Pyrimidines

Adding a certain compound to certain chemical reactions, such as: 5305-59-9, 6-Chloropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 6-Chloropyrimidin-4-amine, blongs to pyrimidines compound. name: 6-Chloropyrimidin-4-amine

6-Chloropyrimidin-4-amine (4.1 g, 31.6 mmo1)was suspended in acetonitrile. DMAP (0.966 g, 7.91 mmo1) anddi-tert-butyl dicarbonate (14.74 g, 67.5 mmo1) were addedand the mixture was stirred at rt for 3 days. The solvent wasevaporated and the residue was purified by silica gel using0-15% ethyl acetate in hexanes to give 6[bis(tert-butoxycarbony1)amino ]-4-ch1oropyrimidine as a white solid (6.27 g,19.01 mmo1,60%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5305-59-9, 6-Chloropyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, JAMES H; MCDONALD, IVAR M; KING, DALTON; OLSON, RICHARD E; WANG, NENGHUI; IWUAGWU, CHRISTIANA I; ZUSI, F.CHRISTOPHER; MACOR, JOHN E; (330 pag.)JP5714745; (2015); B2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 767-15-7, name is 2-Amino-4,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Amino-4,6-dimethylpyrimidine

3. The 150 g compound 5, 200g of N – bromosuccinimide added 1 L in acetonitrile, 80 C heated 6 h. Precipitate is filtered, washed with cold acetonitrile, under the condition of vacuum drying, to obtain white solid (compound 6).

With the rapid development of chemical substances, we look forward to future research findings about 767-15-7.

Reference:
Patent; China Agricultural University; Wang Zhanhui; Shen Jianzhong; Wen Kai; Li Chenglong; Ke Yuebin; Zhang Suxia; Shi Weimin; (17 pag.)CN109824604; (2019); A;,
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Synthetic Route of 356058-42-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.356058-42-9, name is 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid, molecular formula is C16H15FN2O3S, molecular weight is 334.3653, as common compound, the synthetic route is as follows.

To an ice cold suspension ofintermediateA4 (2.0 g, 1 equiv) in dichloromethane (15 ml) (wherein a drying tube was used to insulate moisture) were added thionyl chloride (0.47 ml) and DMF (2 drops, catalyst). The mixture was stirred for 0.5 h to get a brown clear solution and then added slowly to a flask containing strong aqua (20 ml) over 10 mm in an ice bath with vigorous stirring. The solid thus formed was collected by filtration, washed to white with water and ethanol, and then dried in vacuo to give the title compound(1.0 g). MS (ESI): 334 (M+H).

Statistics shows that 356058-42-9 is playing an increasingly important role. we look forward to future research findings about 2-(2-((4-Fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetic acid.

Reference:
Patent; Shen, Jianhua; Wang, Yiping; Wang, Kai; US2014/171431; (2014); A1;,
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Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 107407-80-7, name is Ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate. A new synthetic method of this compound is introduced below., Product Details of 107407-80-7

[1120] Ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate (4.1 g, 21.2 mmol) is dissolved/suspended in 100 mL concentrated HCl. The mixture is heated under reflux. After 4 h, the reaction is cooled and the solvent is removed in vacuo. Absolute EtOH is added and the solvent is removed (twice) to afford a yellow-green solid. The solid is triturated with Et2O and dried to give 4.28 g (100%) of pyrrolo[1,2-c]pyrimidine-3-carboxylic acid as the hydrochloride salt. The solid can be recrystallized from EtOH. 1H NMR (400 MHz, DMSO) delta 9.24, 8.21, 7.90, 7.06, 6.85.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 107407-80-7, Ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate.

Reference:
Patent; Rogers, Bruce N.; Piotrowski, David W.; Walker, Daniel Patrick; Jacobsen, Eric Jon; Acker, Brad A.; Wishka, Donn G.; Groppi JR., Vincent E.; US2003/236264; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3934-20-1, name is 2,4-Dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2,4-Dichloropyrimidine

General procedure: A mixture of 2,4-dichloropyrimidine (6.71 mmol), ary-boronic acid (6.71 mmol). DMF or dioxane (10 ml) was added to the above mixture followed by aqueous sodium carbonate (2 M, 6 ml,). The reaction mixture was degassed with argon for 15 min. Pd(PPh3)4 (50 mg, 0.17 mmol) was added and again degassed 5 min. The reaction mixture was maintained at rt for 12 h. The mixture was subsequently filtered and the remaining solid was washed with EtOAc. The filtrate was washed again with water and brine. The organic layer was separated, dried with anhydrous Na2SO4 and filtered. The organic layer was purified by silica gel column chromatography to give the desired product.

With the rapid development of chemical substances, we look forward to future research findings about 3934-20-1.

Reference:
Article; Toviwek, Borvornwat; Suphakun, Praphasri; Choowongkomon, Kiattawee; Hannongbua, Supa; Gleeson, M. Paul; Bioorganic and Medicinal Chemistry Letters; vol. 27; 20; (2017); p. 4749 – 4754;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H6N2O3, blongs to pyrimidines compound. Computed Properties of C5H6N2O3

(B) The 1-methylpyrimidine-2,4,6-trione prepared above is uniformly mixed with phosphorus oxychloride, and then controlled to react at 0 C for 0.8 h, followed by controlling the reaction at 50 C. After 1.5 h, finally purified and dried to obtain 3-methyl-6-chlorouracil

The synthetic route of 2565-47-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anyang Normal University; Wang Xin; Sun Kai; Lv Yunhe; (12 pag.)CN109503551; (2019); A;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 514854-13-8, 6-Ethyl-5-iodopyrimidine-2,4-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 514854-13-8, blongs to pyrimidines compound. Recommanded Product: 6-Ethyl-5-iodopyrimidine-2,4-diamine

General procedure: The alkyne (1.2 eq), iododiaminoethyl pyrimidine (1.0 eq) was dissolved in anhydrous DMF (0.15M) and sonicated under argon. Pd(PPh3)2Cl2 (0.1 eq), CuI (0.21 eq), Et3N (24 eq) were added and again sonicated under argon for 15 minutes. The reaction mixture was heated at 60 C for 12h under argon. The reaction mixture was then concentrated in vacuo before preabsorbing onto a mixture of amine and 25% cysteine preabsorbed silica gel (1:1 /wt) and filterted through a plug of silica gel with 5% MeOH/ CH2Cl2. The collected reaction mixture was concentrated in vacuo, and further purified by preparative HPLC to furnish the final product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,514854-13-8, its application will become more common.

Reference:
Article; Lombardo; Dayanandan; Keshipeddy; Zhou; Si; Reeve; Alverson; Barney; Walker; Hoody; Priestley; Obach; Wright; Drug Metabolism and Disposition; vol. 47; 9; (2019); p. 995 – 1003;,
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Reference of 22536-65-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22536-65-8, name is 2-Chloro-5-methoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 58C (45 mg, 0.124 mmol) was dissolved in Dioxane (621 mu) and 2- chloro-5-methoxypyrimidine (26.9 mg, 0.186 mmol), dicyclohexyl(2′,4′,6′-triisopropyl- 3,6-dimethoxy-[l, l’-biphenyl]-2-yl)phosphine (6.66 mg, 0.012 mmol), sodium tert- butoxide (17.89 mg, 0.186 mmol), and palladium(II) acetate (2.79 mg, 0.012 mmol) were added. Reaction was degassed with nitrogen bubbling/sonication for 5 minutes, then it was sealed at heated to 85 C for 14 hours. The reaction was diluted with water, acidified with 1 N HC1, and extracted with EtOAc. The combined organics were dried with sodium sulfate, filtered and concentrated. The crude residue was dissolved in DMF, filtered, and purified via preparative HPLC to give Racemic Example 63 (2.5 mg, 0.006 mmol, 4.6%). LC-MS Anal. Calc’d for C24H34N4O4 442.26, found [M+H] 443.3. Tr = 1.869 min (Method B). 1H MR (500 MHz, DMSO-d6) delta: 8.62 (s, IH), 8.34 (s, 2H), 8.12 (d, J=2.7 Hz, IH), 7.14 (d, J=8.7 Hz, IH), 6.35 (dd, J=8.5, 2.7 Hz, IH), 4.72 (q, J=6.5 Hz, IH), 3.83 (s, 3H), 1.76-1.91 (m, 2H), 1.67 (d, J=10.9 Hz, 2H), 1.51-1.54 (m, IH), 1.49 (d, J=6.6 Hz, 3H), 1.15 (t, J=7.2 Hz, 9H), 0.81 (br. s., 6H)

According to the analysis of related databases, 22536-65-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; CHERNEY, Emily Charlotte; MARKWALDER, Jay A.; SHAN, Weifang; WILLIAMS, David K.; (203 pag.)WO2016/210414; (2016); A1;,
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Pyrimidine – Wikipedia

Related Products of 876343-10-1 , The common heterocyclic compound, 876343-10-1, name is 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3ClIN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

te^-ButyI4-(4-chloro-7Jy-pyrrolo[2,3-«qpyrimidm-6-yl)-3,6-dihydropyridine-l(2fl)-carboxylate (compound of Formula VIII-Boc).; IXMKCn[228] To a suspension of 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine (5.0g,O.OlSmol) in 1,4-dioxane (120mL) and water (30mL) were added 4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-l-carboxylic acid tert-butyl ester (5.97g,0.0193mol), potassium carbonate (4.9g, 0.036mol) and PdCl2(dppf)-CH2Cl2 (0.73g,0.89mmol). The flask was evacuated and refilled with N2 (3x). The mixture was heated at100C overnight. LC-MS showed the reaction was complete. The mixture was diluted withethyl acetate (200mL), then washed with brine (2x50mL), and dried over anhydrous sodiumsulfate. The filtrate was concentrated under reduced pressure to wlOOmL, the resulting whiteprecipitate was collected by filtration to give the first batch of the title compound. The filtratewas concentrated and the residue was purified by chromatography on silica gel, eluting withHex:EtOAc = 70:30 -> 50:50 to give a white solid (containing pinacol), which was furthercrystallized with EtOAc/hexanes to give the second batch of the title compound as a whitesolid. LC-MS (ES, Pos.): 335/337 (3/1) [MH+]. ‘H NMR (CDC13,400 MHz): 5 = 1.51 (s,9H), 2.61 (m, 2H), 3.70 (m, 2H), 4.20 (m, 2H), 6.27 (s, 1H), 6.55 (s, 1H), 8.61 (s, 1H), 10.3(brs, 1H).

The synthetic route of 876343-10-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2006/17443; (2006); A2;,
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Synthetic Route of 428854-24-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 428854-24-4, name is 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine. This compound has unique chemical properties. The synthetic route is as follows.

Example 51 4-Amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5,8-dihydropteridine-6,7-dione 300 mg (0.856 mmol) of the compound from example 1A were dissolved in 3 ml of ethanol, and 116 mul (0.856 mmol) of diethyl oxalate and 79 mg (1.156 mmol) of sodium methoxide were added. The mixture was heated to reflux for 10 h. The reaction mixture was stirred with 10 ml of ethanol. The precipitate was filtered off and stirred with 10 ml of water and then with 10 ml of acetonitrile. The precipitate was filtered off and dried under high vacuum. 112 mg of the title compound were obtained (30% of theory). LC-MS (method 2): Rt=0.80 min; MS (EIpos): m/z=405 (M+H)+. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=5.82 (s, 2H), 7.12-7.25 (m, 4H), 7.33-7.40 (m, 2H), 8.64 (dd, 1H), 9.14 (dd, 1H), 12.44 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 428854-24-4, 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian; Baerfacker, Lars; Weigand, Stefan; US2014/148433; (2014); A1;,
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