Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 65-86-1, formula is C5H4N2O4, Name is 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Name: 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid.
Peralta, Guillermo H.;Burgi, Maria D. Milagros;Martinez, Luciano J.;Albarracin, Virginia H.;Wolf, I. Veronica;Perez, Adrian A.;Santiago, Liliana G.;Hynes, Erica R.;Bergamini, Carina V. research published 《 Influence of three ultrasound treatments on viability, culturability, cell architecture, enzymatic activity and metabolic potential of Lacticaseibacillus paracasei 90》, the research content is summarized as follows. The effects of ultrasonic bath (UB) and ultrasonic probe (UP) treatments on culturability, viability, cell architecture, and enzymic activity of Lacticaseibacillus paracasei 90 (L90) were studied by cell count, flow cytometry, SEM (SEM) and enzyme activity determinations To evaluate the metabolic potential of the treated cells, milk was inoculated with treated or untreated bacteria, and incubated for 20 h at 37°C. SEM revealed cellular damage in some UP-treated cells; flow cytometry and enzyme activity anal. reflected an overall increase in permeability and lysis. UB increased the proteolytic activity of L90 and reduced its ability to produce acid. The damage of the cellular integrity caused by UP led to an increase in enzyme accessibility to the substrate, pos. correlated with enhanced diacetyl and acetoin production Depending on equipment used and exposure time, ultrasonic waves may be used to enhance the metabolic potential of starter and adjunct cultures.
Name: 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Orotic acid anhydrous is a hydrogen bonding interaction that can be found in biological systems. It plays a role in the physiological effects of orotic acid, which is a metabolite of uridine and an intermediate in the synthesis of pyrimidine nucleotides. Orotic acid has antimicrobial properties and has been shown to inhibit enzyme activities involved in energy metabolism, such as polymerase chain reaction (PCR) and adenosine triphosphate (ATP) synthase. Orotic acid also inhibits the growth of bacteria, fungi, and parasites. Orotic acid anhydrous is used for treating myocardial infarcts or brain functions. The untreated group was given no treatment at all.
Orotic acid, also known as orotate or orotsaeure, belongs to the class of organic compounds known as pyrimidinecarboxylic acids. These are pyrimidines with a structure containing a carboxyl group attached to the pyrimidine ring. Orotic acid exists as a solid, slightly soluble (in water), and a moderately acidic compound (based on its pKa). Orotic acid has been found in human liver and pancreas tissues, and has also been primarily detected in saliva, feces, urine, and blood. Within the cell, orotic acid is primarily located in the cytoplasm and mitochondria. Orotic acid exists in all eukaryotes, ranging from yeast to humans. Orotic acid participates in a number of enzymatic reactions. In particular, Orotic acid can be biosynthesized from L-dihydroorotic acid and quinone; which is mediated by the enzyme dihydroorotate dehydrogenase (quinone), mitochondrial. In addition, Orotic acid and phosphoribosyl pyrophosphate can be converted into orotidylic acid through its interaction with the enzyme uridine monophosphate synthetase isoform a. In humans, orotic acid is involved in the pyrimidine metabolism pathway. Orotic acid is also involved in several metabolic disorders, some of which include the mngie (mitochondrial neurogastrointestinal encephalopathy) pathway, dihydropyrimidinase deficiency, UMP synthase deficiency (orotic aciduria), and Beta ureidopropionase deficiency. Outside of the human body, orotic acid can be found in a number of food items such as green vegetables, alaska blueberry, chickpea, and colorado pinyon. This makes orotic acid a potential biomarker for the consumption of these food products. Orotic acid is a potentially toxic compound. Orotic acid has been found to be associated with several diseases known as phosphoenolpyruvate carboxykinase deficiency 1, cytosolic and hyperornithinemia-hyperammonemia-homocitrullinuria; orotic acid has also been linked to several inborn metabolic disorders including n-acetylglutamate synthetase deficiency, lysinuric protein intolerance, and ornithine transcarbamylase deficiency.
Orotic acid appears as white crystals or crystalline powder.
Orotic acid is a pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6. It has a role as a metabolite, an Escherichia coli metabolite and a mouse metabolite. It derives from a uracil. It is a conjugate acid of an orotate., 65-86-1.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia