled to -78 C, slowly added morpholine (4.30 mL,49.40mmol), after adding, the reaction was stirred for 1 to 2 hours, TLC (petroleum ether: ethyl acetate = 6:1) was used to detect the reaction of the starting material 8 and the reaction was stopped. The reaction solution was poured into 150 mL of water, and the mixture was separated. Methyl chloride layer, the aqueous layer was extracted with 50 mL of dichloromethaneThe methylene chloride layer was combined and washed twice with saturated sodium chloride solution (80 mL¡Á2), dried over anhydrous Na 2 SO 4 , filtered and filtered.The crude product was obtained by adding a mixed solvent (petroleum ether: ethyl acetate = 50:1, 100 mL) for 2 hours, suction filtration, and drying to give a white solid.The body was 9.4 g, and the yield was 73.7%.
According to the analysis of related databases, 3764-01-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; China Pharmaceutical University; Hefei Medical Engineering Pharmaceutical Co., Ltd.; Xu Yungen; Zhu Qihua; Wang Junwei; Chu Zhaoxing; Li Hui; Ge Yiran; He Guangwei; (22 pag.)CN109810100; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia