Pyrimidines

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. 2380-63-4

Example 1 : Preparation of 3-iodo-lH-pyrazolor3.4-dlpyrimidin-4-amine (Formula III, when X is iodine) A mixture of lH-pyrazolo[3,4-d]pyrimidin-4-amine (Formula II, 20 g), N- iodosuccinimide (41.6 g), and dimethylformamide (300 mL) was stirred at 75C to 80C for 16 hours. Water (1 L) was added to the reaction mixture, and then the mixture was stirred at 15C for 4 hours. The solid obtained was filtered, then washed with water (100 mL), and then washed with cold ethanol (60 mL). The resulting solid was dried at 45C under vacuum for 16 hours to obtain the title compound. Yield: 26.8 g

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Patent; SUN PHARMACEUTICAL INDUSTRIES LIMITED; SHARMA, Kapil; THANKI, Bhavin Prabhudas; KHANNA, Mahavir, Singh; PRASAD, Mohan; (23 pag.)WO2016/151438; (2016); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate. This compound has unique chemical properties. The synthetic route is as follows. 2244-11-3

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds. 5.1.2.1 5-[2-(3′-Nitrobiphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (7) 64% Yield, mp 246-8 C 1H NMR delta 11.46 (s, 2H, NH), 8.51 (s, 1H), 8.21-8.29 (m, 2H), 8.09 (d, 2H, Jo = 8.1), 7.96 (d, 2H, Jo = 8.1), 7.79 (t, 1H, Jo = 8.1), 7.33 (s, 1H, OH), 3.95 (s, 2H). Anal. % (C18H13N3O7) calculated: C 56.40, H 3.42, N 10.96; found C 56.28, H 3.37, N 10.68.

Statistics shows that 2244-11-3 is playing an increasingly important role. we look forward to future research findings about Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate.

Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
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Adding a certain compound to certain chemical reactions, such as: 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1780-26-3, blongs to pyrimidines compound. 1780-26-3

Example 9; 4-(l-{ [6-(2-Methoxy-phenyl)-2-methyl-pyrimidin-4-yll-hvdrazono}-ethyl)- phenyll -dimethylamine; Step-1; 4-Chloro-6-hydrazino-2-methylpyrimidine; To a solution of 4,6-dichloro-2-methylpyrimidine (1Og, 0.061 mo 1) in dry THF (500ml) was added anhydrous hydrazine (1.96g, 0.06 lmol) followed by potassium carbonate (12.7g, 0.092mol). The reaction mixture was stirred at room temperature for 13h and filtered. The filtrate was evaporated under reduced pressure to afford 9.3g (45%) of the titled compound as a solid.MP: 164-1720C, MS: Mass found (M+l, 158.9), 1H NMR (CDCl3, 300MHz): delta 2.49(3H, s), 3.05(2H, bs), 6.59(1H, bs), 6.67(1H, s).; Example 27; N-[6-(2-Fluoro-phenyl)-2-methyl-pyrimidin-4-yll-N’-[l-p-tolyl- ethylidenel -hydrazine; Step-1; 4-Chloro-6-hydrazino-2-methylpyrimidine; To a solution of 4,6-dichloro-2-methylpyrimidine (1Og, 0.061 mo 1) in dry THF (500ml) was added anhydrous hydrazine (1.96g, 0.06 lmol) followed by potassium carbonate (12.7g, 0.092mol). The reaction mixture was stirred at room temperature for 13h and filtered. The filtrate was evaporated under reduced pressure to afford 9.3g (45%) of the titled compound as a solid.LCMS: Mass found (M+l, 158.9), MP: Started melting at 1460C and decomposed at 22O0C, 1H NMR (CDCl3, 300MHz): delta 2.49(3H, s), 3.05(2H, bs), 6.59(1H, bs), 6.67(1H, s).

With the rapid development of chemical substances, we look forward to future research findings about 1780-26-3.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2007/65940; (2007); A1;,
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672-45-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 672-45-7, name is 2,4-Dihydroxy-6-trifluoromethylpyrimidine, the common compound, a new synthetic route is introduced below.

SYNTHESIS EXAMPLE 20 (2,4-dinitro-6-trifluoromethylphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione (compound No. 5.65 of this invention) 1.0 g of 6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione was added to 10 ml of dimethylformamide, followed by addition of 0.65 g of sodium hydride (purity: 55%) with stirring at 0 C. The mixed solution was stirred at room temperature for 30 minutes, then cooled to 0 C. and added dropwise with a 5 ml dimethylformamide solution of 1.89 g of 2-chloro-3,5-dinitrobenzotrifluoride. After the solution was further stirred at room temperature for 3 hours, the solvent was distilled away under reduced pressure. After addition of cooled dilute hydrochloric acid thereto, the residue was extracted with 100 ml of ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate and then the solvent was distilled away under reduced pressure to form a crude product. This crude product was recrystallized from a mixed solvent of chloroform and petroleum ether to obtain 0.77 g of the objective compound. M.p.: 219.0~220.5 C. 1 H-NMR (CDCl3 +CD3 OD, TMS, delta ppm): 6.10 (1H,s), 8.78 (1H,d,J=3.0 Hz), 9.08 (1H,d,J=3.0 Hz).

Statistics shows that 672-45-7 is playing an increasingly important role. we look forward to future research findings about 2,4-Dihydroxy-6-trifluoromethylpyrimidine.

Reference:
Patent; Nissan Chemical Industries Ltd.; US5116404; (1992); A;,
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703-95-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 703-95-7, name is 5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below.

General procedure: To an ice-cooled solution of amine (1.0 mmol) in DMF were added Boc-AA-OH or carboxylic acid (1.0 mmol), followed by EDC*HCl (1.2 mmol), HOBt*H2O (1.2 mmol) and Et3N (1.2 mmol) were then added. The reaction mixture was stirred for 12 h at room temperature. After removal of the solvent in vacuo, the residue was dissolved in EtOAc (20 mL), extracted with 10% citric acid (aq) (3 ¡Á 5 mL), saturated solution of NaHCO3 (aq) (3 ¡Á 5 mL), and finally washed with brine (1 ¡Á 5 mL), then dried over Na2SO4, and finally evaporated to give the crude product which was further purified by using column chromatography and then subjected to tert-butyloxycarbamate deprotection by using general procedure A. The obtained product was then subjected to the next step or purified by using preparative HPLC in the case of target compounds. Purified target compounds were immediately lyophilized to afford their respective amorphous powders.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 703-95-7, 5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tagad, Harichandra D.; Hamada, Yoshio; Nguyen, Jeffrey-Tri; Hidaka, Koushi; Hamada, Takashi; Sohma, Youhei; Kimura, Tooru; Kiso, Yoshiaki; Bioorganic and Medicinal Chemistry; vol. 19; 17; (2011); p. 5238 – 5246;,
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A common compound: 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine,molecular formula is C5H5N5, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 2380-63-4

Compound C (2.367 g, 17.5 mmol) and N-iodosuccinimide (4.810 g, 21.4 mmol) were added to dimethylformamide (60 mL) and stirred at 50C for 24 hours. Another batch of N-iodosuccinimide (0.871 g, 3.8 mmol) was added to the reaction mixture and was allowed to stir for an additional 24 hours. The reaction mixture was cooled to room temperature and water (100 mL) was added, forming a precipitate that was collected by filtration to yield D (4.1 g, 89%). lR NMR (DMSO- d6, 300 MHz) delta 8.18 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 2380-63-4.

Reference:
Patent; UNIVERSITY OF WASHINGTON; VAN VOORHIS, Wesley, C.; HOL, Wilhelmus, G.J.; LARSON, Eric, T.; MALY, Dustin, James; MERRITT, Ethan; OJO, Kayode, K.; WO2011/94628; (2011); A1;,
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720-01-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 720-01-4, name is Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate, molecular formula is C8H6ClF3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of ethyl-4-chloro-2-(trifluoromethyl)pyrimidin-5-carboxylate (24) (510 mg, 2.0 mmol) in DCM (10 ml_) at 0C was added diisobutylaluminum hydride (1 M solution in toluene) (6.0 ml_, 6.0 mmol). The mixture was slowly allowed to warm to room temperature and was stirred overnight. The reaction mixture was quenched with sat. aq. Rochelle’s salt and stirred for 30 min before concentrating down the solution. The product was then extracted into EtOAc (3 x 30 ml_) and the combined organic layers were washed with brine (50 ml_), dried (MgS04) and solvent evaporated to leave a clear oil. The crude was purified by column chromatography (S1O2, 10 g, gradient elution 10% EtOAc in petrol to 50% EtOAc in petrol). The desired fractions were concentrated under reduced pressure to afford the title compound as a yellow oil (96 mg, 23%); 1H NMR (500 MHz, Chloroform- d) d 9.01 (s, 1 H), 4.92 (s, 2H); LCMS (4 minute method) product at Rt = 0.44 min and ES+ m/z the desired mass ion was not observed.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 720-01-4, Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE UNIVERSITY OF SUSSEX; CARDIFF UNIVERSITY; UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED; WARD, Simon; BESWICK, Paul; PENNICOTT, Lewis; REUILLON, Tristan; CHUCKOWREE, Irina; VILLALONGA-BARBER, Carolina; PORTER, Roderick, Alan; (120 pag.)WO2019/166822; (2019); A1;,
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65-71-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65-71-4, name is 5-Methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

Was added to the reactor5-methylthymidine20-2 (0.530 g, 4.2 mmol),Compound 21-1 (0.328 g, 1.4 mmol) and40 ml of anhydrous acetonitrile, argon was added dropwise to the solution at room temperatureBis (trimethylsilyl) acetamide(2.2 mL, 8.7 mmol),After stirring for 3 hours, the temperature was lowered to -30 C,To the system was added trimethylsilyl trifluoromethanesulfonate (1 mL, 5.6 mmol)Stir at room temperature, TLC followed the reaction.The reaction product was added with dichloromethane,The organic layers were washed with saturated sodium bicarbonate solution, water and saturated brine, respectively,Dried, concentrated, column chromatography (MeOH: CHCl3 = 3: 100)And purified to give the title product 21-2 (yield 70%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 65-71-4, 5-Methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Soochow University (Suzhou); Zou Jianping; Zhang Peizhi; Li Jianan; (13 pag.)CN106496130; (2017); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1193-24-4, name is 4,6-Dihydroxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 1193-24-4

Example 15A 5-(4-Methoxyphenyl)furo[2,3-d]pyrimidin-4(3H)-one Analogously to a literature procedure [D. Dauzonne, Tetrahedron, 1992, 3069-3080], a suspension of 10.1 g (47.4 mmol) of 1-[(Z)-2-chloro-2-nitrovinyl]-4-methoxybenzene and 5.8 g (52.2 mmol) of 4,6-dihydroxypyrimidine in 200 ml of ethanol is stirred at 85 C. for ten minutes. 15.6 ml (15.9 g, 104.3 mmol) of 1,8-diazabicyclo[5.4.0]undec-7-ene are then added slowly. The mixture is stirred at this temperature for 15 h and then concentrated under reduced pressure. The residue is taken up in dichloromethane and chromatographed on silica gel (mobile phase: dichloromethane/methanol 95:5). The solid obtained is triturated with acetonitrile and filtered. This gives 2.3 g (20% of theory) of the target product. LC-MS (method 3): Rt=1.57 min.; m/z=290 (M+H)+ 1H-NMR (400 MHz, CDCl3): delta=12.66 (s, NH), 8.15 (s, 1H), 8.14 (s, 1H), 7.92 (d, 2H), 6.98 (d, 2H), 3.79 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1193-24-4, 4,6-Dihydroxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/166163; (2011); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32779-36-5, name is 5-Bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below., 32779-36-5

To a solution of 5-bromo-2-chloropyrimidine (4 g, 20.68 mmol) in acetonitrile (40 mL) was added 2-methoxyethanamine (5.5 mL, 63 mmol) and potassium carbonate (14 g, 100 mmol) . The mixture was heated at 100 and stirred for 6 h. The reaction mixture was concentrated to remove solvent. The residue was diluted with water (30 mL) . The resulting mixture was extracted with DCM (50 mL ¡Á 3) . The combined organic layers were dried over anhydrous Na2SO4and concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with PE/EtOAc (v/v) 9/1 to give a colorless oily product (4.43 g, 92.3) .[1798]MS (ESI, pos. ion) m/z: 233.2 [M+1]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,32779-36-5, 5-Bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHANG, Yingjun; CHENG, Changchung; HUANG, Jiuzhong; BAI, Shun; REN, Xingye; LI, Zhi; ZHOU, Youbai; (368 pag.)WO2016/615; (2016); A1;,
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