Pyrimidines

Adding a certain compound to certain chemical reactions, such as: 13223-43-3, 5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 13223-43-3, blongs to pyrimidines compound. Recommanded Product: 13223-43-3

2-Amino-5,7-dimethoxy [1,2,4] triazolo [1,5-a] pyrimidine (25.4g, 0.13mol) Add to 137g of dichloromethane, After stirring, 4-dimethylaminopyridine (0.006 g, 0.05 mmol) and 2-methoxy-4-(trifluoromethyl)-pyridine-3-sulfonyl chloride (27.5 g, 0.1 mol), After stirring for 30 minutes, Triethylamine (13.1 g, 0.13 mol) was added dropwise at room temperature. Finally, the temperature was raised to 35 C for 3 h. The mixture was then treated with 4N HCl (60g), was stirred at 25 1 hour, cooled to 10 , filtered, washed with water, washed with methanol and dried to give 40.8 g of pyroxsulam, 94% yield, 98.5% purity (HPLC).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13223-43-3, 5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Changzhou Woteng Chemical Technology Co., Ltd.; Cao Wei; (5 pag.)CN108892671; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-42-6, name is 1,3-Dimethylbarbituric acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 769-42-6

General procedure: A mixture of isatin (1 mmol), malononitrile (1 mmol) and dimedone (1 mmol) was stirred at room temperature in the presence of SnO2 nanoparticles and 2 mL of EtOH. The reaction progress was monitored by TLC (n-hexane/ethyl acetate, 2:1 ratio). After that, the resulted mixture (containing the solid product and nano catalyst) was dissolvedin acetone and filtered for separation of the catalyst. Finally, the product 5a was obtained after evaporation of acetone and for further purification recrystallized from EtOH.

With the rapid development of chemical substances, we look forward to future research findings about 769-42-6.

Reference:
Article; Moradi, Leila; Ataei, Zeynab; Zahraei, Zohreh; Journal of the Iranian Chemical Society; vol. 16; 6; (2019); p. 1273 – 1281;,
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Pyrimidine – Wikipedia

Electric Literature of 5750-76-5, Adding some certain compound to certain chemical reactions, such as: 5750-76-5, name is 2,4,5-Trichloropyrimidine,molecular formula is C4HCl3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5750-76-5.

Step 2: Preparation of 2-((2,5-dichloropyrimidin-4-yl)amino)-N-methylbenzamide (3); 2-Arrdno-N-iTiethylbenzarnide (2, 9 g, 60 mmol) and potassium carbonate ( 16.5 g, 120 mmol) were taken up in dimethylformamide (DMF )( 100 mL) to form a mixture and the mixture was stirred for 10 min. 2,4,5-trichloropyrimidine ( 1 1 g, 60 mmol) was added drop wise to the mixture and the mixture was stirred at 80 C for 1 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was cooled and filtered through a Buckner funnel. The filtered solid was washed with water and dried to afford 2-((2,5-dichloropyrimidin-4-yl)amino)-N-methylbenzamide as a light yellow solid (3, 15.2 g, 85.8%). NMR (DMSO-i/6): delta 8.90 (bs, 1 H), 8.60-8.40 (m, 1 H), 7.80-7.60 (d, 1 H), 7.70-7.50 (t, 1 H), 7.30-7.20 (t, 1 H), 2.80 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5750-76-5, 2,4,5-Trichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GATEKEEPER PHARMACEUTICALS, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun; WO2011/140338; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 955368-90-8, 2-Allyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Allyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one, blongs to pyrimidines compound. Quality Control of 2-Allyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one

N, N-dimethyiethane- 1 ,2-diamine (0.023 m L,0.213 mmoi) was added to a stirred soiution of 2-aiiyi-6-(methyithio)- 1 H-pyrazoio[3,4- d]pyrimidin-3(2H)-one (47.3 mg, 0.213 mmoi) [Prepared according to EP2213673B1 (Production Exampie 1, p37)], [(6-bromopyridin-2-yi)(methyi)oxo-lambda6- suifanyiidene](methyi)amine (53.1 mg, 0.213 mmoi), copper(i) iodide (40.6 mg, 0.213 mmoi), and potassium carbonate (41.2 mg, 0.298 mmoi) in 1,4-dioxane (1.0 mL) at RT. The reaction mixture was heated to 95 00 After 20 h, the reaction mixture was partitioned between saturated ammonium hydroxide (aq) soiution and EtOAc, separated, extracted (EtOAc x 3), organics combined, dried (Phase Separator), the soivents were removed in vacuo, and the remaining residue was purified by fiash chromatography (0-100%, EtOAc in cyciohexane) to give the titie compound (7.1 mg, 9%) as a paie yeiiow oii.LCMS (Method A): RT = 0.91 mm, mlz = 391 [M+H]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,955368-90-8, 2-Allyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one, and friends who are interested can also refer to it.

Reference:
Patent; ALMAC DISCOVERY LIMITED; BURKAMP, Frank; ROUNTREE, James Samuel Shane; TREDER, Adam Piotr; (155 pag.)WO2018/11569; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 25193-95-7, Adding some certain compound to certain chemical reactions, such as: 25193-95-7, name is 5-(Hydroxymethyl)pyrimidine,molecular formula is C5H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25193-95-7.

[0219] Step 4. 5-(Chloromethyl)pyrimidine. To a solution of pyrimidin-5-ylmethanol (1. lg, 10 mmol, 1.00 equiv) in dichloromethane (30 mL) was added thionyl chloride (2 mL)dropwise with stirring. The resulting solution was stirred at rt for 2 h then concentrated in vacuum to give 1.1 g of crude 5-(chloromethyl)pyrimidine as a yellow oil. TLC: ethyl acetate/petroleum ether (1:1), Rf = 0.4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25193-95-7, 5-(Hydroxymethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang; WO2013/130935; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 3680-69-1 ,Some common heterocyclic compound, 3680-69-1, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a suspension of sodium hydride (36.141 g, 903.62 mmol) in N,N-dimethylacetamide (118 mL) at -5 C. (ice/salt bath) was added a dark solution of 4-chloropyrrolo[2,3-d]pyrimidine (119.37 g, 777.30 mmol) in N,N-dimethylacetamide (237 mL) slowly. The flask and addition funnel were rinsed with N,N-dimethylacetamide (30 mL). A large amount of gas was evolved immediately. The mixture became a slightly cloudy orange mixture. The mixture was stirred at 0 C. for 60 min to give a light brown turbid mixture. To the mixture was slowly added [2-(trimethylsilyl)ethoxy]methyl chloride (152.40 g, 914.11 mmol) and the reaction was stirred at 0 C. for 1 h. The reaction was quenched by addition of 12 mL of H2O slowly. More water (120 mL) was added followed by methyl tert-butyl ether (MTBE) (120 mL). The mixture was stirred for 10 min. The organic layer was separated. The aqueous layer was extracted with another portion of MTBE (120 mL). The organic extracts were combined, washed with brine (120 mL×2) and concentrated under reduced pressure to give the crude product 4-chloro-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine as a dark oil. Yield: 85.07 g (97%); LC-MS: 284.1 (M+H)+. It was carried to the next reaction without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3680-69-1, its application will become more common.

Reference:
Patent; Huang, Taisheng; Xue, Chu-Biao; Wang, Anlai; Kong, Ling Quan; Ye, Hai Fen; Yao, Wenqing; Rodgers, James D.; Shepard, Stacey; Wang, Haisheng; Shao, Lixin; Li, Hui-Yin; Li, Qun; US2011/224190; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 918340-51-9, 4-Chlorofuro[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Chlorofuro[2,3-d]pyrimidine, blongs to pyrimidines compound. Safety of 4-Chlorofuro[2,3-d]pyrimidine

To a stirred solution of trans-4-(dimethylamino)cyclohexanol in freshly distilled THF (8 mL), cooled to 0C, was slowly added sodium hydride (40 mg, 1.00 mmol, 2.58 equiv, 60% dispersion in mineral oil) under nitrogen. The mixture was stirred at 0C for 30 min and then 4- chlorofuro[2,3-d]pyrimidine (60 mg, 0.39 mmol, 1.00 equiv) was added and the reaction was stirred overnight at 50C. The reaction solution was then quenched by the addition of water, extracted with ethyl acetate. The organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product (80 mg) was purified by Prep-HPLC with the following conditions (SHIMADZU): Column, SunFire Prep CI 8, 19* 150mm 5um; mobile phase, water with 1% HCOOH and CH3CN (3.0% CH3CN up to 8.0% in 10 min); Flow rate: 20 mL/min; UV detection at 254/220 nm. The product-containing fractions were collected and partially evaporated to remove solvents under reduced pressure. The residue was lyophilized overnight to give the resulted tra/?5-4-(furo[2,3-d]pyrimidin-4-yloxy)-N,N- dimethylcyclohexanamine formate (37.3 mg, 31%) as a white solid. LCMS: (ES, m/z): 262 [M- HCOOH+H]+. 1H NMR: (400 MHz, CD3OD): delta 8.53 (1H, brs), 8.50 (1H, s), 7.84 (1H, d), 6.92 (1H, d), 5.37-5.31 (1H, m), 3.32-3.15 (1H, m), 2.74 (6H, s), 2.45 (2H, d), 2.20 (2H, d), 1.81-1.65 (4H, m).

The synthetic route of 918340-51-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NIMBUS IRIS, INC.; HARRIMAN, Geraldine C.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; WESSEL, Matthew David; GREENWOOD, Jeremy Robert; WO2014/11911; (2014); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1193-24-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1193-24-4, name is 4,6-Dihydroxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

With a reflux condenser, thermometer,In the device of the agitator and the constant pressure dropping funnel,Add 4,6-dihydroxypyrimidine (114.3 g, content 98%, 1 mol), phosphorus oxychloride (1140 g, 99%) and mix well.The temperature was raised to 95-100 C, and phosgene (220 g, 99%, 2.2 mol) was slowly added to carry out the reaction, and the sample was taken after 8 hours.HPLC analysis of 4,6-dihydroxypyrimidine content of 0.9%,The content of 4,6-dichloropyrimidine was 98.3%, and the reaction was over.Vacuum distillation reaction mixture (oil bath temperature 95 C,Vacuum degree -0.095MPa),Obtained 1082 g of phosphorus oxychloride (content 99%); 142.8 g of 4,6-dichloropyrimidine (content 99.0%),Yield 94.9% (based on 4,6-dihydroxypyrimidine), wherein W (DCP) refers to the mass of DCP, and W (DHP) refers to the mass of DHP.The content refers to the mass content of DCP, and 112 is the molecular weight of DHP.149 is the molecular weight of DCP.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1193-24-4, 4,6-Dihydroxypyrimidine.

Reference:
Patent; Lianyungang Guosheng Chemical Co., Ltd.; Xu Chen; Zhu Guoqing; Zhang Xin; Zhou Tulin; (6 pag.)CN108178749; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, molecular formula is C5H6N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 2565-47-1

General procedure: A mixture of compound 4a (1 mmol, 245 mg) and 5a (1 mmol, 156 mg) was taken in a round bottomed flask containing ethanol (5 ml). To this, catalytic amount of diisopropylethylamine (DIPEA) was added and the reaction mixture was stirred at room temperature for 1 h. The solid formed in the reaction process was filtered and purified by washing with ethanol and dried. The structure of the compound was ascertained as 6a from spectroscopic data.

With the rapid development of chemical substances, we look forward to future research findings about 2565-47-1.

Reference:
Article; Borah, Pallabi; Bhuyan, Pulak J.; Tetrahedron Letters; vol. 54; 50; (2013); p. 6949 – 6951;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 32779-36-5, Adding some certain compound to certain chemical reactions, such as: 32779-36-5, name is 5-Bromo-2-chloropyrimidine,molecular formula is C4H2BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32779-36-5.

Step 1: tent-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate Into a 200 mL pressure flask equipped with a magnetic stir bar was added tert-butyl piperazine-1-carboxylate (4.8 g, 25.8 mmol), 5-bromo-2-chloropyrimidine (5.0 g, 25.8 mmol) and 2-propanol (50 mL). DIPEA (5.0 mL, 28.4 mmol) was added, the vial was sealed and the reaction mixture heated to 120 C. for 1 h. The cooled reaction mixture was poured into a 250 mL separatory funnel containing water (125 mL) and extracted with EtOAc (3*75 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated. Recrystallization from EtOAc (about 40 mL) and hexanes (about 150 mL) at -78 C. afforded crystals which were collected by filtration through filter paper on a Hirsch funnel under vacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 32779-36-5, 5-Bromo-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia