Pyrimidines

Electric Literature of 91717-22-5 ,Some common heterocyclic compound, 91717-22-5, molecular formula is C10H16N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 100 mL jar, 2-amino-4-piperidinyl-6-methylpyrimidine (0.001 mol) was added,Furfural (0.001 mol), dimethyl malonate (0.0015 mol), and p-xylene (30 mL) as the solvent,The reaction was terminated after 50 minutes in a microwave at 100C, and paraxylene was recovered under reduced pressure.Column chromatography (petroleum ether:ethyl acetate=4:1 V/V) gave the desired product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 91717-22-5, 2-Amino-4-piperidino-6-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guizhou Institute Of Technology; Bai Song; Zhu Yunying; Wei Xian; Wu Qin; Zou Shuliang; Tang Qin; Gong Zhihai; Zhou Han; Zhou Hang; (14 pag.)CN108101855; (2018); A;,
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Pyrimidine – Wikipedia

Related Products of 10070-92-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10070-92-5, name is Pyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of pyrimidine-5-carbaldehyde (500 mg, 4.6 mmol) in MeOH (10 mL) at 0, was added NaBH4 (262 mg, 6.9 mmol) in one portion. The mixture was stirred at RT for 4 h. It was then washed with brine and extracted with EA. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated to give pyrimidin-5- ylmethanol as a white solid (456 mg, 89%). LC-MS (ESI): m/z (M+H) =111.13

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10070-92-5, Pyrimidine-5-carbaldehyde.

Reference:
Patent; REMEDY PLAN, INC.; CRIMMINS, Gregory, Thomas; DE JESUS DIAZ, Dennise, Alexandra; BHURRUTH-ALCOR, Yushma; (483 pag.)WO2019/213570; (2019); A1;,
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Pyrimidine – Wikipedia

Related Products of 26830-94-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of Compound 2 (26.13 g, 123.6 mmol) in Et20 (500 mL) was added a mixture of 0.5 M NH3 in dioxane (250 mL, 125 mmol) and DIPEA (22 mL, 126 mmol) dropwise over 50 min. After stirring at RT overnight the reaction mixture was concentrated in vacuo to give a residue that was purified by flash chromatography (Si02, 10-50% EtOAc/hexanes). The product obtained was triturated with 10 mL 10% EtOAc/hexanes and filtered to give 9.74 g (41%) of Compound 3 as an orange crystalline solid. ]H NMR (400 MHz, DMSO-d6): delta 8.40 (br s, 1H), 8.16 (br s, 1H), 8.10 (s, 1H). LC/MS: m/z= 192 [M+H]+ (Calc: 191).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.

Reference:
Patent; PURDUE PHARMA L.P.; LYNCH, Stephen, M.; WO2015/112801; (2015); A1;,
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Pyrimidine – Wikipedia

Related Products of 3680-69-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4ClN3, molecular weight is 153.5691, as common compound, the synthetic route is as follows.

To a suspension of commercial 4-chloro-7H-pyrrolo[2,3-d]pyrimidine 10.75 g (70.00 mmol) in 150mL DCM, and added 1-bromopyrrolidine-2,5-dione (18.69 g, 105.00 mmol) at ambient temperature overnight. Upon the reaction completion, large amounts of precipitates formed. The precipitates were collected by filtration, and the filtrate was removed under reduced pressure to get the solid, washed with DCM, to yield of the title compound as yellow solid (15.00 g, 92% yield). 1H NMR (400 MHz, DMSO) delta 12.97(s, 1H), 8.63 (s, 1H), 7.95 (d, J 2.6 Hz, 1H).

Statistics shows that 3680-69-1 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Article; Zhang, Chufeng; Pei, Heying; He, Jun; Zhu, Jiali; Li, Weimin; Niu, Ting; Xiang, Mingli; Chen, Lijuan; European Journal of Medicinal Chemistry; vol. 169; (2019); p. 121 – 143;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 99586-66-0, 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile, blongs to pyrimidines compound. Recommanded Product: 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile

The procedure mentioned in Scheme 6 was used with (S)-methyl 6-((2-(1- ((tert-butoxycarbonyl)amino)propyl)-4-oxo-3 -phenyl-3 ,4-dihydroquinazolin-5- yl)amino)hexanoate 1.3b (110.0 mg, 0.21 mmol) and trifluoroacetic acid (480.0 mg, 4.21 mmol, 0.32 ml) in dichioromethane (2.1 ml). The resulting mixture was stirred at room temperature for 3 hours and worked-up (Method A) to form (S)-methyl 6-((2-(1- aminopropyl)-4-oxo-3 -phenyl-3 ,4-dihydroquinazolin-5-yl)amino)hexanoate 6.11. This free amine 6.11 was used with 2-amino-4-chloro-6-methylpyrimidine-5-carbonitrile (53.0 mg, 0.32 mmol) and diisopropylethylaime (81.0 mg, 0.63 mmol, 110.0 pi) in n-butanol (0.5 ml) and heated at 130 C for 2 hours. The remaining residue was purified by flash chromatography on silica gel using 0-100% EtOAc/Hexanes to afford the product methyl (5)- 6-((2-(1-((2-amino-5-cyano-6-methylpyrimidin-4-yl)amino)propyl)-4-oxo-3-phenyl-3,4- dihydroquinazolin-5-yl)amino)hexanoate 6.2q (97.0 mg, 0.174 mmol) in 83% yield. LC-MS (method 1): tR = 3.25 mi mlz (M + H)+ = 555.3.

The synthetic route of 99586-66-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; GREWAL, Gurmit; THAKUR, Ashish; TAWA, Gregory James; FERRER, Marc; SIMEONOV, Anton M.; (191 pag.)WO2018/237007; (2018); A1;,
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Pyrimidine – Wikipedia

Related Products of 13509-52-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13509-52-9, name is 1,3,6-Trimethylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 1 l ,3-Dimethyl-lH-pyrroIo[3,2-<;phiyrimidine-2,4(3H,5//)-dione:Step 1 l,3,6-Trimethyl-5-nitrouracil: A mixture of concentrated H2SO4 (7.0 mL) and fuming HNO3 (7.0 mL) was cooled to 0-50C and l,3,6-trimethylpyrimidine-2,4(lH,3H)- dione (3.5 g, 22.702 mmol) was gradually added to the reaction mixture. After stirring for 2 h. at the same temperature the reaction mixture was partitioned between ethyl acetate (200 mL) and water (100 mL). The organic layer was washed with brine (2 x 50 mL), dried (Na2SO4) and evaporated under reduced pressure. Crude product obtained was purified by column chromatography to give 1.30 g of the product as yellow solid; 1H NMR (delta ppm, 300-MHz, DMSO-J6) 2.38 (s,~3H), 3.20 (s, 3H), 3.40 (s, 3H); APCI-MS (m/z) 198.30 (M-H). According to the analysis of related databases, 13509-52-9, the application of this compound in the production field has become more and more popular. Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; DESHMUKH, Vishal, Govindrao; DHONE, Sachin Vasantrao; CHIKHALE, Rajendra, Prakash; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil; WO2010/109287; (2010); A1;,
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Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2,4,6-Trichloropyrimidine

2,4,6-trichloropyrimidin (10g, 54.51mmol), phenylboronic acid (16.6g, 136,29mmol), Pd(PPh3)4 (3.15g, 2.72mmol), 2M K2CO3 (50ml), toluene (100ml) and ethanol (30ml)were mixed and stirred under reflux. 4 hours later, the mixture was cooled room temperature, distilled water was added. After extracting with EA and drying with anhydrous MgSO4, distillation under reduced pressure followed by column separation yielded Compound 2-1 (7g, 26.24mmol, 48.14%).

With the rapid development of chemical substances, we look forward to future research findings about 3764-01-0.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; KIM, Chi Sik; EUM, Sung Jin; CHO, Young Jun; KWON, Hyuck Joo; KIM, Bong Ok; KIM, Sung Min; YOON, Seung Soo; WO2011/10839; (2011); A1;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C22H15BrN2, blongs to pyrimidines compound. COA of Formula: C22H15BrN2

Synthesis of Intermediate GIn a 500 ml three necked round bottom flask, 38.7 g (100 mmol) of 4-(4-bromophenyl)-2,6-diphenylpyrimidine, 2.7 g (3 mmol) of Pd2(dba)3,2.21 g (6 mmol) tricyclohexylphosphine,55.9 g (220 mmol) of bis (pinacorate) diborane and 39.25 g (400 mmol) of potassium acetate put it in nitrogen,300 ml of 1,4-dioxane was added and stirred for 4 hours at reflux.After completion of the reaction, the mixture was extracted with Methylene Chloride, the organic layer was dried with MgSO4, purified by column chromatography, and crystallized with n-Hexane to give 36 g (82.9.%) As intermediate G.

The synthetic route of 58536-46-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jinung Industry Co., Ltd.; Lee Eung; Lee Jong-ryun; Cho Eun-sang; Lee Ji-hwan; Kuk Chang-hun; (29 pag.)KR102052332; (2019); B1;,
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Pyrimidine – Wikipedia

Electric Literature of 3680-69-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4ClN3, molecular weight is 153.5691, as common compound, the synthetic route is as follows.

Compound 13a (5.0 g, 32.56 mmol, 1.00 equiv) was taken up in DMF 60 mL. and to the resulting solution was added N-iodosuccinimide (7.3 g, 32.45 mmol, 1.00 equiv) in portions at room temperature. The resulting reaction was allowed to stir for 2 hours at room temperature, and then was concentrated in vacuo. The resulting residue was purified using flash column chromatography on silica gel and eluted with ethyl acetate/petroleum ether (1:3) to provide 6.7 g (74%) of compound 13b as a white solid.

Statistics shows that 3680-69-1 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; VERMA, Vishal; ARASAPPAN, Ashok; NJOROGE, F. George; GIRIJAVALLABHAN, Vinay; BOGEN, Stephane, L.; DANG, Qun; OLSEN, David, B.; WO2013/9735; (2013); A1;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 90213-66-4, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, blongs to pyrimidines compound. Safety of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

A mixture of 2, 4-Dichloro-7H-pyrrolo[2,3-Patent; PORTOLA PHARMACEUTICALS, INC.; WO2009/131687; (2009); A2;,
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Pyrimidine – Wikipedia