Pyrimidines

Electric Literature of 62846-82-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62846-82-6, name is Ethyl 4-pyrimidinecarboxylate. This compound has unique chemical properties. The synthetic route is as follows.

General Procedure 14 was followed in the preparation of Intermediate 21. 2149 General Procedure 14 2151 Intermediate 19 Intermediate 21 2152 [0246] Intermediate 19 (1.6 g, 10.5 mmol) was added dropwise to a vigorously stirring 2153 mixture of aminoguanidine sulfate (10.3 g, 42.1 mmol, 4 eq) in freshly prepared NaOMe 2154 (using 968 mg, 42.1 mmol of Na in 28 mL of dry MeOH) at 0 C. The resulting mixture was 2155 heated to reflux for 20 h. The mixture was then cooled to RT, carefully poured over ice cold 2156 water (20 mL) and concentrated in vacuo. The crude residue was purified over neutral 2157 alumina using 4-10% MeOH-CHCl3 as the eluent to give Intermediate 21 (5 OOmg, 26%) . 2158 MS: 163 [M + H]+; TLC: 20% MeOH in CHC13: Rf: 0.20.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62846-82-6, Ethyl 4-pyrimidinecarboxylate.

Reference:
Patent; VERSEON, INC.; SHORT, Kevin, Michael; PHAM, Son, Minh; WILLIAMS, David, Charles; KITA, David, Ben; WO2014/145986; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Reference of 1032452-86-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole, molecular formula is C13H10ClN3, molecular weight is 243.69, as common compound, the synthetic route is as follows.

The compound 3- (2-chloro-4-yl) -1-methyl-indole (300mg, 1.23mmol)And methyl 4-amino-2-nitro-5-(trifluoromethoxy)benzoate (257 mg, 1.48 mmol)Into the reaction flask,Then add 1,4-dioxane(10mL),p-Toluenesulfonic acid (254 mg, 1.48 mmol) was added with stirring.Heat to 85C for 10 hoursAfter the reaction is completed,Cool to room temperaturePrecipitation of solids,Filter and filter cake washed with acetonitrileDry to give a yellow solid (460 mg,Yield: 98.08%).

The chemical industry reduces the impact on the environment during synthesis 1032452-86-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; Tian Hongqi; Huang Gongchao; Cheng Ying; (48 pag.)CN107793413; (2018); A;,
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Reference of 7431-45-0, Adding some certain compound to certain chemical reactions, such as: 7431-45-0, name is 2-Phenylpyrimidine,molecular formula is C10H8N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7431-45-0.

General procedure: To a dried Schlenk tube was equipped with a magnetic stirbar. [Cp*RhCl2]2 (0.005 mmol, 2.5 mol %, 3.1 mg), AgSbF6 (0.03 mmol, 15 mol %,10.3 mg), substrate 1 (0.2 mmol or 0.4 mmol), HOAc (1 ml), substrate 2 (0.24 mmolor 0.2 mmol) were added sequentially under argon. The tube was stirred at roomtemperature or 80 C for 12 h. After completion of the reaction, the mixture wasdiluted with EtOAc (10 mL), filtered through a short pad of silica gel and washedwith EtOAc (30 mL). The filtrate was pre-absorbed on silica gel and concentrated byrotary evaporation. The crude product was purified by flash silica gel (300-400 mesh)chromatography to afford the desired products product 3.

According to the analysis of related databases, 7431-45-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Duan, Chang-Lin; Liu, Xing-Yu; Tan, Yun-Xuan; Ding, Rui; Yang, Shiping; Tian, Ping; Lin, Guo-Qiang; Synlett; vol. 30; 8; (2019); p. 932 – 938;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2217-08-5, name is 5,5-Dipropylbarbituric acid, the common compound, a new synthetic route is introduced below. Recommanded Product: 5,5-Dipropylbarbituric acid

EXAMPLE 7 1-(3-n-butoxy-2-hydroxypropyl)-5,5-dipropyl-(1H,3H,5H)pyrimidine-2,4,6-trione A solution of 5,5 dipropyl-(1H,3H,5H)-pyrimidine-2,4,6-trione (30.8 g, 0.15 mole) in dimethylformamide (30 ml) containing triethylamine (2.02 g, 0.2 mole) was mixed with butyl glycidyl ether (13 g, 0.1 mole). The mixture was heated at 60 C. for 6 hours. The solution was then diluted with water (150 ml) and extracted with toluene (2*50 ml). The organic layer was separated, washed with water (2*100 ml) dried and extracted with 5% aqueous sodium carbonate (6*100 ml). The toluene phase was then extracted with 1M aqueous sodium hydroxide (2*100 ml), the aqueous layers separated, washed with toluene (100 ml) and the pH was adjusted to 3 with sulphuric acid. The precipitated oily product was extracted with toluene (100 ml), and the organic layer was separated, washed with water, dried and evaporated to yield the title compound (16.3 g; 51.6%); purity by HPLC 96.5%.

The synthetic route of 2217-08-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sapos S.A.; US5262402; (1993); A;,
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Electric Literature of 110099-94-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110099-94-0, name is 2-(Methylthio)pyrimidine-5-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of crude 19 (100 mg, 0.48 mmol ) in THF (5 mL) is added isobutyl chloroformate (0.05 mL, 0,58 mmol) followed by NMM (0.06 mL, 0.58 mmol) at – 10 C. After stirring for 10 minutes, the mixture is filtered and sodium borohydride (37 mg, 0,96 mmol) in water (0.2 mL) is added dropwise at 0 C. After stirring at room temperature for 20 minutes, the mixture is concentrated and the residue is partitioned between EA (20 mL) and water (10 mL). The organic layer is washed with brine (10 mL), dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography (MeOH:DCM = 1 : 100) to give A38 as a colorless oil (50 mg, 74% yield). (MS: i 1 · 1 11 194.1 ).Following the procedure for A38 using 133 (1.18 g, 6.9 mmoi), NMM (695 mg.6.9 mmoi), THF (20 mL), isohutyl chioroformate (1.13 g. 8.25 mmol), sodium borodeuteride(289 mg, 6.9 mmoi), and deueterate water (0.5 mL), then purii with silica gel columnchromatography (EA:PE == 1:5) to give i13d2 as a light yellow solid (290 rng, 25%). (MS:[M+H] 159.1)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110099-94-0, 2-(Methylthio)pyrimidine-5-carboxylic acid.

Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 29274-24-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29274-24-6, name is 5-Chloropyrazolo[1,5-a]pyrimidine, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The residue B-2 prepared in the above Example 7 was added to 9 mL of 1:1 sulfuric acid nitric acid at 0 C. Controlling the reaction temperature did not exceed 5, reaction time 2h, after the reaction is completed, carefully add water. The product was filtered off, and the product was crystallized from ethyl acetate to give the product 5.1 g, yield 86%. HPLC purity ? 99%.

According to the analysis of related databases, 29274-24-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang Normal University; Li Xinsheng; Chen Xiuhua; Chen Xueke; Luo Hongmin; (13 pag.)CN109354578; (2019); A;,
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Pyrimidine – Wikipedia

Reference of 2972-52-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2972-52-3, name is 2,4-Dichloro-5-pyrimidinecarbonyl chloride, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 3 Synthesis of 5-carboxyamide-2,4-dichloropyrimidine To a 2 L round bottom flask equipped with water condenser and a CaCl2 drying tube, 2,4-dihydroxypyrimidine (25 g, 0.16 mole) was added to PCl5 (117 g, 0.56 mole), and POCl3 (250 ml, 2.6 mole). The mixture was heated at 115 C. overnight to give a clear, slightly light yellow solution. The mixture was cooled to room temperature, and was concentrated under reduced pressure to give pale yellowish oil. To this oil, anhydrous 1,4-dioxane (300 ml) was added and the mixture was cooled to 0 C. in an ice/water bath. 35 ml of NH3 in water (28%) was added dropwise to the mixture with stirring, temperature was kept below 5 C. The mixture changed from clear to white with precipitate forming, and was stirred for 1 hour at 0 C., reaction was followed by TLC (1:1 Hexanes:Ethyl Acetate). Ethyl acetate (700 ml) and water (500 ml) were added to the mixture, the 2 layers were separated. The organic layer was dried with Na2SO4, and filtered. The solution was concentrated under reduced pressure to give a light yellow solid. This light yellow solid was sonicated with methylene chloride (200 ml), and filtered to give a pale yellow solid (16 g). This pale yellow solid was dissolved into ethyl acetate (1.5 L) and washed with sat. NaHCO3 (500 ml). The organic layer was dried with Na2SO4, filtered, and concentrated under reduced pressure to give 13.1 g of product as a white solid (44% yield). 1H NMR (DMSO-d6, 300 MHz): delta 8.86 (s, 1H), 8.14 (bs, 1H), 8.02 (bs, 1H).

According to the analysis of related databases, 2972-52-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Holland, Sacha; Kolluri, Rao; Alvarez, Salvador; Duncton, Matthew; Singh, Rajinder; Zhang, Jing; Masuda, Esteban; US2012/22092; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 69034-12-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69034-12-4, name is 2-Chloro-5-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A reaction mixture of methyl 4-((4,4,4-trifluoro-1-(2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butyl)amino)benzoate (5.6 g) obtained in Example 1, step F, 2-chloro-5-(trifluoromethyl)pyrimidine (2.36 g), tetrakistriphenylphosphinepalladium (0.678 g), 2M aqueous sodium carbonate solution (17.6 mL) and dimethoxyethane (52.8 mL) was stirred at 100C overnight under a nitrogen atmosphere. The reaction mixture was added to saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (4.93 g). MS (ESI-), found: 496.3.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 69034-12-4, 2-Chloro-5-(trifluoromethyl)pyrimidine.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SASAKI, Minoru; FURUKAWA, Hideki; HIDAKA, Kousuke; TOYOFUKU, Kyoko; YOGO, Takatoshi; MURATA, Toshiki; EP2832725; (2015); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 62802-42-0, Adding some certain compound to certain chemical reactions, such as: 62802-42-0, name is 2-Chloro-5-fluoropyrimidine,molecular formula is C4H2ClFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62802-42-0.

2-Chloro-5-fluoropyrimidine (541mg, 4.0mmol) was added to suspension of N (800mg, 3.72mmol) and potassium carbonate (l .Og, 7.44mmol) in diglyme(15mL), the resulting mixture was stirred at 100 C for 6 h. On completion the mixture was cooled to 0C and filtered, the solid was taken in water (50mL) and stirred for 30 mins. The suspension was filtered, the solid cake was washed with water (50mL), pet ether (15mL) and dried under vacuum to afford l .Og (86%) of P as yellow color solid. [TLC system:Ethyl acetate:pet ether (3 :7).-R/value:0.701.

According to the analysis of related databases, 62802-42-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F2G LIMITED; SIBLEY, Graham Edward Morris; LAW, Derek; OLIVER, Jason David; BIRCH, Michael; (76 pag.)WO2016/79536; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 16234-10-9 ,Some common heterocyclic compound, 16234-10-9, molecular formula is C6H4N2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of DMF (13.2 mL, 170 mmol) in DCM (100 mL) at 0C was added oxalyl chloride (22 mL, 252 mmol) in DCM (100 mL) very slowly over 1 hour. To the resulting white gel solution was added the 3H-thieno [3,2-d] pyrimidin-4-one (12 g, 79 mmol). The mixture was refluxed for 4 hours. After cooling, the mixture was purred into water (500 mL) and extracted with DCM (3×250 mL). Then the organic phase was dried over magnesium sulfate, filtered and concentrated to afford 7-chloro-thieno [3,2-b] pyridine as white solid (13.4 g, 99%). 1H NMR (CDCl3, 400 Hz) 8 9.00 (s, 1H), 8.06 (d, J=5.6Hz, 1H), 7.61 (d, J=5.6Hz, 1H). MS (ESI+) [M+H] + 170

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16234-10-9, its application will become more common.

Reference:
Patent; ARRAY BIOPHARMA INC.; WO2005/51304; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia