The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 65-86-1, formula is C5H4N2O4, Name is 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Category: pyrimidines.
Putri, Safira Latifa Erlangga;Suantika, Gede;Situmorang, Magdalena Lenny;Putri, Sastia Prama;Fukusaki, Eiichiro research published 《 Metabolomics approach to elucidate the importance of count size in commercial penaeid shrimps: white leg shrimp (Litopenaeus vannamei) and black tiger shrimp (Penaeusmonodon)》, the research content is summarized as follows. Currently, count size is applied globally as a grading standard to sell head-less shell-on farmed shrimp. Although count size does not indicate directly the quality of shrimp, the price of shrimp generally increases proportionally with the increase of shrimp size. The importance of the size of white leg shrimp has been previously reported, where a strong correlation was found between size and metabolome data. In this study, we aimed to improve the predictive power of the orthogonal projection to latent structure (OPLS) model by expanding the metabolite coverage using liquid chromatog. mass-spectrometry (LC/MS) and gas chromatog.-mass spectrometry (GC/MS) anal. The training set consisted of 11 different-sized white leg shrimps from Indonesia and was validated in a step-wise manner by introducing an independent dataset consisting of com. shrimp from the Japanese market. The first validation set consisted of com. white leg shrimp, resulting in standard deviation error estimation and prediction values of 1.648 and 2.617, resp. IMP and AMP, which are metabolites responsible for the umami taste in crustaceans, showed the highest variable importance in projection (VIP) scores and pos. correlated with the increase in shrimp size. The second validation was carried out to evaluate the applicability of the size-metabolome relationship to other com. penaeid shrimp species. The com. black tiger shrimps with count sizes of 31/40, 21/25, 16/20, and 13/15 failed to predict the size of shrimp, suggesting that the importance of size in relation to the metabolome profile was rather species-specific.
65-86-1, Orotic acid anhydrous is a hydrogen bonding interaction that can be found in biological systems. It plays a role in the physiological effects of orotic acid, which is a metabolite of uridine and an intermediate in the synthesis of pyrimidine nucleotides. Orotic acid has antimicrobial properties and has been shown to inhibit enzyme activities involved in energy metabolism, such as polymerase chain reaction (PCR) and adenosine triphosphate (ATP) synthase. Orotic acid also inhibits the growth of bacteria, fungi, and parasites. Orotic acid anhydrous is used for treating myocardial infarcts or brain functions. The untreated group was given no treatment at all.
Orotic acid, also known as orotate or orotsaeure, belongs to the class of organic compounds known as pyrimidinecarboxylic acids. These are pyrimidines with a structure containing a carboxyl group attached to the pyrimidine ring. Orotic acid exists as a solid, slightly soluble (in water), and a moderately acidic compound (based on its pKa). Orotic acid has been found in human liver and pancreas tissues, and has also been primarily detected in saliva, feces, urine, and blood. Within the cell, orotic acid is primarily located in the cytoplasm and mitochondria. Orotic acid exists in all eukaryotes, ranging from yeast to humans. Orotic acid participates in a number of enzymatic reactions. In particular, Orotic acid can be biosynthesized from L-dihydroorotic acid and quinone; which is mediated by the enzyme dihydroorotate dehydrogenase (quinone), mitochondrial. In addition, Orotic acid and phosphoribosyl pyrophosphate can be converted into orotidylic acid through its interaction with the enzyme uridine monophosphate synthetase isoform a. In humans, orotic acid is involved in the pyrimidine metabolism pathway. Orotic acid is also involved in several metabolic disorders, some of which include the mngie (mitochondrial neurogastrointestinal encephalopathy) pathway, dihydropyrimidinase deficiency, UMP synthase deficiency (orotic aciduria), and Beta ureidopropionase deficiency. Outside of the human body, orotic acid can be found in a number of food items such as green vegetables, alaska blueberry, chickpea, and colorado pinyon. This makes orotic acid a potential biomarker for the consumption of these food products. Orotic acid is a potentially toxic compound. Orotic acid has been found to be associated with several diseases known as phosphoenolpyruvate carboxykinase deficiency 1, cytosolic and hyperornithinemia-hyperammonemia-homocitrullinuria; orotic acid has also been linked to several inborn metabolic disorders including n-acetylglutamate synthetase deficiency, lysinuric protein intolerance, and ornithine transcarbamylase deficiency.
Orotic acid appears as white crystals or crystalline powder.
Orotic acid is a pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6. It has a role as a metabolite, an Escherichia coli metabolite and a mouse metabolite. It derives from a uracil. It is a conjugate acid of an orotate., Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia