Pyrimidines

90213-66-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2,4-dichloro-7H-pyrrolo[2,3-djpyrimidine 34 (237 mg, 1.26 mmol) in CH3CN (1 mL) was added NaH (33.3 mg, 1.39 mmol) portion- wise at 0 C. The reaction mixture was stirred at room temperature for 20 mm until gas evolution was ceased. Methyl iodide (86.4 i.il, 1.39 mmol) was added and stirred the reaction mixture for 1 h at room temperature. To the reaction mixture was added water and extracted with ethyl acetate (2 x 30 mL). The combined organic layers were dried over Mg504, and then concentrated under vacuum. The resultant crude residue was purified by silica-gel column chromatography to afford 35 (144 mg, 58%) as white solid. ?H-NMR (400 MHz, DMSO-d6) oe 7.76 (d, J = 3.6 Hz, 1H), 6.71 (d, J = 3.6 Hz, 1H), 3.81 (s, 3H); MS: (m/z) [M+Hjb 204.02.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90213-66-4, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY; TSANTRIZOS, Youla S.; SEBAG, Michael; (120 pag.)WO2018/137036; (2018); A1;,
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156-83-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 156-83-2, name is 6-Chloropyrimidine-2,4-diamine, molecular formula is C4H5ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of NaH (2.77 g, 69.2 mmol) in ethanol (150 ml) was added 2,6-diamino-4-chloropyrimidine (5.0 g, 34.6 mmol). The mixture was refluxed for 6 h. After cooling, the solution was neutralized with a 5-6 N HCl solution in isopropyl alcohol. After removing the solvents in vacuo, the residue was purified by chromatography on silica gel (CH2Cl2/MeOH 40:1), yielding the title compound as a white solid (4.0 g, 75%). Mp 164-165 C. 1H NMR (300 MHz, DMSO, 25 C): delta = 6.00 (s, 2H, NH2), 5.88 (s, 2H, NH2), 5.03 (s, 1H, CH), 4.13 (q, J = 7.1 Hz, 2H, CH2), 1.22 (t, J = 7.1 Hz, 3H, CH3) ppm. 13C NMR (75 MHz, DMSO, 25 C): delta = 170.0, 165.9, 162.9, 76.1, 60.2, 14.7 ppm. HRMS: calcd for C6H11N4O [M+H]+ 155.09329, found 155.09260.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 156-83-2, 6-Chloropyrimidine-2,4-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jang, Mi-Yeon; Jonghe, Steven De; Segers, Kenneth; Anne, Jozef; Herdewijn, Piet; Bioorganic and Medicinal Chemistry; vol. 19; 1; (2011); p. 702 – 714;,
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109-12-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-12-6, name is Pyrimidin-2-amine, the common compound, a new synthetic route is introduced below.

General procedure: 0.5 mol% ruthenium(II) catalyst was stirred with 4 mmol ofKOH in toluene. To this mixture, 2 mmol of alcohol and 2 mmolof amine were added and the temperature was raised up to120 C. The progress of the reactions was monitored using TLC.As soon as the reaction was completed, the mixture was cooledto room temperature and added 3 mL of distilled water. The combinedmixture was extracted with CH2Cl2 and dried by addingmagnesium sulfate. The crude product was purified by columnchromatography (n-hexane/EtOAc) and characterized by 1H NMRspectral analyses. The 1H NMR data obtained for the catalytic productswere compared with literature [19].

Statistics shows that 109-12-6 is playing an increasingly important role. we look forward to future research findings about Pyrimidin-2-amine.

Reference:
Article; Prakash, Govindan; Ramachandran, Rangasamy; Nirmala, Muthukumaran; Viswanathamurthi, Periasamy; Sanmartin, Jesus; Inorganica Chimica Acta; vol. 427; (2015); p. 203 – 210;,
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1780-26-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1780-26-3 as follows.

Into clean and dry 5.0 L 4-neck RB flask charged 2-amino-N-(2-chloro-6-methyl (0125) phenyl)-5-thiazole-l-carboxamide (200gm), 4,6-dichloro-2-methyl (0126) pyrimidine(146 g), 2.0 L of THF under nitrogen atmosphere. Clear solution (0127) formation was observed, cooled the reaction mass to temperature 10-20C, added (0128) 30% sodium -t-butoxide (845gm) solution to the reaction mass over a period of 60- (0129) 75min at temperature 10-20C. Brown coloured solution formation was observed. (0130) Reaction mass temperature was raised to 25-30C and maintained the reaction (0131) mass temperature to 25-30C for 90-120 min, cooled the mass to temperature 0- (0132) 5C and added 2N HCl solution to the reaction mass over a period of 60-90min at 0-5C and maintained for 105-120min. Transferred the reaction mass into a buchner funnel and flask kept under plant vacuum. Washed the wet cake with 600.0mlof water.Suck dried thoroughly for 45-60 mi and dried the wet material in a drier at temperature 60-65 C for 8-10hrs. (0133) Weight: 210 gm

The chemical industry reduces the impact on the environment during synthesis 1780-26-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NATCO PHARMA LIMITED; KONAKANCHI, Durga Prasad; GONGALLA, Buchappa; KOTRA, Uma Naresh Babu; SAKKANI, Srinivasulu; RAGIDI, Dharmender; SIKHA, Kotayyababu; NANNAPANENI, Venkaiah Chowdary; (18 pag.)WO2018/100585; (2018); A1;,
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109-12-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-12-6, name is Pyrimidin-2-amine, molecular formula is C4H5N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1), weighing 1.008g 2-amino pyrimidine (10.6mmol), 1.480g chloro acetyl chloride (13.1mmol), 1.779g potassium carbonate (12.9mmol) and 13 ml dichloromethane;(2), will step one (1) weighed in 2-amino pyrimidine, potassium carbonate and two-thirds the volume of dichloromethane (about 9 ml) with nitrogen protection device is of the three-port flask, in 0 C under the condition of stirring to dissolve;(3), will step one (1) weighed chloroacetic chloride in and the remaining dichloromethane (about 4 ml) in the constant voltage dropping funnel, then with a constant acceleration of 0.25 ml/min into the three-port flask, 20 min the completion of the dropping, the continued after dropping 0 C stirring reaction under the conditions of 3h, obtaining a reaction product;(4), using vacuum filtration device, step a (3) in the obtained after filtering the reaction product is the reaction product of in addition to the solvent, each with 10 ml deionized water washing the product, washing a total of 5 times, at a temperature of 45 C the product under the conditions of drying, drying time is 5h, the lime-green powdery solid, lime-green powdery solid is acetyl-2-amino pyrimidine, weighing mass is 1.550g, yield 85.22%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-12-6, Pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Qiqihar University; Wang, Liyan; Liu, Shifu; Tian, Ying; He, Xianyou; Zhang, Hui; (10 pag.)CN105906572; (2016); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 147118-37-4, name is N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide. A new synthetic method of this compound is introduced below., 147118-37-4

EXAMPLES Preparation of rosuvastatin (+)- (3R, 5S)-7- [4- (4-FLUOROPHENYL)-6-ISOPROPYL-2- (N-METHYL-N-METHANESULFONYLAMINO) PYRIMIDIN-5-YL]-3, 5-DIHYDROXY-6 (E) -heptenoic acid calcium salt (2: 1). EXAMPLE 1 Step A Preparation of condensed product N- [5- [- (TERT-BUTYL-DIMETHYL-SILANYLOXY)-6- CYANO-3-OXO-HEX-1-ENYL]-4- (4-FLUOROPHENYL)-6-ISOPROPYL-PYRIMIDIN-2-YL]-N- METHYL-METHANESULFONAMIDE (Condensed product, Formula IV) To a solution of pyrimidine aldehyde (1. 0GM) of Formula III in toluene (20MOI), 1-cyano (2S)-2-[(TERT-BUTYIDIMETHYLSILYL) OXY]-5-OXO-6-TRIPHENYLPHOSPHANYLIDENE hexanenitrile of formula 11 was added and the reaction mixture was REFLUXED for about 24 hours. The reaction mixture was concentrated and the residue titurated with cyclohexane (50ML). The cyclohexane layer was concentrated to give a residue which was purified by silica gel chromatography, eluted with toluene to obtain 1.60gm of the condensed product as a thick oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147118-37-4, N-(4-(4-Fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide, and friends who are interested can also refer to it.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2004/52867; (2004); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below., 56-09-7

1.1 Preparation of 2-Amino-4,6-dichloro-5-pyrimidine Carbaldehyde Phosphorus oxychloride (21.6 ml; 0.236 mol) was cooled in an ice-bath (~5 C.) before slow addition of dry N,N-dimethylformamide (DMF, 7.0 ml) over 15 mins. No precipitate occurred as previously reported, and the reaction mixture was removed from the ice-bath. Commercially available 2-Amino-4,6-dihydroxypyrimidine (5.6 g; 0.044 mol) was added in small portions over 30 mins. The resulting suspension was heated at 90 C. for 1 h, then at 105 C. for a further 5 h. forming a red-brown solution which was chilled at 4 C. overnight. Distillation of 3-4 ml of excess phosphorus oxychloride at atmospheric pressure produced a viscous suspension which was poured into ice-water (100 ml). A gum formed which dissolved as the temperature of the water increased to 20 C. Ammonium hydroxide was added dropwise until the solution reached pH 7 and a yellow precipitate formed which was collected by filtration. The product was recrystallized from ethyl acetate (5.15 g; 0.027 mol; 61%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; Cancer Research Campaign Technology Limited; US6677345; (2004); B1;,
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108-79-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108-79-2, name is 4,6-Dimethylpyrimidin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

Example 246 Methyl-phenyl-carbamic Acid 4,6-dimethyl-pyrimidin-2-yl Ester A solution of 4,6-dimethyl-2-hydroxypyrimidine (0.37 g, 3.00 mmol)), 1-methyl-3-(methyl-phenyl-carbamoyl)-3H-imidazol-1-ium iodide (1.03 g, 3.00 mmol) and triethylamine (0.42 ml, 3.00 mmol) in acetonitrile (15 ml) was stirred at room temperature for 18 hours. The solvent was evaporated in vacuo and the residue was purified by flash column chromatography (SiO2, ethyl acetate:heptane (50:50)) yielding the title compound (0.46 g, 60% yield) as a white solid. 1H NMR (300 MHz, CDCl3): delta 2.48 (s, 6H), 3.43 (br.s, 3H), 6.92 (br.s, 1H), 7.22 (m, 1H), 7.37 (m, 4H); HPLC-MS (Method A): m/z=258 (M+H); Rt=2.77 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 108-79-2, 4,6-Dimethylpyrimidin-2(1H)-one.

Reference:
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 302964-08-5, blongs to pyrimidines compound. 302964-08-5

To the stirred suspension of compound 5 (10.0 g, 0.03 mol), in n-pentanol (120.0 mL) was added N-Boc piperazine(9.5g, 0.05 mol)) and N,N-diisopropylethylamine (DIPEA) (6.6 g, 0.06 mol) and refluxed for 8h, cooled to 25-30C and charged water (80.0 mL). The precipitated solid was collected by vacuum filtration and washed the wet cake with n-pentanol (15.0 mL) followed by water (30.0 mL), yielded the intermediate 3 (11.6 g, 84%) as off white solid.MR: 293-295C; IR (KBr, cm-1): 3397.4 (N-H), 3061.7 (Ar C-H), 1617.0 (amide C=O); 1706.9 ( Boc C=O); 1HNMR spectrum (400 MHz, DMSO-d6), delta, ppm (J, Hz): 11.53 (bs, 1H, thiazole-NH), 9.89 (s, 1H, amide-NH), 8.23(s, 1H, thiazole-H), 7.40 (d, 1H, J =6.9, Ar-H), 7.30-7.23 (m, 2H, Ar-H), 6.06 (s, 1H, pyrimidine-H), 3.53 (bs, 4H,4piperazine-CH2), 3.42 (bs, 4H, piperazine-CH2), 2.42 (s, 3H, Ar-CH3), 2.24 (s, 3H, pyrimidine-CH3), 1.40 (s, 9H,Boc-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), delta, ppm: 165.2 (pyrimidine-C), 162.4 (pyrimidine-C), 161.9(pyrimidine-C), 160.1 (amide-C), 156.9 (thiazole-C), 151.4 (Boc-C), 140.5 (Ar-C), 139.1 (thiazole-C), 133.7(thiazole-C), 132.0 (Ar-C), 129.5 (Ar-C), 128.4 (Ar-C), 127.6 (Ar-C), 125.1 (pyrimidine-C), 81.6 (pyrimidine-C),80.2 (Boc-C), 50.2 (piperazine-2C), 49.9 (piperazine-2C), 29.1 (Boc-CH3), 25.6 (Ar-CH3), 18.2 (pyrimidine-CH3);HPLC Purity 96.7%; MS (ESI) m/z 544.1 [M + H] +; Anal. Calcd % for C25H30ClN7O3S: C 55.19; H 5.56; N 18.02.Found: C 55.07; H 5.41; N 18.17.

With the rapid development of chemical substances, we look forward to future research findings about 302964-08-5.

Reference:
Article; Suresh, Garbapu; Nadh, Ratnakaram Venkata; Srinivasu, Navuluri; Yennity, Durgaprasad; Synthetic Communications; vol. 47; 17; (2017); p. 1610 – 1621;,
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Adding a certain compound to certain chemical reactions, such as: 1004-38-2, 2,4,6-Triaminopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-38-2, blongs to pyrimidines compound. 1004-38-2

General procedure: A 10 mL Schlenk tube was charged with III (0.0174 g, 0.01 mmol), N,N’-diisopropylcarbodiimide (0.504 g, 4 mmol), and 1,4-diaminobenzene (0.216 g, 2 mol) under dried argon. The resulting mixture was stirred at 25 C for 2 h. The reaction mixture was extracted with ether and filtered to give a clean solution. After removing the solvent under vacuum, the residue was recrystallized in ether to provide a white solid 25 in 99% yield.

With the rapid development of chemical substances, we look forward to future research findings about 1004-38-2.

Reference:
Article; Zhang, Xingmin; Wang, Chuanyong; Qian, Cunwei; Han, Fubin; Xu, Fan; Shen, Qi; Tetrahedron; vol. 67; 45; (2011); p. 8790 – 8799;,
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