Pyrimidines

Adding a certain compound to certain chemical reactions, such as: 330794-31-5, 1-Cyclopentyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-Cyclopentyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, blongs to pyrimidines compound. Safety of 1-Cyclopentyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Synthesis of tert-butyl 5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylate (BA88); A solution of tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate (130 mg, 0.38 mmol) in EtOH (3.3 ml) was added to a solution of 3-iodo-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (50 mg, 0.15 mmol) in DME (12 ml). Pd(PPh3)4 (30 mg, 0.03 mmol) and saturated Na2CO3 (1.9 ml) were added and the reaction was heated to 80 C. under an argon atmosphere overnight. After cooling, the reaction was extracted with saturated NaCl and CH2Cl2. Organic phases were combined, concentrated in vacuo and purified by RP-HPLC (MeCN:H2O) to yield BA88. ESI-MS (M+H)+ m/z calcd 419.2, found 419.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,330794-31-5, 1-Cyclopentyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Regents of the University of California; US2007/293516; (2007); A1;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 13223-25-1, 2-Chloro-4,6-dimethoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 13223-25-1, blongs to pyrimidines compound. Recommanded Product: 13223-25-1

A mixture of 2-chloro-4,6-dimethoxypyrimidine (1.05 g, 6.0 mmol), (2S,6 )-2,6- dimethylmorpholine (0.78 mL, 6.3 mmol) and triethylamine (0.84 mL, 6.0 mmol) in NMP (12.0 mL) was sealed in a vial then heated at 140C under microwave irradiation for 2 h. The reaction mixture was cooled to rt, and /V-chlorosuccinimide (1.60 g, 12.0 mmol) was added and the mixture was stirred at 60C overnight. The mixture was poured into water forming a brown precipitate which was collected under vacuum filtration. The aqueous filtrate was extracted with EtOAc and combined with the solid obtained earlier. The mixture was loaded onto silica and purified by flash chromatograph (50 g KP-sil; 10-30% EtOAc in cyclohexane) afforded (2S,6 )-4-(5-chloro-4,6-dimethoxypyrimidin-2-yl)-2,6-dimethylmorpholine (916 g, 53%) as a white solid. 1H NMR (500 MHz, CDCh) d 4.47-4.43 (m, 2 H), 3.95 (s, 6 H), 3.62 (dqd, J = 10.6, 6.2, 2.5 Hz, 2 H), 2.55 (dd, J = 13.3, 10.6 Hz, 2 H), 1.25 (d, J = 6.2 Hz, 6 H); LCMS (Method T2) RT 1.62 min; m/z 288.32 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13223-25-1, 2-Chloro-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; BELLENIE, Benjamin Richard; CHEUNG, Kwai Ming Jack; DAVIS, Owen Alexander; HOELDER, Swen; HUCKVALE, Rosemary; COLLIE, Gavin; MENICONI, Mirco; BRENNAN, Alfie; LLOYD, Matthew Garth; (222 pag.)WO2019/197842; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2927-71-1, blongs to pyrimidines compound. category: pyrimidines

A solution of isopropylamine (2.66 mL, 29.95 mmol) and DIPEA (5.16 mL, 29.95 mmol) in THF (50 mL) was stirred at -10 C., while 2,4-dichloro-5-fluoropyrimidine (5 g, 29.95 mmol) was added portion wise. The resulting mixture was stirred at ambient temperature overnight. The mixture was diluted with 100 mL ethyl acetate and 50 mL diisopropylether. This solution was twice washed with water. The organic phase was dried over MgSO4, filtered and evaporated, yielding 67. The residue was used as such. LC-MS ES+ m/z=189; Rt: 1.65 min, method B.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2927-71-1, its application will become more common.

Reference:
Patent; Janssen Sciences Ireland UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; RABOISSON, Pierre Jean-Marie Bernard; EMBRECHTS, Werner Constant Johan; GUILLEMONT, Jerome Emile Georges; (42 pag.)US2017/253600; (2017); A1;,
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Application of 3029-64-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3029-64-9 as follows.

8.79 g (35 mmol) of isopropyl carbazole was added to a 250 ml three-necked flask, and 100 ml of N,N-dimethylformamide was added as a reaction solvent in an ice bath.Stir on a magnetic stirrer for 10 min. 0.72 g (30 mmol) of NaH was added portionwise to the reaction flask and stirring was continued for 1 h.4.97 g (10 mmol) of 2,4,6-trichloro-5-cyanopyrimidine was dissolved in 40 ml of N,N-dimethylformamide solution, and added dropwise to the reaction system. After the addition, at room temperature The reaction was carried out for 24 h. After the reaction was completed, the reaction solution was poured into 200 ml of 10percent diluted hydrochloric acid, and the mixture was filtered under reduced pressure, washed with water and dried, and the crude product was obtained from petroleum ether and dichloromethane (PE: DCM=10: 1) Pass the column for the mobile phase. Obtained 7.98 g of a white solid powder in a yield of50.2percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3029-64-9, its application will become more common.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Gao Wenzheng; Huang Xinxin; Ren Xueyan; (27 pag.)CN109553606; (2019); A;,
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Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4472-45-1, name is 4-Chloro-2,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-2,6-dimethylpyrimidine

General procedure: N-(2-Chloropyrimidin-5-yl)acetamide (CAS 1353776-97-2; 0.89 mg, 0.36 mmol) was added to a stirred solution of Intermediate 14 (130 mg, 0.42 mmol) and diisopropylethylamine (0.13 mL, 0.91 mmol) in isopropanol (1.7 mL) at rt. The mixture was stirred at 100 C for 16 h and then the volatiles were evaporated in vacuo. The residue thus obtained was purified by flash column chromatography (silica gel, MeOH in DCM, 0/100 to 10/90). The desired fractions were concentrated in vacuo to yield a crude product that was further purified by RP HPLC (stationary phase: CI 8 XBridge 30 x 100 mm 5 muetaiota; mobile phase: gradient from 90% lOmM NH4CO3H pH 9 solution in water, 10% CH3CN to 0% lOmM NH4CO3H pH 9 solution in water, 100% CH3CN). The desired fractions were concentrated in vacuo to yield product 16 (40 mg, 27% yield) as a solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4472-45-1, 4-Chloro-2,6-dimethylpyrimidine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres Avelino; MARTINEZ VITURRO, Carlos Manuel; (116 pag.)WO2018/141984; (2018); A1;,
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Related Products of 271-70-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 271-70-5 as follows.

To a stirred solution of 7H-pyrrolo[2,3-d]pyrimidine (11.5 g, 73.92 mmol) in DMF (350 mL) was added a solution of bromine (11.8 g, 73.84 mmol) in DMF (50 mL) at 0C. The cooling bath was removed and the reaction stirred at 20C for 8h, then the reactionmixture was poured into ice-water and basified with Na2CO3. The mixture was extracted with ethyl acetate. The combined organic layers were washed with 10% aq. Na25203 solution, brine, dried over Mg504, the solids were removed by filtration, and the filtrate was concentrated under reduced pressure to afford 16, 5-bromo-7H-pyrrolo- [2,3-d]pyrimidine as yellow solid, used in the next step without further purification. 1H NMR(400 MHz, DMSO-d6) 6 ppm 7.84 (s, 1 H), 8.84 (s, 1 H), 8.92 (s, 1 H), 12.57 (br, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,271-70-5, its application will become more common.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; GUILLEMONT, Jerome Emile Georges; COOYMANS, Ludwig Paul; EMBRECHTS, Werner Constant Johan; BUYCK, Christophe Francis Robert Nestor; BALEMANS, Wendy Mia Albert; RABOISSON, Pierre Jean-Marie Bernard; (34 pag.)WO2017/89518; (2017); A1;,
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Pyrimidine – Wikipedia

Related Products of 26305-13-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine, molecular formula is C6H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 1,3-Dibenzoyl-6-methyluracil (3). To a suspension of 6-methyluracil (5.0 g, 0.040 mol) in anhydrous MeCN (100 mL) and anhydrous pyridine (20 mL) benzoyl chloride (12.5 mL, 0.108 mol) was added in one portion and stirred at room temperature for 24 h. The reaction mixture was concentrated in vacuo at a bath temperature not exceeding 60 C, cooled and the residue partitioned between CHCl3(200 mL) and ice water (100 mL). The organic phase was separated, dried over sodium sulfate, filtered and evaporated in vacuo at a bath temperature not exceeding 60 C. The residue was crystallized from Et2O (25 mL) to give 10.0 g (76%) of compound 3 as a yellow crystalline solid with mp 80-82 .

According to the analysis of related databases, 26305-13-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ozerov, Alexander; Novikov, Mikhail; Khandazhinskaya, Anastasiya; Solyev, Pavel; Heterocycles; vol. 94; 5; (2017); p. 912 – 922;,
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Synthetic Route of 171178-47-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.171178-47-5, name is 6-Chloropyrido[3,4-d]pyrimidin-4(3H)-one, molecular formula is C7H4ClN3O, molecular weight is 181.58, as common compound, the synthetic route is as follows.

Step (F) : 4- (6-CHLORO-4-OXO-4H-PYRIDO [3,4-d] pyrimidin-3-ylmethyl)-benzoic acid tert-butyl ester A suspension of 6-chloro-3H-pyrido [3,4-d] PYRIMIDIN-4-ONE in DMF (230mL) was treated with cesium carbonate and stirred at room temperature for 1 hour. The mixture was treated with 4-aminomethylbenzoic acid tert-butyl ester (62.2g, 195mmol, 0. 85 mole equivalents) and reaction mixture solidified almost immediately; an additional 100mL of DMF was added. The reaction mixture was stirred at room temperature for 2 hours, heated overnight at 60C, and cooled to room temperature. The mixture was filtered to remove the cesium carbonate, and the filtercake was washed with DMF. Upon standing, a white solid began to form in the filtrate. This solid was collected by filtration, washed with DMF, and then ethyl acetate. The filtrate was evaporated to dryness, and the resulting SOLID/OIL mixture was treated with ethyl acetate and IN HCI, giving two layers. The layers were separated, and the organic portion was evaporated to dryness. The residue was triturated with hot HEXANES/ETHYL acetate 3: 1 and cooled to room temperature. The resulting solid was collected by filtration and washed with hexanes/ethyl acetate 3: 1. The initial white solid from the cesium carbonate wash was combined with this solid, and the combined material was triturated with hot HEXANES/ETHYL acetate 3: 1, cooled to room temperature, and further cooled in a refrigerator for 45 minutes. The solids were collected by filtration, washed with hexanes/ethyl acetate 4: 1, and dried to give 46.32g of 4- (6-chloro-4-oxo-4H-pyrido [3,4- D] PYRIMIDIN-3-YLMETHYL)-BENZOIC acid tert-butyl ester as a light yellow solid (89.5% yield). 1H NMR (400 MHz, DMSO-D6) 8 ppm 1.5 (s, 9H), 3.9 (s, 3H), 5.3 (s, 2H), 7.5 (d, J=8. 5HZ, 2H), 7.8 (d, J=8. 5HZ, 2H), 8.5 (s, 1H), 8.8 (s, 1H), 9.1 (s, 1H) MS (APCI) M+1 = 372.1

The chemical industry reduces the impact on the environment during synthesis 171178-47-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/16926; (2005); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 50593-92-5 , The common heterocyclic compound, 50593-92-5, name is 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid, molecular formula is C6H5BrN2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 29 (1052) Methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate (1053) A solution of 5-bromo-2-(methylthio)pyrimidine-4-carboxylic acid (7.64 g, 30.7 mmol) in MeOH (60 ml_) was treated with sulfuric acid (2 ml_) and heated to reflux for 24 hours. The mixture was poured onto ice water and extracted with DCM. The organic layer was washed with saturated aqueous NaHC03, dried (MgS04) and concentrated in vacuo to afford the title compound (6.42 g, (1054) 80%). (1055) 1 H NMR (500 MHz, CDCb): delta ppm 8.72 (s, 1 H), 4.01 (s, 3H), 2.58 (s, 3H). LCMS (ESI) Rt = 2.35 minutes, MS m/z 263 [M+H]+

The synthetic route of 50593-92-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; WOODWARD, Hannah; INNOCENTI, Paolo; NAUD, Sebastien; BLAGG, Julian; HOELDER, Swen; WO2015/128676; (2015); A1;,
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Pyrimidine – Wikipedia

Related Products of 955368-90-8 , The common heterocyclic compound, 955368-90-8, name is 2-Allyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one, molecular formula is C9H10N4OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a pre-dried thumb flask, 59-1 (0.8 g, 3.42 mmol), I1 (690.72 mg, 3.11 mmol), cuprous iodide (591.84 mg, 3.11 mmol), potassium carbonate (588.42 mg, 4.26 mmol) N,N’-dimethylethylenediamine (301.33 mg, 3.42 mmol, 367.92 muL,) and 1,4-dioxane (20 mL) were added in sequence, the reaction mixture was replaced by nitrogen for 3 times, then heated and stirred in an oil bath at 95C for 13 hours. For another batch, 59-1 (200.85 mg, 858.21 mumol), I1 (190.75 mg, 858.21 mumol), cuprous iodide (163.45 mg, 858.21 mumol), potassium carbonate (162.50 mg, 1.18 mmol), N,N’-dimethylethylenediamine (83.22 mg, 944.04 mumol, 101.61 muL) and 1,4-dioxane (5 mL) were added sequentially in a pre-dried thumb flask, the reaction mixture was replaced by nitrogen for 3 times, then heated and stirred in an oil bath at 95C for 13 hours. Half of the reaction mixture and previous batch of the reaction mixture were combined and directly evaporated. The residue was purified by a silica gel column (100-200 mesh silica gel, PE_EA=5/1-0/1) to give 0.7 g pale brown oily product. 0.5 g of the oily product was added into 20 mL water, then extracted by 60 mL DCM for 3 times, the organic phase was dried, then filtered and evaporated to dry. The residue was purified by a silica gel column (100-200 mesh silica gel, PE_EA=5/1-0/1) to give 59-2. 1H NMR (400 MHz, CDCl3): 8.97 (s, 1H), 8.09-8.06 (m, 1H), 7.70-7.43 (m, 2 H), 5.71-5.64 (m, 1H), 5.07-5.05 (d, J=10.4 Hz, 1H), 4.93-4.88 (m, 1H), 4.81-4.79 (d, J=6.4 Hz, 2H), 2.61 (s, 3H), 1.81-1.75 (m, 6H)

The synthetic route of 955368-90-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shijiazhuang Sagacity New Drug Development Co., Ltd.; QIAN, Wenyuan; YANG, Chundao; LI, Zhengwei; LI, Jie; LI, Jian; CHEN, Shuhui; (137 pag.)EP3572413; (2019); A1;,
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