Pyrimidines

Rosemeyer, Helmut’s team published research in International Journal of Biological Macromolecules in 1987-08-31 | 84955-32-8

International Journal of Biological Macromolecules published new progress about Enzyme kinetics. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Related Products of 84955-32-8.

Rosemeyer, Helmut; Kaiser, Klaus; Seela, Frank published the artcile< Dextran-linked 7-deazaguanine - a polymer-bound inhibitor of xanthine oxidase>, Related Products of 84955-32-8, the main research area is xanthine oxidase deazaguanine dextran inhibitor; immobilized deazaguanine xanthine oxidase inhibition.

Dextran-linked 7-deazaguanine as well as 7-deazahypoxanthine and allopurinol derivatives were prepared by carbodiimide condensation of the 2-carboxyethyl intermediates with N-(6-aminohexyl)carbamoylmethylated dextran T80. The dextran-linked bases are degradable by endo-dextranase (EC 3.2.1.11) as demonstrated by time-dependent viscosity measurements. Monomeric as well as polymer-linked purine analogs were tested as inhibitors of xanthine oxidase (EC 1.2.3.1) from cow’s milk. Whereas the allopurinol- and 7-deazahypoxanthine derivatives no longer bind to the enzyme, the 7-deazaguanine derivatives are strong competitive inhibitors of xanthine oxidase even in the polymer-linked state.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Fun, Hoong-Kun’s team published research in Acta Crystallographica, Section E: Structure Reports Online in 2010-02-28 | 5018-38-2

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, SDS of cas: 5018-38-2.

Fun, Hoong-Kun; Yeap, Chin Sing; Chidan Kumar, C. S.; Yathirajan, H. S.; Siddegowda, M. S. published the artcile< 4,6-Dichloro-5-methoxypyrimidine>, SDS of cas: 5018-38-2, the main research area is crystal structure dichloromethoxypyrimidine; mol structure chloromethoxypyrimidine; pyrimidine dichloromethoxy crystal mol structure.

The mol. of 4,6-dichloro-5-methoxypyrimidine, C5H4Cl2N2O, is close to being planar (root-mean-square deviation = 0.013 Å), apart from the C atom of the methoxy group, which deviates by 1.082(2) Å from the mean plane of the other atoms. In the crystal, short Cl···N contacts [3.0940(15) and 3.1006(17) Å] generate a 3-dimensional framework. Crystallog. data are given.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Anderson, Neal G’s team published research in Organic Process Research & Development in 1997-08-31 | 5018-38-2

Organic Process Research & Development published new progress about Antidepressants. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, SDS of cas: 5018-38-2.

Anderson, Neal G.; Ary, Thomas D.; Berg, James L.; Bernot, Peter J.; Chan, Yeung Y.; Chen, Chien-Kuang; Davies, Merrill L.; DiMarco, John D.; Dennis, Ronald D.; Deshpande, Rajan P.; Do, Hoang D.; Droghini, Roberto; Early, William A.; Gougoutas, Jack Z.; Grosso, John A.; Harris, John C.; Haas, Oscar W.; Jass, Paul A.; Kim, Daniel H.; Kodersha, Gus A.; Kotnis, Atul S.; LaJeunesse, Jean; Lust, David A.; Madding, Gary D.; Modi, Sandeep P.; Moniot, Jerome L.; Nguyen, Andrew; Palaniswamy, Venkatapuram; Phillipson, Douglas W.; Simpson, James H.; Thoraval, Dominique; Thurston, David A.; Tse, Kai; Polomski, Robert E. published the artcile< Process Development of 5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1- piperazinyl]propyl]-1H-indole Dihydrochloride>, SDS of cas: 5018-38-2, the main research area is fluoromethoxy pyrimidinyl piperazinylpropyl indole dihydrochloride synthesis; antidepressant fluoromethoxypyrimidinyl piperazinylpropyl indole dihydrochloride preparation.

5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]propyl]-1H-indole dihydrochloride (1) facilitates 5-HT neurotransmission and was an antidepressant drug candidate. The development of a safe, rugged process for the large-scale, chromatog.-free preparation of this compound is described. The main areas of optimization included a Fischer indole synthesis, preparation and chlorination of a monohydroxypyrimidine, and coupling of the resultant fragments to prepare the drug substance.

Organic Process Research & Development published new progress about Antidepressants. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, SDS of cas: 5018-38-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Winkeler, Heinz Dieter’s team published research in Journal of Organic Chemistry in 1983-09-09 | 84955-32-8

Journal of Organic Chemistry published new progress about Nucleosides. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Application of C7H8N4O.

Winkeler, Heinz Dieter; Seela, Frank published the artcile< Synthesis of 2-amino-7-(2'-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, a new isostere of 2'-deoxyguanosine>, Application of C7H8N4O, the main research area is pyrrolopyrimidine deoxynucleoside; deoxyerythropentofuranosylpyrrolopyrimidinone.

The title compound (I) was prepared by treating 2-amino-4-methoxypyrrolo[2,3-d]pyrimidine with the sugar II, acidifying to deacylate, and demethylating with 4-MeC6H4SNa.

Journal of Organic Chemistry published new progress about Nucleosides. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Application of C7H8N4O.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mantymaki, Miia’s team published research in Chemistry of Materials in 2013-05-14 | 2244-11-3

Chemistry of Materials published new progress about Adhesive films. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Formula: C4H4N2O5.

Mantymaki, Miia; Hamalainen, Jani; Puukilainen, Esa; Sajavaara, Timo; Ritala, Mikko; Leskela, Markku published the artcile< Atomic layer deposition of LiF thin films from Lithd, Mg(thd)2, and TiF4 precursors>, Formula: C4H4N2O5, the main research area is atomic layer deposition lithium fluoride thin film precursor epitaxy; film adhesion.

Lithium fluoride is an interesting material because of its low refractive index and large band gap. Previously LiF thin films have been deposited mostly by phys. methods. In this study a new way of depositing thin films of LiF using at. layer deposition (ALD) is presented. Mg(thd)2(2,2,6,6-tetramethyl-3,5-heptanedionate) TiF4 and Lithd were used as precursors, and they produced crystalline LiF at a temperature range of 300-350 °C. The films were studied by UV-vis spectrometry, field emission SEM (FESEM), X-ray diffraction (XRD), at. force microscopy (AFM), time-of-flight elastic recoil detection anal. (ToF-ERDA), and energy dispersive X-ray spectroscopy (EDX). In addition, film adhesion was tested by a Scotch tape test. This method results in LiF films with a growth rate of approx. 1.4 Å per cycle. According to the ToF-ERDA measurements, the films are pure LiF with very small Mg and Ti impurities, the largest impurity being hydrogen with contents below 1 atom %.

Chemistry of Materials published new progress about Adhesive films. 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Formula: C4H4N2O5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Park, Tae-Hong’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2011-02-07 | 89793-12-4

Chemical Communications (Cambridge, United Kingdom) published new progress about Adsorption (isotherm). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Safety of Ethyl 2-chloropyrimidine-5-carboxylate.

Park, Tae-Hong; Cychosz, Katie A.; Wong-Foy, Antek G.; Dailly, Anne; Matzger, Adam J. published the artcile< Gas and liquid phase adsorption in isostructural Cu3[biaryltricarboxylate]2 microporous coordination polymers>, Safety of Ethyl 2-chloropyrimidine-5-carboxylate, the main research area is gas liquid adsorption copper isostructural biaryltricarboxylate microporous polymer; crystal structure copper carboxypyrimidinyl carboxypyridinyl isophthalate microporous coordination polymer; copper biaryltricarboxylate microporous polymer preparation gas liquid adsorption.

N-Heteroarene substitution in biphenyl-based linkers enhances the uptake of electron-rich organosulfur mols. in microporous coordination polymers (MCP). Three isostructural MCPs are prepared (Cu3L2) possessing nearly uniform surface areas from homologous biaryl tricarboxylate linkers containing Ph (biphenyltricarboxylate UMCM-150), pyrimidine (carboxypyrimidinyl-isophthalate UMCM-150N2), and pyridine (carboxypyridinyl-isophthalate UMCM-150N1) units, building the ideal system to probe linker influence upon guest adsorption. The almost identical isotherms of H2 and CO2 in these MCPs imply that the N-heteroaryl linkers in the UMCM-150 analogs do not considerably affect the gas phase adsorption behavior. The electronic nature and contact interactions with the aromatic linker play an important role to enhance interactions between the host MCP framework and the large guest organic mols. in the liquid phase.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Okui, Kiyoshi’s team published research in Journal of Heterocyclic Chemistry in 1972 | 3286-55-3

Journal of Heterocyclic Chemistry published new progress about 3286-55-3. 3286-55-3 belongs to class pyrimidines, and the molecular formula is C5H6ClN3O, Related Products of 3286-55-3.

Okui, Kiyoshi; Ito, Kiyohiko; Koizumi, Masuo; Fukumoto, Keiichiro; Kametani, Tetsuji published the artcile< Syntheses of heterocyclic compounds. CDXCI. Pyrimidine derivatives. V. Abnormal condensation products of 4-amino-6-chloro-2-methoxypyrimidine with p-nitrobenzenesulfonyl chloride>, Related Products of 3286-55-3, the main research area is pyridinium pyrimidine betaines.

Condensation of 4-amino-6-chloro-2-methoxypyrimidine with p-O2NC6H4SO2Cl gave, in addition to 6-chloro-2-methoxy-4-(p-nitrobenzenesulfonamido)pyrimidine (I), two abnormal by-products, 1-[2-methoxy-4-(p-nitrobenzenesulfonamido)pyrimidin-6-yl]pyridinium N,N-betaine (II) and N-(p-nitrobenzenesulfonyl)-β-ureido-β-pyridinium arcylamide N,N-betaine (III).

Journal of Heterocyclic Chemistry published new progress about 3286-55-3. 3286-55-3 belongs to class pyrimidines, and the molecular formula is C5H6ClN3O, Related Products of 3286-55-3.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Schomaker, Jennifer M’s team published research in Journal of Organic Chemistry in 2001-10-19 | 3921-01-5

Journal of Organic Chemistry published new progress about Arylation. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, COA of Formula: C4H2Br2N2.

Schomaker, Jennifer M.; Delia, Thomas J. published the artcile< Arylation of Halogenated Pyrimidines via a Suzuki Coupling Reaction>, COA of Formula: C4H2Br2N2, the main research area is Suzuki coupling arylation halopyrimidine; pyrimidine aryl preparation.

The Suzuki coupling reaction was used extensively for the synthesis of a wide variety of unsym. biaryl compounds The authors have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines.

Journal of Organic Chemistry published new progress about Arylation. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, COA of Formula: C4H2Br2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Johns, Stephen C’s team published research in Tetrahedron Letters in 2014-05-28 | 2244-11-3

Tetrahedron Letters published new progress about Acridines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2244-11-3 belongs to class pyrimidines, and the molecular formula is C4H4N2O5, Recommanded Product: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.

Johns, Stephen C.; Crouch, Laurie L. E.; Grieve, Stephen; Maloney, Holly L.; Peczkowski, Gary R.; Jones, Allison E.; Sharp, Duncan; Smith, Robert B. published the artcile< A rapid, chromatography-free route to substituted acridine-isoalloxazine conjugates under microwave irradiation>, Recommanded Product: Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, the main research area is acridine isoalloxazine conjugate preparation condensation microwave irradiation.

Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine-isoalloxazine conjugates. The combination of these two moieties, both of biol. interest, was achieved by a chromatog.-free route.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Amano, Yohei’s team published research in Chemical & Pharmaceutical Bulletin in 2014-03-31 | 89793-12-4

Chemical & Pharmaceutical Bulletin published new progress about Aromatic amines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Safety of Ethyl 2-chloropyrimidine-5-carboxylate.

Amano, Yohei; Noguchi, Masayuki; Shudo, Koichi published the artcile< Diarylamines incorporating hexahydrophenalene or octahydrobenzoheptalene as retinoid X receptor (RXR)-specific agonists>, Safety of Ethyl 2-chloropyrimidine-5-carboxylate, the main research area is arylamino hexahydro phenalene preparation retinoid X receptor agonist; octahydro benzoheptalene arylamino preparation retinoid X receptor agonist.

A series of diarylamines I (X = CH2, R1 = H, Me; X = CH2CH2, R1 = H; Z = CH, N; R2 = H, Me, Et, cyclopropylmethyl, i-Bu, PhCH2) incorporating hexahydrophenalene or octahydrobenzoheptalene as a hydrophobic moiety was synthesized and examined for their activities towards retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Most of these compounds showed agonistic activity towards RXRs, but were inactive towards RARs. These RXR-specific ligands showed synergistic activity in RARα,β ligand-induced terminal differentiation of leukemia cell line HL-60.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia