Pyrimidines

On January 31, 2017, Zimin, Yu. S.; Borisova, N. S.; Timerbaeva, G. R.; Gimadieva, A. R.; Mustafin, A. G. published an article.Synthetic Route of 626-48-2 The title of the article was Preparation, Toxicity, and Anti-Inflammatory Activity of Complexes of Uracil Derivatives with Polyfunctional Acids. And the article contained the following:

Uracil derivatives (6-methyluracil, 5-hydroxy-6-methyluracil) and polyfunctional acids (citrus pectin, oxidized fraction of citrus pectin, and 5-aminosalicylic acid) were shown to form rather stable 1:1 complexes, i.e., one uracil mol. for each carboxylic acid of the polyfunctional acid. Synthetic methods for these complexes were developed based on the results. Their toxicity and anti-inflammatory activity were studied. It was established that complexes of 6-methyluracil with the oxidized fraction of citrus pectin and of 5-hydroxy-6-methyluracil with 5-aminosalicylic acid possessed low toxicity and high anti-inflammatory activity. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to uracil derivative complexation toxicity antiinflammatory, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 5, 2021, Saulnier, Mark George; Chen, Jesse Jingyang; Karra, Srinivasa; Sprott, Kevin Tyler; Wiles, Jason Allan; Ray, Soumya published a patent.SDS of cas: 785777-98-2 The title of the patent was ASGPR-binding compounds for the degradation of extracellular proteins. And the patent contained the following:

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).SDS of cas: 785777-98-2

The Article related to asgpr ligand preparation extracellular protein degradation disease therapy, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.SDS of cas: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Bohacova, Sona; Ludvikova, Lucie; Postova Slavetinska, Lenka; Vanikova, Zuzana; Klan, Petr; Hocek, Michal published an article in 2018, the title of the article was Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photo-cleavable groups as building blocks for polymerase synthesis of photo-caged DNA.Name: 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Nucleosides, nucleotides and 2′-deoxyribonucleoside triphosphates (dNTPs) containing 5-(hydroxymethyl)uracil protected with photo-cleavable groups (2-nitrobenzyl-, 6-nitropiperonyl or 9-anthrylmethyl) were prepared and tested as building blocks for the polymerase synthesis of photo-caged oligonucleotides and DNA. Photo-deprotection (photo-release) reactions were studied in detail on model nucleoside monophosphates and their photoreaction quantum yields were determined Photo-caged dNTPs were then tested and used as substrates for DNA polymerases in primer extension or PCR. DNA probes containing photo-caged or free 5-hydroxymethyluracil in the recognition sequence of restriction endonucleases were prepared and used for the study of photo-release of caged DNA by UV or visible light at different wavelengths. The nitropiperonyl-protected nucleotide was found to be a superior building block because the corresponding dNTP is a good substrate for DNA polymerases, and the protecting group is efficiently cleavable by irradiation by UV or visible light (up to 425 nm). The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Name: 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

The Article related to hydroxymethyluracil nucleotide preparation photocleavable polymerase photocaged dna, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.Name: 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Qiu, Yan; Zhang, Yang; Li, Yuhang; Ren, Jie published an article in 2016, the title of the article was Discovery of uracil derivatives as potent inhibitors of fatty acid amide hydrolase.Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biol. degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties. In the present study, a conjugated 2,4-dioxo-pyrimidine-1-carboxamide scaffold was confirmed as a novel template for FAAH inhibitors, based on which, a series of analogs had been prepared for an initial structure-activity relationship (SAR) study. Most of the synthesized compounds displayed moderate to significant FAAH inhibitory potency. Among them, compounds 11 and 14 showed better activity than others, with IC50 values of 21 and 53 nM. SAR anal. indicated that 2,4-dioxopyrimidine-1-carboxamides represented a novel class of potent inhibitors of FAAH, and substitution at the uracil ring or replacement of the N-terminal group might favor the inhibitory potency. Selected compounds of this class may be used as useful parent mols. for further investigation. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to fatty acid amide hydrolase uracil ethanolamide, faah inhibitor, amidation, fatty acid amide hydrolase (faah), uracil derivatives, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 31, 2017, Zhang, Ben-Hou; Kong, Jing-Jing; Huang, Yang; Lou, Yue-Guang; Li, Xiao-Fei; He, Chun-Yang published an article.HPLC of Formula: 626-48-2 The title of the article was Benign perfluoroalkylation of uracils and uracil nucleosides via visible light-induced photoredox catalysis. And the article contained the following:

In this work, an efficient and facile method for the preparation of 5-perfluoroalkylation uracils and uracil nucleosides through visible-light-mediated reaction has been developed. The reaction processes in high efficiency under mild reaction conditions and show broad substrate scope by employing com. available perfluoroalkyl sources, thus demonstrates high potent application in life and medicinal science. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to perfluoroalkyled uracil nucleoside visible light photoredox synthesis, perfluoroalkylation uracil nucleoside visible light photoredox, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 2020, Sharipova, R. R.; Saifina, L. F.; Belenok, M. G.; Semenov, V. E.; Kataev, V. E. published an article.HPLC of Formula: 626-48-2 The title of the article was First Analog of Pyrimidine Nucleosides with Two D-Ribofuranose Residues. And the article contained the following:

The reaction of 1,3-bis(pent-4-yn-1-yl)-6-methyluracil with 2,3,5-tri-O-acetyl-β-D-ribofuranosyl azide gave 1,3-bis{3-[1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,3-triazol-4-yl]propyl}-6-methyluracil which was deprotected by treatment with a solution of sodium methoxide in methanol to obtain 1,3-bis{3-[1-(β-D-ribofuranosyl)-1H-1,2,3-triazol-4-yl]propyl}-6-methyluracil as a first analog of pyrimidine nucleosides containing two D-ribofuranose fragments. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to click alkyne azide triazole cycloaddition catalyst preparation, pyrimidine nucleoside preparation ribofuranose pentynylmethyluracil ribofuranosyl azide, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 21, 2019, Andreeva, Olga V.; Belenok, Maya G.; Saifina, Liliya F.; Shulaeva, Marina M.; Dobrynin, Alexey B.; Sharipova, Radmila R.; Voloshina, Alexandra D.; Saifina, Alina F.; Gubaidullin, Aidar T.; Khairutdinov, Bulat I.; Zuev, Yuriy F.; Semenov, Vyacheslav E.; Kataev, Vladimir E. published an article.HPLC of Formula: 626-48-2 The title of the article was Synthesis of novel 1,2,3-triazolyl nucleoside analogs bearing uracil, 6-methyluracil, 3,6-dimethyluracil, thymine, and quinazoline-2,4-dione moieties. And the article contained the following:

A series of novel 1,2,3-triazolyl nucleoside analogs was synthesized via the CuAAC reaction of N1-alkynyl uracil, 6-methyluracil, 3,6-di-Me uracil, thymine and quinazolin-2,4-dione with protected azido β-D-ribofuranose. The obtained compounds differ in both the nature of the pyrimidine-2,4-dione fragment and the length of the polymethylene linker connecting it with the β-D-ribofuranosyl-1,2,3-triazol-4-yl moiety. The 1,2,3-triazolyl nucleoside analogs were evaluated for their cytotoxicity in vitro. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to quinazolinedione nucleoside analog preparation human angiogenic crystal structure, click alkyne azide triazole cycloaddition catalyst preparation nucleoside analog, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 6, 2016, Jones, Alison; Kemp, Mark; Stockley, Martin; Gibson, Karl; Whitlock, Gavin published a patent.Category: pyrimidines The title of the patent was 1-Cyanopyrrolidine compounds as USP30 inhibitors and their preparation. And the patent contained the following:

The invention relates to compounds of formula I and method for the manufacture of inhibitors of deubiquitylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of formula I wherein Z is absent and CR6R7; Y is a bond, C0-3 alkylene-NR11-C0-3 alkylene and (un)substituted C1-3 alkylene; R1, R6, R7 and R8 are independently H, F, CN, OH, (un)substituted C1-3 alkyl and (un)substituted C1-3 alkoxy; R2 is H, (un)substituted C1-6 alkyl, (un)substituted C1-6 alkoxy, (un)substituted 4- to 10-membered heteroaryl, etc.; R3, R4 and R5 are independently (un)substituted alkyl and (un)substituted C1-3 alkoxy; R9 is H, CN, OH, (un)substituted C1-6 alkyl, etc.; R10 is H, (un)substituted C1-6 alkyl; R11 is H, (un)substituted C1-6 alkyl, 4- to 10-membered heteroaryl, heterocyclyl, aryl, etc.; R9R10 can be taken together to form (un)substituted heterocyclic ring; R10R11 can be taken together to form (un)substituted (mono/bi)cyclic ring; R12 is (un)substituted (mono/bi/tri)cyclic 3- to 14-membered heteroaryl, heterocyclyl, cycloalkyl and aryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amidation of 5-phenylpyridine-2-carboxylic acid with (R)-3-amino-1-(tert-butoxycarbonyl)pyrrolidine; the resulting tert-Bu (R)-3-(5-phenylpicolinamido)pyrrolidine-1-carboxylate underwent hydrolysis to give (R)-5-phenyl-N-(pyrrolidin-3-yl)picolinamide TFA, which underwent cyanation to give compound II. The invention compounds were evaluated for their USP30 inhibitory activity (data given). The experimental process involved the reaction of 5-Phenylpyrimidine-2-carboxylic acid(cas: 85386-20-5).Category: pyrimidines

The Article related to cyanopyrrolidine preparation usp30 inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 26, 2014, Teimoory, Faranak; Loppnow, Glen R. published an article.Category: pyrimidines The title of the article was Initial Excited-State Structural Dynamics of 6-Substituted Uracil Derivatives: Femtosecond Angle and Bond Lengthening Dynamics in Pyrimidine Nucleobase Photochemistry. And the article contained the following:

Substituents on the pyrimidine ring of nucleobases appear to play a major role in determining their initial excited-state structural dynamics and resulting photochem. To better understand the determinants of nucleobase initial excited-state structural dynamics, we have measured the absorption and resonance Raman excitation profiles of 6-deuterouracil (6-d-U) and 6-methyluracil (6-MeU). Simulation of the resonance Raman excitation profiles and absorption spectrum with a self-consistent, time-dependent formalism shows the effect of the deuterium and Me group on the photochem. active internal coordinates, i.e. C5C6 stretch and C5X and C6X bends. The Me group on either the C5 or C6 position of uracil equally increases the excited-state reorganization energies along the C5C6 stretch. However, a lower reorganization energy of the C5X + C6X bends in 6-MeU than uracil and 5-MeU shows that C6 Me substituents reduce the bending reorganization energy. In addition, deuterium substitution at either C5 or C6 has a much smaller effect on the initial excited-state structural dynamics than Me substitution, consistent with a mass effect. These results will be discussed in light of the resulting photochem. of pyrimidine nucleobases. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Category: pyrimidines

The Article related to excited state structure dynamic uracil angle bond dft b3lyp, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Abdelaziz, A.; Zaitsau, D. H.; Buzyurov, A. V.; Verevkin, S. P.; Schick, C. published an article in 2020, the title of the article was Sublimation thermodynamics of nucleobases derived from fast scanning calorimetry.Name: 5-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

The five fundamental units of the genetic code: uracil (U), thymine (T), cytosine (C), adenine (A) and guanine (G) are known for extremely low vapor pressure and low thermal stability at elevated temperatures Therefore, application of conventional techniques for the determination of sublimation enthalpies and vapor pressures fails to provide accurate results. Recently, a Fast Scanning Calorimetry method (FSC) for vapor pressure determination was developed for investigation of extremely low volatile, as well as for thermally unstable mol. and ionic mols. This success has encouraged application of the FSC method for determination of vapor pressures and sublimation enthalpies of the five nucleobases, where available literature data are in disarray. The thermodn. data of the nucleobases available in the literature were collected, evaluated, and combined with our exptl. results to reconcile available exptl. data. The set of evaluated thermochem. data on the five nucleobases was recommended as the benchmark properties for these thermally labile compounds The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Name: 5-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to nucleic acid base sublimation enthalpy vapor pressure heat capacity, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Name: 5-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia