Pyrimidines

Related Products of 130645-48-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130645-48-6, name is 2-Bromo-4-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

PREPARATION EXAMPLE 54 Synthesis of 4-methyl-2-(3,4,5-Trimethoxyphenyl)-pyrimidine 2-Bromo-4-methylpyrimidine (1.5 g) and 3,4,5-trimethoxyphenylboronic acid (1.83 g) were reacted in the same manner as in Preparation Example 1 to obtain the title compound. Yield: 1.49 g (67%). 1H-NMR (400 MHz, CDCl3) delta: 2.57 (s, 3H), 3.92 (s, 3H), 3.99 (s, 6H), 7.01 (d, 1H, J=5.1 Hz), 7.77 (s, 2H), 8.61 (d, 1H, J=5.1 Hz).

According to the analysis of related databases, 130645-48-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kowa Co., Ltd.; US6509329; (2003); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 851984-15-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.851984-15-1, name is 6-Chloro-5-fluoropyrimidin-4-amine, molecular formula is C4H3ClFN3, molecular weight is 147.54, as common compound, the synthetic route is as follows.

To a solution of trans-3 -((3 -chloro-S-(trifluoromethyl)phenyl)amino) -2-oxo- [1,3 ?-bipiperidine] -4?-carboxamide 13 (42 mg, 0.10 mmol, 1.0 equiv) in 1-butanol (2 mL), 6-chloro-S-fluoropyrimidin-4-amine (18 mg, 0.12 mmol, 1.2 equiv) was added DIPEA (26 mg, 0.20 mmol, 2.0 equiv). The reaction solution was stirred at 120 C for 16 h. The mixture was diluted with EtOAc (20 mL), washed with H20 (10 mL) and brine (10 mL), dried (Na2504), filtered, and concentrated in vacuo. The crude was by purified by pre-HPLC (MeOHIH2O with 0.05% TFA as mobile phase) to give the compound (trans)- 1 ?-(6-amino-S -fluoropyrimidin-4-yl)-3 -((3 -chloro-S – (trifluoromethyl)phenyl)amino)-2-oxo-[ 1,3 ?-bipiperidine] -4?-carboxamide 14 (44 mg, yield:83%) as a yellow solid. ESI-MS (M+H) : 530.0. HPLC: (214 nm: 100%, 254 nm: 100%). ?H NMR (400 MHz, CD3OD) 5: 7.97 (s, 1H), 6.84 (s, 1H), 6.81 (s, 1H), 6.76 (s, 1H), 4.58-4.52 (m, 2H), 4.09-4.03 (m, 1H), 3.52-3.35 (m, 3H), 3.29-3.27 (m, 4H), 3.12-3.05 (m, 1H), 2.24-2.17 (m,1H), 2.02-1.91 (m, 3H), 1.80-1.63 (m, 2H).

Statistics shows that 851984-15-1 is playing an increasingly important role. we look forward to future research findings about 6-Chloro-5-fluoropyrimidin-4-amine.

Reference:
Patent; BIOGEN MA INC.; SUNESIS PHARMACEUTICALS, INC.; MACPHEE, J. Michael; NEUMAN, Linda L.; (89 pag.)WO2018/17153; (2018); A1;,
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Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. name: 6-Aminopyrimidine-2,4(1H,3H)-dione

To a suspended solution of 6-aminouracil (12.7 g, 100 mmol) and sodium acetate (8.2 g, 100 mmol) in H20 (100 mL) at a temperature of 70-75 ¡ãC was added a solution of chloroacetaldehyde (50percent in water, 23.6 g, 150 mmol). The resulting reaction mixture was stirred at 80 ¡ãC for 20 mm and then cooled to room temperature. The resulting solid was collected by filtration, washed with water and acetone, and dried in vacuo to give the title compound as a light-brown solid (14.74 g, 98percent yield). ?HNMR(DMSO-d6, 400 MHz) 11.38 (br, 1H), 11.10 (br, 1H), 10.46 (s, 1H), 6.53 (s, 1H), 6.18 (s, 1H), MS m/z 152.43 [M+1].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael, S.; HATCHER, John; CHOI, Hwan, Geun; (198 pag.)WO2016/130920; (2016); A2;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18740-38-0, name is Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, molecular formula is C6H4N2O2S, molecular weight is 168.1732, as common compound, the synthetic route is as follows.Recommanded Product: Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

3 g (0.018 mol) of the intermediate lib was placed in a 100 mL three-necked flask,30 mL (0.329 mol) of phosphorus oxychloride was slowly added dropwise,After 30 min addition, 2 drops of DMF were added to the reaction mixture and the reaction was heated to reflux for 8 h. The reaction was poured into 1000 g of ice water with stirring, and a large amount of orange-colored solid was precipitated. The filter cake was washed with a large amount of water and dried at 45 C for 24 hours to obtain 1.8 g of an orange solid in a yield of 49%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18740-38-0, Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; Jiangxi science and technology Normal University; Zhu, wufu; Zheng, PengWu; Chen, Chen; Xu, Yuan; Sun, chengyu; Wu, Chunjiang; Tu, Qidong; (22 pag.)CN103980287; (2016); B;,
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Application of 24415-66-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 24415-66-5 as follows.

The preparation method of the compound e30 comprises the steps of: taking about 1 mmol of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine and about 3 mmol.6-Methyl-1H-indole was added to a 10 mL microwave reaction tube.Further, 2 mL of hexafluoroisopropanol solvent and about 0.1 mmol of bistrifluoromethanesulfonimide catalyst were added, sealed and heated to 100 C with stirring and reacted for about 6 h.Then, the reaction system was monitored by TLC, and after the reaction system was cooled to room temperature, it was separated and purified by column chromatography to obtain pure compound e30.The compound e30 is a yellow solid with a yield of 63%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,24415-66-5, its application will become more common.

Reference:
Patent; Zhengzhou University; Liu Hongmin; Yu Bin; Zheng Yichao; Yuan Shuo; Shen Dandan; (27 pag.)CN109020976; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.32779-36-5, name is 5-Bromo-2-chloropyrimidine, molecular formula is C4H2BrClN2, molecular weight is 193.4291, as common compound, the synthetic route is as follows.Recommanded Product: 32779-36-5

Reference example 77; (1); To 5-bromo-2-chloropyrimidine 2.90g, 1-tert-butoxycarbonylpiperazine 4.19g in 1,4-dioxane 70ml was added potassium carbonate 3.73g, and the mixture was stirred under reflux for 1.5 hours. Thereto was added water and the mixture was extracted with diethyl ether twice. The combined organic layer was dried and the solvent was removed and purified with silica gel column chromatography (hexane:ethyl acetate=15:1?8:1) to give compound (2) (5.09g) as a colorless solid. APCI-MS (m/e): 343/345 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,32779-36-5, 5-Bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP1956009; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 62802-42-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62802-42-0, name is 2-Chloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: (0552) To 2-chloro-5-fluoropyrimidine (2 g, 15 mmol) in a 250-mL round bottom flask was added DMA (8 mL), tris(dibenzylideneacetone)dipalladium (0.544 g, 0.6 mmol), 1,1?-bis(diphenylphosphino)ferrocene (0.67 g, 1.2 mmol), zinc cyanide (1.15 g, 9.8 mmol), and zinc dust (0.237 g, 3.62 mmol). The flask was capped, flushed with nitrogen, and stirred for 2.5 h at 100 C. The reaction was cooled to room temperature, filtered through celite, and washed with DCM. The filtrate was poured into water and extracted with DCM. The combined organic layers were dried (MgSO4), filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (0-10% EtOAc/hexanes over 20 minutes) to provide the nitrile compound (0.58 g, 31%).

According to the analysis of related databases, 62802-42-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; Scott, Jack D.; Stamford, Andrew W.; Gilbert, Eric J.; Cumming, Jared N.; Iserloh, Ulrich; Misiaszek, Jeffrey A.; Li, Guoqing; US2015/307465; (2015); A1;,
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Pyrimidine – Wikipedia

Application of 29274-24-6 ,Some common heterocyclic compound, 29274-24-6, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

N-Iodosuccinimide (1.61 g, 7.16 mmol) was added to a solutionof 5-chloropyrazolo[1,5-a]pyrimidine (7) (1 g, 6.51 mmol) in anhydrousDMF (10 mL). After stirring at RT for 4 h the reaction was poured into 10% sodium thiosulfate (75 mL). The resulting precipitate was isolated via filtration and dried (Whatman PS1 filterpaper) to give 19 as a pale brown solid (1.62 g, 89%). 1H NMR deltaH (d6-DMSO, 300 MHz), 9.19 (d, J 7.2, 1H), 8.38 (s, 1H), 7.18 (d, J7.2, 1H). LC-MS tR 6.37 min; LC254 99%; m/z 280.1/282.0 [M+H].This was used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,29274-24-6, its application will become more common.

Reference:
Article; Phillipson, Louisa J.; Segal, David H.; Nero, Tracy L.; Parker, Michael W.; Wan, Soo San; De Silva, Melanie; Guthridge, Mark A.; Wei, Andrew H.; Burns, Christopher J.; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6280 – 6296;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 582313-57-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 582313-57-3 as follows.

This compound is synthesized using a procedure such as that described by ?.Vorbruggen and U. Niedballa in J. Org. Chem., 39: 3654-3660 (1974). The 4-chloro-5-fluoro-7H- pyrrolo[2,3-d]pyrimidine (1?) used in this transformation is prepared following the procedure described by A. B. Eldrup, et al. in J. Med. Chem.. 47: 5284 (2004).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,582313-57-3, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2006/65335; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 85979-59-5, Adding some certain compound to certain chemical reactions, such as: 85979-59-5, name is 2-Chloro-4-(4-fluoro-phenyl)-pyrimidine,molecular formula is C10H6ClFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 85979-59-5.

To a solution of 68 (109 mg, 0.25 mmol) and 2-chloro-4-phenylpyrimidine (77 mg,0.37 mmol) in t-BuOH (3 mL) was added conc. HCI (0.25 mL). The reaction was heatedat 80 C for 8 hours before concentrated under reduced pressure. The residue was dissolved in CH3CN and basified with Et3N. The resulting solution was purified by reverse prep-HPLC and then silica gel prep-TLC to give 3-((4-(4-fluorophenyl)pyrimidin- 2-yl)amino)-4-methyl-N-(3-(4-methyl-1 H-imidazol-1 -yl)-5-(4-methylpiperazin-1 -yl)phenyl)benzenesulfonamide (21 mg, 14%) as an off-white solid.

According to the analysis of related databases, 85979-59-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CARDIO THERAPEUTICS PTY LTD; TREUTLEIN, Herbert; ZENG, Jun; DIXON, Ian; JAMES, Ian; PALMER, James T; (169 pag.)WO2018/165718; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia