Pyrimidines

Related Products of 49845-33-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A heterogeneous solution of 2.4-dichloro-5-nitro-pyrimidine (1.0 eq.) and iron (6.0 eq) in acetic acid, at a concentration of 0.4 M, was stirred vigorously for 14 hours. The mixture was then passed through a celite pad, eluting with MeOH. Upon removal of the volatiles in vacuo, the residue was dissolved in EtOAc, washed with Na2CO3(sat.), NaCl(sat.), was dried over MgSO4, was filtered and the volatiles were removed in vacuo yielding 2,4-dichloropyrimidin-5-amine (80%). LCMS (m/z): 157.0 (MH+); LC Rt=1.85 min.

According to the analysis of related databases, 49845-33-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Burger, Matthew; Lindvall, Mika; US2011/195980; (2011); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, the common compound, a new synthetic route is introduced below. name: 4,6-Dichloro-2-methylpyrimidin-5-amine

Preparation 1 6-Chloro-N*4*-(4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine; 4,6-dichloro-2-methyl-pyrimidin-5-ylamine (985.3 g, 5.53 MoI) was added with stirring to a 2OL reactor charged with EtOH (4.0 L) over 3 minutes to give complete solution. p-Anisidine (718.0 g, 5.83 MoI) was then added with stirring over 3 minutes. A dark brown solution was observed and addition of both reagents gave an exotherm of 130C. EtOH (1 L) was then added followed by a premixed solution of c.HCI (0.5 L) in EtOH (2 L) at a steady rate over 40 minutes. A slight exotherm up to approx 2O0C was noted. The solution was then warmed to 8O0C and held at that temperature for 3.5 hours during which a grey precipitate appeared. Heating was continued for a further 2 hours then the temperature was reduced to 490C, and stirring was continued for 19 hours. The reaction mixture was allowed to cool to 3O0C, before draining out of 2OL reactor. The reaction mixture was filtered to collect a beige precipitate. Washed with EtOH (2.5 L), the MTBE (2.5 L) and sucked dry under N2(g) for 22 hours. The filter cake was then dried under vacuum at 5O0C for 60 hours, to yield title compound, as the hydrochloride salt, as a beige solid (1.465 Kg, 88%). 1H NMR (400MHz, DMSO-d6) delta = 2.27 (s, 3H), 3.71 (s, 3H), 6.90 (d, 2H), 7.58 (d, 2H), 9.10 (bs, 1 H). LCMS (System 4): 2.4 mins m/z (APCI) 265 [MH+]

The synthetic route of 39906-04-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; WO2009/144632; (2009); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22536-66-9, name is 2-Chloropyrimidine-4-carboxamide, the common compound, a new synthetic route is introduced below. Quality Control of 2-Chloropyrimidine-4-carboxamide

A mixture of 3-{[2-amino-6-(3-chloro-2-methylphenyl) pyrimidin-4-yl]ami no}propan1-01 (intermediate 24), 2-chloropyrimidine-4-carboxamide (1.1 equiv.) and 0s2003(2.0 equiv.) in DMSO was heated in a sealed tube at 90C for 2 h. After coolingwas methanol added to the solution, followed by filtration and purification by preparative LC to furnish the title compound. LCMS [M+H]414. 1H NMR (400MHz, METHANOL-d4) oe ppm 8.79 (d, J=5.1 Hz, 1 H), 7.69 (s, 1 H), 7.55 – 7.63(m, 1 H), 7.30 – 7.41 (m, 3 H), 6.04 (s, 1 H), 4.59 (t, J=6.0 Hz, 2 H), 3.76 (t, J=6.8Hz, 2 H), 2.18 (quin, J=6.3 Hz, 3 H).

The synthetic route of 22536-66-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; JACQUES, Sylvain; HOMAN, Evert; HELLEDAY, Thomas; WO2015/187088; (2015); A1;,
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Related Products of 1753-50-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1753-50-0, name is 2-Chloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of compound HK (0.2 g, 0.67 mmol) in EtOH (5 mL) was added DIPEA (0.25 g, 2.01mmol) followed by 2-chloropyrimidine-5-carbonitrile (AF, 0.09 g, 0.67 mmol) and the reaction mixture was stirred at 90C for 16 h. The progress of reaction was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to yield crude compound which was purified by silica gel column chromatography using 50% EtOAc/hexane to afford compound HL (0.7 g, 65.5%) as an off white solid. 1H NMR (400 MHz, DMSO-d6): _ 8.83 (d, / = 8.4 Hz, 1H), 8.71 (d, J = 2.8 Hz, 2H), 7.53 (d, = 8.0 Hz, 2H), 7.35 (d, = 8.4 Hz, 2H), 7.27 (t, = 5.8 Hz, 1H), 5.27-5.21 (m, 1H), 3.46-3.34 (m, 2H), 2.84 (s, 3H); LC-MS: mJz 402.10 [M+H]+.

According to the analysis of related databases, 1753-50-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VPS-3, INC.; YATES, Christopher, M.; (397 pag.)WO2018/165520; (2018); A1;,
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Application of 7752-78-5, Adding some certain compound to certain chemical reactions, such as: 7752-78-5, name is 5-Bromo-2-methylpyrimidine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7752-78-5.

To the above mixture, 5-bromo-2-methylpyrimidine (75.7 mg, 0.44 mmol) was added followed by water (1 mL) and K2C03 (110.4 mg, 0.80 mmol), and the mixture was degassed under N2 three times. Pd(PPh3)4 (46.2 mg, 0.04 mmol) was added, and the resulting mixture was stirred at 95 °C under N2 atmosphere for 16 hours. The reaction mixture was concentrated to dryness and diluted with EtOAc, washed with water and brine, dried over Na2SO4 and concentrated to dryness. The residue was purified by column chromatography on silica gel (PE: EtOAc= 2: 1) to give compound 44S-13 (110 mg, 62.9percent yield) as a white solid. LC/MS (ESI) m/z: 437 (M+H)t

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7752-78-5, 5-Bromo-2-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; CHEN, Dawei; GADHACHANDA, Venkat, Rao; BARRISH, Joel, Charles; AGARWAL, Atul; EASTMAN, Kyle, J.; (0 pag.)WO2018/160892; (2018); A1;,
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Synthetic Route of 14080-59-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 14080-59-2 as follows.

General procedure: alpha,beta-unsaturated tosylhydrazones 1 (0.11 mmol, 1.1 equiv), heteroaryl chlorides 2 (0.1 mmol, 1 equiv), Cs2CO3 (0.25 mmol, 2.5 equiv) and MeCN (1 mL) were added to a tube. The mixture was stirred at 60 C until the heteroaryl chlorides was completely disappeared for 4-8h. After cooling to room temperature, the mixture was quenched with NH4Cl (2 mL, saturated aqueous solution) and extracted with CH2Cl2 (3 × 2 mL). The combined organic phases were dried over Na2SO4 and solvents removed in vacuo. The residue was purified by flash column chromatography on silica gel with ethyl acetate/petroleum ether (1:10-1:4, V/V) as the eluent, affording the desired product 3 and 4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14080-59-2, its application will become more common.

Reference:
Article; Zeng, Lin; Guo, Xiao-Qiang; Yang, Zai-Jun; Gan, Ya; Chen, Lian-Mei; Kang, Tai-Ran; Tetrahedron Letters; vol. 60; 33; (2019);,
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Application of 90213-67-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 90213-67-5, name is 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of 2,4-dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (200 mg, 0.99 mmol), (+/-)-trans-methyl 3-aminobicyclo[2.2.2]octane-2-carboxylate (200 mg, 1.09 mmol) and K2C03 (273 mg, 1.98 mmol) in DMF (10 mL) was stirred at rt overnight. To the reaction mixture was added H20 (100 mL) to quench the reaction, and the mixture was extracted with EtOAc (50 mL x 3). The combined organic layers were washed with saturated brine (80 mL x 3), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated in vacuo,and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 3/1) to give the title compound as a white solid (144 mg, 42 %).MS (ESI, pos. ion) m/z: 349.10 [M+Hfb.

According to the analysis of related databases, 90213-67-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; ZHANG, Yingjun; (264 pag.)WO2018/33082; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 3764-01-0, 2,4,6-Trichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,4,6-Trichloropyrimidine, blongs to pyrimidines compound. Safety of 2,4,6-Trichloropyrimidine

Reference Example 11; (6-Chloro-2-morpholin-4-vI-pyrimidm-4-yl)-(2-pyridin-3-yl- ethvD-amine; To a stirred solution of 2,4,6-trichloropyrimidine (10 ml; 87 mmol), and DIPEA (16 mL; 92 mmol) in dioxane (60 mL) at 5 C was added morpholine (8 ml; 91 mmol) over 5 minutes (a white solid separates during addition). The reaction mixture was stirred whilst allowing to warm to r.t. overnight (16 h). Volatiles were removed in vacuo, the resulting residue was redissolved (CH2Cl2) and evaporated onto silica and purified by flash chromatography (90:10 to 50:50 petrol/EtOAc as eluent) to afford the regioisomeric products: 4-(4,6-dichloro-pyrimidin-2-yl)-morpholine (2.46 g; 12 %); and 4-(2,6-dichloro-pyrimidin-4- yl)-morpholine (9.72 g; 48 %).

The synthetic route of 3764-01-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH; WO2008/125835; (2008); A1;,
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Synthetic Route of 24415-66-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 24415-66-5, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Adding 85 mg (about 0.5 mmol) to a 10 mL microwave reaction tube.7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, 324 mg (about 1.5 mmol)1-(prop-2-yn-1-yl)-1H-indole, 14 mg (about 10 mol%) of the catalyst bistrifluoromethylsulfonimide and 1 mL of the solvent HFIP, and then the microwave reaction tube was sealed.Then, the reactant in the microwave reaction tube was stirred at 100 C for 6 hours, and the solvent was distilled off under reduced pressure.And purified by column chromatography using DCM / MeOH as eluent to give about 117 mg of pure product e23 as a green solid with a yield of 81%;

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 24415-66-5, 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.

Reference:
Patent; Zhengzhou University; Liu Hongmin; Yu Bin; Yuan Shuo; Wang Shuai; Li Zhonghua; (21 pag.)CN109180684; (2019); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1224944-77-7, name is Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate, the common compound, a new synthetic route is introduced below. name: Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate

A mixture of ethyl 5-chloropyrazolo[1 ,5-a]pyrimidine-3-carboxylate (677 mg, 3.00 mmol), tert15 butyl piperazine-1-carboxylate (838 mg, 4.50 mmol) and N,N-diisopropylethylamine (1.6 ml,9.0 mmol) in 2-propanol (20 ml) was ref luxed for 5 h. Upon cooling, ice water was added and the mixture was extracted with ethyl acetate (3x). The combined organic phases were filtrated through a silicone filter and concentrated to give the title compound.[C-MS (Method 1): R = 1.11 mm; MS (ESIpos): m/z = 376 [M+H]

The synthetic route of 1224944-77-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERMANN, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; HOLTON, Simon; BENDER, Eckhard; LI, Volkhart; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; BAIRLEIN, Michaela; VON NUSSBAUM, Franz; HERBERT,Simon; KOPPITZ, Marcus; (734 pag.)WO2016/177658; (2016); A1;,
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