Pyrimidines

Synthetic Route of 2434-56-2, Adding some certain compound to certain chemical reactions, such as: 2434-56-2, name is 4,6-Diaminopyrimidine,molecular formula is C4H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2434-56-2.

The hydrochloric acid reaction solution was diluted to 1.5 mol / L,Cooled to -10 C,Add 82g in batchesSodium nitrite,After stirring for 1.5 h, sodium carbonate was added and the reaction solution was neutralized to pH neutral,Filtered to give a damp 4,6-diamino-5-nitrosylpyrimidine cake.The yield was 85%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2434-56-2, 4,6-Diaminopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University of Technology; Li, Yongshu; Yan, Yiyi; Chen, Liqi; Mao, Liping; Wang, Yunlong; (17 pag.)CN103709164; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 62458-96-2, 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C14H15N3O, blongs to pyrimidines compound. Computed Properties of C14H15N3O

B. 7-Benzyl-4-chloro-5, 6,7, 8-tetrahydropyrido [3, 4-d] pyrimidine [00228] 7-Benzyl-5, 6,7, 8-tetrahydro-3H-pyrido [3,4-d] pyrimidin-4-one (9.4g, 39mmol) was dissolved in anhydrous 1,2-dichloroethane and stirred under N2 (g) atmosphere. To the mixture was added POC13 (29mL, 312mmol), followed by N, N-dimethyl aniline (4.75g, 39mmol). The mixture was refluxed for 2 h and the solvents were removed under vacuum to give a red residue. The residue was dissolved in 20 mL of ethyl acetate and 20ml of water was added. The solution was neutralized with ice and solid NaHC03. After neutralization, ethyl acetate was added and the orgarhC layer’was washed with water ana Dnne. ine organic layer was dried over Na2SO4 and the solvents were removed under vacuum. The resulting red residue was purified using a gradient of ethyl acetate: hexane (0-100%) to give the desired compound as yellow crystals (3.8g, 38%).

The synthetic route of 62458-96-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RENOVIS, INC.; WO2005/66171; (2005); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 89793-12-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate, molecular formula is C7H7ClN2O2, molecular weight is 186.6, as common compound, the synthetic route is as follows.

0126] A mixture of aniline (3.7 g, 40 mmol), ethyl 2-chloropyrimidine-5-carboxylate 1 (7.5 g, 40 mmol), K2CO3 (11 g, 80 mmol) in DMF (100 mL) was degassed and stirred at 120C under N2 overnight. The reaction mixture was cooled to it and diluted with EtOAc (200 mL), then washed with saturated brine (200 mL x 3). The organic layer was separated and dried over Na2SO4, evaporated to dryness and purified by silica gel chromatography (petroleum ethers EtOAc=101) to give the desired product as a white solid (6.2 g, 64%).

The chemical industry reduces the impact on the environment during synthesis 89793-12-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; Golonzhka, Olga; Jarpe, Matthew B.; (30 pag.)US2017/114023; (2017); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5750-76-5, name is 2,4,5-Trichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 5750-76-5

2,5-dichloro-N-[2-(propan-2-ylsulfonyl)phenyl]pyrimidin-4-amine (0440) To a solution of 1-Amino-2-(isopropylsulphonyl)benzene (0.955 g, 4.80 mmol) in 2 mL of DMF at 0 C. was added NaH (60% in oil, 0.349 g, 8.72 mmol) in one portion. After stirring fro 20 min, 2,4,5-trichloropyrimidine was added. The mixture was stirred at 0 C. for 30 minutes, and then at room temperature for 2 h. After quenching with saturated ammonium chloride solution, the mixture was poured in water and ethyl acetate mixture. Yellow suspension was filtered as final product (0.3 g, 20% yield). MS/ES+: m/z=346.

With the rapid development of chemical substances, we look forward to future research findings about 5750-76-5.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; Wang, Yihan; Huang, Wei-Sheng; Liu, Shuangying; Shakespeare, William C.; Thomas, Ranny M.; Qi, Jiwei; Li, Feng; Zhu, Xiaotian; Kohlmann, Anna; Dalgarno, David C.; Romero, Jan Antoinette C.; Zou, Dong; US2015/225436; (2015); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 626-48-2, Adding some certain compound to certain chemical reactions, such as: 626-48-2, name is 6-Methylpyrimidine-2,4(1H,3H)-dione,molecular formula is C5H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-48-2.

To a stirred mixture of 96% H2S04(15 mL) and of 70% HN03(15 mL) was added 6- methyl pyrimidine-2,4-(lH,3H)-dione (2.5 g,19.8 mmol). The solution was kept at 50 C for lOh. The mixture was cooled to room temperature and poured into a large volume of ice water. The solid was collected and dried in vacuo. Recrystallization with MeOH gave the final compound (2.7g,16.2 mmol) as yellows solid.1H NMR (200 MHz,DMSO) delta 2.31 (s,3H), 11.82 (s,1H), 11.85 (s,1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-48-2, 6-Methylpyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TES PHARMA S.R.L.; PELLICCIARI, Roberto; (253 pag.)WO2018/69532; (2018); A1;,
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Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1012785-51-1, name is 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

To a mixture of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (5 g, 15.93 mmol) in DMF (40 mL) was added NaH (764 mg, 19.1 1 mmol, 60% purity) in one portion at 0 C under N2. The mixture was stirred at 25 C for 30 min, SEMC1 (3.19 g, 19.12 mmol, 3.39 mL) was added to the mixture at 0 C and stirred for 1.5 h at 25 C. The mixture was poured into ice-water (40 mL), extracted with EtOAc (3 chi 30 mL). The combined organic phase was washed with brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc = 10: 1) to afford 2-[(2,4-dichloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl- tnmethyl-silane as a yellow solid. LCMS: RT 0.996 mm, m/z = 444 j M H | . N MR (400 MHz, DMSO): delta 8.15 (s, 1 H), 5.55 (s, 2 H), 3.49 – 3.56 (m, 2 H), 0.81 – 0.87 (m, 2 H), -0.08 (s, 9 H).

The synthetic route of 1012785-51-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DENALI THERAPEUTICS INC.; ESTRADA, Anthony A.; FENG, Jianwen A.; LYSSIKATOS, Joseph P.; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (271 pag.)WO2017/87905; (2017); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 7752-82-1 ,Some common heterocyclic compound, 7752-82-1, molecular formula is C4H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[00159] Scheme 1. Preparation of relevant pyri(mi)dyl halides A-H. Key: (a) NBS, NH4OAc, MeCN, rt, 5 min, pyr: 85-90%; pym: quant; (b) pyr: RCHO, Na(CN)BH3, MeCN, reflux, 1-12h (82%, R = C5Hn); pym: NaH, Rl, THF, rt, overnight (85%, R = Me); (c) Me3(Bn)NBr, f-BuONO, CH2Br2, rt, overnight, pyr: 77-83%; pym: 30- 40%; (d) pym: HI, CH2CI2, 0C, 80-85%; (e) i. NaOH, Br2, H20, rt, 50-60%, ii. POCI3, PhNEt2, reflux, 4h, 75-85%, iii. HI, CH2CI2, 0C, 80-85%; (f) ROH, Na, rt, 1-12 h, quant.; (g) RZnl, CI2Pd(PPh3)2, DMF/THF, rt, overnight, pyr (Br): 72% (R = C6H13), pym (I) 81 %, (R = C6H13); (h) alkyne, Cul, CI2Pd(PPh3)2, Et3N, MeCN, rt, 1-12 h, quant. [00161] The pyrimidyl bromides were prepared in a similar manner, beginning with bromination of 2-aminopyrimidine. N-Alkylation could not be achieved by reductive amination (presumably due to the decreased nucleophilicity of the amine) and was instead accomplished using NaH and an appropriate alkyl halide to give (B). Nonaqueous diazotization/halo-dediazoniation was used to prepare 5-bromo-2- halopyrimidines, but in diminished yield relative to the analogous reaction with the 2- aminopyridine (again, presumably due to the decreased nucleophilicity of the amine group). Alternatively, 2-pyrimidinone could serve as a precursor to 5-bromo-2- halopyrimidines (Lutz, F.; Kawasaki, T.; Soai, K. Tetrahedron-Asymmetry 2006, 17, 486.) or as a substrate for alkylation to generate 5-bromo-2-alkoxypyrimidines (D) (Kokatla, H. P.; Lakshman, M. K. Org. Lett. 2010, 12, 4478.) Introduction of an alkyne substituent at the 2-position to give ( proceeded satisfactorily under Sonogoshira conditions, but alkylation using Negishi conditions was unselective. Since reduction of the 2- alkynylpyrimidyl bromide (F) to the corresponding 2-alkyl pyrimidyl bromide (H) was complicated by competing removal of the bromine, we turned to 5-bromo-2- iodopyrimidine as a precursor for the cross coupling reactions and saw a dramatic improvement in selectivity and yields.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7752-82-1, its application will become more common.

Reference:
Patent; QUEEN’S UNIVERSITY AT KINGSTON; UNIVERSITA DI BOLOGNA; PRATT, Derek A.; HANTHORN, Jason, J.; VALGIMIGLI, Luca; WO2012/162818; (2012); A1;,
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Pyrimidine – Wikipedia

Related Products of 120747-84-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below.

Preparation 3: Step 2: To a mixture of 20 (166 mg, 1.35 [MMOL),] DMAP (17 mg, 0.14 [MMOL)] and Et3N (418 [LLI,] 3.00 [MMOL)] in THF (10 ml) was added (BOC) [20] (589 mg, 2.7 [MMOL).] The mixture was stirred at RT for 5 h, concentrated-dry loaded on silica gel and flash chromatographed (1-3% [ACETONE/CH2CI2)] to produce 21 (117 mg, 0.36 [MMOL] ; 27%) as a clear oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,120747-84-4, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; WO2004/831; (2003); A1;,
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Pyrimidine – Wikipedia

Related Products of 4786-52-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4786-52-1 as follows.

Ethyl 4-hydroxypy?miotadiotane-5-carboxylate (380 mg, 2.26 mmol) was dissolved in THF (5 mL) and treated with thionyl chloride (1.65 ml, 22.6 mmol). The solution was heated to reflux for 4 h and then concentrated in vacuo, yielding 417 mg (99%) of the crude product This material was used without purification or characterization

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4786-52-1, its application will become more common.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/49681; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 3680-69-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Example 1 Preparation of 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine The solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (6.08 g, 39.07 mmol) in CH2Cl2 (100 mL) was heated to 60 C. for for 30 min. A solution of NBS (5.40 g, 39.07 mmol) in CH2Cl2 (100 mL) was added slowly in portions to this mixture. The mixture was refluxed for an additional 50 min and allow to cool to rt. Filter off the off white solid and washed with water, dried in vacuum oven to give 7.7 g of 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine. MS (ESI) 234.5 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3680-69-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; Dillon, Michael Patrick; Bois, Daisy Joe Du; Lai, Yingjie; Hawley, Ronald Charles; Wang, Beihan; US2010/144758; (2010); A1;,
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Pyrimidine – Wikipedia