Pyrimidines

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 147118-40-9, name is Rosuvastatin methyl ester. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Rosuvastatin methyl ester

The synthetic route is shown in flow diagram 4:The detailed preparing process is as follows:150mL acetonitrile and 18g (3R,5S,6E)-7-[4-(4-flurophenyl)-6-(1-methyl ethyl)-2-[methyl (methyl sulfonyl) amino]-5-pyrimidyl]-3,5-dihydroxy-6-methyl heptenoate were added to a 500mL reaction flask.Once the product was fully dissolved, 40mL purified water was added and the mixture was heated to 40°C.Subsequently, 42mL 1N sodium hydroxide solution was added at constant speed, wherein the addition process took around 15 minutes, and then the mixture was reacted at 40°C for 2.5 hours.The obtained solution was vacuum distilled to remove acetonitrile at 45°C, 30mL water was then added, and the mixture was cooled to 30°C with ice water.The mixture was washed three times with ethyl ether (50mL each time), wherein it was stirring for 15 minutes during each washing, the obtained mixture was allowed to stand for layering, and the water phase was collected.Then 3g activated carbon was added, the mixture was heated to 40°C and stirred for 60 minutes, the obtained mixture was filtered, the filter cake was washed with 10mL purified water, the filtrate and washing solution were combined and cooled to 20°C, and then 90mL ethyl ether was added.The pH value was adjusted to 5 with 0.5N hydrochloric acid, the mixture was stirred for 15 minutes and allowed to stand for layering for 15 minutes.The water phase was extracted twice with ethyl ether (60mL each time), wherein it was stirring for 15 minutes during each extraction, and then was allowed to stand for layering.The organic phases were combined and washed twice with saturated sodium chloride solution (60mL each time) and then allowed to stand for layering.The water phase was removed, while 6g anhydrous sodium sulfate was added to the organic phase and stirred for 35 minutes.The obtained mixture was filtered to remove anhydrous sodium sulfate, the filtrate was vacuum distilled to remove ethyl ether at 30°C, then 50g DMF and 2.5g K2CO3 were added.The mixture was vacuum distilled for 1.5 hours at 30°C to remove ethyl ether.As a result, 69.6g DMF solution containing (3R,5S,6E)-7-[4-(4-flurophenyl)-6-(1-methyl ethyl)-2-[methyl (methyl sulfonyl) amino]-5-pyrimidyl]-3,5-dihydroxy-6-heptonic acid was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 147118-40-9, Rosuvastatin methyl ester.

Reference:
Patent; Changzhou Pharmaceutical Factory; EP2298745; (2011); A1;,
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Pyrimidine – Wikipedia

Related Products of 3289-50-7, Adding some certain compound to certain chemical reactions, such as: 3289-50-7, name is 4-Amino-2,6-dimethoxypyrimidine,molecular formula is C6H9N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3289-50-7.

A solution of N-benzylidene-2,6-dimethoxypyrimidin-4-amine in methanol was prepared by heating a solution of benzaldehyde (0.100 ml0.987 mmol) and 2,6-dimethoxypyrimidin-4- amine (0.136 g; 0.877 mmol) in methanol (1 ml_) at 70C for 18 h. The formation of the imine was quantitative and the solution was used without further purification. ESI/APCI(+): 244 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3289-50-7, 4-Amino-2,6-dimethoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim; WO2013/45516; (2013); A1;,
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Related Products of 1088994-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1088994-22-2, name is 5-Methyl-2-(pyrimidin-2-yl)benzoicacid, molecular formula is C12H10N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(S)-(5-methyl-2-(pyrimidin-2-yl)phenyl)(5-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)methanone 5-methyl-2-(pyrimidin-2-yl)benzoic acid (1 eq; prepared according to WO 2008147518), intermediate 2 (1 eq) and DIPEA (2 eq) were dissolved in dichloromethane (5 ml/mmol) at 0 C., then T3P (50% in dichloromethane, 1.2 eq) was added. The mixture is stirred at reflux for 3-5 hours then at RT overnight. The reaction was washed with NaOH 1M and water, dried (Na2SO4) and evaporated. The crude was purified by silica gel column chromatography (DCM to DCM/MeOH=9/1) to obtain the title compound with yield of 44%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1088994-22-2, 5-Methyl-2-(pyrimidin-2-yl)benzoicacid.

Reference:
Patent; ROTTAPHARM S.P.A.; Stasi, Luigi Piero; Rovati, Lucio; US2013/310400; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 7752-74-1, 5-Iodo-6-methylpyrimidin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Iodo-6-methylpyrimidin-4(1H)-one, blongs to pyrimidines compound. Application In Synthesis of 5-Iodo-6-methylpyrimidin-4(1H)-one

Reference Example 64-Chloro-6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidine5-Iodo-6-methyl-4(3H)-pyrimidinone and [4-(trifluoromethyl)phenyl]ethynylzinc bromide were reacted in a solvent mixture of tetrahydrofuran and N,N-dimethylformamide (1:1) in the presence of tetrakis(triphenylphosphine)palladium while stirring under room temperature to heating to obtain a compound. The compound was mixed with POCl3 and reacted while heating under reflux to obtain a target substance. The target substance was subjected to e.g., proton nuclear magnetic resonance spectrometry (1H-NMR) and mass spectrometry (MS) and confirmed as the titled compound. Furthermore, MS measurement result is shown.Mass spectrum: 297,299.

The synthetic route of 7752-74-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nishio, Tetsuya; US2011/319618; (2011); A1;,
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Electric Literature of 3001-72-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3001-72-7 as follows.

General procedure: The reaction mixture of azlactones 1a-p (0.2mmol) and DBN (2b, 0.03mL, 0.22mmol) was stirred at room temperature for the appropriate time according to Scheme 2. After completion of the reaction as monitored by TLC (eluent: petroleum ether/ethyl acetate, 4:1), the mixture was extracted with ethyl acetate (3×5mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by silica gel column chromatography (10-35% ethyl acetate in petroleum ether) afforded the products 3ab-pb.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3001-72-7, its application will become more common.

Reference:
Article; Parhizkar, Golnaz; Khosropour, Ahmad Reza; Mohammadpoor-Baltork, Iraj; Parhizkar, Elahehnaz; Rudbari, Hadi Amiri; Tetrahedron; vol. 73; 11; (2017); p. 1397 – 1406;,
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Application of 4359-87-9, Adding some certain compound to certain chemical reactions, such as: 4359-87-9, name is 2,4,6-Trichloro-5-nitropyrimidine,molecular formula is C4Cl3N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4359-87-9.

A solution of compound 37 (3.33 gm) in water (30 mL) and NaHC03 was added dropwise to a solution of 2,4,6-trichloro-5-nitropyrimidine 31 in THF (40 mL) at 5-10C. The resulting reaction mixture was stirred at RT for 2h and layers were separated. The THF layer was then distilled off and the residue was extracted with ethyl acetate (2 x 100 mL). The combined organic layers were washed with brine, dried over sodium sulfate and concentrated under vacuum. The resulting residue was purified by column chromatography to obtain 4.8 gm of 38. NMR (400 MHz, CDC13): 5 8.55 (d, 1H), 4.84-4.82 (m, 1 H), 4.61 (d, 1 H), 4.46 (d, 1 H), 4.0 (d, lH), 3.83-3.75 (m, 3H), 3.66-3.63 (m, 1H), 3.34 (bs, 1 H), 2.37-2.32 (m, 1 H), 1.95-1.88 (m, 3H), 1.72-1.62 (m, 6H).

According to the analysis of related databases, 4359-87-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ANLON CHEMICAL RESEARCH ORGANIZATION; RASADIA, Punitkumar Rameshbhai; RAMANI.Vaibhav Narendrakumar; PANDEY, Bipin; BHADANI, Vijay Nagjibhai; VACHHANI, Dipakkumar Dhanjibhai; SHAH, Anamik Kantilal; WO2015/162630; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7461-50-9, name is 2-Chloropyrimidin-4-amine, molecular formula is C4H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Chloropyrimidin-4-amine

4-Amino-2-chloropyrimindine (1.3 g, 10.03 mmol) was suspended in Ac20 (9.47 mL, 100 mmol) then heated at 140 C for 3 h. The reaction was cooled to rt then Et20 (50 mL) was added and the resulting precipitate was filtered off This solid was purified by normal phase column chromatography [CyH/(EtOAc/EtOH 3:1) 90/10 to 50/501 to afford N-(2- chloropyrimindin-4-yl)acetaminde (500 mg, 2.91 mmol, purity: 100 %, recovery: 29 %) as awhite powder. LCMS (m/z) 172 and 174 (M+H), retention time: 1.29 min LC/MS Method1.

With the rapid development of chemical substances, we look forward to future research findings about 7461-50-9.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DAUGAN, Alain Claude-Marie; DONCHE, Frederic G.; FAUCHER, Nicolas Eric; GEORGE, Nicolas S.; (243 pag.)WO2018/92089; (2018); A1;,
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Electric Literature of 35265-83-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 35265-83-9, name is 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Reference Example 26 2-Chloro-4-ethylamino-7-methylthieno[3,2-d]pyrimidine In DMF was dissolved 700 mg (3.2 mmol) of 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine, and then an aqueous solution of 338 mg (7.5 mmol) of ethylamine was added dropwise to the resulting solution under ice cooling over 5 minutes. The reaction mixture was stirred at 0 C. for one hour and then allowed to resume room temperature, followed by stirring for one hour. After completion of the reaction, ice water was added to the reaction mixture, followed by extraction with ethyl acetate (50 ml*3). After the organic layer was washed successively with 1N hydrochloric acid, water and brine and dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent: ethyl acetate-hexane=1/6) to give 524 mg (yield: 72.0%) of the title compound. NMR (delta, CDCl3): 1.34 (3H, t, J=7 Hz), 2.42 (3H, s), 3.68-3.74 (2H, m), 4.97 (1H, br), 7.35 (1H, s)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 35265-83-9, 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine.

Reference:
Patent; NAKASHIMA, YOSHIHARU; FUJITA, TAKASHI; HIZUKA, MICHIYO; IKAWA, HIROSHI; HIRUMA, TORU; US2001/6969; (2001); A1;,
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Synthetic Route of 32779-36-5, Adding some certain compound to certain chemical reactions, such as: 32779-36-5, name is 5-Bromo-2-chloropyrimidine,molecular formula is C4H2BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32779-36-5.

To a mixture of benzyl alcohol (0.123 g, 1.14 mmol) and tetrahedrofuran (12.0 mL) was added sodium hydride (60 percent oil suspension, 0.050 g, 1.2 mmol) portionwise. After 10 min, 5-bromo-2-chloropyrimidine (0.200 g, 1.034 mmol) was added, and the mixture was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residue was partitionated between ethyl acetate and water. The separated organic phase was washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to give 2- benzyloxy-5-bromopyrimidine (0.269 g, 98 percent) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 32779-36-5, 5-Bromo-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER HEALTHCARE AG; WO2004/69805; (2004); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,4-Dichlorofuro[3,2-d]pyrimidine

A mixture of(lr,4r)-4-morpholinocyclohexan-1-ol (0.53 g, 2.9 mmol, 1.1 eq) in 5.0 mL of THF was prepared and 60% NaH (0.56 g, 14 mmol, 5.3 eq) was added. The reaction mixture was stirred at room temperature for 30 mm and 2,4-dichlorofuro[3,2-djpyrimidine (0.50 g, 2.6 mmol, 1.0 eq) was added and the resulting mixture was heated at 60 C for 3 hr. The reaction was cooled to room temperature and quenched with saturated aqueous ammonium chloride. The quenched mixture was rotary evaporated and purified on normal phase Combi-Flash using a 40 g column and eluting with a gradient of 0-20% MeOH/CH2C12 in 10 mm. The product containing fractions were combined and rotary evaporated to give 2-chloro-4-(((lr,4r)-4- morpholinocyclohexyl)oxy)furo[3,2-djpyrimidine (0.59 g, 1.7 mmol, 60% yield) as a white solid. LC-MS:M+H=338.0

With the rapid development of chemical substances, we look forward to future research findings about 956034-07-4.

Reference:
Patent; PHARMACYCLICS LLC; CHEN, Wei; JIA, Zhaozhong, J.; THOMAS, William, D.; WONE, David; (147 pag.)WO2017/205766; (2017); A1;,
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