Pyrimidines

Related Products of 1820-81-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1820-81-1, name is 5-Chlorouracil, molecular formula is C4H3ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Thymidine (dThd) and 2′-deoxyuridine (dUrd) were assayed as sugar donors. Different purine and pyrimidine bases were tested: 5-fluorouracil (5FUra), 5-bromouracil (5BrUra), 5-chlorouracil (5ClUra), 6-chloropurine (6ClPur), 6-bromopurine (6BrPur) and 6-chloro-2-fluoropurine (6Cl2FPur). Reactions were performed using 100 mg/mL of immobilized LaNDT, 6 mM nucleoside and 2 mM base, 30 C and 200 rpm. At different times (5-8 h), 20 muL aliquots were taken and centrifuged at 10,000 x g, and the supernatant was analyzed by HPLC to evaluate yield expressed as percentage and product conversion expressed as mg of product per gram of support.

According to the analysis of related databases, 1820-81-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Britos, Claudia N.; Lapponi, Maria Jose; Cappa, Valeria A.; Rivero, Cintia W.; Trelles, Jorge A.; Journal of Fluorine Chemistry; vol. 186; (2016); p. 91 – 96;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4316-97-6, name is 4,6-Dichloro-5-methylpyrimidine, molecular formula is C5H4Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C5H4Cl2N2

To a stirred solution of 4,6-dichloro-5-methylpyrimidine (1.0 g, 6.1 mmol), cyclopropylmethanol (0.49 g, 6.8 mmol) in THF (25 mL) is added potassium tert-butoxide (0.83 g, 7.4 mmol) at 0 oC, and the reaction mixture is stirred at 0 oC for 2 hours.The reaction mixture is added saturated aqueous NH 4Cl (20 mL) and water (80 mL), and extracted with EtOAc (80 mL).The organic layer is washed with water (80 mL x 2), and dried over sodium sulfate.Insoluble materials are separated by filtration and the filtrate is concentrated.The residue is purified by column chromatography on silica-gel eluting with n-hexane / EtOAc (99:1 to 95:5) to give 1.2 g (98% yield) of the title compound as a white solid. 1H-NMR (400 MHz, CDCl 3) delta 8.38 (1H, s), 4.27-4.18 (2H, d, J = 7.4 Hz), 2.25 (3H, s), 1.34-1.24 (1H, m), 0.65-0.59 (2H, m), 0.38-0.34 (2H, m), MS (ESI) m/z: 199 (M+H) +.

With the rapid development of chemical substances, we look forward to future research findings about 4316-97-6.

Reference:
Patent; RAQUALIA PHARMA INC.; XUANZHU PHARMA CO., LTD.; KAWAMURA, Kiyoshi; YAMAGISHI, Tatsuya; SHISHIDO, Yuji; MORITA, Mikio; YAMAGUCHI, Ryuichi; OHMI, Masashi; (182 pag.)WO2019/45035; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 29274-24-6, 5-Chloropyrazolo[1,5-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 5-Chloropyrazolo[1,5-a]pyrimidine, blongs to pyrimidines compound. name: 5-Chloropyrazolo[1,5-a]pyrimidine

5-Chloropyrazolo[1,5-a]pyrimidine (1 g, 6.51 mmol) was dissolvedin anhydrous DMF (10 mL) and cooled to 5 C. Phosphorousoxychloride (1.82 mL, 19.5 mmol) was added and thereaction was allowed to warm slowly to RT and stirred for 16 h.The reaction was poured onto ice (200 g) and the pH wasadjusted to pH 10 with 1 M NaOH. The aqueous suspension wasextracted with CH2CL2 (100 mL) and the aqueous layer was washedwith CH2Cl2 (2 50 mL). The combined organic layers werewashed with water (2 70 mL), brine (50 mL), dried (WhatmanPS1 filter paper) and the solvent was removed in vacuo. The crudeproduct was adsorbed onto silica and purified by automated flashchromatography on silica gel (0-50% EtOAc-cyclohexane) to yieldthe title compound (8) (864 mg, 73%) as a colourless solid. 1H NMRdH (d6-DMSO, 300 MHz), 10.09 (s, 1H), 9.39 (d, J 7.2, 1H), 8.77 (s,1H), 7.49 (d, J 7.2, 1H); LC-MS tR 4.08 min; LC254 99.0%; m/z182.2/184.1 [M+H].

The synthetic route of 29274-24-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Phillipson, Louisa J.; Segal, David H.; Nero, Tracy L.; Parker, Michael W.; Wan, Soo San; De Silva, Melanie; Guthridge, Mark A.; Wei, Andrew H.; Burns, Christopher J.; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6280 – 6296;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 5305-40-8, 4,6-Dichloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

Ammonia was bubbled through a solution of 4,6-dichloro-pyrimidine-5-carbaldehyde (1 g, 5.68 mmol) in toluene (100 mL) for 10 min and the solution was stirred at room temperature overnight. The yellow precipitate was filtered off, washed with EOAc and dried in vacuo to afford the pure product (880 mg, 99%). 1H NMR (DMSO-d6) delta 10.23 (s, 1H), 8.72 (br, 1H), 8.54 (br, 1H), 8.38 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5305-40-8, 4,6-Dichloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Baumann, Christian Andrew; Gaul, Michael David; US2006/281755; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 6713-54-8 , The common heterocyclic compound, 6713-54-8, name is 2,4,6,8-Tetrahydroxypyrimido[5,4-d]pyrimidine, molecular formula is C6H4N4O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(f) Pyrimidine [5,4-d] pyrimidine-2,4,6,8-tetraol (10.9 g, 55.2 mmol) was added to a 500 three-necked flask,(8 · lml, 110 · Ommol, P = 1.638 g / ml), 200 ml of dioxane was reacted as a reaction solvent for 1 hour,After adding DMF (4.2 ml, 55.2 mmol) = 0.95 g / ml), the reaction was dark for 1.5 hours.After completion of the reaction, the solvent was removed under reduced pressure,The solid was extracted with hot toluene solution,The crude product was subjected to column chromatography using PE: DCM = 2: 1,To give a white solid 13. lg, yield 88.59%

The synthetic route of 6713-54-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dalian Wanfu Pharmaceutical Co., Ltd.; Sun Qingfa; (9 pag.)CN106946887; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 934524-10-4, name is 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

A solution of Pd(PPh3 )2C12 (0.073 g, 0.12 mmol), 7 (0.19 g, 1.3 mmol), 8 (0.40 g, 1.2 mmol), and triethylamine (0.5 mL, 3.5 mmol) in DMF (5 mL) was purged for 5 min with argon and added CuI (0.022g, 0.12 mmol). The reaction mixture was heated for Ih at 80 0C and cooled to room temperature. The resulting mixture was concentrated and purified by silica gel chromatography (hexanes/EtOAc 100:0 to 90:10 gradient) to afford the title compound as a yellow solid (0.35 g, 67%).[0161] 1H NMR (500 MHz, DMSO-J6): delta 1.29 (d, J= 6.9 Hz, 6H), 2.38 (s, 3H), 3.47 (qn, J = 6.8 Hz, IH), 7.01 (d, J = 4.1 Hz, IH), 7.32 (t, J = IA Hz, IH), 7.47 (t, J = 1.6 Hz, IH), 7.50 (d, J = 8.4 Hz, 2H), 7.53 (d, J = 1.1 Hz, IH), 7.73 (d, J = 7.8 Hz, IH), 8.04 (d, J = 8.4 Hz, 2H), 8.12 (d, J = 4.0 Hz, IH) [0162] MS (ES+): m/z 450 (M+H)+

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 934524-10-4, 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; TARGEGEN INC.; WO2009/55674; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.21236-97-5, name is 6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H7N3O2, molecular weight is 141.128, as common compound, the synthetic route is as follows.Recommanded Product: 21236-97-5

General procedure: A mixture of phenylisothio-cyanate 1a (1 mmol, 0.135 g), benzaldehyde 2a (1 mmol, 0.106 g) and N,N-dimethyl-6-amino uracil 3a (1 mmol, 0.155 g) in water (5 mL) was refluxed for 1 h in the presence of catalytic amount of p-TSA (20 mol %). After completion of the reaction (monitored by TLC), the mixture was cooled to room temperature, filtered and washed with water (25 mL). The crude product was purified by recrystallization from EtOH to give 4a.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,21236-97-5, 6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Article; Majumder, Swarup; Borah, Pallabi; Bhuyan, Pulak J.; Tetrahedron Letters; vol. 55; 6; (2014); p. 1168 – 1170;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5413-85-4 ,Some common heterocyclic compound, 5413-85-4, molecular formula is C4H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 4, 6-dichloropyrimidin -5-amine (20.0 g, 122 mmol), ethanamine hydrochloride (EtNH 2 · HCl) (19.9 g, 243 mmol), and potassium carbonate (50.7 g, 367 mmol) in ethanol (100 ml) was heated to 50 for 39 h. The reaction mixture was then cooled to RT, after which it was diluted with DCM (750 ml) and filtered. The filter cake was washed with DCM (250 ml). The combined filtrate was concentrated to dryness to provide 6-chloro -N 4 -ethylpyrimidine-4, 5-diamine MS (ESI) Calc’d for C 6 H 10 ClN 4 [M + H] + 173;. found 173.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5413-85-4, 5-Amino-4,6-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MCGOWAN, Meredeth Ann; ZHOU, Hua; KATZ, Jason D.; YANG, Lihu; METHOT, Joey; LIPFORD, Kathryn Ann; XU, Shimin; FU, Ning; XU, Guoquan; BIAN, Deqian; FU, Jianmin; LI, Yabin; FONG, Kin Chiu; (124 pag.)WO2017/125; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, blongs to pyrimidines compound. Safety of 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione

General procedure: A mixture of barbituric acid 1 (1 mmol) and aldehyde 2 (1mmol) was refluxed in 5 mL of water for an appropriate timeuntil the generation of 5-arylidenebarbituric acid as indicatedby TLC. Next 2-aminothiophenol (3, 1 mmol) and benzaldehyde(2a, 1 mmol) were added, and the reaction mixture was furtherrefluxed for an appropriate time. On completion of the reactionas indicated by TLC the reaction mixture was allowed to cool toroom temperature and was extracted with EtOAc (3 × 10 mL).After drying with anhydrous Na2SO4 and evaporation underreduced pressure, the crude product was purified suitablyeither by recrystallization from a DCM/EtOH (1:1) solventmixture or column chromatography on silica gel usingEtOAc/hexane (2:8) as the eluent to afford 5-monoalkylbarbiturate4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, and friends who are interested can also refer to it.

Reference:
Article; Kalita, Subarna Jyoti; Deka, Dibakar Chandra; Synlett; vol. 29; 4; (2018); p. 477 – 482;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1192479-35-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1192479-35-8, name is 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Step 4 To 49 (55 mg, 0.12 mmol) in toluene (0.5 mL) was bubbled nitrogen gas for 5 minutes. To the reaction mixture was added 2-chloro-5-fluoro-4-methoxypyridine 29 (25 mg, 0.14 mmol), Pd(dba)2 (3.4 mg, 0.006 mmol), 2-i/ -/-butylphosphino-2′-(N^ -dimethylamino) biphenyl (2.0 mg, 0.006 mmol), and sodium ?e/-f-butoxide (25 mg, 0.26 mmol). Nitrogen was bubbled through the reaction mixture for 5 minutes. The reaction mixture was heated to 65 C and stirred for 3.5 h. The reaction mixture was cooled to room temperature and saturatedNH4CI was added. The mixture was extracted with EtOAc. The combined organic layers were washed with water and brine. The organic layer was dried (MgSC^), filtered, and concentrated in vacuo. The residue was purified by preparative silica gel TLC (30%EtOAc/hex) to provide 50 (32 mg, 46%).

According to the analysis of related databases, 1192479-35-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STAMFORD, Andrew, W.; GILBERT, Eric, J.; CUMMING, Jared, N.; WO2012/138590; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia