The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Formula: C4H3ClN2.
Shultz, Zachary;Shan, Chuan;Wojtas, Lukasz;Lopchuk, Justin M. research published 《 A modular approach for the installation of functionalized phosphonates to heterocycles》, the research content is summarized as follows. Phosphonic acids and esters are pervasive throughout the discovery sciences, from medicine and agriculture, to materials and asym. synthesis. The ability to install and construct mol. architecture containing phosphonic functionality has led to the development of new medicines and catalyst systems in the field of organo- and organometallic catalysis. To continue the advancement in the field, improved synthetic access to phosphorous-containing motifs is required. In particular, heterocyclic phosphonates and their acid derivatives are so far underdeveloped. The method described herein provides a robust and operationally simple procedure for the installation of various phosphonates to a wide range of electrophilic heterocycles.
1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., Formula: C4H3ClN2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia