Pyrimidines

HPLC of Formula: 944401-55-2On October 11, 2018 ,《Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS》 was published in Journal of Medicinal Chemistry. The article was written by Hodges, Timothy R.; Abbott, Jason R.; Little, Andrew J.; Sarkar, Dhruba; Salovich, James M.; Howes, Jennifer E.; Akan, Denis T.; Sai, Jiqing; Arnold, Allison L.; Browning, Carrie; Burns, Michael C.; Sobolik, Tammy; Sun, Qi; Beesetty, Yugandhar; Coker, Jesse A.; Scharn, Dirk; Stadtmueller, Heinz; Rossanese, Olivia W.; Phan, Jason; Waterson, Alex G.; McConnell, Darryl B.; Fesik, Stephen W.. The article contains the following contents:

Son of sevenless homolog 1 (SOS1) is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS. In its active form, GTP-bound RAS is responsible for numerous critical cellular processes. Aberrant RAS activity is involved in ∼30% of all human cancers; hence, SOS1 is an attractive therapeutic target for its role in modulating RAS activation. Here, we describe a new series of benzimidazole-derived SOS1 agonists. Using structure-guided design, we discovered small mols. that increase nucleotide exchange on RAS in vitro at submicromolar concentrations, bind to SOS1 with low double-digit nanomolar affinity, rapidly enhance cellular RAS-GTP levels, and invoke biphasic signaling changes in phosphorylation of ERK 1/2. These compounds represent the most potent series of SOS1 agonists reported to date. The experimental part of the paper was very detailed, including the reaction process of 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine(cas: 944401-55-2HPLC of Formula: 944401-55-2)

4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine(cas: 944401-55-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. HPLC of Formula: 944401-55-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 1965,Chemical & Pharmaceutical Bulletin included an article by Nitta, Yoshihiro; Okui, Kiyoshi; Ito, Kiyohiko. Product Details of 3286-56-4. The article was titled 《Pyrimidine derivatives. I. Synthesis of a new series of sulfanilamides having dialkylamino groups in the pyrimidine nucleus》. The information in the text is summarized as follows:

A solution of 7.1 g. Na in 300 mL. ROH was added dropwise to 50 g. 4-amino-2,6-dichloropyrimidine (I) in 3 l. of ROH during 6 h. at 50-60°. After 20 h. ROH was removed, mixture washed with H2O and crystallized to give II (R1 = Cl) (R, m.p., % yield, crystallization solvent given): MeO, 127-8°, 72, H2O; EtO, 128-9°, 75, MeOH-H2O; PrO, 114-15°, 78, MeOH-H2O; iso-Pr, 134-5°, 72, MeOH-H2O. The Cl compounds heated at 120° for 4-6 h. in a sealed tube with 20% Me2NH/MeOH gave II (R1 = NMe2) (R, m.p., % yield, crystn solvent given): MeO, 158-9°, 85, H2O; EtO, 136-7°, 95, C6H6; PrO, 96-7°, 87, ligroine; iso-Pr, 105-6°, 82, ligroine. II (R = Cl, R1 = MeO) (IIa) (16 g.) heated on the steam bath 2 h. in 200 mL. 10% NaOH and acidified with AcOH (pH 6) gave 12 g. 4-amino-6-chloro-2(1H)-pyrimidone (III), m. >300° (H2O). IIa treated with Me2NH as above and treated with NaOH gave 4-amino-6-dimethylamino-2(1H)-pyrimidone (IV), m. >300° (H2O). III and Me2N also gave IV. I (60 g.) in 300 mL. of 20% R3R2NH/MeOH became clear after stirring sometimes with heat for 4 h. Concentration and crystallization gave II (R = Cl) (R1, m.p., % yield, crystallization solvent given): Me2N, 152-3°, 73, H2O; Et2N, 124-5°, 75, C6H6; (CH2)4N, 184-5°, 90, MeOH-H2O; morpho-linoe, 153-4°, 84, MeOH-H2O; (H2C:CHCH2)2N, 91-3° (acetyl derivative), –, ligroine. Na(7.1 g.)in 3 mL. MeOH added to 50 g. I in 2.5 l. MeOH during 6 h. at 50-60°, the solution concentrated after 20 h. to 300 mL. and diluted with 700 mL. hot H2O gave IIa. The filtrate chilled to -10° gave a mixture which washed with MeOH and crystallized from MeOH gave II (R = MeO, R1 = Cl) (IIb), 3.5 g., m. 187-8°. IIb (0.01 mol) in 100 mL. 1% NH3/MeOH hydrogenated over 0.2 g. 10% Pd/C gave II (R = MeO, R1 = H), m. 155-6° (C6H6). Prepared similarly were II (R1 = H) (R, m.p., % yield given): EtO, 151-2°, 86; PrO, 132-3°, 90; iso-PrO, 93-4°, 92; BuO, 126-7°, 85; iso-BuO, 132-4°, 75; tert-BuO, 66-7°, 75. Similarly, from the 2-alkoxy-4-amino-6-chloropyrimidines were prepared II (R = H) (R1, m.p., % yield, crystallization solvent given): MeO, 168-9°, 75, H2O; EtO, 83-6°, 86, ligroine; PrO, 77-8°, 86, ligroine; iso-PrO, 75-6°, 85, ligroine. II (R and R1 = alkoxy) were obtained from II (R = XO, R1 = Cl) with NaOH and an alc. (R, R1, m.p., % yield, all crystallized from MeOH-H2O): MeO, MeO, 150-1°, 96; MeO, EtO, 144-5°, 94; MeO, iso-PrO, 98-9°, 91; EtO, MeO, 112-13°, 95. II (R = XO, R1 = Cl) and NaSR in the corresponding alcs. heated 3 h. on the steam bath, diluted with H2O and the product crystallized from dilute MeOH gave II (R, R1, m.p., % yield given): MeO, MeS, 143-4°, 94; MeO, EtS, 116-17°, 83; MeO, PrS, 99-100°, 80; MeO, iso-PrS, 116-17°, 86; EtO, MeS, 92-3°, 93; EtO, iso-PrS, 74-5°, 95. II (R = XO, R1 = Cl) (0.01 mol) in 200 mL. 10% Me2NH/MeOH heated at 100° 5 h. in a sealed tube gave II (R, R1, m.p., % yield, crystallization solvent given): MeO, Me2N, 93-4°, 95, ligroine; EtO, Me2N, 86-7°, 87, MeOH-H2O; H, Me2N, 153-5°, 90, C6H6. I (30 g.) in 200 mL. 20% Me2NH/MeOH heated at 120-130° for 6 h. in a sealed tube, concentrated, and diluted with 100 mL. of 10% NaOH gave 25 g. II (R = R1 = NMe2), m. 116-17° (H2O). Acetyl derivatives of the following II were prepared and crystallized from MeOH or dilute MeOH (R, R1, m.p., yield % given): Cl, MeO, 195-6°, 94; Cl, EtO, 194-6°, 94; MeO, Cl, 216-17°, 93; EtO, Cl, 215-16°, 90; MeO, H, 138-9°, 94; EtO, H, 130-1°, 95; PrO, H, 135-6°, 74; iso-PrO, H, 105-6°, 70; BuO, H, 95-6°, 63; MeO, Me2N, 187-8°, 90; EtO, Me2N, 166-7°, 92; PrO, Me2N, 165-7°, 84; iso-PrO, Me2N, 156-7°, 87; EtS, Me2N, 155-6°, 83; PrS, Me2N, 165-7°, 94; iso-PrS, Me2N, 186-7°, 90. The 4-aminopyrimidines and p-MeCONHC6H4SO2Cl in C5H5N (1 mL./g. chloride) at room temperature 12 h. were diluted with H2O and the crude products (V) (R2 = Ac) hydrolyzed in 10 volumes of 10% NaOH at 100° for 1 h. and neutralized with AcOH to give V (R2 = H). V (R2 = Ac) (R, R1, m.p., % yield, crystallization solvent given): Me2N, MeO, 218-20°, 82, MeOH; Me2N, EtO, 220-4°, 74, MeOH; Me2N, PrO, 215-16°, 70, MeOH; Me2N, iso-PrO, 166-7°, 74, MeOH; MeO, Me2N, 251-3°, 69, MeOH; EtO, Me2N, 223-4°, 75, MeOH; PrO, Me2N, 161-2°, 73, MeOH; EtS, Me2N, 226-7°, 81, MeOH-H2O; PrS, Me2N, 203-5°, 75, MeOH-H2O; iso-PrS, Me2N, 180-2°, 86, MeOH-H2O; Cl, Me2N, 261-2°, 70, MeOH; Cl, Et2N, 194-5°, 50, MeOH; Cl, (C3H6)2N, 178-9°, 29, MeOH-H2O; Cl, (CH2)4N, 234-5°, 81, MeOH-H2O; Cl, morpholino, 273-4°, 75, Me2CO; Me2N, H, 296-7°, 72, MeOH; Me2N, Me2N, 210-15° (crude), 32, –; Me2N, MeS, 230-5° (crude), 85, –. V (R2 = H, given as above): Me2N, MeO, 207-8°, 95, MeOH; Me2N, EtO, 228-30°, 87, MeOH-H2O; Me2N, PrO, 182-3°, 92, MeOH-H2O; Me2N, iso-PrO, –, 92, MeOH-H2O; MeO, Me2N, 218-20°, 90, MeOH-H2O; EtO, Me2N, 185-6°, 90, MeOH-H2O; PrO, Me2N, 90-1°, 65, Me2CO-C6H6; EtS, Me2N, 139-40°, 87, MeOH-H2O; PrS, Me2N, 165-7°, 70, MeOH-H2O; iso-PrS, Me2N, 170-1°, 76, MeOH-H2O; Cl, Me2N, 203-4°, 92, Me2CO-H2O; Cl, Et2N, 178-80°, 93, MeOH-H2O; Cl, (C3H5)2N, 170-2°, 98, MeOH-H2O; Cl, (CH2)4N, 234-5°, 84, Me2CO-H2O; Cl, morpholino, 280-2°, 89, Me2CO-H2O; Me2N, H, 276-7°, 64, MeOH; Me2N, Me2N, 221-3°, 56, MeOH; Me2N, MeS, 242-3°, 68, MeOH-H2O. V (R = R2 = H, R1 = Me2N), m. 146-7° (MeOH-H2O), was prepared in 82% yield from V (R = Cl, R1 = Me2N, R2 = H). V (R = MeO, R1 = Et2N, R2 = H), m. 186-8° (MeOH-H2O), was prepared in 85% yield from V (R = Cl, R1 = Et2N, R2 = H). V (R = Cl, R1 = NR3R4, R2 = H) showed good antibacterial properties. After reading the article, we found that the author used 6-Chloro-2-ethoxypyrimidin-4-amine(cas: 3286-56-4Product Details of 3286-56-4)

6-Chloro-2-ethoxypyrimidin-4-amine(cas: 3286-56-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Product Details of 3286-56-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sakamoto, Takao; Ono, Takayasu; Sakasai, Takeji; Yamanaka, Hiroshi published an article on January 31 ,1980. The article was titled 《Studies on pyrimidine derivatives. XV. Homolytic acylation and amidation of simply substituted pyrimidines》, and you may find the article in Chemical & Pharmaceutical Bulletin.COA of Formula: C6H8N2O The information in the text is summarized as follows:

The reaction of 2,6-disubstituted pyrimidines with acyl radicals generated either from pyruvic acid-AgNO3-(NH4)2S2O8 or from aldehyde-FeSO4-Me3COOH in aqueous H2SO4, gave the corresponding 2,6-disubstituted 4-acylpyrimidines. 4,6-Disubstituted pyrimidines gave 2-acetyl- and 2,5-diacetyl-4,6-disubstituted pyrimidines under the same conditions. Homolytic amidation of pyrimidines in which the 2- or 4-positions are free yielded pyrimidine-2- or -4-carboxamides. The experimental process involved the reaction of 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6COA of Formula: C6H8N2O)

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sakamoto, Takao; Satoh, Chisato; Kondo, Yoshinori; Yamanaka, Hiroshi published an article on January 31 ,1993. The article was titled 《Condensed heteroaromatic ring systems. XXI. Synthesis of pyrrolo[2,3-d]pyrimidines and pyrrolo[3,2-d]pyrimidines》, and you may find the article in Chemical & Pharmaceutical Bulletin.Category: pyrimidines The information in the text is summarized as follows:

The title compounds, e.g., I and II were synthesized in high yields by the palladium-catalyzed reaction of 4-acetylamino-5-bromopyrimidines and 5-acetylamino-4-iodopyrimidines with (Z)-1-ethoxy-2-(tributylstannyl)ethene followed by cyclization under acidic conditions.4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Category: pyrimidines) was used in this study.

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2014,O’Brien, Nathan J.; Brzozowski, Martin; Buskes, Melissa J.; Deady, Leslie W.; Abbott, Belinda M. published 《Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors》.Bioorganic & Medicinal Chemistry published the findings.Category: pyrimidines The information in the text is summarized as follows:

3-Phosphoinositide-dependent kinase 1 (PDK1), a biol. target that has attracted a large amount of attention recently, is responsible for the pos. regulation of the PI3K/Akt pathway that is often activated in a large number of human cancers. A series of second-generation 2-anilino-4-substituted-7H-pyrrolopyrimidines were synthesized by installation of various functions at the 4-position of the 7H-pyrrolopyrimidine scaffold. All compounds were screened against the isolated PDK1 enzyme and dose response anal. was obtained on the best compounds of the series.2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Category: pyrimidines) was used in this study.

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2018,Ding, Xiao; Stasi, Luigi Piero; Ho, Ming-Hsun; Zhao, Baowei; Wang, Hailong; Long, Kai; Xu, Qiongfeng; Sang, Yingxia; Sun, Changhui; Hu, Huan; Yu, Haihua; Wan, Zehong; Wang, Lizhen; Edge, Colin; Liu, Qian; Li, Yi; Dong, Kelly; Guan, Xiaoming; Tattersall, F. David; Reith, Alastair D.; Ren, Feng published 《Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.HPLC of Formula: 90213-66-4 The information in the text is summarized as follows:

Inhibition of LRRK2 kinase activity with small mols. has emerged as a potential novel therapeutic treatment for Parkinson’s disease. Herein the authors disclose the discovery of a 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine series as potent LRRK2 inhibitors identified through a kinase-focused set screening. Optimization of the physicochem. properties and kinase selectivity led to the discovery of compound 7 ((4-((4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone), which exhibited potent in vitro inhibition of LRRK2 kinase activity, good physicochem. properties and kinase selectivity across the kinome. Moreover, compound 7 was able to penetrate into the CNS, and in vivo pharmacol. studies revealed significant inhibition of Ser 935 phosphorylation in the brain of both rats (30 and 100 mg/kg) and mice (45 mg/kg) following oral administration. After reading the article, we found that the author used 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4HPLC of Formula: 90213-66-4)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. HPLC of Formula: 90213-66-4They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors》 were Rowlands, Rachel A.; Cato, M. Claire; Waldschmidt, Helen V.; Bouley, Renee A.; Chen, Qiuyan; Avramova, Larisa; Larsen, Scott D.; Tesmer, John J. G.; White, Andrew D.. And the article was published in ACS Medicinal Chemistry Letters in 2019. Application In Synthesis of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine The author mentioned the following in the article:

The ability of G protein-coupled receptor (GPCR) kinases (GRKs) to regulate desensitization of GPCRs has made GRK2 and GRK5 attractive targets for treating heart failure and other diseases such as cancer. Although advances have been made toward developing inhibitors that are selective for GRK2, there have been far fewer reports of GRK5 selective compounds Herein, we describe the development of GRK5 subfamily selective inhibitors, 5 and 16d that covalently interact with a nonconserved cysteine (Cys474) unique to this subfamily. Compounds 5 and 16d feature a highly amenable pyrrolopyrimidine scaffold that affords high nanomolar to low micromolar activity that can be easily modified with Michael acceptors with various reactivities and geometries. Our work thereby establishes a new pathway toward further development of subfamily selective GRK inhibitors and establishes Cys474 as a new and useful covalent handle in GRK5 drug discovery. The results came from multiple reactions, including the reaction of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4Application In Synthesis of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine)

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(cas: 90213-66-4) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Application In Synthesis of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidineThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Toviwek, Borvornwat; Phuangsawai, Oraphan; Konsue, Adchatawut; Hannongbua, Supa; Riley, Jennifer; Mutter, Nicole; Anderson, Mark; Webster, Lauren; Hallyburton, Irene; Read, Kevin D.; Gleeson, M. Paul published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Preparation, biological & cheminformatics-based assessment of N2,N4-diphenylpyrimidine-2,4-diamine as potential Kinase-targeted antimalarials》.Application In Synthesis of 2,4-Dichloropyrimidine The article contains the following contents:

Twenty eight new N2,N4-diphenylpyrimidine-2,4-diamines have been prepared in order to expand our understanding of the anti-malarial SAR of the scaffold. The aim of the study was to make structural modifications to improve the overall potency, selectivity and solubility of the series by varying the anilino groups attached to the 2- and 4-position. We evaluated the activity of the compounds against Plasmodium falciparum (Pf) 3D7, cytotoxicity against HepG2, % inhibition at a panel of 10 human kinases, solubility, permeability and lipophilicity, and human and rat in vitro clearance. 11 was identified as a potent anti-malarial with an IC50 of 0.66 μM at the 3D7 strain and a selectivity (SI) of ∼ 40 in terms of cytotoxicity against the HepG2 cell line. It also displayed low exptl. logD7.4 (2.27), reasonable solubility (124 μg/mL), good metabolic stability, but low permeability. A proteo-chemometric workflow was employed to identify putative Pf targets of the most promising compounds Ligand-based similarity searching of the ChEMBL database led to the identification of most probable human targets. These were then used as input for sequence-based searching of the Pf proteome. Homol. modeling and mol. docking were used to evaluate whether compounds could indeed bind to these targets with valid binding modes. In vitro biol. testing against close human analogs of these targets was subsequently undertaken. This allowed us to identify potential Pf targets and human anti-targets that could be exploited in future development. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dichloropyrimidine(cas: 3934-20-1Application In Synthesis of 2,4-Dichloropyrimidine)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Application In Synthesis of 2,4-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sharma, Lalit Kumar; Yun, Mi Kyung; Subramanian, Chitra; Tangallapally, Rajendra; Jackowski, Suzanne; Rock, Charles O.; White, Stephen W.; Lee, Richard E. published an article in 2021. The article was titled 《LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators》, and you may find the article in Bioorganic & Medicinal Chemistry.Category: pyrimidines The information in the text is summarized as follows:

Pantothenate kinase (PANK) is the critical regulator of intracellular levels of CoA and has emerged as an attractive target for treating neurol. and metabolic disorders. This report describes the optimization, synthesis, and full structure-activity relationships of a new chem. series of pantothenate competitive PANK inhibitors. Potent drug-like mols. were obtained by optimizing a high throughput screening hit, using lipophilic ligand efficiency (LipE) derived from human PANK3 IC50 values to guide ligand development. X-ray crystal structures of PANK3 with index inhibitors from the optimization were determined to rationalize the emerging structure activity relationships. The anal. revealed a key bidentate hydrogen bonding interaction between pyridazine and R306′ as a major contributor to the LipE gain observed in the optimization. A tractable series of PANK3 modulators with nanomolar potency, excellent LipE values, desirable physicochem. properties, and a well-defined structural binding mode was produced from this study. The experimental process involved the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Category: pyrimidines)

2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 4,6-DichloropyrimidineIn 2020 ,《Ruthenium, rhodium and iridium complexes containing pyrimidine based thienyl pyrazoles: Synthesis and antibacterial studies》 was published in Journal of Organometallic Chemistry. The article was written by Lapasam, Agreeda; Mawnai, Ibaniewkor L.; Banothu, Venkanna; Kaminsky, Werner; Kollipara, Mohan Rao. The article contains the following contents:

The reaction of pyrimidine based electron-rich heterocyclic thiophene pyrazoles and halide bridged arene d6 metal precursors yielded a series of mononuclear and dinuclear half sandwich d6 metal complexes. Mononuclear and dinuclear complexes formed by the ratio-based reaction between ligand and metal precursor. All these cationic complexes have been characterized by IR, UV-Vis, 1H NMR, 13C NMR spectroscopic techniques. Complex 5 has been established by single-crystal anal. X-ray diffraction studies revealed the formation of mononuclear and dinuclear complexes and suggest that the vicinity around the metal atom is distorted octahedral. An in vitro study to screen the antibacterial potential of these complexes against pathogenic bacteria, S. aureus, K. pneumoniae, and E. coli was addressed. All the complexes display a better zone of inhibitions for both Gram-pos. (S. aureus) and Gram-neg. strains (K. pneumoniae, and E. coli). The min. inhibitory concentrations (MICs) for the most active complex ranged from 0.125 to 0.25 mg/mL for S. aureus and Klebsiella Pneumoniae and 0.25-0.5 mg/mL for E. coli. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Quality Control of 4,6-Dichloropyrimidine)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Quality Control of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia