The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Recommanded Product: Pyrimidin-2-amine.
Panigrahi, Uttam Kumar;Bhat, Venugopal T.;Ramakrishnan, Vengadesh Kumara Mangalam research published 《 Magnetically Recyclable Heterogeneous Cobalt Ferrite Catalyst for the Direct N-Alkylation of (Hetero)aryl Amines with Alcohols》, the research content is summarized as follows. Herein we report the use of spinel cobalt ferrite nanoparticles as an efficient and selective catalyst for the mono N-alkylation of aryl and hetero aryl amines with various aromatic and aliphatic alcs. Based on our experiments, the optimum condition for good to excellent yield were observed with alc. (1.0 mmol), aniline (1.2 mmol), KOH (0.5 equiv), and CoFe2O4 nanocatalyst (10 mol%) in toluene at 130°C in 24 h. Further control experiment studies revealed that the reaction does not proceed in the absence of the catalyst or a strong base. This magnetically recyclable nanocatalyst does not require any ligands and is easily synthesized at low temperature The reutilization of the recovered catalyst in a fresh reaction gave good to excellent yield. The experiment results strongly suggest a borrowing hydrogen pathway for N-alkylation under our standard conditions. The utility of these nanocatalysts was also demonstrated for the dehydrogenative synthesis of heterocycles like indole and quinolines.
Recommanded Product: Pyrimidin-2-amine, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia