Pyrimidines

Adding a certain compound to certain chemical reactions, such as: 6303-46-4, 6-Chloro-N-(3,4-dichlorophenyl)pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6303-46-4, blongs to pyrimidines compound. Computed Properties of C10H6Cl3N3

General procedure: 5.1.4 4-(6-{[4-(Trifluoromethyl)phenyl]amino}pyrimidin-4-yl)benzoic acid (4-1) 22 Under a nitrogen atmosphere, 6-chloro-N-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine (3-1) (4.10 g, 10 mmol), 4-carboxyphenylboronic acid (2) (2.00 g, 12 mmol), Pd(PPh3)4 (0.60 g, 0.50 mmol) and Cs2CO3 (13.0 g, 30 mmol) were suspended in a mixture of CH3CN/H2O (100 mL, V:V = 1:1). The mixture was heated under reflux for 48 h at 90 C. The hot suspension was filtered and the filtrate distilled by rotary evaporation to remove acetonitrile. Water was added, and the mixture was extracted three times with EtOAc (3 * 30 ml). The aqueous layer was acidified with conc. HCl and extracted two more times with EtOAc. The combined organic layers were washed with brine and dried over Na2SO4. Evaporation of the solvent gave the crude product, which was purified by flash column chromatography to afford the product (2.90 g, 81%). The key intermediate Compounds (4-1) – (4-19) were preparedby using the general procedure described above.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6303-46-4, its application will become more common.

Reference:
Article; Dong, Jinyun; Lu, Wen; Pan, Xiaoyan; Su, Ping; Shi, Yaling; Wang, Jinfeng; Zhang, Jie; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6876 – 6884;,
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Pyrimidine – Wikipedia

Reference of 3524-87-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-87-6, name is 6-Methylpyrimidin-4(3H)-one, molecular formula is C5H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 70 g (0.64 mol) A-l in acetic acid is added 127 g (0.56 mol) NIS portion wise at RT within 15 min. The reaction is stirred at RT until all starting material is consumed (30 h). The reaction mixture is diluted with water and the solid product is filtered off, washed with an aqueous sodium thiosulfate solution to remove excess iodine and dried in vacuo. Yield: 90 g (60 %).

According to the analysis of related databases, 3524-87-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; VEEN, Van Der, Lars; KRAEMER, Oliver; WO2012/101186; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 504-17-6, 4,6-Dihydroxy-2-mercaptopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 504-17-6, blongs to pyrimidines compound. Product Details of 504-17-6

General procedure: A mixture of aldehyde (0.25 mmol), 2-thiobarbituric acid(0.5 mmol), ammonium acetate (0.3 mmol) and CuFe2O4 (10 mol%)in distilled H2O was stirred for an appropriate time. After completionof the reaction (monitored by TLC), the resulted precipitatewasfiltered and dissolved in hot methanol and the catalyst was separatedand collected by an external magnetic and washed withacetone and EtOH several times and dried in an oven at 70 C toreuse in next reactions. The pure solid product was obtained viaevaporation the 2/3 of methanol and filtration. The solid productwas recrystallized from water/ethanol as solvent to afford the pureproducts. All of the products were identified by physical andspectroscopic data. Yellow powder; M.P: 242 C decompose. IR (KBr) n (cm1): 3591,3447 (NH), 3166 (CeH, sp2 stretch), 2922 (CeH, sp3), 1632 (C]O),1437, 1536 (C]C, Ar). 1H NMR (DMSO-d6, 400 MHz) d (ppm): 3.63(s, 3H), 5.91e5.97 (s, 1H), 6.49e6.52 (s, 1H), 6.56e6.57 (m, 1H),6.62e6.64 (m, 1H), 6.93 (s, 1H), 7.06 (s, 2H), 7.19e7.23 (s, 1H), 11.56e11.73 (m, 4H). 13C NMR (DMSO-d6, 100 MHz) d (ppm): 30.89,55.24, 96.21, 109.8, 113.61, 119.62, 129.09, 145.24, 159.42, 173.22.Anal. Calcd for C16H15N5O3S2: C, 49.34; H, 3.88; N, 17.98, %; Found C,49.38; H, 3.90; N, 18.02%.

The synthetic route of 504-17-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Naeimi, Hossein; Didar, Asieh; Journal of Molecular Structure; vol. 1137; (2017); p. 626 – 633;,
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Reference of 7752-82-1 ,Some common heterocyclic compound, 7752-82-1, molecular formula is C4H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A sealed tube is charged with [5-[[[8-(1-methylindol-6-yl)quinoxalin-6- yl]amino]methyl]-3-pyridyl]boronic acid (Intermediate 25) (130.00 mg; 0.20 mmol; 1.00 eqf.), 5-bromopyrimidin-2-ylamine (37.70 mg; 0.22 mmol; 1.10 eqf.), solution of 2M Na2C03 (0.30 mL; 0.59 mmol; 3.00 eqf.), EtOH (2.00 mL) and toluene (2.00 mL). RM is purged with argon and then Pd(PPh3)4 (22.76 mg; 0.02 mmol; 0.10 eqf.) is added. The resulting mixture is heated at 120C for 24 h. After this time, the mixture is diluted with EtOAc. The organic layer is washed with water, brine, dried over MgSO4 and evaporated. The residue is purified by FCC (EtOAc/MeOH; gradient). N-{[5-(2-Aminopyrimidin-5- yl)pyridin-3-yl]methyl}-8-(1 -methyl- 1 H-indol-6-yl)quinoxalin-6-amine (64.00 mg; yield 65.1 %; 92 % by HPLC) is obtained as a yellow powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7752-82-1, 5-Bromopyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 74901-69-2, 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, blongs to pyrimidines compound. Recommanded Product: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Intermediates VII (180 g, 852 mmol) and A (129 g, 937 mol) were sequentially charged into a multi-neck vessel equipped with a condenser, thermocouple thermometer and nitrogen line. Acetonitrile (900 ml) and triethylamine (594 ml, 4.26 mol) were then added at 22 C and the mixture was stirred at 75-77 C for 12 h. Water (1 .2 I) was charged slowly over 20 min, the mixture was seeded with Compound VIII crystals (0.3 g) at 40 C and then cooled to 25 C over 2 h. The mixture was stirred for an additional 12h at normal room temperature and the resulting solid was collected by filtration. The filter cake was rinsed with 2:1 mixture of water/MeCN (400 mL) followed by water (200 ml). The resulting solid was dried under vacuum at 50 C for 12 h to afford 132 g (57% yield) of compound VIII: 1H NMR (400 MHz, CDCIs) delta 1 .85-2.05 (m, 2H), 2.10-2.21 (m, 2H), 2.32-2.41 (m, 2H), 3.27 (dd, J = 8.0, 8.4 Hz, 2H), 3.43 (dd, J = 8.0, 8.4 Hz, 2H), 3.91 (s, 2H), 4.67 (s, 1 H); 13C NMR (CDCI3, 100 MHz) delta 14.8, 30.7, 31 .2, 36.7, 59.7, 67.6, 1 14.7, 156.1 , 156.2, 168.0.

The synthetic route of 74901-69-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LUIPPOLD, Gerd; NICKOLAUS, Peter; STREICHER, Ruediger; WO2014/124860; (2014); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride, the common compound, a new synthetic route is introduced below. Formula: C5HCl3N2O

To a solution of 2,6-dichloropyrimidine-4-carbonyl chloride (1-158) (500 mg, 2.37 mmol), and TEA (718 mg, 7.1 1 mmol) in CH2CI2 (30 ml_) was added (2R)-2-aminopropyl benzoate hydrochloride (354 mg, 1 .98 mmol) in portions at 0 C under a nitrogen atmosphere, and the mixture was stirred at 0 ~ 10 C for 1 hr. TLC (EtOAc) showed the reaction was completed. The mixture was quenched with H20 (20 ml_) and extracted with CH2CI2 (2 x 50 ml_). The combined organic layers were washed with brine (3 x 30 ml_), dried over Na2S04 and concentrated. The residue was purified by silica gel chromatography (petroleum ether/EtOAc = 6/1 , Rf = 0.4) to give (2R)-2-{[(2,6-dichloropyrimidin-4-yl)carbonyl]amino}propyl benzoate (1-182) (3S5 mg, 46%) as an oil, which was used without further purification.

The synthetic route of 26830-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
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Electric Literature of 2972-52-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2972-52-3, name is 2,4-Dichloro-5-pyrimidinecarbonyl chloride, molecular formula is C5HCl3N2O, molecular weight is 211.43, as common compound, the synthetic route is as follows.

2,4-dichIoro-2,4-(morpho A solution of 2,4-dichloropyrimidine-5-carbonyl chloride (422mg, 2,0 mmoi) in dichloromethane (10 mL) was added 4-(morpholinosulfonyl)aniline (508 nig. 2.1 mmoi) and DIEA (387 mg, 3.0 mmoi) at 0 C. The resulting mixture was stirred at 0 C for 1 h, Then, water was added. The resulting mixture was extracted with EtOAc (3x). The combined organic layers were dried (NaSO4), filtered and concentrated. The residue was purified on ISCO to give the title compound as a white solid (701.2 mg, 84%). 1H NMR (400 MHz, DMSO-d6) delta 1 1.98 – 1 1.90 (m5 I B), 8.29 (d, J = 6.4 Hz, IH), 7.89 (d, J = 8.8 Hz, 2H), 7.69 (d, J= 8.8 Hz, 2H), 3.65 – 3.56 (m, 4H), 2.87 – 2.78 (m, 4H); MS m/z 418,30 [M+H]+

Statistics shows that 2972-52-3 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-5-pyrimidinecarbonyl chloride.

Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; WANG, Xiaodong; ZHANG, Weihe; KIREEV, Dmitri; LIU, Jing; MCIVER, Andrew Louis; WO2014/85225; (2014); A1;,
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Application of 1448307-66-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1448307-66-1, name is 1-(2-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde, molecular formula is C9H7ClN4O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A stirred suspension of commercially available l-(2-chloro-4-pyrimidinyl)-3-methyl- lH-pyrazole-4-carbaldehyde (222 mg, 1.0 mmol) and 3-azetidinol hydrochloride (219 mg, 2.0 mmol) in dichloromethane (10 mL) was treated with triethylamine (700 muTau, 5.0 mmol) followed by portionwise addition of Na(OAc)3BH (636 mg, 3.0 mmol). The resulting mixture was stirred at room temperature overnight. Next morning, LCMS indicated clean conversion to product. The reaction mixture was transferred to a separately funnel, diluted with dichloromethane, washed with saturated aqueous NaHC03 solution. The organic layer was dried over anhydrous MgS04, filtered and concentrated in vacuo. The crude product was obtained as a white foam (185 mg, 0.66 mmol, 66%) and used directly in the next step. LC/MS – HPLC (254 nm) – Rt 1.04 min. MS (ESI) m/z 280.5 [M+ + H+]. Purity = 95 % by UV (254 nm).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1448307-66-1, 1-(2-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde.

Reference:
Patent; SIGNALRX PHARMACEUTICALS, INC.; MORALES, Guillermo, A.; GARLICH, Joseph, R.; DURDEN, Donald, L.; (155 pag.)WO2018/226739; (2018); A1;,
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Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1005-37-4, name is 6-Chloro-N4-methylpyrimidine-2,4-diamine. A new synthetic method of this compound is introduced below., Computed Properties of C5H7ClN4

General procedure: General Procedure 5: To a mixture of a suitable chloropyrimidine derivative (1 equiv.) in DMF/water (9: 1) is added the appropriate boronic acid (or boronic ester) derivative (1.1 equiv.), Na2C03 (2 equiv.) and Pd(PPh3)4 (0.1 equiv.). The mixture is heated at 120 C overnight or in the microwave until the reaction is complete as shown by LCMS. The crude mixture is then purified by preparative HPLC to afford the desired product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1005-37-4, 6-Chloro-N4-methylpyrimidine-2,4-diamine.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1820-81-1, 5-Chlorouracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1820-81-1, blongs to pyrimidines compound. category: pyrimidines

Method 19 2,4,5-Trichloropyrimidine 5-Chlorouracil (10.0 g, 68.5 mmol) was dissolved in phosphorus oxychloride (60 ml) and phosphorus pentachloride (16.0 g, 77 mmol) was added. The reaction mixture was then stirred at reflux (110 C.) for 16 hrs then allowed to cool to 20 C. The reaction mixture was then poured slowly and carefully into water (200 ml) at 25 C. with vigorous stirring. Then stirred well for 90 minutes before addition of EtOAc (250 ml). Organic layer separated off and aqueous layer re-extracted into EtOAc (250 ml). The organic layers were then combined and washed with sodium bicarbonate (200 ml aqueous solution), brine (200 ml) and then evaporated to a yellow liquid. The crude material was purified by column chromatography eluding with dichloromethane to afford the product as a yellow liquid (6.37 g, 51%). NMR (CDCl3): 8.62 (s, 1H); MS (M+): 182, 184,186.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1820-81-1, its application will become more common.

Reference:
Patent; Pease, Elizabeth Janet; Breault, Gloria Anne; Morris, Jeffrey James; US2003/149064; (2003); A1;,
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