Pyrimidines

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 936643-80-0, name is 2-(Chloromethyl)pyrimidine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 936643-80-0

To a stirred solution of 38-D (75 mg, 0.232 mmol) in DMF (6 mL) was added K2CO3 (128 mg, 0.928 mmol), followed by 38-E (57 mg, 0.348 mmol). The resulting mixture was stirred at 70 C. overnight. Diluted the reaction mixture with EtOAc and washed with H2O. The organic layer was dried over Na2SO4 and evaporated in vacuo. The residue was then purified by column chromatography (EtOAc:hexanes=2:3) to afford Compound II-56.

With the rapid development of chemical substances, we look forward to future research findings about 936643-80-0.

Reference:
Patent; Gilead Sciences, Inc.; US2012/289493; (2012); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 89793-12-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate, molecular formula is C7H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In step 4 manufactured benzyl 4-amino-4-phenylpiperidine-1-carboxylate hydrochloride (3.000 g, 8.649 mmol), ethyl 2-chloropyrimidine-5-carboxylate (1.614 g, 8.649 mmol) and N,N-diisopropylethylamine (3.465 mL, 19.893 mmol) was dissolved in 1,4-dioxane (30 mL) at room temperature and stirred at 110 °C for 17 hours, and then the reaction was terminated by lowering the temperature to room temperature. The solvent was removed from the reaction mixture under reduced pressure and the concentrate was purified by column chromatography (SiO2, 40 g cartridge; ethyl acetate / hexane = 5percent to 40percent) and concentrated to give the title compound (1.900 g, 51.5percent was obtained in the form of a yellow solid.

According to the analysis of related databases, 89793-12-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
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Electric Literature of 4595-61-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4595-61-3, name is Pyrimidine-5-carboxylic acid, molecular formula is C5H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of 5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine To a solution of pyrimidine-5-carboxylic acid (200 mg, 0.70 mmol) in pyridine (1.0 mL) is added thionyl chloride (61 muL, 0.84 mmol). The mixture is stirred at room temperature for 15 minutes before I-14 (91 mg, 0.74 mmol) is added. The resulting mixture is heated at 110° C. for 18 h then concentrated in vacuo. The residue is partitioned between EtOAc and saturated aqueous NaHCO3, washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give the title compound (236 mg); m/z 373.0, 375.0 [M, M+2H]

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4595-61-3, Pyrimidine-5-carboxylic acid.

Reference:
Patent; Boehringer Ingelheim International GmbH; BYLOCK, Lars Anders; US2013/195879; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 6-Aminopyrimidine-2,4(1H,3H)-dione

6-Aminouracil (5) (5.18 g, 40.7 mmol) was suspended in HM DS (25 mL) and H2S04 (0.1 m L) was added. The mixture was heated at reflux for 3 h then concentrated in vacuo. The residue was dissolved in DM F (30 mL), Mel (8.5 mL, 136.5 mmol) was added, and stirring was continued for 72 h at room temperature. The reaction was cooled to 0 C and NaHC03 was carefully added. The mixture was stirred at 0 C until no more bubbling was observed. The precipitate was filtered, washed with MeOH and H20 and dried to give the title compound 6 (4.49 g, 78%) as a yellow solid which was used without further purification.Rf 0.23 (EtOAc-MeOH-N H4OH, 7:2.7:0.3);H NMR (400 MHz, DMSO-d6) delta 10.36 (1H, s, Ntf), 6.16 (2H, s, Ntf2), 4.56 (1H, s, tf-5); 3.04 (3H, s, NCtf3); 13C NMR (100 M Hz, DMSO-d6) delta 163.3 (C-4), 153.5 (C-6), 151.1 (C-2), 74.0 (C-5), 25.9 (NCH3);MP Lit: 327 C19, found: 320-323 C;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; COMVITA LIMITED; BRIMBLE, Margaret Anne; SCHLOTHAUER, Ralf Christian; PRIJIC, Gordana; STEPHENS, Jonathan; DANIELS, Benjamin; (57 pag.)WO2017/99612; (2017); A1;,
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Related Products of 90914-41-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90914-41-3, name is 3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C5H2BrClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of N-Boc-4-(p-chlorophenyl)-piperidine-4-carbamide (135 mg, 0.40 mmol) in DMF (4 mL) was added NaH (60% in mineral oil, 20 mg, 0.5 mmol). The stirring was continued for 30 min. Then 3-(diethylamino)propyl chloride (90 mg, 0.60) was added. The mixture was then warmed to 90 0C. The stirring was continued for another 3 h. To the cooled mixture was added H2O. It was then extracted with EtOAc. The organic phase was washed with brine, and dried over Na2SO4. Removal of EtOAc gave the crude product. The crude product (about 0.4 mmol) obtained above was treated with excess TFA in DCM for 30 min. Upon removal of excess TFA and DCM, the residue was free-based and then reacted with 3-Bromo-4-chloro-lH-pyrazolo[3,4-d]pyrimidine (40 mg, 0.17 mmol) in the presence of Et3N (152 mg, 1.5 mmol) in 1,4-dioxane (2 mL) at 70 0C for 1 h. The mixture was concentrated. The crude product was purified by preparation EtaPLC. LC-MS (M+l): 550.4 (100%), 548.4 (80%).1H NMR (400 MHz, DMSO-d6) delta 8.31 (s, 1 H), 7.83 (t, J = 5.5 Hz, 1 H), 7.41 (s, 4 H), 4.25 (br d, J = 13.4 Hz, 2 H), 3.37 (br t, J = 11.9 Hz, 2 H), 3.08 (q, J = 6.4 Hz, 2 H), 2.63 (br d, J = 13.7 Hz, 2 H), 2.34 (q, J = 7.2 Hz, 4 H), 2.23-2.19 (m, 2 H), 1.99-1.92 (m, 2 H), 1.49-1.41 (m, 2 H), 0.85 (t, J = 7.2 Hz, 6 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 90914-41-3, 3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine.

Reference:
Patent; EXELIXIS, INC.; WO2006/71819; (2006); A1;,
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Pyrimidine – Wikipedia

Related Products of 68797-61-5, Adding some certain compound to certain chemical reactions, such as: 68797-61-5, name is 5-Bromo-4,6-dichloropyrimidine,molecular formula is C4HBrCl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68797-61-5.

To a mixture of compound 18-1-1 (1 g, 5 mmol) in DCM (10 mL) was added DIPA (1.29 g, 10 mmol) and compound 18-1 (1.13 g, 5 mmol) at 0 C., and the reaction solution was stirred at r.t. for 1 h, followed by evaporation. The solvent was removed and the residue was purified by column chromatography to give compound 18-2 (1 g, Yield 78%). 1H NMR (400 MHz, CDCl3): delta ppm 1.39 (brs, 9H), 1.50-1.61 (m, 1H), 1.62-1.73 (m, 1H), 1.73-1.82 (m, 1H), 1.82-1.93 (m, 1H), 3.24-3.35 (m, 1H), 3.42-3.53 (m, 2H), 3.53-3.62 (m, 1H), 4.11 (d, J=2.65 Hz, 1H), 5.69 (m, 1H), 8.234-8.230 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 68797-61-5, 5-Bromo-4,6-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.; Humanwell Healthcare (Group) Co., Ltd.; Wang, Xuehai; Wu, Chengde; Xu, Yong; Shen, Chunli; Li, Li’e; Hu, Guoping; Yue, Yang; Li, Jian; Guo, Diliang; Shi, Nengyang; Huang, Lu; Chen, Shuhui; Tu, Ronghua; Yang, Zhongwen; Zhang, Xuwen; Xiao, Qiang; Tian, Hua; Yu, Yanping; Chen, Hailiang; Sun, Wenjie; He, Zhenyu; Shen, Jie; Yang, Jing; Tang, Jing; Zhou, Wen; Yu, Jing; Zhang, Yi; Liu, Quan; (251 pag.)US2017/313683; (2017); A1;,
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Pyrimidine – Wikipedia

Related Products of 289042-12-2, Adding some certain compound to certain chemical reactions, such as: 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate,molecular formula is C29H40FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289042-12-2.

BEM (20.0 g) was dissolved in acetonitrile (140 ml) at 40 C., then cooled to 35 C. before gradual addition of hydrochloric acid (0.02M, 35 ml) at 35 C. The resulting solution was stirred at 35 C. until the reaction was complete then cooled to 25 C. Further acetonitrile (8 ml) was added before sodium hydroxide (1.0M, 38 ml) was added at 25 C. and the resulting mixture stirred at this temperature until the reaction was complete. Aqueous hydrochloric acid (0.1M) was added to adjust the pH of the solution to approximately pH10.5. Water was added so that the combined volume of water and hydrochloric acid (0.1M) (from the previous pH adjustment step) added was 100 ml. Toluene (125 ml) was then added and the mixture stirred at 40 C. for 30 minutes before it was allowed to settle for 1 hour at 40 C. The aqueous phase was then separated from the organic phase at 40 C. The aqueous phase was distilled under reduced pressure (53 mBar, 40 C.) until the volume was reduced to 135 ml. The resulting aqueous solution was filtered through a filter pad and the filter washed with water and combined with the aqueous reaction solution, such that the total volume of the resulting aqueous solution was 170 ml. This solution was heated to 40 C. before addition of a solution of calcium chloride di-hydrate (3.05 g) in water (29.5 ml) over 20 min, maintaining the reaction mixture at 38-41 C.The reaction mixture was stirred for a further 15 min at 40 C., then cooled to 20 C. and stirred at this temperature for a further 15 min. The resulting suspension was filtered, washed with water (3×53 ml) and dried to give (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt (14.7 g(at)100% strength, 85% yield).1HNMR delta: 1.21 (d+d, 6H) 1.32 (dt, 1H) 1.51 (dt, 1H) 2.00 (dd, 1H) 2.14 (dd, 1H) 3.42 (spt, 1H)* 3.45 (s, 3H) 3.54 (s, 3H) 3.77 (m, 1H) 4.21 (q, 1H) 5.53 (dd, 1H) 6.51 (dd, 1H) 7.27 (t, 2H) 7.71 (dd, 2H) *partially obscured[The 1H NMR was carried out as a 3% w/v solution in d6 DMSO (where d5 DMSO=2.51delta)].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William; US2008/207903; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 4349-07-9, Adding some certain compound to certain chemical reactions, such as: 4349-07-9, name is 5-Iodopyrimidin-4-ol,molecular formula is C4H3IN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4349-07-9.

To a stirred solution containing 7.7 mL (99 MMOL) of DMF and 150 mL of DICHLOROETHANE at 0C was added 12.7 mL (144.6 MMOL) of OXALYL chloride slowly to control vigorous gas evolution. After the evolution of gas had ceased, 10.0 g of iodopyrimidone was added and the reaction mixture was heated at reflux for 3h, then cooled to room temperature and partitioned between water and DICHLOROMETHANE. The organic layers were dried over MGS04 and the solvent was removed under reduced pressure to give 9.6 g (88%) of the title COMPOUND. 1H-NMR (300 MHz, CDCI3) A 8. 89 (s, 1H) and 8.98 (s, 1H) ; ESIMS : 241.1 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4349-07-9, 5-Iodopyrimidin-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/16914; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 372118-67-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.372118-67-7, name is Pyrimidin-2-ylmethanamine hydrochloride, molecular formula is C5H8ClN3, molecular weight is 145.5901, as common compound, the synthetic route is as follows.

A mixture of 8-bromo-5-[5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5- (trifluoromethyl)-3-isoxazolyl]isoquinoline (180 mg, 0.35 mmol), 2-aminomethylpyrimidine hydrochloride (154 mg, 1.41 mmol), [l,r-bis(diphenylphosphino)ferrocene]- dichloropalladium(II) (29 mg, 0.04 mmol) and triethylamine (0.49 mL, 3.5 mmol) in toluene (10 mL) was stirred at 80 C under one atmosphere of carbon monoxide for 6 hr. The reaction mixture was then filtered through a short pad of Celite, rinsed with ethyl acetate, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography using ethyl acetate/methanol as eluent to afford the title compound, a compound of this disclosure, as a yellow solid (88 mg, 45% yield, 0.16 mmol). 1H NMR (DMSO-d6): 9.83 (s, 1H), 9.46 (t, 1H), 8.86 (d, 2H), 8.71 (s, 2H), 8.17 (d, 1H), 7.92 (d, 1H), 7.90 (s, 1H), 7.88 (s, 1H), 7.47 (t, 1H), 4.78 (d, 2H), 4.62 (d, 1H), 4.58 (d, 1H).

Statistics shows that 372118-67-7 is playing an increasingly important role. we look forward to future research findings about Pyrimidin-2-ylmethanamine hydrochloride.

Reference:
Patent; FMC CORPORATION; XU, Ming; LAHM, George Philip; (109 pag.)WO2020/55955; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1337532-51-0, name is 5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Run 3: To a stirred solution of 1-(4-bromo-3-fluorophenyl)-3-(2,5- difluorobenzyl)imidazolidin-2-one (450 mg, 1.16 mmol) in 1 ,4-dioxane (18 ml_) was added bis(pinacolato)diboron (300 mg, 1.16 mmol, 1 equiv), and potassium acetate (340 mg, 3.48 mmol, 3 equiv). The reaction mixture was degassed with N2 for 5 min. PdCI2(dppf)- CH2CI2 adduct (48 mg, 0.058 mmol, 0.05 equiv) was added and degassed with N2 for additional 5 min. The reaction mixture was stirred for 16 h at 100C in a sealed vessel. The reaction was cooled to room temperature, 5-bromo-7-methyl-7/-/-pyrrolo[2,3- <^pyrimidin-4-amine (260 mg, 1.16 mmol, 1.0 equiv), saturated aqueous NaHC03 (6 ml_) and PdCI2(dppf)-CH2CI2 adduct (48 mg, 0.058 mmol, 0.05 equiv) were added and the reaction mixture was degassed with N2 for 5 min. The vessel was sealed and the reaction mixture was stirred for 16 h at 100C. The reaction mixture was cooled to room temperature & filtered through celite and the filtrate was extracted with ethyl acetate. The organic layer was dried over Na2S04 and concentrated to obtain dark oily compound. The crude product was purified over silica gel flash column chromatography using 2% MeOH in DCM as mobile phase. Compound containing pure fractions were evaporated to obtain 1-(4-(4-amino-7-methyl-7/-/-pyrrolo[2,3-c]pyrimidin-5-yl)-3-fluorophenyl)-3-(2,5- difluorobenzyl) imidazolidin-2-one (70 mg, 13.5 %) as an off white solid. LCMS (ES) m/z = 453.2 [M+H]+. H NMR (400 MHz, DMSO-d6) delta ppm 3.46 (t, J = 8.0 Hz, 2H), 3.73 (s, 3H), 3.88 (t, J = 7.6 Hz, 2H), 4.46 (s, 2 H), 5.94 (br. s., 2H), 7.19 - 7.26 (m, 4H), 7.31- 7.40 (m, 1 H), 7.42-7.45 (m, 1 H), 7.70 (d, J = 13.2 Hz, 1 H), 8.13 (s, 1 H). If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1337532-51-0, 5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AXTEN, Jeffrey Michael; FAUCHER, Nicolas Eric; DAUGAN, Alain Claude-Marie; (153 pag.)WO2017/46739; (2017); A1;,
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