Pyrimidines

Adding a certain compound to certain chemical reactions, such as: 10320-42-0, 2-Chloro-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 10320-42-0, blongs to pyrimidines compound. SDS of cas: 10320-42-0

A mixture of 1 ,4-diazabicyclo[3.2.2]nonane (0.87 g, 6.90 mmol), 2-chloro-5- nitro-pyrimidine (1.56 g, 6.27 mmol) and dioxane (75 ml) was stirred at room- temperature for 15 h. Aqueous sodium bicarbonate (20 ml, 10percent) was added followed by extraction with ethylacetate (3 x 20 ml). The organic phase was dried and evaporated and a yellow powder was isolated. Yield 0.86 g (55percent). Mp 135-139°C.

The synthetic route of 10320-42-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEUROSEARCH A/S; WO2009/62987; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 13418-77-4, 2-Amino-5-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H7N3O, blongs to pyrimidines compound. COA of Formula: C5H7N3O

Step 1: Synthesis of N-{4-[(5-methoxypyrimidin-2-yl)sulfamoyl] phenyl}acetamide 20.1 [00358] To a solution of 5-methoxypyrimidin-2-amine (200 mg, 1.6 mmol) in MeCN (5 ml) was added pyridine (86 mu, 1.07 mmol) and the resulting solution was cooled to 0C. A solution of 4-(acetylamino)benzenesulfonyl chloride (250 mg, 1.07 mmol) in MeCN (10ml) was added drop wise over five minutes, the resulting mixture was stirred under nitrogen at 0C then allowed to warm to rt and stirred for 18h. The solvent was removed in vacuo and the remaining solid was purified by flash column chromatography (DCM/iPrOH 99/1 to 90/10) to afford 190 mg (41%) of N-{4-[(5-methoxypyrimidin-2-yl)sulfamoyl]phenyl}acetamide 20.1 as a white powder.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13418-77-4, 2-Amino-5-methoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; RAZE THERAPEUTICS, INC.; SAIAH, Eddine; (148 pag.)WO2016/40449; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 4316-97-6, Adding some certain compound to certain chemical reactions, such as: 4316-97-6, name is 4,6-Dichloro-5-methylpyrimidine,molecular formula is C5H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4316-97-6.

Example 971-(2-(6-chloro-5-methylpyrimidin-4-yloxy)benzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea [Show Image] A solution of 4,6-dichloro-5-methylpyrimidine (82 mg) in acetone (1mL) was cooled to 0C, and 1-(2-hydroxybenzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea (189 mg) and aqueous 1N sodium hydroxide solution (0.6 mL) were added thereto. This reaction mixture was allowed to warm to room temperature and stirred overnight. Saturated ammonium chloride was added to the reaction mixture, and the resulting mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane = 1/1) to obtain the desired product (166 mg, yield: 66%). 1H-NMR (CDCl3):delta 8.19 (s, 1H), 7.37-7.02 (m, 8H), 6.14 (s, 1H), 5.95 (s, 1H), 5.11 (t, 1H, J = 5.6 Hz), 4.31 (d, 2H, J = 5.6 Hz), 2.39 (s, 3H), 2.37 (s, 3H), 1.32 (s, 9H) MS (ESI):505 (M+H+)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4316-97-6, 4,6-Dichloro-5-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TORAY INDUSTRIES, INC.; EP1970375; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Amino-6-hydroxypyrimidin-4(3H)-one

Intermediate 292-Amino-4,6-dichloropyrimidine-5-carbaldehvdePhosphorus oxychloride (93 mL, 1020.54 mmol) was cooled to 50C using an ice bath. Dry DMF (35 mL) was added slowly with stirring over 30 min to the phosphorus oxychloride. A white precipitate formed during the addition. The reaction mixture was gently warmed (450C) to dissolve the precipitate and produce a clear solution to which was added 2- aminopyrimidine-4,6-diol (24.2 g, 190.40 mmol) in small portions over 1 h, then the mixture was heated at 8O0C. The reaction mixture turned a dark red-brown color. After 12 hours, the reaction mixture was cooled to room temperature and excess POCl^ was removed by rotary evaporation. The oily residue was poured over ice. The mixture became homogeneous and was allowed to stir at room temperature overnight to hydrolyze the Vilsmeier adduct. A yellow solid precipitated from solution and was collected by filtration, washed with water and dried under vacuum. The solid precipitate was recrystallized from hot EtOAc. Isolation gave27.7 grams of the title compound. Reference: Bell, L., et ah, J. Heterocyclic Cheni., 1983,20, 41.LC/MS (ES+)[(M+H)+]: 192, 194 for C5H3ClN3O. 1H NMR (300 MHz, d6-DMSO): 8.51 (s,2H), 10.06 (s, IH).

The synthetic route of 56-09-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/27732; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2972-52-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2972-52-3, name is 2,4-Dichloro-5-pyrimidinecarbonyl chloride, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 9 g (42.8 mmol) of 2,4-dichloro-5-pyrimidinecarboxylic acid chloride (Manchester Organics Limited) in 60 mL of ether are added 10 mL of water and the reaction mixture is stirred vigorously at 35 C. for 1 hour. After addition of ether and separation of the phases by settling, the organic phase is dried over Na2SO4, filtered and concentrated under vacuum. 7.7 g of a colourless oil that solidifies rapidly in air, and which is used immediately in the following step, are obtained. Yield=93%.

According to the analysis of related databases, 2972-52-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANOFI; US2012/277220; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 71406-78-5 ,Some common heterocyclic compound, 71406-78-5, molecular formula is C7H8ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of tert-butyl-N-tert-butoxycarbonyl-N-((2-(piperazin-1- yl)pyrimidin-5-yl)methyl)carbamate (8.3 g, 21.09 mmol, 1.0 equiv) in MeCN (100 mL) was added ethyl 4-amino-2-chloropyrimidine-5-carboxylate (4.04 g, 20.04 mmol, 0.95 equiv) and K2CO3 (8.75 g, 63.28 mmol, 3.0 equiv). The mixture was stirred at 80 C for 3 h. The reaction was then cooled to room temperature, DCM (150 mL) was added, and the reaction mixture was stirred for 30 min. The suspension was filtered, the filter cake was washed with DCM (3 x 100 mL), and the filtrate was concentrated under reduced pressure. Purification by silica gel chromatography (0%100% EtOAc/petroleum ether) afforded the desired product (8.35 g, 67% yield) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,71406-78-5, its application will become more common.

Reference:
Patent; REVOLUTION MEDICINES, INC.; PITZEN, Jennifer; GLIEDT, Micah James Evans; BURNETT, G. Leslie; AGGEN, James Bradley; KISS, Gert; CREGG, James Joseph; SEMKO, Christopher Michael; WON, Walter; WANG, Gang; LEE, Julie Chu-Li; THOTTUMKARA, Arun P.; GILL, Adrian Liam; MELLEM, Kevin T.; (484 pag.)WO2019/212990; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 3993-78-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3993-78-0, name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A light yellow suspension of 4-chloropyrimidin-2-amine (5.01 g, 38.7 mmol), pyrrolidine (2.50 g, 2.91 ml, 35.2 mmol) and potassium carbonate (9.72 g, 70.3 mmol) in N-methyl-2- pyrrolidinone (15.0 mL) was stirred under argon at 120 C for 2 h and at room temperature overnight. The reaction mixture was cooled to room temperature and was poured into NaOH (1 M, 200 mL) and ice. The aqueous layer was extracted with ethyl acetate (200 mL) whereof part of the product precipitated in the water phase. The precipitate was filtered, washed water, triturated with dichloromethane and dried to obtain 3.1 g product as white solid. The separated ethyl acetate phase was dried over MgS04, filtered and concentrated in vacuum. The resulting light yellow solid was triturated with dichloromethane and dried to obtain 1.1 g product as white solid. The aqueous phase was extracted with dichloromethane (3 x 100 mL), dried over MgS04, filtered and concentrated in vacuum. The resulting light yellow solid was triturated with dichloromethane to obtain another 0.52 g product as white solid. The dichloromethane layers were combined, concentrated in vacuum and the product was purified by flash chromatography (using silica gel and a dichloromethane/methanol/ammonia gradient) to yield another 0.46 g product as light yellow. In total 5.18 g (89.7 ) of a light yellow solid were obtained. MS: m/z = 165.3 (M+H)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3993-78-0, 2-Amino-4-chloropyrimidine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GOBBI, Luca; KNUST, Henner; KOERNER, Matthias; MURI, Dieter; WO2014/187762; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 36847-10-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 36847-10-6, name is 4,6-Dibromopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

4,6-dibromopyrimidine (300 mg) and 1-cyclopropylmethanamine (130 p1) were stirred in dioxane 1,4-dioxane (6.0 ml) for 2h at 110?C. The mixture was then concentrated under reduced pressure. The crude was solubilised in DCM and water was added. The aqueous phase was extracted two times with EtOAc. The organic phase was dried (silicone filter) andconcentrated under reduced pressure. The crude was used without further purification.LC-MS (Method 2): Rt 0.99 mm; MS (ESIpos): mlz = 228 [M+H]

According to the analysis of related databases, 36847-10-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; PRINZ, Florian; LEFRANC, Julien; SCHROeDER, Jens; MENGEL, Anne; BONE, Wilhelm; BALINT, Joszef; WENGNER, Antje; EIS, Knut; IRLBACHER, Horst; KOPPITZ, Marcus; BOeMER, Ulf; BADER, Benjamin; BRIEM, Hans; LIENAU, Philip; CHRIST, Clara; STOeCKIGT, Detlef; HILLIG, Roman; (1256 pag.)WO2017/102091; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 72411-89-3, Adding some certain compound to certain chemical reactions, such as: 72411-89-3, name is 4-Methoxypyrimidine-5-carboxylic acid,molecular formula is C6H6N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72411-89-3.

Step A: Preparation of N,4-dimethoxy-N-methylpyrimidine-5-carboxamide. [00254] In a 500 mL single-neck flask equipped with a stir bar, 4-methoxypyrimidine-5- carboxylic acid (8.0 g, 33.2 mmol) and N,0-dimethylhydroxylamine hydrochloride (4.30 g, 43.2 mmol) were stirred in DCM (166 ml). DMAP (6.15 g, 49.8 mmol) and EDC hydrochloride (7.72 g, 39.9 mmol) were added. The mixture was stirred at 18 °C for 64 h, then silica (-50 g) was added to the reaction mixture. The yellow suspension was concentrated then loaded onto silica (-100 g). Chromatographed through a silica column (80 g) using EtOAc. The product fractions were concentrated to provide 2.4 g (36percent) of the title compound a colorless oil which was used without further purification. 1H NMR (400 MHz, CDC13) delta 8.81 (s, 1H), 8.48 (s, 1H), 4.05 (d, J = 0.7 Hz, 3H), 3.55 (s, 3H), 3.35 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72411-89-3, 4-Methoxypyrimidine-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DOW AGROSCIENCES LLC; LOSO, Michael R.; GUSTAFSON, Gary D.; KUBOTA, Asako; YAP, Maurice C.; BUCHAN, Zachary A.; STEWARD, Kimberly M.; SULLENBERGER, Michael T.; HOEKSTRA, William J.; YATES, Christopher M.; WO2015/160665; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 175791-49-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 175791-49-8, name is 5-Bromo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To dried tetrahydrofuran (20 mL) was added 5-bromo-7H-pyrrolo[2,3-d]pyrimidine (1.00 g, 5.05 mmol) . Sodium hydride (404 mg, 10.10 mmol, 60mass) was added to the solution at 0, and the resulting mixture was stirred at 0 for 30 min. Then p-toluenesulfonyl chloride (1.16 g, 6.06 mmol) was added to the mixture, and the mixture was warmed to rt and stirred overnight. The reaction was quenched with water (100 mL) , and the aqueous layer was extracted with ethyl acetate (100 mL × 3) . The combined organic layers were dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to dry and the residue was purified by silica gel column chromatography (n-hexane/EtOAc (v/v) 5/1) to give the title compound as a yellow solid (1.40 g, 79 %) . MS (ESI, pos. ion) m/z: 351.9 [M+H]+ 1H NMR (400 MHz, CDCl3) delta (ppm) : 9.08 (s, 1H) , 8.92 (s, 1H) , 8.12 (d, J 8.3 Hz, 2H) , 7.80 (s, 1H) , 7.35 (d, J 8.1 Hz, 2H) , 2.43 (s, 3H) .

According to the analysis of related databases, 175791-49-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; ZHANG, Yingjun; (161 pag.)WO2018/41091; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia