Pyrimidines

Inhibition of demethylases by GSK-J1/J4 was written by Kruidenier, Laurens;Chung, Chun-wa;Cheng, Zhongjun;Liddle, John;Che, KaHing;Joberty, Gerard;Bantscheff, Marcus;Bountra, Chas;Bridges, Angela;Diallo, Hawa;Eberhard, Dirk;Hutchinson, Sue;Jones, Emma;Katso, Roy;Leveridge, Melanie;Mander, Palwinder K.;Mosley, Julie;Ramirez-Molina, Cesar;Rowland, Paul;Schofield, Christopher J.;Sheppard, Robert J.;Smith, Julia E.;Swales, Catherine;Tanner, Robert;Thomas, Pamela;Tumber, Anthony;Drewes, Gerard;Oppermann, Udo;Patel, Dinshaw J.;Lee, Kevin;Wilson, David M.. And the article was included in Nature (London, United Kingdom) in 2014.Recommanded Product: 3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid The following contents are mentioned in the article:

Our result sshow that GSK-J1 and GSK-J4 inhibit demethylases in addition to KDM6B and KDM6A. Therefore,this compound can not be used alone for demonstrating a role for H3K27 demethylationin biol. processes. This study involved multiple reactions and reactants, such as 3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid (cas: 1373422-53-7Recommanded Product: 3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid).

3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid (cas: 1373422-53-7) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 3-((2-(Pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Microwave promoted efficient synthesis of substituted uracils and thiouracils under solvent-free conditions was written by Mojtahedi, Mohammad M.;Saidi, Mohammad R.;Shirzi, Jafar S.;Bolourtchian, Mohammad. And the article was included in Synthetic Communications in 2002.Related Products of 39083-15-3 The following contents are mentioned in the article:

Several substituted uracils and thiouracils were synthesized in good yields by one-pot condensation reaction of Me or Et β-ketoesters and urea (or thiourea) in solvent-free conditions under microwave irradiation and in short time. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Related Products of 39083-15-3).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 39083-15-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kinetics of the reaction of 2-thiouracil derivatives with chloroacetic acid amides was written by Jasinskas, L.;Urbonas, A.;Dienyte, J.. And the article was included in Lietuvos TSR Aukstuju Mokyklu Mokslo Darbai, Chemija ir Chemine Technologija in 1971.Application In Synthesis of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one The following contents are mentioned in the article:

Rate constants and activation energies were determined for the reaction of 2-thiouracil anions (I; R = Me, NH2, CO2Bu; R1 = H, Me, Et) with ClCH2COR2 (R2 = NHPh, NEt2, morpholino, NHC6H4NO2-m). The reaction occurred by an SN2 mechanism. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Application In Synthesis of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application In Synthesis of 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

An epigenetic therapy for diffuse intrinsic pontine gliomas was written by Ramaswamy, Vijay;Remke, Marc;Taylor, Michael D.. And the article was included in Nature Medicine (New York, NY, United States) in 2014.Electric Literature of C24H27N5O2 The following contents are mentioned in the article:

A review. Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts. This study involved multiple reactions and reactants, such as Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate (cas: 1373423-53-0Electric Literature of C24H27N5O2).

Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate (cas: 1373423-53-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Electric Literature of C24H27N5O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and Functionalization of 5-Alkyl-6-methyl-2-thiouracils was written by Babushkina, A. A.;Egorov, D. M.;Kaskevich, K. I.. And the article was included in Russian Journal of General Chemistry in 2020.Synthetic Route of C7H10N2OS The following contents are mentioned in the article:

Number of 5-alkyl-6-methyl-2-thiouracils were obtained, the further introduction of which into the reaction with dialkyl chloroethynylphosphonates afforded a series of new dialkyl (6-alkyl-5-oxo-7-methyl-5H-thiazolo[3,2-a]pyrimidin- 3-yl)phosphonates. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Synthetic Route of C7H10N2OS).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Synthetic Route of C7H10N2OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Alkylated derivatives of uracil. VI. Synthesis and properties of 5,6-oligomethyleneuracils was written by Frass, Elzbieta;Draminski, Marcin;Fiszer, Bernard. And the article was included in Roczniki Chemii in 1974.Synthetic Route of C7H10N2OS The following contents are mentioned in the article:

Reaction of β-keto esters and thiourea gave I (n = 1, 2, 3; X = S) and II (R = Me, Et; R1 = Me, Et, Pr; X = S) I (X = S) were converted to I (X = O) by heating with 10% ClCH2CO2H. Irradiation of I and II with a low pressure lamp gave only 10% yields of products. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Synthetic Route of C7H10N2OS).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Synthetic Route of C7H10N2OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of the bicyclic secondary amines via dimethylaminomethylene ketones from 3-pyrrolidone and 4-piperidone was written by Fukui, Hideto;Inoguchi, Kiyoshi;Nakano, Jun. And the article was included in Heterocycles in 2002.SDS of cas: 157327-52-1 The following contents are mentioned in the article:

The reaction of N-protected 3-pyrrolidone and 4-piperidone with N,N-dimethylformamide di-Me acetal gave the dimethylaminomethylene ketones, which reacted with several types of hydrazines, amidines, and guanidine to afford the secondary amines having fused ring system. This study involved multiple reactions and reactants, such as 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine dihydrochloride (cas: 157327-52-1SDS of cas: 157327-52-1).

6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine dihydrochloride (cas: 157327-52-1) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 157327-52-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of the bicyclic secondary amines via dimethylaminomethylene ketones from 3-pyrrolidone and 4-piperidone was written by Fukui, Hideto;Inoguchi, Kiyoshi;Nakano, Jun. And the article was included in Heterocycles in 2002.Recommanded Product: 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride The following contents are mentioned in the article:

The reaction of N-protected 3-pyrrolidone and 4-piperidone with N,N-dimethylformamide di-Me acetal gave the dimethylaminomethylene ketones, which reacted with several types of hydrazines, amidines, and guanidine to afford the secondary amines having fused ring system. This study involved multiple reactions and reactants, such as 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride (cas: 157327-49-6Recommanded Product: 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride).

5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride (cas: 157327-49-6) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation. [Erratum to document cited in CA149:445018] was written by Byron, Sara A.;Gartside, Michael G.;Wellens, Candice L.;Mallon, Mary A.;Keenan, Jack B.;Powell, Matthew A.;Goodfellow, Paul J.;Pollock, Pamela M.. And the article was included in Cancer Research in 2008.Name: 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea The following contents are mentioned in the article:

On page 6902, the grant support information was omitted, and should read: “Grant support: A V Scholar Grant from The V Foundation for Cancer Research (P.M. Pollock), a Postdoctoral Fellowship PF-07-215-01-TBE from the American Cancer Society (S.A. Byron), and an R01 CA071754 from the NIH (P.J. Goodfellow).”. This study involved multiple reactions and reactants, such as 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7Name: 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea).

1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

(2,3-Dibromopropyl)sulfonylarenes in S,N-Tandem Heterocyclizations. A New Synthesis of Thiazolopyrimidines was written by Shklyarenko, A. A.;Chernitsa, B. V.;Yakovlev, V. V.. And the article was included in Russian Journal of Organic Chemistry in 2005.HPLC of Formula: 39083-15-3 The following contents are mentioned in the article:

A new method for the synthesis of dihydrothiazolo[3,2-a]pyrimidinones, e.g. I, via S,N-tandem heterocyclization/alkylation of aryl 2,3-dibromopropyl sulfones and 2-thiouracils, is reported. The absence of isomeric products in the reaction mixtures indicates high chemo- and regioselectivity of this tandem reaction and suggests a concerted mechanism. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3HPLC of Formula: 39083-15-3).

5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.HPLC of Formula: 39083-15-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia