Pyrimidines

Disrupting Transcription and Folate Biosynthesis Leads to Synergistic Suppression of Escherichia coli Growth was written by Chen, Pei-Hsin;Sung, Li-Kang;Hegemann, Julian D.;Chu, John. And the article was included in ChemMedChem in 2022.Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The use of synergistic antibiotic combinations has emerged as a viable approach to contain the rapid spread of antibiotic-resistant pathogens. Here we report the discovery of a new strongly synergistic pair – microcin J25 and sulfamonomethoxine. The former is a lasso peptide that inhibits the function of RNA polymerase and the latter is a sulfonamide antibacterial agent that disrupts the folate pathway. Key to our discovery was a screening strategy that focuses on an antibiotic (microcin J25) that targets a hub (transcription) in the densely interconnected network of cellular pathways. The rationale was that disrupting such a hub likely weakens the entire network, generating weak links that potentiate the growth inhibitory effect of other antibiotics. We found that MccJ25 potentiates five other antibiotics as well. These results showcase the merit of taking a more targeted approach in the search and study of synergistic antibiotic pairs. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application In Synthesis of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors was written by Martinez-Gonzalez, Sonia;Alvarez, Rosa M.;Martin, Jose I.;Garcia, Ana Belen;Riesco-Fagundo, Concepcion;Varela, Carmen;Rodriguez Hergueta, Antonio;Gonzalez Cantalapiedra, Esther;Albarran, M. I.;Gomez-Casero, Elena;Cebria, Antonio;Aguirre, Enara;Ajenjo, Nuria;Cebrian, David;Di Geronimo, Bruno;Cunningham, Darren;O閳ョ澇eill, Michael;Dave, Harish P. G.;Blanco-Aparicio, Carmen;Pastor, Joaquin. And the article was included in ACS Medicinal Chemistry Letters in 2021.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine This article mentions the following:

The PI3K/AKT/mTOR and PIM kinase pathways contribute to the development of several hallmarks of cancer. Cotargeting of these pathways has exhibited promising synergistic therapeutic effects in liquid and solid tumor types. To identify mols. with combined activities, we cross-screened our collection of PI3K/(鍗TOR) macrocycles (MCXs) and identified the MCX thieno[3,2-d]pyrimidine derivative 2 as a moderate dual PI3K/PIM-1 inhibitor. We report the medicinal chem. exploration and biol. characterization of a series of thieno[3,2-d]pyrimidine MCXs, which led to the discovery of IBL-302 (31), a potent, selective, and orally bioavailable triple PI3K/mTOR/PIM inhibitor. IBL-302, currently in late preclin. development (AUM302), has recently demonstrated efficacy in neuroblastoma and breast cancer xenografts. Addnl., during the course of our experiments, we observed that macrocyclization was essential to obtain the desired multitarget profile. As a matter of example, the open precursors 35-37 were inactive against PIM whereas MCX 28 displayed low nanomolar activity. In the experiment, the researchers used many compounds, for example, 4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine).

4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Casein Kinase 1鏈?钄?Inhibitor PF-5006739 Attenuates Opioid Drug-Seeking Behavior was written by Wager, Travis T.;Chandrasekaran, Ramalakshmi Y.;Bradley, Jenifer;Rubitski, David;Berke, Helen;Mente, Scot;Butler, Todd;Doran, Angela;Chang, Cheng;Fisher, Katherine;Knafels, John;Liu, Shenping;Ohren, Jeff;Marconi, Michael;DeMarco, George;Sneed, Blossom;Walton, Kevin;Horton, David;Rosado, Amy;Mead, Andy. And the article was included in ACS Chemical Neuroscience in 2014.Application In Synthesis of 4-Dimethoxymethylpyrimidin-2-ylamine This article mentions the following:

Casein kinase 1 delta (CK1鏈? and casein kinase 1 epsilon (CK1钄? inhibitors are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing a CNS kinase inhibitor has been limited by an inability to identify safe brain-penetrant compounds with high kinome selectivity. Guided by structure-based drug design, potent and selective CK1鏈?钄?inhibitors have now been identified that address this gap, through the design and synthesis of novel 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine derivatives PF-5006739 (6) possesses a desirable profile, with low nanomolar in vitro potency for CK1鏈?钄?(IC₅₀ = 3.9 and 17.0 nM, resp.) and high kinome selectivity. In vivo, 6 demonstrated robust centrally mediated circadian rhythm phase-delaying effects in both nocturnal and diurnal animal models. Further, 6 dose-dependently attenuated opioid drug-seeking behavior in a rodent operant reinstatement model in animals trained to self-administer fentanyl. Collectively, our data supports further development of 6 as a promising candidate to test the hypothesis of CK1鏈?钄?inhibition in treating multiple indications in the clinic. In the experiment, the researchers used many compounds, for example, 4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6Application In Synthesis of 4-Dimethoxymethylpyrimidin-2-ylamine).

4-Dimethoxymethylpyrimidin-2-ylamine (cas: 165807-05-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Application In Synthesis of 4-Dimethoxymethylpyrimidin-2-ylamine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Risk assessment and investigation of landfill leachate as a source of emerging organic contaminants to the surrounding environment: a case study of the largest landfill in Jinan City, China was written by Wang, Kun;Reguyal, Febelyn;Zhuang, Tao. And the article was included in Environmental Science and Pollution Research in 2021.Synthetic Route of C11H12N4O3S This article mentions the following:

Emerging organic contaminants (EOCs) have been widely studied in landfill leachates but not in the surrounding environment of landfills. In this study, two sampling campaigns were conducted to determine 45 EOCs in landfill leachates and environmental samples near a landfill in East China. Our study focused on the seasonal occurrence and spatial distribution of the target EOCs, as well as their ecol. risks. The results showed 13 out of 45 EOCs were detectable and achieved individual concentrations that ranged from 2.0 to 5080 ng/L in the landfill leachates. Most of the detected EOCs exhibited higher concentrations in the leachates collected in summer than in winter. The contamination levels of the target EOCs in groundwater decreased with the distance of sampling sites from the landfill. In soil samples, the occurrence of target EOCs was not consistent with raw or treated landfill leachates. Risk assessment suggested that the individual EOC likely posed medium to high risks to aquatic organisms in groundwater while negligible impacts to human health through consumption of vegetables. To the best of our knowledge, this is the first report on the contribution of landfill leachates to EOC contamination in both aquatic and soil environments in East China. Our findings emphasized the importance of investigating EOCs in landfill leachates and accumulative environmental risks of EOCs in the neighboring environment of landfills in China. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Occurrence of antibiotics in the different biological treatment processes, reclaimed wastewater treatment plants and effluent-irrigated soils was written by Pu, Miao;Ailijiang, Nuerla;Mamat, Anwar;Chang, Jiali;Zhang, Qiongfang;Liu, Yifan;Li, Nanxin. And the article was included in Journal of Environmental Chemical Engineering in 2022.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Reclaimed wastewater is increasingly being used for agricultural irrigation to address water scarcity, particularly in arid and semiarid areas. In this study, the occurrence and removal of 24 antibiotics were investigated in two wastewater treatment systems (WWTSs) and their irrigation areas located in the arid northwestern region of China. The different WWTSs included absorption-biodegradation (AB) + anaerobic-anoxic-oxic (AAO) and AAO + AAO + membrane bioreactor (MBR). Nineteen antibiotics were detected, with concentrations ranging from low to 60.8娓璯/L. The dominant antibiotic classes were quinolones (QNs) and macrolides (MLs) in winter, and MLs and sulfonamides (SAs) in summer. The AAO + AAO + MBR system exhibited better removal efficiencies for most antibiotics, improving their adsorption and biodegradation Except for ofloxacin (OFC) and norfloxacin (NFC), the concentrations of the detected antibiotics were higher in summer than in winter. However, the antibiotic removal efficiency increased by 2-141% in summer compared to winter due to the increase in microbial activity with temperature Even though reclaimed treatment water plants contributed to the removal of antibiotics, residual antibiotics still affected the soil environment after green irrigation. In irrigated soil, QNs were predominantly detected, with a maximum concentration of 150.9 ng/kg for NFC. An ecol. risk assessment showed that OFC, NFC, enrofloxacin, and lomefloxacin presented low or medium ecol. risks in at least two irrigated sites. Thus, more attention should be given to the reuse of reclaimed wastewater, as it may pose toxicity risks to organisms in the soil environment. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Transformation of food waste to source of antimicrobial proteins by black soldier fly larvae for defense against marine Vibrio parahaemolyticus was written by Zhang, Shouyu;Xiong, Pu;Ma, Yongsheng;Jin, Ning;Sun, Shibo;Dong, Xiaoying;Li, Xiaodong;Xu, Jianqiang;Zhou, Hao;Xu, Weiping. And the article was included in Science of the Total Environment in 2022.Reference of 1220-83-3 This article mentions the following:

Insect biorefinery by black soldier fly larvae (BSFL), Hermetia illucens, has emerged as an innovative technique for the valorization of food waste. However, despite BSFL being an attractive natural source of antimicrobial proteins (AMPs), there is a scarcity of research on the antimicrobial activity and transcriptome expression of AMPs derived from BSFL following waste treatment. In the present study, food waste treatment was performed by BSFL with a substrate C/N ratio ranging from 21:1 to 10:1, marine Vibrio parahaemolyticus (VP) was selected as the model aquaculture pathogen, the antimicrobial activities of AMPs in vitro and zebrafish in vivo were examined, and the mol. mechanism of the C/N-dependent AMP difference was expounded. Findings were made that the AMP extract of C/N16:1 resulted in relatively higher antimicrobial activity in vitro than that of other C/Ns. Further, the AMPs of C/N16:1 exhibited a promising in vivo defense effect for elevating the 96-h survival rate of zebrafish from 0% to 39% after VP infection, comparable to the animal antibiotic sulfamethoxidine. The results of transcriptome anal. reveal that lysozymes were the highest expressed components in the AMP gene family. The C/N16:1 BSFL significantly up-regulated 12 out of 51 lysozyme genes compared with C/N21:1, which likely contributed to the improvement of AMP antimicrobial activity. Further, C/N16:1 significantly up-regulated the expression of lysozyme, glycosyl hydrolase and muscle protein genes compared with C/N21:1, which likely enhanced the defense ability of the immune system, the utilization of the starch-like substrate, and the mobility of the larvae, thereby facilitating the larval transformation and AMP production Overall, such results indicate that waste C/N ratio interacted with the activity and expression of BSFL AMPs through transcriptome regulation, and the BSFL AMPs derived from food waste could be used for the defense against marine pathogens to support the sustainable development of aquaculture. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Reference of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Reference of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Dynamics of antibiotics and antibiotic resistance genes in four types of kitchen waste composting processes was written by Zhao, Changxun;Xin, Liqing;Xu, Xingkun;Qin, Yong;Wu, Weixiang. And the article was included in Journal of Hazardous Materials in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Kitchen waste might be a potential source of antibiotics and antibiotic resistance genes. Composting is recognized as an effective way for kitchen waste disposal. However, the effects of different kitchen waste composting types on the removal of antibiotics and antibiotic resistance genes haven’t been systematically studied. In this study, the dynamics of antibiotics and antibiotic resistance genes from kitchen waste of four composting processes were compared. Showed that although kitchen waste was composted, it remained an underestimated source of antibiotics (25.9-207.3娓璯/kg dry weight) and antibiotic resistance genes (1012-1017 copies/kg dry weight). Dynamic composting processes (i.e., dynamic pile composting and mech. composting) decreased the antibiotic removal efficiency and increased the abundance of some antibiotic resistance genes (5.35-8534.7% enrichment). Partial least-squares path model anal. showed that mobile genetic elements played a dominant role in driving antibiotic resistance genes dynamics. Furthermore, redundancy anal. revealed that temperature, pH, and water content considerably affected the removal of antibiotics and mobile genetic elements. This study provides further insights into exploring the effective strategies in minimizing the risk of antibiotic resistance from kitchen waste via composting process. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Seasonal occurrence of multiple classes of antibiotics in East China rivers and their association with suspended particulate matter was written by Wang, Kun;Su, Zhaoxin;Reguyal, Febelyn;Bian, Rongxing;Li, Weihua;Yu, Haofeng;Sun, Yingjie;Zhuang, Ying;Shang, Wan. And the article was included in Science of the Total Environment in 2022.Synthetic Route of C11H12N4O3S This article mentions the following:

Understanding the occurrence and fate of antibiotics from different categories is vital to predict their environmental exposure and risks. This study presents the spatiotemporal occurrence of 45 multi-class antibiotics and their associations with suspended particulate matter (SPM) in Xiaoqing River (XRB) and Yellow River (YRB) via 10-mo monitoring in East China. Thirty-five and 31 antibiotics were detected in XRB and YRB, resp. Among them, fluoroquinolones (FQs) had the highest total mean concentration (up to 24.8娓璯/L in XRB and 15.4娓璯/L in YRB), followed by sulfonamides (SAs) (14.0娓璯/L and 15.4娓璯/L) and macrolides (MLs) (1.1娓璯/L and 1.6娓璯/L). Significant spatial-temporal variations were found in both rivers where higher concentrations of antibiotics were observed in urban and densely populated areas during winter and spring. Hydrol. factors such as river flow and water volume, instream attenuation and antibiotic usage may cause the observed variabilities in the seasonal patterns of antibiotic pollution. Using linear regression anal., for the first time, this study confirmed that the total concentrations of MLs (p < 0.05), FQs (p < 0.001) and SAs (p < 0.001) were strongly correlated with the turbidity/total suspended solids in the studied rivers (except MLs in YRB). It is thus suggested that partitioning processes onto SPM might affect the distribution of detected antibiotics in rivers, which are largely dependent on SPM composition and characteristics. The risk quotient (RQ) determined for up to 87% of individual compound was below 0.1 in both rivers; however, the high joint toxicity reflected by the mixed RQs of detected antibiotics may rise risk alarm for aquatic species. Further aspects regarding active mechanisms of SPM-antibiotic interactions and ecol. risks of coexistence of multiple antibiotics need to be investigated. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Global retention models and their application to the prediction of chromatographic fingerprints was written by Gisbert-Alonso, A.;Navarro-Huerta, J. A.;Torres-Lapasio, J. R.;Garcia-Alvarez-Coque, M. C.. And the article was included in Journal of Chromatography A in 2021.Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The resolution of samples containing unknown compounds of different nature, or without standards available, as is the case of chromatog. fingerprints, is still a challenge. Possibly, the most problematic aspect that prevents systematic method development is finding models that describe without bias the retention behavior of the compounds in the samples. In this work, the use of global models (able to describe the whole sample) is proposed as an alternative to the use of individual models for each solute. Global models contain parameters that are specific for each solute, while other parameters -related to the column and solvent- are common for all solutes. A special regression procedure is presented for the construction of global models, which are applied to predict highly complex chromatograms, such as chromatog. fingerprints, for diverse exptl. conditions in isocratic and gradient elution. Another interesting application is the prediction of mol. properties, such as log P_o/w, from the specific solute parameters of the global models. The examined adapted models are based on the equations proposed by Snyder, Schoenmakers, Neue and Kuss, Jandera, and Bosch Rose鑹?to describe the retention. In all cases, the predictive capability was very satisfactory. Two cases of study were considered: chromatograms of chamomile extracts analyzed using acetonitrile gradients, and a set of 145 known compounds in a wide range of structures and functionalities, eluted isocratically with acetonitrile/water mobile phases. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Suzuki-Miyaura cross-coupling reaction of aryl and heteroaryl pinacol boronates for the synthesis of 2-substituted pyrimidines was written by Asano, Shigehiro;Kamioka, Seiji;Isobe, Yoshiaki. And the article was included in Tetrahedron in 2012.Computed Properties of C8H10ClN3O This article mentions the following:

Suzuki-Miyaura cross-coupling reaction with 2-heteroarylboronic acids is generally challenging due to easy decomposition of these acids. To overcome this problem, we developed a coupling method that uses 2-heteroaryl pinacol boronates in the presence of 1.0 mol % Pd(OAc)₂ and 2.0 mol % S-Phos with 4 equiv amount of LiOH in dioxane and H₂O at 80 鎺矯 for 30 min. This developed method allowed for the synthesis of a wide variety of 2-heteroaryl pyrimidines from 2-chloropyrimidyl derivatives in high yields, and is also useful in the preparation of various biaryl derivatives from heteroaryl chlorides. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Computed Properties of C8H10ClN3O).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Computed Properties of C8H10ClN3O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia