Pyrimidines

A general and practical bifunctional cobalt catalytic system for N-heterocycle assembly via acceptorless dehydrogenation was written by Tian, Haitao;Xue, Wenxuan;Wu, Jingtao;Yang, Ziguang;Lu, Hongcheng;Tang, Conghui. And the article was included in Organic Chemistry Frontiers in 2022.Electric Literature of C16H13N3 This article mentions the following:

A novel and highly-efficient N-heterocycle assembly methodol. catalyzed by a cobalt-N,N-bidentate complex had been established. The cobalt complex was unprecedented, phosphine-free and easily-prepared, and was used in the synthesis of pyrimidines such as I [R = NH₂, Ph; Ar¹ = Ph, 2-MeOC₆H₄, 2-naphthyl, etc.; Ar² = Ph, 2-thienyl, 4-MeC₆H₄, etc.], quinolines such as II [R¹ = H, 8-Me; R² = H, Me; R³ = t-Bu, Ph, 2-naphthyl, etc.], imidazoles III [R⁴ = H, Me; R⁵ = H, Me, Cl; R⁶ = H, Me, Cl; R⁵R⁶ = CH=CH-CH=CH; Ar³ = Ph, 2-MeC₆H₄, 3-ClC₆H₄, etc.], quinoxalines such as IV [R⁷ = H, 5-Me, 6,7-di-Me, 6,7-di-Cl] and indole from readily available alcs. and amines via acceptorless dehydrogenation. More importantly, all N-heterocycles were obtained under nearly identical reaction conditions, which further demonstrated the generality and practicability of the catalytic system. Mechanistically, this cobalt complex formed a catalytic active species upon base treatment and was capable of realizing the alc. AD process via metal-ligand cooperation. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Electric Literature of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Electric Literature of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and characterization of some new 2-amino-4-(4′-substituted)-6-(4”-substituted)diphenyl pyrimidines was written by Hasan, Aurangzeb;Khaleeq, Musfirah;Riaz, Uzma. And the article was included in Asian Journal of Chemistry in 2010.Safety of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Synthesis and characterization of some novel 2-amino-4-(4′-substituted)-6-(4”-substituted)diphenylpyrimidines was carried out by the conversion of variably substituted acetophenones and benzaldehydes into corresponding chalcones followed by cyclization with guanidine hydrochloride in the presence of an oxidizing agent. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Safety of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reactions of 6-aminopyrimidines with 2-dimethylaminomethylenetetralone. Regiospecific synthesis of 5,6-dihydrobenzo[h]pyrimido[4,5-b]quinolines was written by Quiroga, Jairo;Insuasty, Braulio;Insuasty, Henry;Abonia, Rodrigo;Ortiz, Antonio;Sanchez, Adolfo;Nogueras, Manuel. And the article was included in Journal of Heterocyclic Chemistry in 2001.Synthetic Route of C6H9N3OS This article mentions the following:

Benzo[h]pyrimido[4,5-b]quinolines, e.g. I (R = H, Me; X = MeO, MeS, NH₂), were prepared via a regiospecific cyclocondensation reaction between 6-aminopyrimidines, e.g. II, and 2-dimethylaminomethylentetralone hydrochloride (III). The linear structures of the final compounds were determined by NMR measurements, especially by ¹H, ¹H-, ¹H, ¹³C COSY and DEPT experiments In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Synthetic Route of C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Microwave-assisted three-component synthesis and in vitro antifungal evaluation of 6-cyano-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones was written by Quiroga, Jairo;Cisneros, Carlos;Insuasty, Braulio;Abonia, Rodrigo;Cruz, Silvia;Nogueras, Manuel;Manuel de la Torre, Jose;Sortino, Maximiliano;Zacchino, Susana. And the article was included in Journal of Heterocyclic Chemistry in 2006.Electric Literature of C6H9N3OS This article mentions the following:

The reaction of 6-aminopyrimidin-4-ones with benzaldehydes and β-iminobutyronitrile or benzoylacetonitrile under microwave irradiation in dry media yields 6-cyano-5,8-dihydropyrido[2,3-d]-pyrimidinones. The structure of the synthesized compounds was determined on the basis of NMR measurements, especially by ¹H,¹H-, ¹H,¹³C COSY, DEPT, and NOESY experiments In contrast with other pyrido[2,3-d]pyrimidine derivatives, these compounds did not show any antifungal in vitro activity â‰?50 μg/mL. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Electric Literature of C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Electric Literature of C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

An efficient synthesis of 4-chloro-2-pyrrolino[2,3-d]pyrimidin-6-one and its 7-substituted analogues was written by Vaid, Radhe K.;Spitler, Jeremy T.;Boini, Sathish;May, Scott A.;Hoying, Richard C.. And the article was included in Synthesis in 2012.Formula: C7H6Cl2N2O2 This article mentions the following:

An efficient synthesis of I [R = H] was achieved in four steps starting from di-Me malonate in 23% overall yield. This synthesis was demonstrated on 100 g scale to obtain I [R = H] in 98.5% purity. Similarly, I [R = 2,4-(MeO)₂C₆H₃, PhCH(Me)] were synthesized by the reaction of Me 2-(4,6-dichloropyrimidin-5-yl)acetate with an appropriately substituted benzylamine. In the experiment, the researchers used many compounds, for example, Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6Formula: C7H6Cl2N2O2).

Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Formula: C7H6Cl2N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Syringe purification with UPLC-MS/MS for detection of antibiotics in tea garden soil after long-term application of manure was written by Zheng, Binyu;Song, Ningying;Wu, Huizhen;Tong, Jianying;Sun, Nabo. And the article was included in Analytical Methods in 2022.Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The residue of antibiotics in the soil is becoming more and more common, which may affect the normal growth of plants and organisms. The aim of this study was to investigate the residues of antibiotics in tea gardens’ soil after a long-term application of manure. An ultra-high performance liquid chromatog.-tandem mass spectrometry method was developed to simultaneously determine the residues of 32 antibiotics in the soil of tea gardens after fertilization. The samples were extracted with methanol-acetonitrile and purified with C18 at the same time. Then, mixed dispersive sorbents dispersed in a syringe were used for the second purification The results showed that the antibiotics have a good linear relationship within the range. The recovery rate is 70.1-120.3%. The applicability of the method was demonstrated by analyzing 30 real samples (with a detection rate of 43.3%). The method is a simple and environmentally friendly method for the anal. of multiple antibiotics in soils, and it could provide a basis for the risk assessment of antibiotics in agricultural environments and the standard application of organic fertilizers in tea gardens. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Novel and simple analytical method for simultaneous determination of sulfonamide, quinolone, tetracycline, macrolide, and chloramphenicol antibiotics in soil was written by Shi, Xiaomeng;Zhang, Shan;Zhang, Yanwei;Geng, Yue;Wang, Lu;Peng, Yi;He, Zeying. And the article was included in Analytical and Bioanalytical Chemistry in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The multiclass determination of antibiotic residues in the soil is challenging because of its complex physicochem. properties. In this study, a simple anal. method was developed to simultaneously extract and determine 58 antibiotics from the soil. A novel acidity-regulated extraction-partition-concentration protocol was established for the simultaneous extraction of five classes (23 sulfonamides, 18 quinolones, five tetracyclines, eight macrolides, and four chloramphenicols) of antibiotics from the soil. Compared to traditional methods, the sample preparation efficiency was significantly improved by four times (45 min vs. 230 min) by optimizing the extraction method and omitting the time-consuming solid-phase extraction (SPE) procedure. The ultra-high-performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) method was optimized to determine the 58 antibiotics in a single run by applying pos./neg. switching acquisition mode in less than 10 min with the baseline separation of sulfameter and sulfamethoxypyridazine. Suitable recoveries, ranging between 60 and 120%, were obtained for most antibiotics, with RSD <20%. The limits of quantification (LOQ) of the method were 2μg/kg and 5μg/kg. Thus, this study provides a simple, reliable, and economical method for accurately and rapidly determining a multiclass of antibiotics in the soil. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Continuous-flow reactors for the rapid evolution and validation of kinetic motifs was written by Hone, Christopher A.;Bourne, Richard A.;Muller, Frans L.. And the article was included in Chimica Oggi in 2015.Product Details of 62968-37-0 This article mentions the following:

In this paper we apply the concept of a kinetic motif as a simple way to represent all the lime-dependent behavior in a single-step or multi-step reaction system. Small-scale continuous-flow reactors offer the potential to rapidly collect large amounts of data while accessing conventionally challenging exptl. conditions. The scope of the approach is demonstrated on reaction case study examples. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Product Details of 62968-37-0).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Product Details of 62968-37-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers was written by Kemnitzer, William;Sirisoma, Nilantha;May, Chris;Tseng, Ben;Drewe, John;Cai, Sui Xiong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Category: pyrimidines This article mentions the following:

We report the discovery of N-((benzo[d][1,3]dioxol-5-yl)methyl)-6-phenylthieno[3,2-d]pyrimidin-4-amine (2a) as an apoptosis inducer using our proprietary cell- and caspase-based ASAP HTS assay, and SAR study of HTS hit 2a which led to the discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers. Compounds 5d and 5e were the most potent with EC₅₀ values of 0.008 and 0.004 μM in T47D human breast cancer cells, resp. Compound 5d was found to be highly active in the MX-1 breast cancer model. Functionally, compounds 5d and 5e both induced apoptosis through inhibition of tubulin polymerization In the experiment, the researchers used many compounds, for example, 4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0Category: pyrimidines).

4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Elucidation and evaluation of substituted pyrimidines was written by Umaa, K.;Ramanathan, M.;Krishnakumar, K.;Kannan, K.. And the article was included in Asian Journal of Chemistry in 2009.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

The title compounds I (R¹ = H, Cl, Me, MeO; R² = H, Cl, Me, MeO) were synthesized via condensation of acetophenones R¹C₆H₄C(O)Me with aromatic aldehydes R²C₆H₄CHO followed by cyclocondensation of the intermediate chalcones with guanidine hydrochloride. The compounds I were evaluated for antimicrobial and antimycobacterial activity using Kirby bauer method and Alamar blue assay technique. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia