Pyrimidines

Related Products of 874-14-6 ,Some common heterocyclic compound, 874-14-6, molecular formula is C6H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 1,3-dimethyluracil 1a (0.20 mmol) in 2,2,2-trifluoroethanol (TFE) (3 mL),(4-chlorophenyl)(hydroxy)iodonium tosylate 2f (0.20 mmol) was added and it was stirred at room temperature. After completion of the reaction, the solvent was removed under vacuum. The product wasthen precipitated by the addition of Et2O with stirring. The precipitate was filtered to giveuracil-iodonium(III) salt 3f as white powder.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,874-14-6, its application will become more common.

Reference:
Article; Takenaga, Naoko; Ueda, Shohei; Hayashi, Takumi; Dohi, Toshifumi; Kitagaki, Shinji; Heterocycles; vol. 97; 2; (2018); p. 1248 – 1256;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 372118-67-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 372118-67-7, name is Pyrimidin-2-ylmethanamine hydrochloride, molecular formula is C5H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Tosyl chloride (254 mg, 1.33 mmol), K2CO3 (538 mg, 3.9 mmol) and 22 (436 mg, 1.33 mmol) were added to acetonitrile (10 mL) and stirred at room temperature overnight. Compound 23 (194 mg, 1.33 mmol) was added to the prepared mixed solution of the mixed anhydride, and the mixture was stirred at room temperature for 20 minutes. After completion of the reaction by TLC, the starting material was reacted. The mixture was diluted with water and washed with ethyl acetate. The aqueous phase was extracted twice more with ethyl acetate. The combined organic phases were dried over anhydrous sodium sulfate and concentrated to give compound 25 (588 mg, yield 93%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 372118-67-7, Pyrimidin-2-ylmethanamine hydrochloride.

Reference:
Patent; Anrun Pharmaceutical (Suzhou) Co., Ltd.; Hong Jian; Xu Xin; Liu Guobin; Liu Huahui; (14 pag.)CN104710411; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 10397-13-4, 4-(4,6-Dichloropyrimidin-2-yl)morpholine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C8H9Cl2N3O, blongs to pyrimidines compound. COA of Formula: C8H9Cl2N3O

5 – azaspiro [2.4] heptane -7 – alcohol (0.4g, 3 . 53mmol) and 4 – (4, 6 – dichloro pyrimidine -2 – yl) morpholine (640 mg, 2 . 72mmol) is dissolved in isopropanol (15 ml), add DIPEA (700 mg, 5 . 44mmol), raising the temperature to 80 C, stirring overnight, the reaction solution concentration, for purification column chromatography (petroleum ether: ethyl acetate=1:1), shall be 5 – (6 – chloro -2 – morphine linlin base pyrimidine -4 – yl) -5 – azaspiro [2.4] heptane -7 – alcohol (400 mg, 49%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10397-13-4, 4-(4,6-Dichloropyrimidin-2-yl)morpholine, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Huilun Life Technology Co., Ltd.; Cheng Jianjun; Qin Jihong; (41 pag.)CN104557871; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32779-36-5, name is 5-Bromo-2-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4H2BrClN2

To a stirred solution of 1-boc-piperazine (6.0 g, 31.5 mmol) in DMF (50 mL), triethyl amine (7 mL, 46.00 mmol) and 5-bromo-2-chloropyrimidine (6.3 g, 37.00 mmol) were added and the reaction mixture was stirred at 90 C for 8 h. The reaction mixture was concentrated under reduced pressure. Water (50 mL) was added and the desired product was extracted with DCM (150 mL). The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by flash chromatography (10% EtOAc in pet ether) to afford the title compound. Yield: 76% (7 g, white). 1H NMR (400 MHz, DMSO-d6): delta 8.46 (s, 2H), 3.68-3.67 (m, 4H), 3.39-3,37 (m, 4H), 1.40 (s, 9H). LCMS: (Method A) 289.0 (M+H), Rt. 5.19 min, 99.05% (Max).

With the rapid development of chemical substances, we look forward to future research findings about 32779-36-5.

Reference:
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 20781-06-0, blongs to pyrimidines compound. HPLC of Formula: C5H6N4O

General procedure: Appropriate substituted benzoyl hydrazine 4 (1 equiv) was added to a solution of intermediate 2 (1mmol) in ethanol (10mL). The reaction mixture was stirred for 3h at reflux under the condition of the presence of acetic acid as catalyzer, then poured into cold water and the resulting solid was collected by filtrated, washed with EtOH (10mL), and dried in the atmospheric pressure to give the desired title compounds A, B, and C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20781-06-0, its application will become more common.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4H5N3O2

To a solution of 2-aminopyrimidine-4,6-diol (1.0 eq) in POCl3 (1M) was stirred at 100 C. for 4 h. The reaction mixture was allowed to cool to rt and the mixture was poured into ice-water. The precipitated solid was collected by filtration. The solid was washed with water and dried in vacuum to give the title compound as a yellow solid.

With the rapid development of chemical substances, we look forward to future research findings about 56-09-7.

Reference:
Patent; Apros Therapeutics, Inc.; WU, Tom Yao-Hsiang; (209 pag.)US2018/155298; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H7ClN2O2

4-(furan-2-yl)-2,6-dimethoxypyrimidine According to the general procedure, a mixture of 6-chloro-2,4-dimethoxypyrimidine (175 mg, 1 .00 mmol), 2-furanboronic acid (168 mg, 1 .50 mmol), (7i-crotyl)Pd(XPhos)CI (14 mg, 0.02 mmol), 2 mL THF, and 4 mL of 0.5 M aqueous K3P04 are stirred at room temperature for 1 hour. The crude material is chromatographed on silica gel with a gradient of 0 – 10 % EtOAc/hexanes as the eluent to give 194 mg (0.94 mmol, 94 %) of 4-(furan-2-yl)-2,6-dimethoxypyrimidine as a colorless solid. H NMR (400 MHz, CDCI3, delta): 7.53 (dd, J = 0.9 Hz, 1 .9 Hz, 1 H), 7.19 (dd, J = 0.7 Hz, 3.5 Hz, 1 H), 6.69 (s, 1 H), 6.53 (dd, J = 1 .7 Hz, 3.4 Hz, 1 H) 4.02 (s, 3H), 3.99 (s, 3H). l3C NMR (100 MHz, CDCI3, delta): 172.6, 165.6, 157.4, 152.2, 144.6, 1 12.3, 1 1 1 .9, 95.0, 54.8, 54.0. Anal. Calcd. for C10H10N2O3: C, 58.25; H, 4.89; N, 13.59. Found: C, 58.19; H, 4.72; N, 13.42

The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; COLACOT, Thomas; CHOW, Ruishan; JON DEANGELIS, Andrew; WO2015/189554; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 306960-77-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 306960-77-0, name is 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Example 340 W-{[1 -ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1 H- pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(trifluoromethyl)-5-pyrimidine carboxamideEthyl 2-(trifluoromethyl)-5-pyrimidinecarboxylate [e.g. available from J. Med. Chem., (2000), 43 (21), 3995 (49mg) in ethanol (0.63ml) was treated with 2N sodium hydroxide (0.443ml) and the solution stirred at room temperature for 24h. 2M Hydrochloric acid (0.31ml) was added and the mixture blown down to dryness. The residue was suspended in dry dichloromethane (0.5ml) and treated at room temperature with oxalyl chloride (0.019ml) and DMF (1 drop). The mixture was stirred at room temperature for 30mins and then added dropwise to a solution of Intermediate 15 (53mg) in acetonitrile (1ml). DIPEA (0.039ml) was added and the mixture was stirred at room temperature for 18h. The mixture was blown down to dryness and the residue was purified by mass directed autoprep HPLC followed by SPE cartridge (1g, aminopropyl) eluting with methanol. The eluent was blown down to dryness to give Example 340 as a beige solid (9mg). LCMS showed MH+ = 464; TRET = 2.42min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 306960-77-0, 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/36733; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 7461-50-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7461-50-9, name is 2-Chloropyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of (6-(6,6-difluoro-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-3-yl)boronic acid (240.0 mg, 1.0 mmol)2-chloropyrimidin-4-amine (129.0 mg, 1.0 mmol) in 1,4-dioxane (5 mL) and H2O (1 mL) was added potassium carbonate (276.4 mg, 2.0 mmol). After the mixture was degassed with N2 for 3 times, Pd(PPh3)4 (57.8 mg, 0.05mmol) was added under N2 and the mixture was stirred at 90 oC for 3 hrs. The reaction mixture was cooled down and poured into EA. The organic phase was separated, washed with water and brine, dried over Na2SO4 and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by chromatography (eluted with PE : EA = 1: 1) to afford the title product (140 mg, 58.1 % yield) as a white solid. Retention time (LC-MS): 0.365 min. MH+ 290.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7461-50-9, 2-Chloropyrimidin-4-amine.

Reference:
Patent; HYDRA BIOSCIENCES, INC.; CHENARD, Bertand, L.; WU, Xinyuan; (351 pag.)WO2016/44792; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3073-77-6, Adding some certain compound to certain chemical reactions, such as: 3073-77-6, name is 2-Amino-5-nitropyrimidine,molecular formula is C4H4N4O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3073-77-6.

Synthesis of I-5 Into a 1-L round-bottom flask, was placed 5-nitropyrimidin-2-amine (30 g, 214.13 mmol, 1.00 equiv), methanol (400 mL), Palladium carbon (12 g). The resulting solution was stirred overnight at room temperature in a hydrogen bath. The solids were filtered out. The resulting mixture was concentrated under vacuum. This resulted in 20 g (85%) of pyrimidine-2,5-diamine as a light brown solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3073-77-6, 2-Amino-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; IRM LLC; LIANG, Fang; MISHRA, Pranab Kumar; MOLTENI, Valentina; NAGLE, Advait Suresh; SUPEK, Frantisek; TAN, Liying Jocelyn; VIDAL, Agnes; US2014/275119; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia