Pyrimidines

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide. A new synthetic method of this compound is introduced below., category: pyrimidines

General procedure: Aq 1 M NaOH (9 mL, 1.5 equiv) was added to a stirred MeOH (20mL) solution of the appropriate aromatic thiol (7.2 mmol, 1.2equiv). The solution was stirred at r.t. for 15 min and then the heterocyclicalkyl bromide 2 or 3 (6 mmol, 1 equiv) was added. When rosuvastatin moiety bromides 2 were used, THF (10 mL) was also added to the mixture to improve solubility. After 18 h, the solvent was evaporated, the residue was dissolved in CH2Cl2 (50 mL), and washed with H2O (100 mL). The aqueous phase was additionally extracted with CH2Cl2 (2 × 25 mL). The combined organic phases were dried (MgSO4) and the solvent was evaporated. The residuewas recrystallized and the isolated product was dried in vacuumovernight at 60 C below 50 mbar to give the pure sulfide heterocyclic precursor 4 or 5 in 75-97% yield.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 799842-07-2, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide.

Reference:
Article; Fabris, Jan; ?asar, Zdenko; Smilovi?, Ivana Gazi?; ?rnugelj, Martin; Synthesis; vol. 46; 17; (2014); p. 2333 – 2346;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3438-46-8, 4-Methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H6N2, blongs to pyrimidines compound. Formula: C5H6N2

To a solution of compound 4-methylpyrimidine (2.07 g, 22.0 mmol) in THF (150 mL) was added AIBN (0.36 g,2.2 mmol) followed by a solution of NBS (4.7 g, 26 mmol) in THF (20 mL) at 0 C,The reaction was then heated to 70 C overnight. After cooling the reaction mixture was filtered through celite, the filtrate was concentrated under reduced pressure,The crude product was purified by silica gel column chromatography (eluent:PE / EtOAc (v / v) = 3/2) to give 1.5 g of a red-brown oil, yield: 39%.

The synthetic route of 3438-46-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Zhou Youbo; Yang Tiping; He Wei; Zhang Yingjun; Zheng Changchun; (103 pag.)CN106749268; (2017); A;,
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Electric Literature of 74356-36-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74356-36-8, name is 2,4-Dimethyl-pyrimidine-5-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

The compound of Reference Example 56 (253mg, 1.00mmol) and 2,4-dimethylpyrimidine-5-carboxylic acid (152mg, 1.00mmol) and 1-hydroxybenzotriazole (135mg, 1.00mmol) and 1-(3 dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (230 mg, 1.20 mmol) and triethylamine (418muL, 3.00mmol) and a mixture of N,N-dimethylformamide (2 mL) was stirred at room temperature for 16 hours. Thereafter, the reaction mixture was purified by directly preparative high-performance liquid column chromatography. Then the obtained product (157mg, 0.50mmol) in tetrahydrofuran (5.0 mL) lithium aluminum hydride (56.9mg, 1.50mmol) of was added at 10 C. After 16 hours with stirring at 10C , the water and 10% sodium hydroxide solution was added, the precipitate was removed by Celite filtration, and the filtrate was concentrated. The resulting concentrated residue was purified by preparative high-performance liquid column chromatography, to give the title compound (4%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 74356-36-8, 2,4-Dimethyl-pyrimidine-5-carboxylic acid.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA COMPANY LIMITED; YOSHINAGA, HIDEFUMI; URUNO, YOSHIHARU; NAGATA, HIDETAKA; HASHIMOTO, MASAKAZU; KATO, TARO; (82 pag.)JP2016/108326; (2016); A;,
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Related Products of 130049-82-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130049-82-0, name is 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one. This compound has unique chemical properties. The synthetic route is as follows.

To a 250 ml three-necked flask, ethanol (100 mL), HW03603-4 (24.2 g, 46 mmol) and 6N HCl or trifluoroacetic acid (50 mL) were sequentially added at room temperature. Then, the reaction system was stirred at room temperature overnight. Depressurization to give a white solid HW03603-5 (about 20g,Yield 100%). Used directly in the next step. Preparation of target compound HW03603: Steps 1-4 of Reference Example 1 Preparation of target compound HW03603: Steps 1-4 of Reference Example 1Add to the 100 ml three-necked bottle at room temperature:Methanol (50 mL), HW03603-5 (4.6 g, 10.8 mmol),HW036-6 (2.62g, 10.8mmol)And N,N-diisopropylethylamine (4.2 g, 32.4 mmol).Then, the reaction system was heated to reflux and stirred overnight.The solvent was evaporated to dryness The organic phase was combined, washed with saturated brine, dried over anhydrous sodium sulfate and filtered.Depressurization to obtain a solid,Recrystallization from methanol gave a white solid HW03603 (3.35 g, yield 49%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one.

Reference:
Patent; Shanghai Kezhen Pharmaceutical Technology Co., Ltd.; Dong Huanwen; Zhang Lurong; (55 pag.)CN109748914; (2019); A;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 83410-15-5, 4-Chloro-5-iodo-6-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-Chloro-5-iodo-6-methylpyrimidine, blongs to pyrimidines compound. Recommanded Product: 4-Chloro-5-iodo-6-methylpyrimidine

A mixture of 2.38 g (9.73 mmol) A-3, 1.55 g (13.1 mmol) D-10, 53 mg (0.28 mmol) CuI, 0.25 g (0.94 mmol) triphenylphosphine, 0.20 g (0.28 mmol) bis(triphenylphosphine)-palladium(II) chloride and 15.6 mL (112 mmol) triethylamine in 15 mL dry THF is stirred under argon atmosphere at 85 C. for 1 h. The reaction mixture is cooled to RT and 100 mL DCM and 100 mL water are added. The phases are separated and the organic phase is washed with water, dried over MgSO4 and concentrated under reduced pressure. The residual product is purified by NP chromatography (silica gel, 2-15% MeOH containing 0.1% NH3 in DCM). Yield: 0.74 g (32%).

The synthetic route of 83410-15-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; KRAEMER, Oliver; van der VEEN, Lars; US2013/23533; (2013); A1;,
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Pyrimidine – Wikipedia

Related Products of 1753-50-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1753-50-0, name is 2-Chloropyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below.

To a stirred solution of compound MZ (3.0 g, 7.77 mmol) in EtOH (50 mL), DIPEA (3.9 mL, 23.31 mmol) and 2-chloropyrimidine-5-carbonitrile (AF, 1.3 g, 9.32 mmol) were added and the reaction mixture was stirred at RT for 12 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude compound was purified by silica gel column chromatography (15% EtOAc/hexane) to afford compound NA (2.9 g, 76.0%) as a light brown sticky viscous liquid. 1H NMR (400 MHz, DMSO-d6): _ 8.66-8.62 (m, 3H), 7.36-7.33 (m, 2H), 7.11 (t, J = 8.8 Hz, 2H), 7.02 (d, J = 8.0 Hz, 1H), 6.50 (s, 1H), 6.40-6.37 (m, 1H), 5.16-5.12 (m, 1H), 3.79 (s, 2H), 3.72 (d, J = 8.8 Hz, 6H), 3.46-3.37 (m, 1H), 3.06-3.00 (m, 1H), 2.92-2.87 (m, 1H) (1H merged in solvent peak).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1753-50-0, its application will become more common.

Reference:
Patent; VPS-3, INC.; YATES, Christopher, M.; (397 pag.)WO2018/165520; (2018); A1;,
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Pyrimidine – Wikipedia

Related Products of 908240-50-6 ,Some common heterocyclic compound, 908240-50-6, molecular formula is C7H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2,4-Dichloropyrido[3,4-d]pyrimidine (49.8 g, 250 mmol),28percent ammonia (94g, 750mmol was added to a flask containing 500mL of ethanol,The reaction was stirred for 48 hours with stirring at room temperature.TLC monitors the endpoint of the reaction.The precipitated solid was filtered, and the ethanol was rinsed.Drying gave Compound 16-1 (27 g, yield 60percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,908240-50-6, its application will become more common.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Sun Entao; Liu Song; Xing Qifeng; Zhang Xianghui; (189 pag.)CN109020975; (2018); A;,
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Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17119-73-2, name is 4-Chloro-6-methyl-2-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-6-methyl-2-(methylthio)pyrimidine

[00237] To the 4-chloro-6-methyl-2-(methylthio)pyrimidine from above was added 30 mL of a solution of 70% ethylamine in water. The reaction mixture was heated to 50 C for 3 h. After completion, excess ethylamine was evaporated on rotary evaporator under vacuum. The solid was filtered and dried under vacuum to afford N-ethyl-6-methyl-2- (methylthio)pyrimidin-4-amine (20 g, 90% yield).

With the rapid development of chemical substances, we look forward to future research findings about 17119-73-2.

Reference:
Patent; EXELIXIS, INC.; WO2008/127678; (2008); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 18740-39-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18740-39-1, name is 2,4-Dichlorothieno[2,3-d]pyrimidine, molecular formula is C6H2Cl2N2S, molecular weight is 205.0645, as common compound, the synthetic route is as follows.

To a solution of 2,4-dichlorothieno[2,3-d]pyrimidine (200 mg, 975.31 umol, 1 eq) in i-PrOH (15 mL) was added DIPEA (630.24 mg, 4.88 mmol, 849.38 uL, 5.0 eq) and 2-(lH-indol-3- yl)ethanamine (203.14 mg, 1.27 mmol, 1.3 eq). The mixture was stirred at 50 °C for 3 h. LC-MS showed the starting material was consumed completely and one main peak with desired MS was detected. The reaction mixture was diluted with H2O (15 mL) and extracted with DCM (15 mL x 3). The combined organic layers were dried over Na2S04 filtered and concentrated under reduced pressure to give a residue which was purified by flash silica gel chromatography (ISCO®; 12 g SepaFlash® Silica Flash Column, Eluent of 20-30percent EtOAc/PE gradient (at) 50 mL/min) to give 2-chloro-N-[2-(lH-indol-3-yl)ethyl]thieno[2,3-d]pyrimidin-4-amine (260 mg, 774.90 umol, 79.4percent yield) as a yellow solid. NMR (400 MHz, CD3OD) delta ppm 7.67 (d, J= 7.9 Hz, 1H), 7.40- 7.35 (m, 2H), 7.31 (d, J = 8.2 Hz, 1H), 7.10-7.05 (m, 2H), 7.00-6.93 (m, 1H), 3.86-3.79 (m, 2H), 3.11 (t, J= 7.4 Hz, 2H); ES-LCMS m/z 329.0, 331.0 [M+H]

The chemical industry reduces the impact on the environment during synthesis 18740-39-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; KYN THERAPEUTICS; CASTRO, Alfredo C.; EVANS, Catherine Anne; (632 pag.)WO2018/195397; (2018); A2;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 130049-82-0, blongs to pyrimidines compound. Safety of 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one

Example-8 Preparation of 3-(2-chloroethyl)-9-oxo-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (formula-9) A solution of oxalylchloride (8.8 ml) in dichloromethane (20 ml) was cooled to -65 C. and a solution of dimethyl sulfoxide (6.5 ml) dissolved in dichloromethane (20 ml) was added to it slowly and stirred for 30 min. keeping the temperature at -65 C. a solution of 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (5 grams) (formula-7) dissolved in dichloromethane (30 ml) was added to it very slowly and stirred for 40 min. Triethyl amine was added to the reaction mixture and then quenched with water. The organic layer was separated, washed with aqueous sodium carbonate and water. The solvent from the organic layer was distilled off under reduced pressure to provide the title compound. Yield: 4.0 grams

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,130049-82-0, its application will become more common.

Reference:
Patent; MSN LABORATORIES LIMITED; US2011/293889; (2011); A1;,
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Pyrimidine – Wikipedia