Formula: C4HCl3N2In 2016 ,《Regioselective 2-Amination of Polychloropyrimidines》 appeared in Organic Letters. The author of the article were Smith, Sean M.; Buchwald, Stephen L.. The article conveys some information:
The regioselective amination of substituted di- and trichloropyrimidines affording the 2-substituted products is reported. While aryl- and heteroarylamines require the use of a dialkylbiarylphosphine-derived palladium catalyst for high efficiency, more nucleophilic dialkylamines produce 2-aminopyrimidines under noncatalyzed SNAr conditions. The key is the use of 5-trimethylsilyl-2,4-dichloropyrimidine as a surrogate for the parent dichloropyrimidine. For more challenging cases, the 2-chloro-4-thiomethoxy analogs were prepared and exclusively afford the desired 2-aminated-4-thiomethoxypyrimidine products. In the experimental materials used by the author, we found 2,4,6-Trichloropyrimidine(cas: 3764-01-0Formula: C4HCl3N2)
2,4,6-Trichloropyrimidine(cas: 3764-01-0) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Formula: C4HCl3N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia