Pyrimidines

On May 2, 2012, Guo, Yufan; Wang, Jiawei; Yang, Jing; Zhang, Ning; Zhang, Fengjun published a patent.Computed Properties of 23256-42-0 The title of the patent was Compound oral solution for treating mixed infection caused by Escherichia coli of poultry. And the patent contained the following:

The title oral solution is composed of distilled liquid from Houttuynia cordata 15-25L, amikacin sulfate 0.5-1, gentamycin sulfate 0.5-1, trimethoprim lactate 0.05-0.2, nicotinamide 3-8, dexamethasone sodium phosphate 0.01-0.05, sodium bisulfite 0.1-0.3kg, lactose 0.1-0.5L and water balance. The invented oral solution has good effects of anti-virus and anti-bacteria, and can resolve the continuous fever caused by infection of Escherichia coli. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0

The Article related to compound oral solution infection escherichia poultry, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Computed Properties of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adarve Garcia, E.; Escario, J.; Martinez Fernandez, A. R. published an article in 1982, the title of the article was Antitoxoplasmic effect of Lactotrim, sulfamethoxazole, and robenidine.Recommanded Product: 23256-42-0 And the article contains the following content:

The i.p. ED50 of Lactotrim (I) [23256-42-0] in mice infected with Toxoplasma gondii was 11 mg/kg. I.p. treatment with sulfamethoxazole (II) [723-46-6] (4-128 mg/kg) (alone was ineffective against the infection. Combined treatment with I and II (1:5; by weight) appeared synergistic, the ED50 being 8 mg/kg. robenidine  [25875-51-8] Alone had an i.p. ED50 of 55 mg/kg; its 50% combination with I had an ED50 of 20 mg/kg. A combination of the 3 drugs (50% robenidine and 50% of the 1:5 mixture of I and II) had an ED50 of 18 mg/kg. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 23256-42-0

The Article related to antitoxoplasmic lactotrim sulfamethoxazole robenidine, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 11, 2012, Xu, Kefu published a patent.HPLC of Formula: 23256-42-0 The title of the patent was Veterinary drug composition for treating enterovirus syndrome of poultry and preparation method thereof. And the patent contained the following:

Veterinary drug composition for treating enterovirus syndrome of poultry and preparation method thereof are provided. The composition is composed of sulfaquinoxaline sodium 5-20, ciprofloxacin hydrochloride 5-15, trimethoprim lactate 1-4, vitamin K3 1-5, NaHCO3 5-20% and addnl. anhydrous glucose. The composition is prepared by pulverizing and sieving the materials resp., mixing according to proportion, then stirring uniformly. Sulfaquinoxaline sodium has strong therapic effect for Eimeria tenella combined with trimethoprim lactate to realize synergism to enhance greatly anti-coccidia ability, ciprofloxacin hydrochloride has strong effect of treating bacterial infection in enterovirus syndrome, so that cause of enterovirus syndrome can be aimingly treated. Vitamin K3 can control the adverse side effect of intestinal tract bleeding caused by enterovirus syndrome, and sodium hydrogen carbonate can reduce the kidney injury to poultry caused by sulfaquinoxaline sodium. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).HPLC of Formula: 23256-42-0

The Article related to poultry enterovirus syndrome veterinary drug preparation, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.HPLC of Formula: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 2, 2014, Liu, Yuanyuan; Hao, Zhihui; Wang, Yanling published a patent.Name: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Soluble powder for treatment of chicken coccidiosis and manufacture method thereof. And the patent contained the following:

The present invention provides soluble powder for treatment of chicken coccidiosis and manufacture method thereof. The drug is oral taken, contains sulfamethazine, trimethoprim lactate, lincomycin hydrochloride, and anhydrous glucose, can be used for treating chicken coccidiosis. The formulation can be blended or dissolved in water for applying. The powder soluble has low cost, good effect, suitable for industrial production The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Name: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to soluble powder chicken coccidiosis sulfamethazine lincomycin, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Name: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 16, 2011, Xu, Kefu published a patent.Computed Properties of 23256-42-0 The title of the patent was Sulfamonomethoxine sodium and ampicillin sodium-containing medical composition for treating swine infectious atrophic rhinitis and its preparation method. And the patent contained the following:

The title medical composition is prepared from (by weight%) sulfamonomethoxine sodium 5-15, trimethoprim lactate 1-3, ampicillin sodium 3-8, sodium carbonate 5, sodium bicarbonate 5-15 and addnl. anhydrous glucose, and prepared by mixing above raw materials according to the formula. Sulfamonomethoxine sodium and ampicillin sodium as antigen components can effectively kill pathogenic microorganism and reduce drug resistance occurrence, and are effective for secondary infection, trimethoprim lactate has synergistic action on sulfamonomethoxine sodium and ampicillin sodium, sodium carbonate has solubilizing action on sulfamonomethoxine sodium and ampicillin sodium, and sodium bicarbonate alleviates side effect of sulfamonomethoxine sodium and prevents crystalluria occurrence. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0

The Article related to sulfamonomethoxine ampicillin swine infectious atrophic rhinitis, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Computed Properties of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 30, 2016, Choofong, Surakarn; Cloutier, Pierre; Sanche, Leon; Wagner, J. Richard published an article.SDS of cas: 4433-40-3 The title of the article was Base release and modification in solid-phase DNA exposed to low-energy electrons. And the article contained the following:

Ionization generates a large number of secondary low-energy electrons (LEEs) with a most probable energy of approx. 10 eV, which can break DNA bonds by dissociative electron attachment (DEA) and lead to DNA damage. In this study, we investigated radiation damage to dry DNA induced by X rays (1.5 keV) alone on a glass substrate or X rays combined with extra LEEs (average energy of 5.8 eV) emitted from a tantalum (Ta) substrate under an atm. of N2 and standard ambient conditions of temperature and pressure. The targets included calf-thymus DNA and double-stranded synthetic oligonucleotides. We developed anal. methods to measure the release of non-modified DNA bases from DNA and the formation of several base modifications by LC-MS/MS with isotopic dilution for precise quantification. The results show that the yield of non-modified bases as well as base modifications increase by 20-30% when DNA is deposited on a Ta substrate compared to that on a glass substrate. The order of base release (Gua > Ade > Thy ∼ Cyt) agrees well with several theor. studies indicating that Gua is the most susceptible site toward sugar-phosphate cleavage. The formation of DNA damage by LEEs is explained by DEA leading to the release of non-modified bases involving the initial cleavage of N1-C1′, C3′-O3′ or C5′-O5′ bonds. The yield of base modifications was lower than the release of non-modified bases. The main LEE-induced base modifications include 5,6-dihydrothymine (5,6-dHT), 5,6-dihydrouracil (5-dHU), 5-hydroxymethyluracil (5-HmU) and 5-formyluracil (5-ForU). The formation of base modifications by LEEs can be explained by DEA and cleavage of the C-H bond of the Me group of Thy (giving 5-HmU and 5-ForU) and by secondary reactions of H atoms and hydride anions that are generated by primary LEE reactions followed by subsequent reaction with Cyt and Thy (giving 5,6-dHU and 5,6-dHT). The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).SDS of cas: 4433-40-3

The Article related to ionizing radiation low energy electron base release modification dna, Radiation Biochemistry: Effects On Biochemical Substances and other aspects.SDS of cas: 4433-40-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 5, 2020, Piccinni, Viviana; Reiter, Sebastian; Keefer, Daniel; de Vivie-Riedle, Regina published an article.Synthetic Route of 65-71-4 The title of the article was Multiscale Conformational Sampling Reveals Excited-State Locality in DNA Self-Repair Mechanism. And the article contained the following:

UV irradiation is known to be responsible for DNA damage. However, exptl. studies in DNA oligonucleotides have shown that UV light can also induce sequence-specific self-repair. Following charge transfer from a guanine adenine sequence adjacent to a cyclobutane pyrimidine dimer (CPD), the covalent bond between the two thymines could be cleaved, recovering the intact base sequence. Mechanistic details promoting the self-repair remained unclear, however. In our theor. study, we investigated whether optical excitation could directly lead to a charge-transfer state, thereby initiating the repair, or whether the initial excited state remains localized on a single nucleobase. We performed conformational sampling of 200 geometries of the damaged DNA double strand solvated in water and used a hybrid quantum and mol. mechanics approach to compute excited states at the complete active space perturbation level of theory. Anal. of the conformational data set clearly revealed that the excited-state properties are uniformly distributed across the fluctuations of the nucleotide in its natural environment. From the electronic wavefunction, we learned that the electronic transitions remained predominantly local on either adenine or guanine, and no direct charge transfer occurred in the exptl. accessed energy range. The investigated base sequence is not only specific to the CPD repair mechanism but ubiquitously occurs in nucleic acids. Our results therefore give a very general insight into the charge locality of UV-excited DNA, a property that is regarded to have determining relevance in the structural consequences following absorption of UV photons. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Synthetic Route of 65-71-4

The Article related to dna cyclobutane pyrimidine dimer repair excited state uv photoexcitation, Radiation Biochemistry: Effects On Biochemical Substances and other aspects.Synthetic Route of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2021, Rozalski, Rafal; Gackowski, Daniel; Skalska-Bugala, Aleksandra; Starczak, Marta; Siomek-Gorecka, Agnieszka; Zarakowska, Ewelina; Modrzejewska, Martyna; Dziaman, Tomasz; Szpila, Anna; Linowiecka, Kinga; Guz, Jolanta; Szpotan, Justyna; Gawronski, Maciej; Labejszo, Anna; Gackowska, Lidia; Foksinski, Marek; Olinska, Elwira; Wasilow, Aleksandra; Koltan, Andrzej; Styczynski, Jan; Olinski, Ryszard published an article.Synthetic Route of 4433-40-3 The title of the article was The urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response. And the article contained the following:

The active DNA demethylation process may be linked to aberrant methylation and may be involved in leukemogenesis. We investigated the role of epigenetic DNA modifications in childhood acute lymphoblastic leukemia (ALL) diagnostics and therapy monitoring. We analyzed the levels of 5-methyl-2′-deoxycytidine (5-mdC) oxidation products in the cellular DNA and urine of children with ALL (at diagnosis and during chemotherapy, n = 55) using two-dimensional ultra-performance liquid chromatog. with tandem mass spectrometry (2D UPLC-MS/MS). Moreover, the expression of Ten Eleven Translocation enzymes (TETs) at the mRNA and protein levels was determined Addnl., the ascorbate level in the blood plasma was analyzed. Before treatment, the ALL patients had profoundly higher levels of the analyzed modified DNA in their urine than the controls. After chemotherapy, we observed a statistically significant decrease in active demethylation products in urine, with a final level similar to the level characteristic of healthy children. The level of 5-hmdC in the DNA of the leukocytes in blood of the patient group was significantly lower than that of the control group. Our data suggest that urinary excretion of epigenetic DNA modification may be a marker of pediatric ALL status and a reliable marker of chemotherapy response. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Synthetic Route of 4433-40-3

The Article related to urinary excretion dna marker pediatric acute lymphoblastic leukemia chemotherapy, Mammalian Pathological Biochemistry: Respiratory Diseases and other aspects.Synthetic Route of 4433-40-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 31, 2011, Xu, Kefu published a patent.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Synergistic pharmaceutical composition for treating swine streptococcosis and preparation method thereof. And the patent contained the following:

Title pharmaceutical composition is prepared from (by%) amoxicillin 3-10, sulfadiazine sodium 5-15, trimethoprim (TMP) lactate 1-3, sodium carbonate 5, sodium bicarbonate 5-15, paracetamol 5-15, and anhydrous glucose in balance, by mixing for 1 h. In the composition, amoxicillin and sulfadiazine sodium are anti-pathogen constituents, can improve susceptibility of pathogen and reduce probability of drug resistance, and are effective to secondary bacterial infection; TMP lactate has remarkable synergism for amoxicillin and sulfadiazine sodium; sodium carbonate acts as cosolvent; sodium bicarbonate can reduce side effect of sulfadiazine sodium and prevent generation of crystalluria; and paracetamol has fast antifebrile and antiinflammatory effects. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to synergistic pharmaceutical composition swine streptococcosis veterinary preparation, amoxicillin sulfadiazine sodium trimethoprim lactate paracetamol, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2020, Ben Imeddourene, A.; Zargarian, L.; Buckle, M.; Hartmann, B.; Mauffret, O. published an article.Application of 65-71-4 The title of the article was Slow motions in A·T rich DNA sequence. And the article contained the following:

In free B-DNA, slow (microsecond-to-millisecond) motions that involve equilibrium between Watson-Crick (WC) and Hoogsteen (HG) base-pairing expand the DNA dynamic repertoire that could mediate DNA-protein assemblies. R1ρ relaxation dispersion NMR methods are powerful tools to capture such slow conformational exchanges in solution using 13C/15N labeled DNA. Here, these approaches were applied to a dodecamer containing a TTAAA element that was assumed to facilitate nucleosome formation. NMR data and inferred exchange parameters assign HG base pairs as the minor, transient conformers specifically observed in three successive A·T base pairs forming the TAA·TTA segment. The abundance of these HG A·T base pairs can be up to 1.2% which is high compared to what has previously been observed Data analyzes support a scenario in which the three adenines undergo non-simultaneous motions despite their spatial proximity, thus optimizing the probability of having one HG base pair in the TAA·TTA segment. Finally, revisiting previous NMR data on H2 resonance linewidths on the basis of our results promotes the idea of there being a special propensity of A·T base pairs in TAA·TTA tracts to adopt HG pairing. In summary, this study provides an example of a DNA functional element submitted to slow conformational exchange. More generally, it strengthens the importance of the role of the DNA sequence in modulating its dynamics, over a nano- to milli-second time scale. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Application of 65-71-4

The Article related to slow motion dna sequence a t protein base pair, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Application of 65-71-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia