Pyrimidines

Solution-phase parallel synthesis using ion-exchange resins was written by Suto, Mark J.;Gayo-Fung, Leah M.;Palanki, Moorthy S. S.;Sullivan, Robert. And the article was included in Tetrahedron in 1998.Recommanded Product: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate This article mentions the following:

Ion-exchange resins are useful as scavengers in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins to facilitate the formation of products and to remove reaction byproducts. Acidic ion-exchange resins have been used as selective amine scavengers in the synthesis of urea and amine libraries. Several compound libraries have been prepared using the basic ion-exchange resin Amberlyst 21 as part of our lead optimization program. The utility of ion-exchange resins as a means of generating both large and small focused libraries is reviewed. In the experiment, the researchers used many compounds, for example, Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6Recommanded Product: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate).

Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (cas: 187035-79-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Molybdenum disulfide (MoS₂): A novel activator of peracetic acid for the degradation of sulfonamide antibiotics was written by Wang, Jingwen;Wang, Zongping;Cheng, Yujie;Cao, Lisan;Bai, Fan;Yue, Siyang;Xie, Pengchao;Ma, Jun. And the article was included in Water Research in 2021.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Sulfonamide antibiotics (SAs) are typical antibiotics and have attracted increasing concerns about their wide occurrence in environment as well as potential risk for human health. In this study, we applied a novel advanced oxidation process in SAs degradation by combining molybdenum sulfide and peracetic acid (MoS₂/PAA). Reactive oxygen species (ROS) including HO•, CH₃C(O)O•, CH₃C(O)OO•, and ¹O₂ were generated from PAA by MoS₂ activation and contributed to SAs degradation The effects of initial pH, the dosages of PAA and MoS₂, and humic acid for SAs degradation were further evaluated by selecting sulfamethoxazole (SMX) as a target SA in the MoS₂/PAA process. Results suggested that the optimum pH for SMX removal was 3, where the degradation efficiency of SMX was higher than 80% after reaction for 15 min. Increasing PAA (0.075-0.45 mM) or MoS₂ (0.1-0.4 g/L) dosages facilitated the SMX degradation, while the presence of humic acids retarded the SMX removal. This MoS2/PAA process also showed good efficiencies in removing other SAs including sulfaguanidine, sulfamonomethoxine and sulfamerazine. Their possible degradation pathways were proposed based on the products identification and DFT calculation, showing that apart from the oxidation of amine groups to nitro groups in SAs, MoS₂/PAA induced SO₂ extrusion reaction for SAs that contained six-membered heterocyclic moieties. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate was written by Wang, Jiawang;Zhao, Jianhong;Gong, Hegui. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Related Products of 257280-25-4 This article mentions the following:

This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with Me tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4Related Products of 257280-25-4).

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 257280-25-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chemotherapy. XII. Some sulfanilamido heterocycles was written by Clark, J. H.;English, J. P.;Winnek, P. S.;Marson, H. W.;Cole, Q. P.;Clapp, J. W.. And the article was included in Journal of the American Chemical Society in 1946.Reference of 40230-24-8 This article mentions the following:

2-Sulfanilamido-4-methoxypyrimidine (I) (C.A. 36, 2532.9) (40 g.) in 400 cc. MeOH and 200 g. NH₃, heated at 110° for 1 h., gives 57% of 2-sulfanilamido-4-aminopyrimidine, m. 225-6° (m.ps. corrected) (C.A. 37, 1402.2). 2-Amino-4-methoxypyrimidine did not react with NH₃ under these conditions; at 200° for 4 h., 2,4-diaminopyrimidine is formed. I (8 g.) and 3.8 g. Et₂N(CH₂)₃NH₂, heated at 100-10° for 45 min., give 45% of 2-sulfanilamido-4-(3-diethylaminopropylamino)pyrimidine, m. 230-2°. Guanidine carbonate (II) (18 g.) and EtOCH₂COCH₂Ac, heated 4 h. on the steam bath, give 69% of 2-amino-4-ethoxymethyl-6-methylpyrimidine, m. 106-8°; the 2-sulfanilamido compound, m. 158-60°, 40%. II (25 g.) and 46.4 g. CH₂Bz₂, heated 3 h. at 180-210°, give 39% of 2-amino-4,6-diphenylpyrimidine, m. 135-7°; 2-sulfanilamido compound, m. 266-8°. The Na salt of 2,2-dimethyl-1,3-dioxolane-4-methanol in 200 cc. dioxane and 20 g. 2-amino-4-chloropyrimidine (extracted with the dioxane in a Soxhlet apparatus by refluxing overnight) give 70% of 2-amino-4-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)pyrimidine, m. 105°; this yields 51% of the N⁴-Ac derivative, m. 249-51°, of the 2-sulfanilamido compound, m. 228-30°. II (50 g.), 43.2 g. of the Cu salt of 4,4-dimethyl-1,3-pentanedione, and 100 cc. EtOH, refluxed 1 h., the residue heated with stirring at 150-70° for 2 h., the cooled mass broken up under 500 cc. 1:4 HCl, the filtrate made basic with NH₄OH, and the precipitate refluxed with hexane, give 44% of 2-amino-4-tert-butylpyrimidine, m. 103-5.5°; the free ketone gives only 18%; 2-sulfanilamido compound, m. 236-7°, 45%; the N⁴-Ac derivative m. 248-51°, 63%. 2-Aminopyrimidine gives 50% of the N⁴-Ac derivative, m. 268°, of 2-(2-methylsulfanilamido)pyrimidine, m. 243-6°. II (10.6 g.) and 13.5 g. 3-methyl-2,4-pentanedione, heated at 150-60° for 1.5 h., give 65% of 2-amino-4,5,6-trimethylpyrimidine, m. 206-7°; 2-sulfanilamido compound, m. 242-4° (N⁴-Ac derivative, m. 286-8°). 2-Aminothiazole (100 g.), added to 200 cc. 20% oleum with cooling during 1 h., heated on a steam bath for 2 h., and poured into 450 cc. H₂O, give 69% of 2-amino-5(or 4)-thiazolesulfonic acid, m. 248° (analyzed as the Ba salt); 2-sulfanilamido comp., m. 258°. 2-Amino-4-methyl-5-thiazolesulfonic acid did not react with 4-AcNHC₆H₄SO₂Cl. H₂NNHCONH₂ (4.6 g.) and 12.7 g. EtO₂CCH₂COCl, heated at 60-70° for 30 min., give 37% of Et 2-amino-1,3,4-thiadiazole-5-acetate, m. 158-60°; coupling and hydrolysis give 2-sulfanilamido-1,3,4-thiadiazole-5-acetic acid, m. 209-12°. Et 2-amino-1,3,4-thiadiazole-5-butyrate, m. 153-4° (41%), yields 2-sulfanilamido-1,3,4-thiadiazole-5-butyric acid, m. 185.5-6.5°. Data are given for the maximum blood level (mg.-% following a single oral dose of 0.5 g. per kg.), bacteriostatic, and antimalarial activities. Only the tri-Me derivative approaches the activity of sulfadiazine in the bacteriostatic test; the extremely low relative activities of the others serve to point out that other factors in addition to the acidity of the compounds in question are important. Simple alkyl substitution of the pyrimidine ring or of the sulfanilamide nucleus does not markedly affect the maximum blood level as compared with sulfadiazine; more complicated substituents reduce this value somewhat; the value is still further reduced by amino substitution; the sulfonic acid group reduces the maximum blood level of sulfathiazole. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Reference of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Reference of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Direct Formic Acid Mediated Z-Selective Reductive Coupling of Dienes and Aldehydes was written by Cooze, Christopher;Dada, Raphael;Lundgren, Rylan J.. And the article was included in Angewandte Chemie, International Edition in 2019.Safety of 2-Methoxypyrimidine-5-carbaldehyde This article mentions the following:

Demonstrated was that formic acid mediated the Rh-catalyzed, Z-selective coupling of dienes and aldehydes. The processed was distinguished by broad tolerance towards reducible or electrophilic groups. Kinetic anal. suggested that generation of the catalytically active Rh intermediate by ligand dissociation was the rate-determining step. The rapid generation and trapping of Rh-allyl intermediates was key to preventing chain-walking isomerization events that plague related protocols. Insights gained through this study may have wider implications in selective metal-catalyzed hydrofunctionalization reactions. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Safety of 2-Methoxypyrimidine-5-carbaldehyde).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Safety of 2-Methoxypyrimidine-5-carbaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Development and validation of a multiclass confirmatory method for the determination of over 60 antibiotics in eggs using liquid-chromatography high-resolution mass spectrometry was written by Paoletti, Fabiola;Sdogati, Stefano;Barola, Carolina;Giusepponi, Danilo;Moretti, Simone;Galarini, Roberta. And the article was included in Food Control in 2021.Category: pyrimidines This article mentions the following:

A multiclass method for the determination of antimicrobial substances in eggs has been developed and validated, covering sixty-three antibiotics belonging to ten families. After extraction with acidified acetonitrile and EDTA, the analytes were injected into a liquid-chromatog. high-resolution mass-spectrometry system operating in pos. ionization mode. The procedure was successfully validated as confirmatory method evaluating selectivity, linearity, precision, recovery, decision limit, detection capability, limits of detection and quantitation. The here developed is the first method including all the antibiotics with Maximum Residue Limit (MRL) in eggs, except very polar drugs (aminoglycosides and colistins), which require specific protocols. Finally, a wide survey was carried out analyzing 100 com. eggs samples from local markets. Only 3% contained residues of authorized substances at concentrations ower than the relevant MRLs. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Category: pyrimidines).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Rapid and ultra-trace levels analysis of 33 antibiotics in water by on-line solid-phase extraction with ultra-performance liquid chromatography-tandem mass spectrometry was written by Shen, Fei;Xu, Yan-Juan;Wang, Ye;Chen, Jing;Wang, Shuo. And the article was included in Journal of Chromatography A in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

A method was developed for the determination of 33 antibiotics belonging to 4 different antibiotic groups, including sulfonamides (16), fluoroquinolones (12), macrolides (1), and tetracyclines (4) in water samples using online solid-phase extraction-ultra performance liquid chromatog.-electrospray ionization tandem mass spectrometry (online SPE-UPLC-MS/MS). The enrichment and anal. conditions were optimized for the determination of trace concentrations (nanogram per L). Aliquots of the water samples (5 mL) were filtered through a membrane and enriched on an online polymeric column with hydrophilic-lipophilic balance (HLB). The analyte was eluted by the mobile phase during online SPE and separated on an Acquity BEH130 column, detected by tandem mass spectrometry, and quantified using an external standard method. The optimization of the anal. methods was discussed, which included optimization of pH of the sample, filtration membrane, Na2EDTA, chromatog. column, formic acid and aqueous ammonia in mobile phase. The detection limit for all test compounds by this method was in the range of 0.2-1.5 ng/L, with recoveries of 76.6-118%. The precision of the method, as indicated by the relative standard deviation, was 2.4-7.9%. Results of anal. of surface water samples demonstrated the ability of the proposed method to analyze ultra-trace levels of antibiotics, without the need for complex manual pretreatment. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling was written by Hofstra, Julie L.;Cherney, Alan H.;Ordner, Ciara M.;Reisman, Sarah E.. And the article was included in Journal of the American Chemical Society in 2018.Safety of 2-Methoxypyrimidine-5-carbaldehyde This article mentions the following:

An asym. Ni-catalyzed reductive cross-coupling has been developed to prepare enantioenriched allylic silanes. This enantioselective reductive alkenylation proceeds under mild conditions and exhibits good functional group tolerance. The chiral allylic silanes prepared here undergo a variety of stereospecific transformations, including intramol. Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Safety of 2-Methoxypyrimidine-5-carbaldehyde).

2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Safety of 2-Methoxypyrimidine-5-carbaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2-Aminopyrimidines with Selectfluor was written by Wang, Chenxi;Cai, Juewang;Zhang, Min;Zhao, Xiaoming. And the article was included in Journal of Organic Chemistry in 2017.COA of Formula: C16H13N3 This article mentions the following:

In the presence of Ag₂CO₃, arylpyrimidinamines I (R = Ph, 4-MeC₆H₄, 4-FC₆H₄; R¹ = PhCH₂, 4-MeC₆H₄CH₂, 4-FC₆H₄CH₂; R = R¹ = Ph, 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 3-ClC₆H₄, 4-MeC₆H₄, 2-thienyl; R² = H) underwent regioselective fluorination with Selectfluor® in MeCN to yield 5-fluoro-2-pyrimidinamines I (R = Ph, 4-MeC₆H₄, 4-FC₆H₄; R¹ = PhCH₂, 4-MeC₆H₄CH₂, 4-FC₆H₄CH₂; R = R¹ = Ph, 4-FC₆H₄,4-ClC₆H₄, 4-BrC₆H₄, 3-ClC₆H₄, 4-MeC₆H₄, 2-thienyl; R² = F) in 44-72% yields. The structures of I (R = Ph; R¹ = PhCH₂; R² = F), I (R = R¹ = 2-thienyl; R² = F), and of the tetrasilver perchlorate complex of I (R = R¹ = Ph; R² = H) with Ph₂PCH₂PPh₂ were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Conversion of 2,4,6-triphenylpyrylium perchlorate to a pyrimidine series compound was written by Zhdanova, M. P.;Zvezdina, E. A.;Dorofeenko, G. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.Name: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Pyrimidinylpyridinium perchlorate (I) was prepared in 63% yield by boiling pyrylium perchlorate (II) with guanidine 20 min in absolute DMF. Treatment of II with 2-amino-4,6-diphenylpyrimidine gave 94% I which confirmed its structure. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Name: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Name: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia